Ca2+ Ions and the Output of Acetylcoenzyme A from Brain
... concentration of pyruvate in the medium probably acted in the same direction (Taylor et al. 1975 ; Kerbey et al. 1976; McCormack et al. 1982). The observation that the rate of pyruvate decarboxylation was unaltered by dichloracetate, supports the view that most of pyruvate dehydrogenase was in a non ...
... concentration of pyruvate in the medium probably acted in the same direction (Taylor et al. 1975 ; Kerbey et al. 1976; McCormack et al. 1982). The observation that the rate of pyruvate decarboxylation was unaltered by dichloracetate, supports the view that most of pyruvate dehydrogenase was in a non ...
Lipotoxicity in steatohepatitis occurs despite an increase in
... fructose (22% by wt), and cholesterol (2% by wt) (10). At 8 wk of TFD feeding, mice had already developed simple steatosis, whereas 24 wk on TFD resulted in development of histological features of NASH as previously reported (Refs. 10 and 46, also see RESULTS). Euglycemic-hyperinsulinemic clamp (ins ...
... fructose (22% by wt), and cholesterol (2% by wt) (10). At 8 wk of TFD feeding, mice had already developed simple steatosis, whereas 24 wk on TFD resulted in development of histological features of NASH as previously reported (Refs. 10 and 46, also see RESULTS). Euglycemic-hyperinsulinemic clamp (ins ...
97-164sr002
... particular woman and her husband; (b) the law relating to infertility treatment in Victoria and the rights of the woman and her husband under that law; (c) the psychosocial and ethical issues related to infertility and infertility treatment procedures; (d) the possible outcomes of an infertility tre ...
... particular woman and her husband; (b) the law relating to infertility treatment in Victoria and the rights of the woman and her husband under that law; (c) the psychosocial and ethical issues related to infertility and infertility treatment procedures; (d) the possible outcomes of an infertility tre ...
PURIFICATION OF TAP TAGGED YEAST PROTEINS Annika Väntänen
... long-chain fatty acids. These mitochondrially synthesised long-chain fatty acids, for example 3-hydroxymyristoyl-ACP, are possibly used for protein acylation which is one type of lipid modifications of proteins. The best characterised physiological function of the pathway is to provide the octanoyl ...
... long-chain fatty acids. These mitochondrially synthesised long-chain fatty acids, for example 3-hydroxymyristoyl-ACP, are possibly used for protein acylation which is one type of lipid modifications of proteins. The best characterised physiological function of the pathway is to provide the octanoyl ...
Oxidation of Glucose
... a) the 2 moles of glyceraldehydes – 3 -PO4 are converted into pyruvate (aerobic glycolysis) or lactate ( anaerobic glycolysis). ...
... a) the 2 moles of glyceraldehydes – 3 -PO4 are converted into pyruvate (aerobic glycolysis) or lactate ( anaerobic glycolysis). ...
A Call to Reduce the Incidence of Alzheimer`s Disease
... may reduce free radical damage as well as reducing inflammatory activities.3,13 Oxidative DNA damage in peripheral blood lymphocytes could be measured serially as an objective test for trial efficacy.37 Intramuscular administration of deferoxamine, an iron chelator, significantly improved daily livi ...
... may reduce free radical damage as well as reducing inflammatory activities.3,13 Oxidative DNA damage in peripheral blood lymphocytes could be measured serially as an objective test for trial efficacy.37 Intramuscular administration of deferoxamine, an iron chelator, significantly improved daily livi ...
Supplemental File: Detailed Clinical Description, Sequencing
... “MitoMet” microarray analysis performed on a clinical diagnostic basis at Baylor Mitochondrial laboratory on the proband’s muscle revealed an increased mtDNA content (240% as compared to age- and tissuematched controls). Extensive molecular testing for nuclear-encoded mitochondrial disease genes on ...
... “MitoMet” microarray analysis performed on a clinical diagnostic basis at Baylor Mitochondrial laboratory on the proband’s muscle revealed an increased mtDNA content (240% as compared to age- and tissuematched controls). Extensive molecular testing for nuclear-encoded mitochondrial disease genes on ...
Tricarboxylic acid cycle dysfunction as a cause of human diseases
... link between the two genetic diseases (48). The very first case of inherited SDH deficiency was found in two sisters with a neurodegenerative disorder presenting as a leukodystrophy (8). CT scan and MRI demonstrated small symmetrical foci of necrosis in the substentia nigra and in the basal ganglia ...
