Application of single-cell RNA sequencing in optimizing a
... within a patient and ultimately to achieve sustainable therapeutic benefit through a rational drug combination design. The magnitude of ITH in ccRCC has been discerned in detail by recent approaches of sequencing multiregional biopsied specimens [7, 8] or single cells [14]. However, experimental app ...
... within a patient and ultimately to achieve sustainable therapeutic benefit through a rational drug combination design. The magnitude of ITH in ccRCC has been discerned in detail by recent approaches of sequencing multiregional biopsied specimens [7, 8] or single cells [14]. However, experimental app ...
Neurons
... glands (continued) – The same principles of connectivity and intensity coding for sensory inputs are used for the brain’s outputs – Which muscles or glands are activated is determined by their connections to the brain or spinal cord – For example, the neurons that activate biceps muscles are differe ...
... glands (continued) – The same principles of connectivity and intensity coding for sensory inputs are used for the brain’s outputs – Which muscles or glands are activated is determined by their connections to the brain or spinal cord – For example, the neurons that activate biceps muscles are differe ...
Протокол
... Because the optic nerve is actually a tract of the central nervous system, myelinated by oligodendrocytes, it is susceptible to demyelinating disease (multiple sclerosis). Cerebrovascular accidents regularly involve the optic tract as it passes the junction of the internal carotid and middle cerebra ...
... Because the optic nerve is actually a tract of the central nervous system, myelinated by oligodendrocytes, it is susceptible to demyelinating disease (multiple sclerosis). Cerebrovascular accidents regularly involve the optic tract as it passes the junction of the internal carotid and middle cerebra ...
Neural Responses to Facial Expression and Face Identity in the
... amygdala leads to the hypothesis that these inputs may be further processed in the amygdala, leading to the selection of social responses based on a combination of identity and facial expression. The present study had two major objectives: 1) to determine the specificity of neural responses to faces ...
... amygdala leads to the hypothesis that these inputs may be further processed in the amygdala, leading to the selection of social responses based on a combination of identity and facial expression. The present study had two major objectives: 1) to determine the specificity of neural responses to faces ...
Multi-chip dataflow architecture for massive scale biophysically
... a way that it is possible to implement it over multiple chips. Experimental results have shown that it is possible to use up to 8 chips and still keeping the communication costs linear with the number of simulated neurons. The systems is very flexible and allows to tune, during run-time, various par ...
... a way that it is possible to implement it over multiple chips. Experimental results have shown that it is possible to use up to 8 chips and still keeping the communication costs linear with the number of simulated neurons. The systems is very flexible and allows to tune, during run-time, various par ...
Spikes, Local Field Potentials, and How to Model Both
... Models Spikes and Generalized Linear Models Example of GLM modeling in rat barrel cortex ...
... Models Spikes and Generalized Linear Models Example of GLM modeling in rat barrel cortex ...
In utero administration of Ad5 and AAV pseudotypes to the
... throughout cortical layers II -- VI (Figures 3f -- h). These cellular tropisms were also observed in the motor and cingulate cortex (data not shown). Examination of the piriform cortex revealed no transduction by Ad5 (Figure 3i). However, all three AAV serotypes mediated gene delivery to cells in th ...
... throughout cortical layers II -- VI (Figures 3f -- h). These cellular tropisms were also observed in the motor and cingulate cortex (data not shown). Examination of the piriform cortex revealed no transduction by Ad5 (Figure 3i). However, all three AAV serotypes mediated gene delivery to cells in th ...
How Inhibition Shapes Cortical Activity
... Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition. Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping spontaneous and sensory-evoked cortical activity and thus underscores how a better knowledge of inhibitory circuits is ne ...
... Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition. Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping spontaneous and sensory-evoked cortical activity and thus underscores how a better knowledge of inhibitory circuits is ne ...
Locus coeruleus - Rice CAAM Department
... Mecp2-deficient mice[12] . However, locus coeruleus cells are not dying but are more likely losing their fully mature phenotype since no apoptotic neurons in the pons were detected[12] . Researchers have concluded that "Because these neurons are a pivotal source of norepinephrine throughout the brai ...
... Mecp2-deficient mice[12] . However, locus coeruleus cells are not dying but are more likely losing their fully mature phenotype since no apoptotic neurons in the pons were detected[12] . Researchers have concluded that "Because these neurons are a pivotal source of norepinephrine throughout the brai ...
Modeling goal-directed spatial navigation in the rat based on physiological
... that operate in parallel without interference. Theta also regulated episodic repetition in a STM buffer. Phase differences betwen regions undergoing theta modulation ensured the correctly timed propagation of activity. Theta modulation in our model is, therefore, crucial in order to accomplish each ...
... that operate in parallel without interference. Theta also regulated episodic repetition in a STM buffer. Phase differences betwen regions undergoing theta modulation ensured the correctly timed propagation of activity. Theta modulation in our model is, therefore, crucial in order to accomplish each ...
ADA Compliant Lecture PowerPoint
... Action Potential In the graph at right, voltage readings are shown at a given place on the neuron over a period of 20 or 30 milliseconds (thousandths of a second). At first the cell is resting; it then reaches threshold and an action potential is triggered. After a brief hyperpolarization period, th ...
... Action Potential In the graph at right, voltage readings are shown at a given place on the neuron over a period of 20 or 30 milliseconds (thousandths of a second). At first the cell is resting; it then reaches threshold and an action potential is triggered. After a brief hyperpolarization period, th ...
Fernando de Castro and the discovery of the arterial chemoreceptors
... it as a constant organ with a well defined relationship to the angle of the common carotid artery bifurcation through a small ligament, which in fact is a pad of fibroelastic tissue through which its arterial supply reaches the organ. In addition to its reddish color, its compactness and its size, lik ...
... it as a constant organ with a well defined relationship to the angle of the common carotid artery bifurcation through a small ligament, which in fact is a pad of fibroelastic tissue through which its arterial supply reaches the organ. In addition to its reddish color, its compactness and its size, lik ...
Integration of Perspective and Disparity Cues in Surface
... Masato Taira. Integration of perspective and disparity cues in surface-orientation–selective neurons of area CIP. J Neurophysiol 86: 2856 –2867, 2001. We investigated the effects of linear perspective and binocular disparity, as monocular and binocular depth cues, respectively, on the response of su ...
... Masato Taira. Integration of perspective and disparity cues in surface-orientation–selective neurons of area CIP. J Neurophysiol 86: 2856 –2867, 2001. We investigated the effects of linear perspective and binocular disparity, as monocular and binocular depth cues, respectively, on the response of su ...
Dehumanizing the Lowest of the Low: Neuroimaging Responses to
... participant by simply subtracting the activation during exposure to each picture from the activation during the fixation-cross display. The resulting maps were then averaged across participants and registered to a standard Talairach brain, with coordinates based on this standard system (Talairach & ...
... participant by simply subtracting the activation during exposure to each picture from the activation during the fixation-cross display. The resulting maps were then averaged across participants and registered to a standard Talairach brain, with coordinates based on this standard system (Talairach & ...
Channelrhodopsin
Channelrhodopsins are a subfamily of retinylidene proteins (rhodopsins) that function as light-gated ion channels. They serve as sensory photoreceptors in unicellular green algae, controlling phototaxis: movement in response to light. Expressed in cells of other organisms, they enable light to control electrical excitability, intracellular acidity, calcium influx, and other cellular processes. Channelrhodopsin-1 (ChR1) and Channelrhodopsin-2 (ChR2) from the model organism Chlamydomonas reinhardtii are the first discovered channelrhodopsins. Variants have been cloned from other algal species, and more are expected.