Antimicrobial drugs in Respiratory Infection
... norfloxacin does not achieve adequate plasma levels for use in most systemic infections. ...
... norfloxacin does not achieve adequate plasma levels for use in most systemic infections. ...
drugs in Dyslipidaemias
... Bile acid binding resins • Cationic polymer resins that bind non-covalently to negatively-charged bile acids in small intestine • Enterohepatic circulation of bile acids interrupted causing up-regulation of 7αhydroxylase in hepatocytes ...
... Bile acid binding resins • Cationic polymer resins that bind non-covalently to negatively-charged bile acids in small intestine • Enterohepatic circulation of bile acids interrupted causing up-regulation of 7αhydroxylase in hepatocytes ...
Protein-Ligand Binding
... HIV/AIDS bind and inhibit the viral enzyme HIV Protease. Cell surface receptors (Figure 2) are another class of therapeutically relevant proteins. Floating in the cell membrane, they are able to bind specific extracellular signaling molecules, such as hormones, and respond by activating the appropri ...
... HIV/AIDS bind and inhibit the viral enzyme HIV Protease. Cell surface receptors (Figure 2) are another class of therapeutically relevant proteins. Floating in the cell membrane, they are able to bind specific extracellular signaling molecules, such as hormones, and respond by activating the appropri ...
Tamsin D Tamsulosin Hydrochloride USP 0.4 mg and
... • Pregnancy and women of childbearing potential. • Pediatric patients. • Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to Dutasteride, other 5 alphareductase inhibitors, Tamsulosin, or any component of this product. PRECAUTI ...
... • Pregnancy and women of childbearing potential. • Pediatric patients. • Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to Dutasteride, other 5 alphareductase inhibitors, Tamsulosin, or any component of this product. PRECAUTI ...
Antifungal Agents
... • Most potent azole possess 2 or 3 aromatic ring at least one of which is halogen substituted. • Nonpolar functional group at 2 or 2,4 yield effective azole compound. • The halogen atom that yield most potent compound is fluorine. • Sulfonic acid substitution yield potent drug. • Substitution at oth ...
... • Most potent azole possess 2 or 3 aromatic ring at least one of which is halogen substituted. • Nonpolar functional group at 2 or 2,4 yield effective azole compound. • The halogen atom that yield most potent compound is fluorine. • Sulfonic acid substitution yield potent drug. • Substitution at oth ...
Factors affecting drug metabolism
... Examples: fluoroquinolones, cimetidine, azoles antifungal ...
... Examples: fluoroquinolones, cimetidine, azoles antifungal ...
pharm 22 A [4-20
... [don’t FIB about being sick] i. used for ischemic events and during/after coronary intervention b. major bleeding c. abciximab binds GPIIb-IIIa site irreversibly (other 2 don't) so it can be reversed w/ admin of fresh platelets; with eptifibatide and tirofiban just have to wait it out 4 classes of a ...
... [don’t FIB about being sick] i. used for ischemic events and during/after coronary intervention b. major bleeding c. abciximab binds GPIIb-IIIa site irreversibly (other 2 don't) so it can be reversed w/ admin of fresh platelets; with eptifibatide and tirofiban just have to wait it out 4 classes of a ...
Binding Studies of Type I, II, and III Kinase Inhibitors against Bcr
... an adjacent allosteric site that is present only in the inactive kinase conformation. Compared to Type I inhibitors, Type II inhibitors have been shown to possess advantageous pharmacological properties, including improved target specificity 2. As such, many Type II inhibitors currently on the marke ...
... an adjacent allosteric site that is present only in the inactive kinase conformation. Compared to Type I inhibitors, Type II inhibitors have been shown to possess advantageous pharmacological properties, including improved target specificity 2. As such, many Type II inhibitors currently on the marke ...
Cardiovascular system pharmacology
... metronidazole) . Mechanism of action : - warfarin block carboxylation for some clotting factors ( II , VII , IX , X) which are essential for coagulating process. - They are biologically inactive unless they are carboxylation by microsomal enzyme system that utilizes reduced Vit.K as cofactor . Vit.k ...
