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This Week in The Journal - Journal of Neuroscience
This Week in The Journal - Journal of Neuroscience

... motor and interneurons in Drosophila and examined the effects at different ages. A␤ accumulated in neuronal somata and axons, and this correlated with accelerated age-related decline of flight behavior and shortened lifespan. The first cellular defect to appear was a reduction in the number of mitoc ...
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... an artificial animal (the Animat) within a simulated environment. Sensory input to the Animat is translated into patterns of electrical stimuli sent back into the network. Fig. 2. A) A culture of live neurons after 3 days in culture on a 8x8 grid of 60- 10 melectrodes separated by 200 m. B) Expand ...
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... Research from the previous decade suggests that word meaning is partially stored in distributed modality-specific cortical networks. However, little is known about the mechanisms by which semantic content from multiple modalities is integrated into a coherent multisensory representation. Therefore w ...


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BASICS OF NEUROBIOLOGY Zsolt Liposits and Imre Kalló 2016
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... 43. Neurotransmitters are released from vesicles located on knoblike terminals at the end of the A) dendrites. B) cell body. C) axon. D) myelin sheath. E) synapse. 44. The chemical messengers released into the spatial junctions between neurons are called A) hormones. B) neurotransmitters. C) synapse ...
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... cortical areas. Unless neurons compensate with larger dendrites and longer intrinsic connections as areas get larger, the computational window or scope of neurons will decrease (Fig. 42.10). For example, as a visual area gets bigger, individual neurons would evaluate information from less and less o ...
Nervous System
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... Classical conditioning of the gill-withdrawal reflex in Aplysia. (Adapted, with permission, from Hawkins et al. 1983.) A. The siphon is stimulated by a light touch and the tail is shocked, but the two stimuli are not paired in time. The tail shock excites facilitatory interneurons that form synapses ...
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... Selective gathering of cells to functional group Cytodifferentiation (axon, dendrite, synaptic patterns) 5. Selective death of some cells in groups (Apoptosis) 6. Outgrowth of axons to specific target cells and establishment of connections 7. Elimination of certain connections and functional stabili ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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