GenoSure Archive : Cell-associated Viral DNA Assay for
... Cell-associated viral DNA assay for HIV-1 protease, reverse transcriptase, and integrase inhibitors Introduction Human immunodeficiency virus type 1 (HIV-1) was identified in 1983 as the cause of acquired immune deficiency syndrome (AIDS). During the decade between 1985 and 1995, more than 100,000 p ...
... Cell-associated viral DNA assay for HIV-1 protease, reverse transcriptase, and integrase inhibitors Introduction Human immunodeficiency virus type 1 (HIV-1) was identified in 1983 as the cause of acquired immune deficiency syndrome (AIDS). During the decade between 1985 and 1995, more than 100,000 p ...
NRTIs NNRTIs PIs Entry Inhibitor Integrase Inhibitors MOA Inhibits
... Entry/Fusion Inhibitors MOA: CCR5 receptor antagonist—prevents CCR5 tropic HIV entry into cells ...
... Entry/Fusion Inhibitors MOA: CCR5 receptor antagonist—prevents CCR5 tropic HIV entry into cells ...
HIV
... protease because it differs significantly from human protease. • The 6 PI’s currently approved for clinical use were all designed by using structure-based drug design methods. ...
... protease because it differs significantly from human protease. • The 6 PI’s currently approved for clinical use were all designed by using structure-based drug design methods. ...
Antiviral Agents
... Other Retroviral RT Inhibitors • Other nucleoside analogs: didanosine, stavudine, zalcitabine: same as AZT but can cause peripheral neuropathy and pancreatitis. Can be used with AZT for enhanced effect and less toxicity. • Non-nucleoside RT inhibitors: e.g. neviparine. Noncompetitive binding to RT ...
... Other Retroviral RT Inhibitors • Other nucleoside analogs: didanosine, stavudine, zalcitabine: same as AZT but can cause peripheral neuropathy and pancreatitis. Can be used with AZT for enhanced effect and less toxicity. • Non-nucleoside RT inhibitors: e.g. neviparine. Noncompetitive binding to RT ...
Drugs used for treatment of AIDS
... Ritonavir it has high bioavailability when given with food administered in slow dose escalation to limit side ...
... Ritonavir it has high bioavailability when given with food administered in slow dose escalation to limit side ...
ANTI VIRAL Agents
... which led to the diagnosis of herpes simplex infection, and a therapy with oral acyclovir was initiated. Two weeks later no improvement was seen and the dose of the drug was increased but without success. Which of the following was most likely the cause of failure of acyclovir therapy? A) Mutation o ...
... which led to the diagnosis of herpes simplex infection, and a therapy with oral acyclovir was initiated. Two weeks later no improvement was seen and the dose of the drug was increased but without success. Which of the following was most likely the cause of failure of acyclovir therapy? A) Mutation o ...
Anti-viral agents
... 1-CMV retinitis in immunocompromised hosts when ganciclovir is contraindicated. 2-acyclovir-resistant HSV and herpes zoster infections. 3-Cidofovir Cidofovir is approved for treatment of CMV-induced retinitis in patients with AIDS when other drugs is unsuitable. ...
... 1-CMV retinitis in immunocompromised hosts when ganciclovir is contraindicated. 2-acyclovir-resistant HSV and herpes zoster infections. 3-Cidofovir Cidofovir is approved for treatment of CMV-induced retinitis in patients with AIDS when other drugs is unsuitable. ...
HIV/AIDS- A Brief History
... Integrase inhibitors – disable integrase, a protein that HIV uses to insert its viral genetic material into that of the infected cell ex: raltegravir (isentress) Fixed dose combination – contain 2 or more meds from 1 or more drug classes ex.- efavirenz, tenofovir (atripla) ...
... Integrase inhibitors – disable integrase, a protein that HIV uses to insert its viral genetic material into that of the infected cell ex: raltegravir (isentress) Fixed dose combination – contain 2 or more meds from 1 or more drug classes ex.- efavirenz, tenofovir (atripla) ...
