INSILICO Research Article S. AMUTHALAKSHMI* AND A. ANTON SMITH
... reversible inhibitors of non-peptide nature are the lipophilic S1 pocket (formed by Tyr631, Val656, Trp659, Tyr662, Tyr666 and Val711) and the negatively charged Glu205/206 pair [15]. Computational power was applied to the combined chemical and biological space in order to rationalize computer aided ...
... reversible inhibitors of non-peptide nature are the lipophilic S1 pocket (formed by Tyr631, Val656, Trp659, Tyr662, Tyr666 and Val711) and the negatively charged Glu205/206 pair [15]. Computational power was applied to the combined chemical and biological space in order to rationalize computer aided ...
Tuberculosis - Current Advances in Development of New Drugs
... 16. Dey T., et al. “Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis”. Journal of Antimicrobial Chemotherapy 68.2 (2013): 284-293. 17. Lechartier B., et al. “Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones a ...
... 16. Dey T., et al. “Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis”. Journal of Antimicrobial Chemotherapy 68.2 (2013): 284-293. 17. Lechartier B., et al. “Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones a ...
Drugs used to treat Hypertension
... Incorporate lifestyle changes, even if medication brings BP within nl. Limits Check BP on regular basis and report significant variations (and pulse) Get out of bed slowly ...
... Incorporate lifestyle changes, even if medication brings BP within nl. Limits Check BP on regular basis and report significant variations (and pulse) Get out of bed slowly ...
Inhibitors of Factor VIIa/Tissue Factor
... sustained plasma levels of ⬇2 mol/L for 0.5 to 2 hours, as estimated by ex vivo plasma activity against human FVIIa/ TF. The oral availability was estimated at ⬇10%. Reviewing the results from these 2 groups, it appears that discovery of a potent FVIIa/TF inhibitor with a neutral P1 moiety remains ...
... sustained plasma levels of ⬇2 mol/L for 0.5 to 2 hours, as estimated by ex vivo plasma activity against human FVIIa/ TF. The oral availability was estimated at ⬇10%. Reviewing the results from these 2 groups, it appears that discovery of a potent FVIIa/TF inhibitor with a neutral P1 moiety remains ...
Poster
... • The potential of ACE inhibitors such as lisinopril to mitigate lung damage following high-dose radiation exposure was analyzed. Findings show that ACE inhibitors are capable of reducing morbidity when treatment is given after the radiation dose. • Our mentor’s study shows that ACE inhibitors have ...
... • The potential of ACE inhibitors such as lisinopril to mitigate lung damage following high-dose radiation exposure was analyzed. Findings show that ACE inhibitors are capable of reducing morbidity when treatment is given after the radiation dose. • Our mentor’s study shows that ACE inhibitors have ...
Hepatitis C therapy-the future looks bright
... by all HCV variants. The rapid rate at which HCV evolves will undoubtedly make the discovery of such a molecule challenging, as well as time-consuming. Until such a magic bullet is discovered, it is likely that a combination therapy consisting of a cocktail of one or more anti-HCV drugs together wit ...
... by all HCV variants. The rapid rate at which HCV evolves will undoubtedly make the discovery of such a molecule challenging, as well as time-consuming. Until such a magic bullet is discovered, it is likely that a combination therapy consisting of a cocktail of one or more anti-HCV drugs together wit ...
Tutorial Kit (Applied Biology and Biotechnology-300 L)
... b. Overcoming barriers of sexual incompatibility: in breeding, sexual crossings at interspecific and intergeneric levels often fail to produce hybrids due to imcompatibility barriers, which can easily be overcome by somatic cell fusion. c. Cytoplasm Transfer: the possibility of transferring cytoplam ...
... b. Overcoming barriers of sexual incompatibility: in breeding, sexual crossings at interspecific and intergeneric levels often fail to produce hybrids due to imcompatibility barriers, which can easily be overcome by somatic cell fusion. c. Cytoplasm Transfer: the possibility of transferring cytoplam ...
Antimicrobial drugs in Respiratory Infection
... norfloxacin does not achieve adequate plasma levels for use in most systemic infections. ...
... norfloxacin does not achieve adequate plasma levels for use in most systemic infections. ...
Chapter 19
... Viruses and Antiviral Drugs Antiviral Drugs Nucleoside analogs substitute an analog for the nucleoside in the viral DNA, effectively crippling it. Nonnucleoside reverse transcriptase inhibitors stop the reverse transcriptase enzyme from making more virus. Protease inhibitors block the enzyme protea ...
