Tutorial - 1: Anti-cancer agents: Introduction, Alkylating and
... A. The anti-cancer drug Thiotepa belongs to a class of aziridine-alkylating agents. B. The anti-cancer drug Carmustine (belonging to the class of nitrosourea-alkylating agents) is highly vesicant and cannot cross blood brain barrier (BBB). C. Extravasation effect of any anti-cancer drug can be incre ...
... A. The anti-cancer drug Thiotepa belongs to a class of aziridine-alkylating agents. B. The anti-cancer drug Carmustine (belonging to the class of nitrosourea-alkylating agents) is highly vesicant and cannot cross blood brain barrier (BBB). C. Extravasation effect of any anti-cancer drug can be incre ...
COX-1
... Notes about atherosclerosis plaques … Using cox2 inhibitor drugs leads to mobilizing of the atherosclerosis plaques this may help in myocardiac infarction, these plaques will be ruptured to smaller ones that may go to small artery[in the brain] leading to stroke or coronary artery leading to myocar ...
... Notes about atherosclerosis plaques … Using cox2 inhibitor drugs leads to mobilizing of the atherosclerosis plaques this may help in myocardiac infarction, these plaques will be ruptured to smaller ones that may go to small artery[in the brain] leading to stroke or coronary artery leading to myocar ...
Acute Coronary Syndrome Therapeutic Intervention
... 2. In order to activate the plasminogen into its active form; Plasmin, human kidneys secrete an enzyme called Urokinase. Urokinase will cleave the Plasminogen to Plasmin through proteolytic mechanism 3. Nevertheless, activated plasmin is vulnerable to be deactivated by plasma AntiPlasmin which can r ...
... 2. In order to activate the plasminogen into its active form; Plasmin, human kidneys secrete an enzyme called Urokinase. Urokinase will cleave the Plasminogen to Plasmin through proteolytic mechanism 3. Nevertheless, activated plasmin is vulnerable to be deactivated by plasma AntiPlasmin which can r ...
Mechanism of Action
... Fluoxetine is eliminated very slowly by the human body. The half-life of fluoxetine after a single dose is two days. The liver metabolizes fluoxetine to a desmethyl metabolite. ...
... Fluoxetine is eliminated very slowly by the human body. The half-life of fluoxetine after a single dose is two days. The liver metabolizes fluoxetine to a desmethyl metabolite. ...
GLAXOSMITHKLINE PLC (Form: 6-K, Received: 06
... Application (NDA). Under the Prescription Drug User Fee Act, the anticipated target action date is six months after receipt of the application by the FDA. The $130 million cost of the voucher will be reported as an R&D expense in GSK's Q2 2017 Adjusted results. Use of dolutegravir and rilpivirine as ...
... Application (NDA). Under the Prescription Drug User Fee Act, the anticipated target action date is six months after receipt of the application by the FDA. The $130 million cost of the voucher will be reported as an R&D expense in GSK's Q2 2017 Adjusted results. Use of dolutegravir and rilpivirine as ...
PHL 424 9th S - Home - KSU Faculty Member websites
... Clindamycin is a chlorine-substituted derivative of lincomycin, an antibiotic produced by Streptomyces lincolnensis Lincomycin, although structurally distinct, resembles erythromycin in activity, but it is toxic and no longer used ...
... Clindamycin is a chlorine-substituted derivative of lincomycin, an antibiotic produced by Streptomyces lincolnensis Lincomycin, although structurally distinct, resembles erythromycin in activity, but it is toxic and no longer used ...
Anticoagulants
... Danaparoid no longer available in the U.S. Drotrecogin Alfa used in patients with sepsis; recombinant form of activated protein C that inhibits f Va and f VIIIa ...
... Danaparoid no longer available in the U.S. Drotrecogin Alfa used in patients with sepsis; recombinant form of activated protein C that inhibits f Va and f VIIIa ...
Review 2 - Psychology
... 26 Alzheimer’s disease is related to an excessive loss of A) A) glial cells B) B) the myelin sheath C) C) ACh neurons D) D) the basal ganglia ...
... 26 Alzheimer’s disease is related to an excessive loss of A) A) glial cells B) B) the myelin sheath C) C) ACh neurons D) D) the basal ganglia ...
Policy and Costs - World Health Organization
... Make a number of standard regimens of medications available Treat side-effects. Offer good overall care, not just drugs ...
... Make a number of standard regimens of medications available Treat side-effects. Offer good overall care, not just drugs ...
Inotropic Agents
... MODE of ACTION of CG IN CASE OF CHF • Increasing of systolic and minute volumes of heart activity (enhancing cardiac muscle contractility, thus increasing output) • Improving of circulation in lungs and peripheral organs, decreasing volume of blood circulation, excretion of surplus liquid from the ...
... MODE of ACTION of CG IN CASE OF CHF • Increasing of systolic and minute volumes of heart activity (enhancing cardiac muscle contractility, thus increasing output) • Improving of circulation in lungs and peripheral organs, decreasing volume of blood circulation, excretion of surplus liquid from the ...
Antidepressant agents - به سامانه مديريت
... MAO-A: inhibition causes antidepressant activity MAO-B: inhibition causes side effects ...
... MAO-A: inhibition causes antidepressant activity MAO-B: inhibition causes side effects ...
