Automatically Extracting Structured Information from Biomedical Text University of Texas at Austin
... Immobilized, recombinant cyclins A and D1 were found to associate with cellular proteins in complexes that contain the p105Rb protein. This study identifies several common aspects of cyclin biochemistry, including tyrosine phosphorylation and the potential to interact directly or indirectly with the ...
... Immobilized, recombinant cyclins A and D1 were found to associate with cellular proteins in complexes that contain the p105Rb protein. This study identifies several common aspects of cyclin biochemistry, including tyrosine phosphorylation and the potential to interact directly or indirectly with the ...
HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated
... more strongly expressed in HeLa cells transfected with rHAUSP (C224S) than with rHAUSP (Fig. 2C). Transfection of pcDNA3-myc-rHAUSP (C224S) leads to cell death of HeLa cells which they died faster than HeLa cells transfected with pcDNA3-myc-rHAUSP. It has been reported that HAUSP affected p53-mediat ...
... more strongly expressed in HeLa cells transfected with rHAUSP (C224S) than with rHAUSP (Fig. 2C). Transfection of pcDNA3-myc-rHAUSP (C224S) leads to cell death of HeLa cells which they died faster than HeLa cells transfected with pcDNA3-myc-rHAUSP. It has been reported that HAUSP affected p53-mediat ...
Outer dense fibre protein 2 (ODF2) is a self
... few have been identified. ODF2 proteins consist of about 590 amino acids with a deduced molecular mass of about 70 kDa (Brohmann et al., 1997; Hoyer-Fender et al., 1998; Petersen et al., 1999). In the C-terminal region (at amino acid positions 392-413 and 530-551 of rat ODF2) two leucine zipper moti ...
... few have been identified. ODF2 proteins consist of about 590 amino acids with a deduced molecular mass of about 70 kDa (Brohmann et al., 1997; Hoyer-Fender et al., 1998; Petersen et al., 1999). In the C-terminal region (at amino acid positions 392-413 and 530-551 of rat ODF2) two leucine zipper moti ...
Diversity of heterotrimeric G-protein γ subunits in plants | SpringerLink
... Background: Heterotrimeric G-proteins, consisting of three subunits Gα, Gβ and Gγ are present in most eukaryotes and mediate signaling in numerous biological processes. In plants, Gγ subunits were shown to provide functional selectivity to G-proteins. Three unconventional Gγ subunits were recently r ...
... Background: Heterotrimeric G-proteins, consisting of three subunits Gα, Gβ and Gγ are present in most eukaryotes and mediate signaling in numerous biological processes. In plants, Gγ subunits were shown to provide functional selectivity to G-proteins. Three unconventional Gγ subunits were recently r ...
Document
... The required signal sequence for a protein to enter the ER is 15– 30 N-terminal amino acids. As the signal sequence is produced by translation, it is bound by a signal recognition particle (SRP) composed of RNA and protein. The SRP suspends translation until the complex binds a docking protein on th ...
... The required signal sequence for a protein to enter the ER is 15– 30 N-terminal amino acids. As the signal sequence is produced by translation, it is bound by a signal recognition particle (SRP) composed of RNA and protein. The SRP suspends translation until the complex binds a docking protein on th ...
sv-lncs - Department of Computer Science and Engineering
... The Minimum Set Cover Problem, MSC, is the problem of finding the minimum size set of sets whose union is equal to the union of all the sets. We approximate the minimum number of domain pairs, which are needed to explain all the protein interactions read from the training data. A protein interaction ...
... The Minimum Set Cover Problem, MSC, is the problem of finding the minimum size set of sets whose union is equal to the union of all the sets. We approximate the minimum number of domain pairs, which are needed to explain all the protein interactions read from the training data. A protein interaction ...
A novel protein transport system involved in the biogenesis of
... Tat signal peptides is currently unclear. Tat signal peptides undoubtedly act as Tat-speci¢c targeting determinants but could they have additional functions? It is likely that the cell has a mechanism to prevent substrate proteins accessing the Tat pathway until cofactor insertion has been completed ...
... Tat signal peptides is currently unclear. Tat signal peptides undoubtedly act as Tat-speci¢c targeting determinants but could they have additional functions? It is likely that the cell has a mechanism to prevent substrate proteins accessing the Tat pathway until cofactor insertion has been completed ...
Heat shock proteins: the search for functions.
... be ones originally selected as bacterial genes involved in the replication of bacteriophages (23, 24). From studies of these mutants we know that the E. coli HSP70 is the product of the dnaK gene and interacts with lambda phage O and P proteins during phage replication (38). This interaction affects ...
... be ones originally selected as bacterial genes involved in the replication of bacteriophages (23, 24). From studies of these mutants we know that the E. coli HSP70 is the product of the dnaK gene and interacts with lambda phage O and P proteins during phage replication (38). This interaction affects ...