... link between the two genetic diseases (48). The very first case of inherited SDH deficiency was found in two sisters with a neurodegenerative disorder presenting as a leukodystrophy (8). CT scan and MRI demonstrated small symmetrical foci of necrosis in the substentia nigra and in the basal ganglia ...
Complex III
... Most of them have a bound heme b molecule and this subunit is often called cytochrome b. All of the membrane subunits have a Q binding site positioned near the interior surface of the membrane at the point where the head subunits are in contact with the membrane subunits. The sequence of reaction ...
... Most of them have a bound heme b molecule and this subunit is often called cytochrome b. All of the membrane subunits have a Q binding site positioned near the interior surface of the membrane at the point where the head subunits are in contact with the membrane subunits. The sequence of reaction ...
products
... both Plants & Animals do this! • They both have to break down food molecules to use the energy and release H2O & CO2 as by products • Remember the Tree diagram! CO2 came out of the tree’s roots & H2O comes out of the leaves ...
... both Plants & Animals do this! • They both have to break down food molecules to use the energy and release H2O & CO2 as by products • Remember the Tree diagram! CO2 came out of the tree’s roots & H2O comes out of the leaves ...
Investigation of Iron-Sulfur Protein Maturation in Eukaryotes
... Fe-S proteins. The so-called mitochondrial iron-sulfur cluster (ISC) assembly machinery is responsible for the de novo synthesis of Fe-S clusters and the insertion of these cofactors into mitochondrial Fe-S apo-proteins. This system is also involved in the maturation of Fe-S proteins that are locate ...
... Fe-S proteins. The so-called mitochondrial iron-sulfur cluster (ISC) assembly machinery is responsible for the de novo synthesis of Fe-S clusters and the insertion of these cofactors into mitochondrial Fe-S apo-proteins. This system is also involved in the maturation of Fe-S proteins that are locate ...
Transcription Factor EB Controls Metabolic Flexibility during
... We next assessed whether these TFEB-mediated changes of mitochondrial morphology and function had any impact on energy production. ATP levels were higher in TFEB-transfected muscles and lower in TFEB-deficient muscles compared to controls (Figure 2G). To understand the mechanisms underlying the sign ...
... We next assessed whether these TFEB-mediated changes of mitochondrial morphology and function had any impact on energy production. ATP levels were higher in TFEB-transfected muscles and lower in TFEB-deficient muscles compared to controls (Figure 2G). To understand the mechanisms underlying the sign ...
The molecular machinery of Keilin`s respiratory chain
... electric-field component (). The classic example of such behaviour is seen in the role of ubiquinone in mitochondria, and the related menaquinone and plastoquinone in bacterial and photosynthetic systems respectively. A range of dehydrogenases and photosystems have quinone reduction sites that ens ...
... electric-field component (). The classic example of such behaviour is seen in the role of ubiquinone in mitochondria, and the related menaquinone and plastoquinone in bacterial and photosynthetic systems respectively. A range of dehydrogenases and photosystems have quinone reduction sites that ens ...
Andrology Laboratory and Reproductive Tissue
... spinning a semen specimen that has been stored at -20˚C. DNA damage test Intact genetic material, or DNA, is important for healthy fertilization. A morphologically normal looking motile sperm can have DNA damage. DNA damage to the sperm can result in impaired fertilization, miscarriage or subsequent ...
... spinning a semen specimen that has been stored at -20˚C. DNA damage test Intact genetic material, or DNA, is important for healthy fertilization. A morphologically normal looking motile sperm can have DNA damage. DNA damage to the sperm can result in impaired fertilization, miscarriage or subsequent ...
Transgenic Plant Cells Lacking Mitochondrial Alternative
... the means ⫾ SE from three to nine independent experiments. In some cases, error bars are smaller than the data symbols. Plant Physiol. Vol. 129, 2002 ...
... the means ⫾ SE from three to nine independent experiments. In some cases, error bars are smaller than the data symbols. Plant Physiol. Vol. 129, 2002 ...
Increased Protein and Lipid Oxidative Damage in
... level is increased and A1-42 is decreased, in contrast to others who showed no differences in A levels [35, 36] or increased A42 in AD patients [37]. These differences could be due to variation of experimental conditions. As noted above, A is produced from the proteolytic cleavage of a transmemb ...
... level is increased and A1-42 is decreased, in contrast to others who showed no differences in A levels [35, 36] or increased A42 in AD patients [37]. These differences could be due to variation of experimental conditions. As noted above, A is produced from the proteolytic cleavage of a transmemb ...