DESIGNING AND COMPUTATIONAL STUDY OF SOME NOVEL LAMIVUDINE ANALOGUES AS
... reverse transcriptase is a dimer having two chains, a 64-KD (p66) subunit and a 51-KD (p51) subunit derived from p66 by proteolytic cleavage. The two chains have similar four domain structure and p66 also has a COOH-terminal RNaseH (1, 2). ...
... reverse transcriptase is a dimer having two chains, a 64-KD (p66) subunit and a 51-KD (p51) subunit derived from p66 by proteolytic cleavage. The two chains have similar four domain structure and p66 also has a COOH-terminal RNaseH (1, 2). ...
Light-activated Binary Nucleotide Reagent For Inactivation Of Dna
... Enzyme Inhibition Enzymes are essential for nearly all biological functions and malfunction of enzymatic activity is commonly associated with disease[1]. As a result, the inhibition of enzymes has been an important tool for both biological research and drug design[1]. Enzymes compose one of the larg ...
... Enzyme Inhibition Enzymes are essential for nearly all biological functions and malfunction of enzymatic activity is commonly associated with disease[1]. As a result, the inhibition of enzymes has been an important tool for both biological research and drug design[1]. Enzymes compose one of the larg ...
Hydrogen Bonding: The Last Mystery in Drug Design?
... The influence of replacing an NH ··· O = C hydrogen bond has been extensively studied in a series of thermolysin inhibitors (Fig. 6). The replacement of the -NH- group of the ligands by –O– reduces binding affinities by a factor of 1 000, which has been explained by the lack of the NH ··· O = C hydr ...
... The influence of replacing an NH ··· O = C hydrogen bond has been extensively studied in a series of thermolysin inhibitors (Fig. 6). The replacement of the -NH- group of the ligands by –O– reduces binding affinities by a factor of 1 000, which has been explained by the lack of the NH ··· O = C hydr ...
Glycolysis as a target for the design of new anti
... acute phase of the disease. There have been significant improvements in the control of Chagas’ disease by breaking the transmission of the disease through targeting the insect vectors.Treatment is available for acute stages of the disease only. New drugs are thus still needed, especially to overcome ...
... acute phase of the disease. There have been significant improvements in the control of Chagas’ disease by breaking the transmission of the disease through targeting the insect vectors.Treatment is available for acute stages of the disease only. New drugs are thus still needed, especially to overcome ...
Exam One Notes
... - Acts on the formation of FH4, hence inhibiting the parasite’s DNA synthesis. - Used for protection against all malaria types. - Resistance develop quickly, which doesn’t improve by using combination of antimalarial drugs. Toxicity: - Injection site can be painful. Sulfonamides: - Competitively blo ...
... - Acts on the formation of FH4, hence inhibiting the parasite’s DNA synthesis. - Used for protection against all malaria types. - Resistance develop quickly, which doesn’t improve by using combination of antimalarial drugs. Toxicity: - Injection site can be painful. Sulfonamides: - Competitively blo ...
Rilpivirine: A second-generation nonnucleoside reverse
... DE. Meryn Sweet is a pharmacy student, Jefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, PA. Address correspondence to Dr. James at the HIV Community ...
... DE. Meryn Sweet is a pharmacy student, Jefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, PA. Address correspondence to Dr. James at the HIV Community ...
women
... No anti-inflammatory effect Tx fever & pain Use with caution with pregnancy & lactation but safest antipyretic for children and pregnancy AEs – hepatic, renal, hematologic & GI systems Issues with self-administration ...
... No anti-inflammatory effect Tx fever & pain Use with caution with pregnancy & lactation but safest antipyretic for children and pregnancy AEs – hepatic, renal, hematologic & GI systems Issues with self-administration ...
Application and Utility of Pharmacogenetics in the Clinical Laboratory
... unmetabolized drugs, thereby potentially placing them at a higher risk of experiencing a toxic or adverse event, or leading to suboptimal drug concentrations and preventing maximum efficacy [39]. In contrast, UMs exhibit extremely high metabolic capacity caused by the amplification, duplication, or ...
... unmetabolized drugs, thereby potentially placing them at a higher risk of experiencing a toxic or adverse event, or leading to suboptimal drug concentrations and preventing maximum efficacy [39]. In contrast, UMs exhibit extremely high metabolic capacity caused by the amplification, duplication, or ...
The Relationship Between Thiopurine
... (ALL) in children, the prognosis for this disease has improved steadily such that most trials now report a long-term survival rate of over 70%.1,2 However, current treatment protocols are complex and are associated with significant toxicity.3-6 There are therefore two major priorities in the treatme ...
... (ALL) in children, the prognosis for this disease has improved steadily such that most trials now report a long-term survival rate of over 70%.1,2 However, current treatment protocols are complex and are associated with significant toxicity.3-6 There are therefore two major priorities in the treatme ...
幻灯片 1
... Mild hypertension can often be controlled with a single drug. More severe hypertension may require treatment with several drugs that are selected to minimize adverse effects of the combined regimen. Treatment is initiated with any of four drugs depending on the individual patient: a diuretic, a b-bl ...
... Mild hypertension can often be controlled with a single drug. More severe hypertension may require treatment with several drugs that are selected to minimize adverse effects of the combined regimen. Treatment is initiated with any of four drugs depending on the individual patient: a diuretic, a b-bl ...