... Viruses and Antiviral Drugs Antiviral Drugs Nucleoside analogs substitute an analog for the nucleoside in the viral DNA, effectively crippling it. Nonnucleoside reverse transcriptase inhibitors stop the reverse transcriptase enzyme from making more virus. Protease inhibitors block the enzyme protea ...
Drugs for Dementia
... renal or hepatic impairment should have doses titrated slowly and be monitored closely for adverse effects. 4. Weight / BMI: Weight loss is associated with Alzheimer’s disease but acetylcholinesterase inhibitors are also reported to cause weight loss. Patients weighing <50kg may experience more adve ...
... renal or hepatic impairment should have doses titrated slowly and be monitored closely for adverse effects. 4. Weight / BMI: Weight loss is associated with Alzheimer’s disease but acetylcholinesterase inhibitors are also reported to cause weight loss. Patients weighing <50kg may experience more adve ...
16ppt
... • Older MAOIs – irreversible inhibitors , covalently modified enzymes (MAO-A, MAO-B). Enzyme activity resumes after ca. 2 weeks, when new enzyme synthesized. • Newer MAOIs are reversible inhibitors, some are selective for one subtype. MAO-B selective reversible inhibitors do not require the same die ...
... • Older MAOIs – irreversible inhibitors , covalently modified enzymes (MAO-A, MAO-B). Enzyme activity resumes after ca. 2 weeks, when new enzyme synthesized. • Newer MAOIs are reversible inhibitors, some are selective for one subtype. MAO-B selective reversible inhibitors do not require the same die ...
Drug - HAL
... primer B, which hybridizes at the ATG of HBV X gene and contains a unique NcoI site, to generate a 2.8 kb amplicon covering around 85% of the HBV genome. When this fragment was cloned into pTriEx-Mod at the NotI site, the +1 of transcription of the HBV pgRNA and the +1 of transcription of the -act ...
... primer B, which hybridizes at the ATG of HBV X gene and contains a unique NcoI site, to generate a 2.8 kb amplicon covering around 85% of the HBV genome. When this fragment was cloned into pTriEx-Mod at the NotI site, the +1 of transcription of the HBV pgRNA and the +1 of transcription of the -act ...
Antibiotics III
... b. Trimethoprim blocks the activation of folic acid. The active form of folic acid is FAH 4 (tetra-hydrofolic). Trimethoprim inhibits the folic acid reductase. Trimethoprim was developed by targeting the bacterial folic acid reductase; the bacterial folic acid reductase differs (modestly) from human ...
... b. Trimethoprim blocks the activation of folic acid. The active form of folic acid is FAH 4 (tetra-hydrofolic). Trimethoprim inhibits the folic acid reductase. Trimethoprim was developed by targeting the bacterial folic acid reductase; the bacterial folic acid reductase differs (modestly) from human ...
Abstract: Live, replicating, vaccines have the advantage that they
... Abstract: Live, replicating, vaccines have the advantage that they closely mimic the actual infection and therefore induce a broad and physiologically relevant immune response, involving both a humoral immune response (antibody production) and cell-mediated immunity (cytotoxic T lymphocytes). Howeve ...
... Abstract: Live, replicating, vaccines have the advantage that they closely mimic the actual infection and therefore induce a broad and physiologically relevant immune response, involving both a humoral immune response (antibody production) and cell-mediated immunity (cytotoxic T lymphocytes). Howeve ...
B-lactam antibiotics
... this group of antibiotics is derived from its complex structure, which includes in the molecules • Macrocycle lacton ring, • one or more deoxysugars. The lactone rings are usually 14, 15 or 16-membered. ...
... this group of antibiotics is derived from its complex structure, which includes in the molecules • Macrocycle lacton ring, • one or more deoxysugars. The lactone rings are usually 14, 15 or 16-membered. ...
Selective Serotonin-Reuptake Inhibitors
... because of its potent antihistaminic activity but it does not cause the antimuscarinic side effects of TCA , or interfere with sexual function as do the SSRI , increase appetite and weight gain frequently occur. 3. Nefazodone and Trazodone. These agents are serotonin reuptake inhibitor. Their therap ...
... because of its potent antihistaminic activity but it does not cause the antimuscarinic side effects of TCA , or interfere with sexual function as do the SSRI , increase appetite and weight gain frequently occur. 3. Nefazodone and Trazodone. These agents are serotonin reuptake inhibitor. Their therap ...
Recreational Use of HIV Antiretroviral Drug Linked To Its
... billion dollars a year. The development of effective drug treatments have allowed people with HIV to live longer with federal health officials now predicting that by 2015 one-half of the population with HIV in the US will be older than 50. Efavirenz (tradenames: Sustiva®, Stocrin®) is an antiretrovi ...