Effect of shRNA knockdown of protein complex subunits on complex
... isomer. We confirm this phenomenon is specific to the Arp complex and validate the effect by SILAC analysis and Western blot analysis. We hypthesize the charge density associated with the TAP tag disrupts complex formation. We plan to validate this hypothesis using SILAC analysis to monitor subunit ...
... isomer. We confirm this phenomenon is specific to the Arp complex and validate the effect by SILAC analysis and Western blot analysis. We hypthesize the charge density associated with the TAP tag disrupts complex formation. We plan to validate this hypothesis using SILAC analysis to monitor subunit ...
Digest Select - Moss Nutrition
... protease, alpha-galactosidase). Enzyme activity is assayed according to current FCC and industry standards, i.e. not less than 85% and not more than 115% of the declared units of enzyme activity. All the microbial enzymes used in Digest Select™ are acid-stable and designed to survive the acidic cond ...
... protease, alpha-galactosidase). Enzyme activity is assayed according to current FCC and industry standards, i.e. not less than 85% and not more than 115% of the declared units of enzyme activity. All the microbial enzymes used in Digest Select™ are acid-stable and designed to survive the acidic cond ...
Biogenesis of photosynthetic complexes in the chloroplast of
... and the novel outer envelope TA protein OEP9 of unknown function (Dhanoa et al., 2010).While in yeast and human only one ARSA-homolog protein is encoded, two and three ARSA genes are present in Chlamydomonas and Arabidopsis, respectively. Different isoforms of ARSA could be required in photosyntheti ...
... and the novel outer envelope TA protein OEP9 of unknown function (Dhanoa et al., 2010).While in yeast and human only one ARSA-homolog protein is encoded, two and three ARSA genes are present in Chlamydomonas and Arabidopsis, respectively. Different isoforms of ARSA could be required in photosyntheti ...
Oligomerization and activation of the FliI ATPase
... energy for assembly at the critical location. Whether this energy is used directly for substrate protein translocation and/or protein unfolding or interaction is not known. Crystal structures of the H. pylori and E. coli hexameric type IV export ATPases (Yeo et al., 2000; Gomis-Ruth et al., 2001) sh ...
... energy for assembly at the critical location. Whether this energy is used directly for substrate protein translocation and/or protein unfolding or interaction is not known. Crystal structures of the H. pylori and E. coli hexameric type IV export ATPases (Yeo et al., 2000; Gomis-Ruth et al., 2001) sh ...
2012 patel DE perox
... the opposite face. When four such helices are linked, the hydrophobic effect drives them to pack against one another, thereby forming a four-helix bundle with non-polar residues pointing toward the protein core, and polar residues exposed to solvent. Several proteins from previously constructed libr ...
... the opposite face. When four such helices are linked, the hydrophobic effect drives them to pack against one another, thereby forming a four-helix bundle with non-polar residues pointing toward the protein core, and polar residues exposed to solvent. Several proteins from previously constructed libr ...
Protein Prenylation: Genes, Enzymes, Targets, and Functions
... by Medical Research Council-Cambridge UK on 11/21/06. For personal use only. ...
... by Medical Research Council-Cambridge UK on 11/21/06. For personal use only. ...
New weapons against inflammation: dual inhibitors of
... biological properties. Lipocortins I and V, as well as rabbit and human uteroglobin, have anti-inflammatory properties that can be explained, at least in part, by their ability to inhibit sPLA2. Human uteroglobin or “Clara Cell 10 kDa protein” is currently in ...
... biological properties. Lipocortins I and V, as well as rabbit and human uteroglobin, have anti-inflammatory properties that can be explained, at least in part, by their ability to inhibit sPLA2. Human uteroglobin or “Clara Cell 10 kDa protein” is currently in ...
University of Birmingham Armadillo repeat proteins: beyond the
... and this interaction is required for microtubule clustering [36]. Notably, a null mutant in the Dictyostelium Smg-GDS homologue is defective in chemotaxis and aggregation, although the mechanism underlying this defect is unclear [37]. Cytoskeletal functions of b-catenin and related proteins The firs ...
... and this interaction is required for microtubule clustering [36]. Notably, a null mutant in the Dictyostelium Smg-GDS homologue is defective in chemotaxis and aggregation, although the mechanism underlying this defect is unclear [37]. Cytoskeletal functions of b-catenin and related proteins The firs ...
Discovering Pheromones of the Red Imported Fire Ant (Solenopsis
... isomers of the same molecule for the sex pheromone, have the same PBP for both molecules (Willett & Harrison 1999). Furthermore, a PBP was found to be incapable of distinguishing between the R and S enantiomers of a beetle pheromone, in contrast to the enantiomer-specific olfactory receptors for thi ...
