Diapositive 1 - Moodle Lille 2
... establish the patient’s HIV drug resistance profile “virogram” to all approved ARV ...
... establish the patient’s HIV drug resistance profile “virogram” to all approved ARV ...
Alkylating agents
... form; Blocks thymidylate synthetase and lowers cellular dTTP (↓DNA synthesis) and is directly incorporated into RNA, interfering with RNA processing and translation. Anti-mitotic agent with metaphase arrest by binding to tubulin: prevents assembly of microtubules. Anti-mitotic agent that binds to mi ...
... form; Blocks thymidylate synthetase and lowers cellular dTTP (↓DNA synthesis) and is directly incorporated into RNA, interfering with RNA processing and translation. Anti-mitotic agent with metaphase arrest by binding to tubulin: prevents assembly of microtubules. Anti-mitotic agent that binds to mi ...
DNA - anna onofri
... • The DNA double helix is anti-parallel, which means that the 5' end of one strand is paired with the 3' end of its complementary strand (and vice versa). • Nucleotides are linked to each other by their phosphate groups, which bind the 3' end of one sugar to the 5' end of the next ...
... • The DNA double helix is anti-parallel, which means that the 5' end of one strand is paired with the 3' end of its complementary strand (and vice versa). • Nucleotides are linked to each other by their phosphate groups, which bind the 3' end of one sugar to the 5' end of the next ...
02_CLINICAL PHARM_ DRUGS_CNS
... They are more effective for: – Transient insomnia in those who normally sleep well but are subject to a disrupting event (e.g. an operation or jet lag). Give 1 or 2 doses. – Short-term insomnia associated with a specific event (e.g. illness or bereavement). Keep treatment to less than 1 week. ...
... They are more effective for: – Transient insomnia in those who normally sleep well but are subject to a disrupting event (e.g. an operation or jet lag). Give 1 or 2 doses. – Short-term insomnia associated with a specific event (e.g. illness or bereavement). Keep treatment to less than 1 week. ...
Antifungal Agents
... Etoposide (VP-16) -- increases the degradation of DNA; useful in small cell lung cancers...as well as others... Paclitaxel (Taxol) -- stabilizes microtubules, so they cannot move Antibiotics: Anthracyclines: -- intercalate between base pairs in DNA, thereby blocking DNA and RNA synthesis Doxorubicin ...
... Etoposide (VP-16) -- increases the degradation of DNA; useful in small cell lung cancers...as well as others... Paclitaxel (Taxol) -- stabilizes microtubules, so they cannot move Antibiotics: Anthracyclines: -- intercalate between base pairs in DNA, thereby blocking DNA and RNA synthesis Doxorubicin ...
Antiviral Agents: Structural Basis of Action and Rational Design
... or disassembly is a still poorly understood process that releases the viral genome from its protein shell (see Chaps. 15 and 16). Disassembly may occur rapidly after fusion, as occurs in HIV, or be triggered by pH variations, as observed in viruses entering the cell by an endocytic pathway (e.g. inf ...
... or disassembly is a still poorly understood process that releases the viral genome from its protein shell (see Chaps. 15 and 16). Disassembly may occur rapidly after fusion, as occurs in HIV, or be triggered by pH variations, as observed in viruses entering the cell by an endocytic pathway (e.g. inf ...
Human Immunodeficiency Virus and Antiretroviral Therapy
... into new viral particles – Virus buds from the cell – Protease enzyme cleaves long protein strands into small functional HIV proteins and enzymes – Mature HIV particles now able to infect other cells and replicate ...
... into new viral particles – Virus buds from the cell – Protease enzyme cleaves long protein strands into small functional HIV proteins and enzymes – Mature HIV particles now able to infect other cells and replicate ...
CANCER CHEMOTHERAPY
... • Rituximab is a genetically engineered chimeric monoclonal antibody used in the treatment of B cell non-Hodgkin's lymphoma, B cell leukemia, and some autoimmune disorders. • The antibody binds to the cluster of differentiation 20 (CD20). CD20 is widely expressed on B-cells and plays a role in activ ...