... billion dollars a year. The development of effective drug treatments have allowed people with HIV to live longer with federal health officials now predicting that by 2015 one-half of the population with HIV in the US will be older than 50. Efavirenz (tradenames: Sustiva®, Stocrin®) is an antiretrovi ...
Harvard-MIT Division of Health Sciences and Technology
... 1. Penicillin inhibits bacterial growth by interfering with the synthesis of the bacterial cell wall after binding to penicillin binding proteins (many of these are enzymes are involved in cell wall biosynthesis). 2. Although penicillins are bacteriocidal drugs, the mechanisms by which they kill bac ...
... 1. Penicillin inhibits bacterial growth by interfering with the synthesis of the bacterial cell wall after binding to penicillin binding proteins (many of these are enzymes are involved in cell wall biosynthesis). 2. Although penicillins are bacteriocidal drugs, the mechanisms by which they kill bac ...
Snímka 1 - TOP Recommended Websites
... Zolpidem • Structurally unrelated but as effective as BDZs. • Minimal muscle relaxing and anticonvulsant effect. • Rapidly metabolized by liver enzymes into inactive metabolites. • Dosage should be reduced in patients with hepatic dysfunction, the elderly and patients taking cimetidine. ...
... Zolpidem • Structurally unrelated but as effective as BDZs. • Minimal muscle relaxing and anticonvulsant effect. • Rapidly metabolized by liver enzymes into inactive metabolites. • Dosage should be reduced in patients with hepatic dysfunction, the elderly and patients taking cimetidine. ...
Anticancer Drugs - Acupuncture and Massage College
... – MOA: recombinant granulocyte colony stimulating factor which induces the synthesis of neutrophils – Indications: replenishment of neutrophils in patients treated with myelosuppressive drugs – Side Effects: medullary bone pain due to rapid cell proliferation in the BM ...
... – MOA: recombinant granulocyte colony stimulating factor which induces the synthesis of neutrophils – Indications: replenishment of neutrophils in patients treated with myelosuppressive drugs – Side Effects: medullary bone pain due to rapid cell proliferation in the BM ...
Pharmacological Management of Congestive Heart Failure
... • Angiotensin converting enzyme inhibitors – Captopril, enalapril, ramipril, lisinopril ...
... • Angiotensin converting enzyme inhibitors – Captopril, enalapril, ramipril, lisinopril ...
2 Non-steroidal anti-inflammatory drugs
... • Food decrease its absorption. • Highly bound to plasma proteins. • Clinical uses & Adverse effects: • Discussed before with general uses and general adverse effects of selective COX-2 inhibitors. ...
... • Food decrease its absorption. • Highly bound to plasma proteins. • Clinical uses & Adverse effects: • Discussed before with general uses and general adverse effects of selective COX-2 inhibitors. ...
ccr5 antagonists in the treatment of treatment
... Union and the United States for the treatment of HIV infection. This is the first medication belonging to the new class of CCR5 antagonists, and the first approval of an oraly available drug in a new class since 1996. Yet another new class, the integrase inhibitors, are available in expanded access ...
... Union and the United States for the treatment of HIV infection. This is the first medication belonging to the new class of CCR5 antagonists, and the first approval of an oraly available drug in a new class since 1996. Yet another new class, the integrase inhibitors, are available in expanded access ...
ANTIVIRAL AGENTS pharm
... proved of little use therapeutically since the virus uses host-cell metabolic reactions and thus, for the most part, anti-viral agents will also be anti-cell agents. Thus, the alternative approach of stimulating the host's immune responses using vaccines has been most often pursued. Nevertheless, th ...
... proved of little use therapeutically since the virus uses host-cell metabolic reactions and thus, for the most part, anti-viral agents will also be anti-cell agents. Thus, the alternative approach of stimulating the host's immune responses using vaccines has been most often pursued. Nevertheless, th ...
No Slide Title
... Primary Drug Resistance – The CATCH Study • The CATCH study evaluated the rate of primary drug resistance in a number of European countries and Israel • Isolates from over 1600 patients were genotyped • Overall rate of genotypic resistance was 9.6% • NRTIs had the highest rate (6.7%), followed by NN ...
... Primary Drug Resistance – The CATCH Study • The CATCH study evaluated the rate of primary drug resistance in a number of European countries and Israel • Isolates from over 1600 patients were genotyped • Overall rate of genotypic resistance was 9.6% • NRTIs had the highest rate (6.7%), followed by NN ...