... metronidazole) . Mechanism of action : - warfarin block carboxylation for some clotting factors ( II , VII , IX , X) which are essential for coagulating process. - They are biologically inactive unless they are carboxylation by microsomal enzyme system that utilizes reduced Vit.K as cofactor . Vit.k ...
Antimicrobial1
... Bacteriocidal – kills the bacteria Bacteriostatic – inhibit growth of bacteria N.B.: Either after arresting the growth of the bacteria by a bacteriostatic or decreasing the number of viable bacteria by a bactericidal ,the body's immune system attacks, immobilizes, and eliminates the pathogens. If th ...
... Bacteriocidal – kills the bacteria Bacteriostatic – inhibit growth of bacteria N.B.: Either after arresting the growth of the bacteria by a bacteriostatic or decreasing the number of viable bacteria by a bactericidal ,the body's immune system attacks, immobilizes, and eliminates the pathogens. If th ...
ANTIMICROBIAL DRUGS
... Note: In concomitant use with Amphotericin b, Aminoglycosides, Colistimethate sodium – increased risk of development and severity of nephrotoxicity, ototoxicity. The use with furosemide - increased risk of ototoxicity ( for all – OTO - and nephro-toxicity). ...
... Note: In concomitant use with Amphotericin b, Aminoglycosides, Colistimethate sodium – increased risk of development and severity of nephrotoxicity, ototoxicity. The use with furosemide - increased risk of ototoxicity ( for all – OTO - and nephro-toxicity). ...
(1)
... Good sterilising property & resistance preventing action. • All sub populations; best on spurters ...
... Good sterilising property & resistance preventing action. • All sub populations; best on spurters ...
FDA-Approved Treatments for Alzheimer`s
... In clinical trials of all three cholinesterase inhibitors, people taking the medications performed better on memory and thinking tests than those taking a placebo, or inactive substance. However, the degree of improvement was small. In terms of overall effect, cholinesterase inhibitors may delay or ...
... In clinical trials of all three cholinesterase inhibitors, people taking the medications performed better on memory and thinking tests than those taking a placebo, or inactive substance. However, the degree of improvement was small. In terms of overall effect, cholinesterase inhibitors may delay or ...
Cancer Treatment Drugs
... menopausal women, whose ovaries are producing large quantities of estrogen. Another strategy for estrogen deprivation is to block the estrogen receptor with tamoxifen, a drug developed in Worcester during the late 1960’s.3 Tamoxifen is a competitive inhibitor of estrogen binding to the estrogen rece ...
... menopausal women, whose ovaries are producing large quantities of estrogen. Another strategy for estrogen deprivation is to block the estrogen receptor with tamoxifen, a drug developed in Worcester during the late 1960’s.3 Tamoxifen is a competitive inhibitor of estrogen binding to the estrogen rece ...
reviews - Medicina
... antibiotics of rifamycin B isolated from Streptomyces mediterrani. This class of drugs inhibits bacterial RNA synthesis by binding to the β subunit of the DNA-dependent polymerase and has no effect on mammalian enzymes. The lipophilic properties of the molecule are important for binding of the drug ...
... antibiotics of rifamycin B isolated from Streptomyces mediterrani. This class of drugs inhibits bacterial RNA synthesis by binding to the β subunit of the DNA-dependent polymerase and has no effect on mammalian enzymes. The lipophilic properties of the molecule are important for binding of the drug ...
Biomarker Identification and Assay Development | Charles River
... Biomarker assays are now an integral part of the drug discovery and development process, acting as indicators of drug efficacy, toxicity and disease progression, as well as assisting in patient selection and design of clinical trials1. In early stage drug discovery, biomarkers are used to validate i ...
... Biomarker assays are now an integral part of the drug discovery and development process, acting as indicators of drug efficacy, toxicity and disease progression, as well as assisting in patient selection and design of clinical trials1. In early stage drug discovery, biomarkers are used to validate i ...