Chapter 49 Antiviral Agents
... during labor and zidovudine syrup to the neonate from birth through 6 weeks of age has been shown to reduce the rate of vertical (mother-to-newborn) transmission of HIV by up to 23% ...
... during labor and zidovudine syrup to the neonate from birth through 6 weeks of age has been shown to reduce the rate of vertical (mother-to-newborn) transmission of HIV by up to 23% ...
Blocviroc - a unique treatment for HIV/AIDS
... human health • Over 40 million people are infected worldwide • There is no known cure. Treatments have improved but there are still problems with virus resistance and patient adherence • Blocviroc is a novel treatment and patients would take one pill per day ...
... human health • Over 40 million people are infected worldwide • There is no known cure. Treatments have improved but there are still problems with virus resistance and patient adherence • Blocviroc is a novel treatment and patients would take one pill per day ...
Antiviral for respiratory viral infection
... Release of viral genes and possibly enzymes into the host cell. Replication of viral components using host-cell machinery. Assembly of viral components into complete viral particles. Release of viral particles to infect new host cells. Anti-viral targeting Before cell entry This stage of vir ...
... Release of viral genes and possibly enzymes into the host cell. Replication of viral components using host-cell machinery. Assembly of viral components into complete viral particles. Release of viral particles to infect new host cells. Anti-viral targeting Before cell entry This stage of vir ...
Antiviral chemotherapy
... • AZT is toxic to bone marrow, for example, it cause severe anaemia and leukopenia In patient receiving high dose. Headache is also common ...
... • AZT is toxic to bone marrow, for example, it cause severe anaemia and leukopenia In patient receiving high dose. Headache is also common ...
Virtual Screening in Drug Discovery: an Overview
... The goal of early stage drug discovery: to identify hits and leads compounds • Most drugs work by interacting with a protein/DNA at a specific target site. • Drug molecules need to (1) bind tightly to the target site (affinity) and exert the desired activity (potency) (2) have minimal off-target bi ...
... The goal of early stage drug discovery: to identify hits and leads compounds • Most drugs work by interacting with a protein/DNA at a specific target site. • Drug molecules need to (1) bind tightly to the target site (affinity) and exert the desired activity (potency) (2) have minimal off-target bi ...
Antiviral_07ho
... passage of H+ ions required for acidification and viral uncoating mild CNS effects ...
... passage of H+ ions required for acidification and viral uncoating mild CNS effects ...
Anti-viral drugs
... • Many antiviral drugs are Purine or Pyrimidine analogs • Many antiviral drugs are Prodrugs. They must be phosphorylated by viral or cellular enzymes in order to become active. • Anti-viral agents inhibits active replication so the viral growth resumes after drug removal ...
... • Many antiviral drugs are Purine or Pyrimidine analogs • Many antiviral drugs are Prodrugs. They must be phosphorylated by viral or cellular enzymes in order to become active. • Anti-viral agents inhibits active replication so the viral growth resumes after drug removal ...
chapter 8 - Lange Textbooks
... that inhibit HSV and to a lesser extent varicella-zoster virus (VZV) 2. Intravenous acyclovir is used for serious HSV ii. Treatment and Prophylaxis 1. Effective against herpes and zoster c. Valacyclovir, Famciclovir, and Penciclovir 1. Valacyclovir is a prodrug of acyclovir that is better absorbed a ...
... that inhibit HSV and to a lesser extent varicella-zoster virus (VZV) 2. Intravenous acyclovir is used for serious HSV ii. Treatment and Prophylaxis 1. Effective against herpes and zoster c. Valacyclovir, Famciclovir, and Penciclovir 1. Valacyclovir is a prodrug of acyclovir that is better absorbed a ...
Antiviral Drugs Part 2
... the infection. The effect of protease inhibitors on the replication of HIV is depicted in the next Figure - Virion: A complete virus particle with its DNA or RNA core and protein coat as it exists outside the cell. Also called a viral particle. ...
... the infection. The effect of protease inhibitors on the replication of HIV is depicted in the next Figure - Virion: A complete virus particle with its DNA or RNA core and protein coat as it exists outside the cell. Also called a viral particle. ...