... • Rituximab is a genetically engineered chimeric monoclonal antibody used in the treatment of B cell non-Hodgkin's lymphoma, B cell leukemia, and some autoimmune disorders. • The antibody binds to the cluster of differentiation 20 (CD20). CD20 is widely expressed on B-cells and plays a role in activ ...
Virus attaches to a cell receptor.
... • Lower dose first 2 weeks and then increased to appropriate therapeutic level to avoid rash • The antibiotic rifampin interferes with this drug • This drug decreases serum concentration of PIs • Must monitor liver functions ...
... • Lower dose first 2 weeks and then increased to appropriate therapeutic level to avoid rash • The antibiotic rifampin interferes with this drug • This drug decreases serum concentration of PIs • Must monitor liver functions ...
3. Quinolones BDS may 2015 (1)
... DNA Gyrase - introduces negative supercoils into DNA (checks mechanical hindrance) ...
... DNA Gyrase - introduces negative supercoils into DNA (checks mechanical hindrance) ...
Quinolones
... DNA Gyrase - introduces negative supercoils into DNA (checks mechanical hindrance) ...
... DNA Gyrase - introduces negative supercoils into DNA (checks mechanical hindrance) ...
The Drugs - chem4520
... • Generally you tried to first attach an electrophilic spacer arm to the bioreduccible portion of the drug which was either purchased or synthesized from alicyclic precursors • Then functional group manipulation and phenanthridine was alkylated by the side chain ...
... • Generally you tried to first attach an electrophilic spacer arm to the bioreduccible portion of the drug which was either purchased or synthesized from alicyclic precursors • Then functional group manipulation and phenanthridine was alkylated by the side chain ...
Influenza Antiviral Drug Development
... but have no activity against influenza B viruses. They are associated with serious side effects, and resistant viruses have emerged. Neuraminidase inhibitors block the release of virions from the host cell. Although they exhibit activity against both influenza A and B viruses, they can cause side ef ...
... but have no activity against influenza B viruses. They are associated with serious side effects, and resistant viruses have emerged. Neuraminidase inhibitors block the release of virions from the host cell. Although they exhibit activity against both influenza A and B viruses, they can cause side ef ...
Chapter 9 - chem.uwec.edu
... The complexity of many natural products makes their synthesis impractical on a commerical basis. This in turn makes it difficult to produce analogues of the natural product. See also sections 9.4.1 and 9.4.2. 3) There is a constant battle going on in the microbiological world between different micro ...
... The complexity of many natural products makes their synthesis impractical on a commerical basis. This in turn makes it difficult to produce analogues of the natural product. See also sections 9.4.1 and 9.4.2. 3) There is a constant battle going on in the microbiological world between different micro ...
Dr.A.K.AL-Yassari 2016-2017 Microbiology Year:third Antibiotics
... Chloramphenicol bind to the bacterial 50S ribosomal subunit and inhibits protein synthesis at the peptidyl transferase reaction. Inhibition of nucleic acid synthesis The quinolones and novobiocin act on enzymes which separate the strands of DNA during bacterial replication such as DNA gyrase (in ...
... Chloramphenicol bind to the bacterial 50S ribosomal subunit and inhibits protein synthesis at the peptidyl transferase reaction. Inhibition of nucleic acid synthesis The quinolones and novobiocin act on enzymes which separate the strands of DNA during bacterial replication such as DNA gyrase (in ...
Aminoglycosides
... Lack activity against most anaerobic or facultative bacteria and activity against G+ve# organisms is limited * in combination # Strept pyogenes is highly resistant ...
... Lack activity against most anaerobic or facultative bacteria and activity against G+ve# organisms is limited * in combination # Strept pyogenes is highly resistant ...
