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NA EXAM 3 (May 2001)
NA EXAM 3 (May 2001)

... thalamus that inhibit movement. By disinhibition (direct) or excitation (indirect), can stimulate or inhibit movement, respectively. However, dopamine stimulation of striatal neurons have opposite effects on the direct (excites) and indirect pathways (inhibits), so the net outcome by either pathways ...
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... The overall rhythmic structure of a song is evident in the power spectral density of the AM signal (see Fig. 1B, C, right panels). Gaps within a syllable result in more prominent higher-frequency spectral components (Fig. 1C, arrow). Distribution of natural A M signals. To restrict attention to carr ...
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... Neural prostheses that can reliably and effectively activate the cortex have the potential to treat a wide range of neurological and psychiatric disorders (1–4). However, effective activation is difficult, given the large diversity of cell types within the cortex coupled with an inability to selecti ...
Nervous System Module - Year 2 Semester 1 Number of Credit – 8
Nervous System Module - Year 2 Semester 1 Number of Credit – 8

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PDF - Center for Theoretical Neuroscience

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Neuroscience Newsletter, May 2015 - MSc/PhD/MD

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... the fibers where no blood vessels were seen. Based upon previous studies (Ballard, 1978; Barker & Saito, 1981; Bombardi et al. 2006), we conclude that this staining is most Iikely located on free nerve endings/nerves with varicose appearance. Autonomic innervation was present only in a low number of ...
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... through the neural matrix; i.e. the refractory period is capable of interference at axon bifurcations and the axon hillock of cell bodies to produce effective deflection of action potentials along different axonal pathways in the neural network or to cause mutual occlusion. ...
Update on CRPS (formerly Reflex Sympathetic Dystrophy)
Update on CRPS (formerly Reflex Sympathetic Dystrophy)

... History of CRPS (20th century), cont.  In 1946, Evans used the term RSD, believing that sympathetic hyperactivity is involved somehow in the abnormal activity in the periphery.   In 1993, the International Association for the Study of Pain (IASP) held a Special Consensus Conference addressing dia ...
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Rheobase



Rheobase is a measure of membrane excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration (in a practical sense, about 300 milliseconds) that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. In Greek, the root ""rhe"" translates to current or flow, and ""basi"" means bottom or foundation: thus the rheobase is the minimum current that will produce an action potential or muscle contraction.Rheobase can be best understood in the context of the strength-duration relationship (Fig. 1). The ease with which a membrane can be stimulated depends on two variables: the strength of the stimulus, and the duration for which the stimulus is applied. These variables are inversely related: as the strength of the applied current increases, the time required to stimulate the membrane decreases (and vice versa) to maintain a constant effect. Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength.The strength-duration curve was first discovered by G. Weiss in 1901, but it was not until 1909 that Louis Lapicque coined the term ""rheobase"". Many studies are being conducted in relation to rheobase values and the dynamic changes throughout maturation and between different nerve fibers. In the past strength-duration curves and rheobase determinations were used to assess nerve injury; today, they play a role in clinical identification of many neurological pathologies, including as Diabetic neuropathy, CIDP, Machado-Joseph Disease, and ALS.
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