... isomers of the same molecule for the sex pheromone, have the same PBP for both molecules (Willett & Harrison 1999). Furthermore, a PBP was found to be incapable of distinguishing between the R and S enantiomers of a beetle pheromone, in contrast to the enantiomer-specific olfactory receptors for thi ...
scf and cullin/ring h2-based
... Identification of the SCFCdc4 ubiquitin ligase complex stemmed from a genetic analysis of the G1/S transition by Schwob et al (1994). These authors demonstrated that budding yeast cdc4ts, cdc34ts, and cdc53ts mutants fail to enter S phase because they are unable to eliminate the S phase cyclin/cycli ...
... Identification of the SCFCdc4 ubiquitin ligase complex stemmed from a genetic analysis of the G1/S transition by Schwob et al (1994). These authors demonstrated that budding yeast cdc4ts, cdc34ts, and cdc53ts mutants fail to enter S phase because they are unable to eliminate the S phase cyclin/cycli ...
Emerging regulatory mechanisms in ubiquitin
... polymerases, repair damage caused by harsh environments and yet still distribute their chromosomes into identical daughter cells. Errors in this program can be deadly for the cell, or, if they result in transformation, have detrimental effects on the organism. To prevent this from happening, the cel ...
... polymerases, repair damage caused by harsh environments and yet still distribute their chromosomes into identical daughter cells. Errors in this program can be deadly for the cell, or, if they result in transformation, have detrimental effects on the organism. To prevent this from happening, the cel ...
Protein-Protein Interactions: Stability, Function and Landscape
... protein-protein interactions, and the same is true for multi-subunit channels or receptors in membranes. Specificity distinguishes such interactions from random collisions that happen by Brownian motion in the aqeous solutions inside and outside of cells. Note that many proteins are known to interac ...
... protein-protein interactions, and the same is true for multi-subunit channels or receptors in membranes. Specificity distinguishes such interactions from random collisions that happen by Brownian motion in the aqeous solutions inside and outside of cells. Note that many proteins are known to interac ...
Self-assembling Protein Cage Systems and - Wiley-VCH
... eukaryotic ferritins, their overall similarities are more important than their differences. Ferritins are large multi-subunit proteins (24 subunits) that self-assemble to form a cagelike architecture (Figure 1a) with a central cavity in which a hydrated ferric oxide (or phosphate) is mineralized. Va ...
... eukaryotic ferritins, their overall similarities are more important than their differences. Ferritins are large multi-subunit proteins (24 subunits) that self-assemble to form a cagelike architecture (Figure 1a) with a central cavity in which a hydrated ferric oxide (or phosphate) is mineralized. Va ...
Active uptake of cyst nematode parasitism proteins into the plant cell
... to develop into a syncytium by activating the cell cycle (Goverse et al., 2000). In brief, the cell cycle consists of the mitotic (M) phase, in which the nuclear division takes place, and the interphase, which can be divided into the first gap (G1), DNA synthesis (S) and second gap (G2) phases. Previ ...
... to develop into a syncytium by activating the cell cycle (Goverse et al., 2000). In brief, the cell cycle consists of the mitotic (M) phase, in which the nuclear division takes place, and the interphase, which can be divided into the first gap (G1), DNA synthesis (S) and second gap (G2) phases. Previ ...
Tackling Unwanted Proteolysis in Plant Production Hosts Used for
... Monoclonal antibodies currently represent the largest class of biopharmaceuticals and thus also represent attractive target molecules for plant production platforms. However, plantproduced full-length antibodies often show degradation of their heavy chains, whereas the light chains usually remain in ...
... Monoclonal antibodies currently represent the largest class of biopharmaceuticals and thus also represent attractive target molecules for plant production platforms. However, plantproduced full-length antibodies often show degradation of their heavy chains, whereas the light chains usually remain in ...
Phytopathogen type III effector weaponry and their plant targets
... Plant innate immunity controls the activation of innate immune responses using mitogen-activated protein kinase (MAPK) cascades and hormones such as salicylic acid (SA). These defences include the deposition of lignin and callose in the cell wall, transcription of pathogenesis-related (PR) genes, an ...
... Plant innate immunity controls the activation of innate immune responses using mitogen-activated protein kinase (MAPK) cascades and hormones such as salicylic acid (SA). These defences include the deposition of lignin and callose in the cell wall, transcription of pathogenesis-related (PR) genes, an ...
Senescence-Associated Vacuoles, a Specific Lytic Compartment for
... developmental transitions [52]. This is the case in senescing leaf cells, where in addition to the central vacuole, there are smaller vacuoles, absent from non-senescing leaves, and therefore termed “senescence-associated vacuoles” (SAVs) [53]. SAVs have been detected in soybean, Arabidopsis and tob ...
... developmental transitions [52]. This is the case in senescing leaf cells, where in addition to the central vacuole, there are smaller vacuoles, absent from non-senescing leaves, and therefore termed “senescence-associated vacuoles” (SAVs) [53]. SAVs have been detected in soybean, Arabidopsis and tob ...
Proteasome
Proteasomes are protein complexes inside all eukaryotes and archaea, and in some bacteria. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.