Recent advances in antiviral therapy
... into the regimens. This compound is a more potent inhibitor of HIV than either ddI or ddC, but when used as monotherapy 3TC selects for resistant strains very rapidly. However, studies of isolates from patients on ZDV/3TC combination treatment showed that the mutation in the reverse transcriptase ge ...
... into the regimens. This compound is a more potent inhibitor of HIV than either ddI or ddC, but when used as monotherapy 3TC selects for resistant strains very rapidly. However, studies of isolates from patients on ZDV/3TC combination treatment showed that the mutation in the reverse transcriptase ge ...
Bio 11 ANSWERS (midyear review, viruses, immune system
... then the cell pulls apart into two new cloned cells Conjugation: sexual reproduction in single celled creatures where some DNA in the form of a plasmid it transferred from one organism to the other 20. Both respiration and fermentation provide energy. In respiration, more energy is created and oxyge ...
... then the cell pulls apart into two new cloned cells Conjugation: sexual reproduction in single celled creatures where some DNA in the form of a plasmid it transferred from one organism to the other 20. Both respiration and fermentation provide energy. In respiration, more energy is created and oxyge ...
Genomics and Personalized Care - Health Computing: Pitt CPATH
... human DNA – determine the sequences of the 3 billion chemical base pairs that make up human DNA – store this information in databases – improve tools for data analysis – transfer related technologies to the private sector – address the ethical, legal, and social issues (ELSI) that may arise from the ...
... human DNA – determine the sequences of the 3 billion chemical base pairs that make up human DNA – store this information in databases – improve tools for data analysis – transfer related technologies to the private sector – address the ethical, legal, and social issues (ELSI) that may arise from the ...
Drug Development in HIV CCR5 Michael Zaiac Pfizer - UK-CAB
... Decreased risk of selection of resistant virus ...
... Decreased risk of selection of resistant virus ...
Model Description Sheet
... Opium and its derivatives have been used for centuries to treat severe acute or chronic pain by binding to opioid receptors in the body, causing beneficial effects of analgesic and harmful effects. Their addictiveness has led to several opiates becoming recreational drugs such as opium, morphine, an ...
... Opium and its derivatives have been used for centuries to treat severe acute or chronic pain by binding to opioid receptors in the body, causing beneficial effects of analgesic and harmful effects. Their addictiveness has led to several opiates becoming recreational drugs such as opium, morphine, an ...
Kineta`s Novel Antiviral Drugs Show Encouraging
... immune modulating drugs for critical disease areas, announced today that its scientists reported encouraging new data from its innate- immune agonist program showing drug activity in vivo against Dengue virus type 2. The molecules induce an innate immune response and generate a broad antiviral cellu ...
... immune modulating drugs for critical disease areas, announced today that its scientists reported encouraging new data from its innate- immune agonist program showing drug activity in vivo against Dengue virus type 2. The molecules induce an innate immune response and generate a broad antiviral cellu ...
Therapeutics for Respiratory viruses
... children, and chronic obstructive pulmonary disease (COPD). • HRV is a major cause of acute viral respiratory tract infections in hospitalized children and is among the leading causes of childhood mortality. ...
... children, and chronic obstructive pulmonary disease (COPD). • HRV is a major cause of acute viral respiratory tract infections in hospitalized children and is among the leading causes of childhood mortality. ...
Next-Generation NNRTIs: Etravirine and Rilpivirine
... Tibotec Pharmaceuticals, were designed specifically to meet the drug-resistance challenges posed by a rapidly evolving viral target. NNRTIs work by binding to amino acids within a “pocket” contained on the reverse transcriptase enzyme, interfering with the enzyme’s function and forestalling the firs ...
... Tibotec Pharmaceuticals, were designed specifically to meet the drug-resistance challenges posed by a rapidly evolving viral target. NNRTIs work by binding to amino acids within a “pocket” contained on the reverse transcriptase enzyme, interfering with the enzyme’s function and forestalling the firs ...