HIV Treatment Updates - Maine Pharmacy Association
... • HIV RNA – May influence decision to start ART and help determine frequency of CD4 monitoring – Critical in determining response to ART • Goal of ART: HIV RNA below limit of detection (ie, ...
... • HIV RNA – May influence decision to start ART and help determine frequency of CD4 monitoring – Critical in determining response to ART • Goal of ART: HIV RNA below limit of detection (ie, ...
Cats with Runny Eyes. Treatment of Feline Herpes Virus Infections
... difficult to obtain because they are not widely available commercially, although they may be ordered from compounding pharmacies (9). Newer recommendations for topical antiviral administration in cats include cidofovir 0.5% (7, 11, 12). Cidofovir, which is not commercially available as an ophthalmic ...
... difficult to obtain because they are not widely available commercially, although they may be ordered from compounding pharmacies (9). Newer recommendations for topical antiviral administration in cats include cidofovir 0.5% (7, 11, 12). Cidofovir, which is not commercially available as an ophthalmic ...
TREATMENT bulletin . 4 - HIV i-Base
... blood as well as in lymphoid tissue. HIV is able to infect a number of different types of immune system cells, and there is mounting evidence that DCs play an important role in the disease. Along with macrophages, DCs are now thought to be responsible for spreading the initial HIV infection, despite ...
... blood as well as in lymphoid tissue. HIV is able to infect a number of different types of immune system cells, and there is mounting evidence that DCs play an important role in the disease. Along with macrophages, DCs are now thought to be responsible for spreading the initial HIV infection, despite ...
Tutorial - 4: Respiratory Drug Development
... Structure (1) is terbutaline, a selective β2 adrenoceptor agonist used as a bronchodilator for the treatment of asthma. Structure (2) is bambuterol, an orally active long acting β2adrenoceptor agonist used in the treatment of asthma. Terbutaline has short duration of action due to the enzymati ...
... Structure (1) is terbutaline, a selective β2 adrenoceptor agonist used as a bronchodilator for the treatment of asthma. Structure (2) is bambuterol, an orally active long acting β2adrenoceptor agonist used in the treatment of asthma. Terbutaline has short duration of action due to the enzymati ...
Antihypertensive Drugs
... vessels: vascular smooth muscle relaxation (↓ PVR), negative chronotropic and ionotropic effects in heart (↓CO) DHPs (amlodipine and nifedipine) have highest smooth muscle ...
... vessels: vascular smooth muscle relaxation (↓ PVR), negative chronotropic and ionotropic effects in heart (↓CO) DHPs (amlodipine and nifedipine) have highest smooth muscle ...
Diuretics and Synthetic Hypoglycemic Drugs
... Sulfonylureas(磺酰脲类) The hypoglycemic(降血糖)effect of salicylates(水杨酸 盐)has been known for 100 years. Clinical use of salicylates was not feasible, since the very large doses required produced intolerable side effects. The hypoglycemic effects of the thiadiazole sulfonamide known as IPTD, used to ...
... Sulfonylureas(磺酰脲类) The hypoglycemic(降血糖)effect of salicylates(水杨酸 盐)has been known for 100 years. Clinical use of salicylates was not feasible, since the very large doses required produced intolerable side effects. The hypoglycemic effects of the thiadiazole sulfonamide known as IPTD, used to ...
Fragment approaches in structure
... of phospho-inositol lipids. These recruit PDK1 to the membrane via its PH domain where it can regulate the activity of a closely related kinase, Akt, by phosphorylation at position T308. Akt modulates the activity of both growth and metabolic pathways through phosphorylation of GSK3-b. In addition, ...
... of phospho-inositol lipids. These recruit PDK1 to the membrane via its PH domain where it can regulate the activity of a closely related kinase, Akt, by phosphorylation at position T308. Akt modulates the activity of both growth and metabolic pathways through phosphorylation of GSK3-b. In addition, ...