Slide 1
... acid pools are the amino acids glutamine and glutamate, and carbon flux in the mitochondrion is organized into two independent linear branches Branch 1 begins with the reductive carboxylation of 2-oxoglutarate to isocitrate, which is then isomerized to citrate. This citrate is cleaved into a C2 co ...
... acid pools are the amino acids glutamine and glutamate, and carbon flux in the mitochondrion is organized into two independent linear branches Branch 1 begins with the reductive carboxylation of 2-oxoglutarate to isocitrate, which is then isomerized to citrate. This citrate is cleaved into a C2 co ...
Thesis - HuVetA
... (but also including a number of other hypothalamus-driven mechanisms, e.g., the foodintake, etc.). Synapse generation and neuronal functions, especially neurotransmission, are highly energy dependent (Laughlin et al., 1998). This statement applies to both inhibitory and excitatory neuronal activitie ...
... (but also including a number of other hypothalamus-driven mechanisms, e.g., the foodintake, etc.). Synapse generation and neuronal functions, especially neurotransmission, are highly energy dependent (Laughlin et al., 1998). This statement applies to both inhibitory and excitatory neuronal activitie ...
electron transport
... • Cytochrome c resides in the intermembrane space and bound tightly to a lipid chain of cardiolipin (diphosphatidylglycerol; p240) in the membrane • Oxidation of bound cardiolipins releases cytochrome c from the inner membrane • Apoptotic signals, including Ca2+, ROS, a family of caspases, and cert ...
... • Cytochrome c resides in the intermembrane space and bound tightly to a lipid chain of cardiolipin (diphosphatidylglycerol; p240) in the membrane • Oxidation of bound cardiolipins releases cytochrome c from the inner membrane • Apoptotic signals, including Ca2+, ROS, a family of caspases, and cert ...
143 BBA 35 oo4 INTERACTION OF NEUROSPORA
... INTERACTION OF NEUROSPORA MITOCHONDRIAL STRUCTURAL P R O T E I N W I T H O T H E R PROTEIN'S AND COENZYME NUCLEOTIDES K E N N E T H D. 3,IUNKRES AND D O W O. W O O D W A R D ...
... INTERACTION OF NEUROSPORA MITOCHONDRIAL STRUCTURAL P R O T E I N W I T H O T H E R PROTEIN'S AND COENZYME NUCLEOTIDES K E N N E T H D. 3,IUNKRES AND D O W O. W O O D W A R D ...
SPiCE View – Springer A++
... pathological models have received little attention, although idebenone is often administered in cases of LHON. In order to better understand the biological bases of these variable impacts of idebenone in LHON patients, we tested the effects of idebenone on complex I activity and mitochondrial respir ...
... pathological models have received little attention, although idebenone is often administered in cases of LHON. In order to better understand the biological bases of these variable impacts of idebenone in LHON patients, we tested the effects of idebenone on complex I activity and mitochondrial respir ...
Considerations on the structures involved in the
... observed that sepsis and septic shock are associated with hyperlactatemia (sepsisassociated hyperlactataemia (SAHL)). SAHL is a strong independent predictor of mortality and the presence and progression is highly valued by physicians in order to define a very high-risk population. Furthermore, labor ...
... observed that sepsis and septic shock are associated with hyperlactatemia (sepsisassociated hyperlactataemia (SAHL)). SAHL is a strong independent predictor of mortality and the presence and progression is highly valued by physicians in order to define a very high-risk population. Furthermore, labor ...
The therapeutic implications of ketone bodies
... In addition to their effects on mitochondrial energetics, the metabolism of ketone bodies has other effects with therapeutic implications. Of major significance is the ability of ketone bodies to increase the concentrations of the metabolites of the first third of the citric acid cycle. Next to causin ...
... In addition to their effects on mitochondrial energetics, the metabolism of ketone bodies has other effects with therapeutic implications. Of major significance is the ability of ketone bodies to increase the concentrations of the metabolites of the first third of the citric acid cycle. Next to causin ...
Biology Name_____________________________________
... information, graphic organizers not only help categorize facts but serve as a memory aid. You will make a graphic organizer that will serve as a study aid for this chapter. Your organizer must include symbols, pictures, diagrams, charts, etc. Do not simply put the words on a piece of paper. This ass ...
... information, graphic organizers not only help categorize facts but serve as a memory aid. You will make a graphic organizer that will serve as a study aid for this chapter. Your organizer must include symbols, pictures, diagrams, charts, etc. Do not simply put the words on a piece of paper. This ass ...