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Voltage-Gated Sodium Channels: Therapeutic Targets
Voltage-Gated Sodium Channels: Therapeutic Targets

Voltage-Gated Sodium Channels
Voltage-Gated Sodium Channels

... elevated temperature, but without global deficits in temperature regulation or orthostatic pressure [59,60]. Early-onset inherited erythromelalgia (also known as erythermalgia) is an autosomal dominant disorder which has been linked to missense mutations in Nav1.7 [58,61–67]. Electrophysiological rec ...
Spike-Wave Complexes and Fast Components of Cortically
Spike-Wave Complexes and Fast Components of Cortically

... component of cortical SW/PSW complexes, whereas they fired single action potentials, spike doublets, or triplets during the fast runs. In TC cells, the cortical fast runs were reflected as excitatory postsynaptic potentials appearing after short latencies that were compatible with monosynaptic activ ...
Media Release
Media Release

... lifetime by creating a special kind of neural network that is “pre-adapted” to face any eventuality. This emerges from a new neuroscience study published in PLOS Computational Biology. Enel et al at the INSERM in France investigate one of the most noteworthy properties of primate behavior, its diver ...
Developmentally regulated expression of reporter gene in adult
Developmentally regulated expression of reporter gene in adult

... with P-GAL4 insertion were crossed to UAS-Nuc LacZ strain and the F1 larval ganglion at different instars was stained for β-galactosidase activity. (a) Second instar, (b) third instar of SG1.1 where the reporter expression appears at 2nd instar stage and becomes strong in the olfactory/mushroom body ...
Cortical Maps - White Rose Research Online
Cortical Maps - White Rose Research Online

... can modulate neuronal activity, such as the location, contrast, color, orientation, or spatial frequency of an edge in an image, the receptive field may be defined functionally in terms of feature dimensions. The receptive field of a neuron thus more generally refers to a localized region in a mult ...
CNS*2004 July 18-22, 2004 Baltimore, Maryland
CNS*2004 July 18-22, 2004 Baltimore, Maryland

... surrounding areas are included on the following pages along with lists of local activities and restaurants. Registration: Meeting registration will be open in the foyer of the Calvert Ballroom beginning Saturday, July 17th from 5:00-7:00 pm. From Sunday, July 18th to Wednesday, July 21st the Regisra ...
The functional role of GABA and glycine in monaural and binaural
The functional role of GABA and glycine in monaural and binaural

... The IC of bats has been studied extensively in neurophysiological and neuroanatomical research (review: Pollak and Casseday 1989). Single unit recordings in the IC have shown that the excitatory tuning curves are flanked by lateral inhibitory sidebands (M611er 1978; Suga 1969; Suga and Schlegel 1973 ...
Next Selection - Guido de Bres
Next Selection - Guido de Bres

...  This common antibiotic, the first “wonder drug”, was ...
Neurons - LPS.org
Neurons - LPS.org

... Perhaps you’re wondering what this chapter is doing here. After all, you signed up for a course in psychology, not biology! In the next two modules, we’ll be covering material that looks suspiciously as though it belongs in a biology textbook. What’s going on? Think of it this way. If your biologica ...
doc midterm 1 chapter notes
doc midterm 1 chapter notes

... He defined the term reflex: An automatic, stereotyped movement that is produced as a direct result of a stimulus. He said that energy coming from an outside source would be reflected back through the nervous system to the muscles, which would contract (we of course have a different explanation for t ...
resting potential
resting potential

... sufficiently, it results in a massive change in membrane voltage called an action potential • Action potentials have a constant magnitude, are all-or-none, and transmit signals over long distances • They arise because some ion channels are voltage-gated, opening or closing when the membrane potentia ...
Chapter 48
Chapter 48

... sufficiently, it results in a massive change in membrane voltage called an action potential • Action potentials have a constant magnitude, are all-or-none, and transmit signals over long distances • They arise because some ion channels are voltage-gated, opening or closing when the membrane potentia ...
The quantitative single-neuron modeling competition | SpringerLink
The quantitative single-neuron modeling competition | SpringerLink

... Edelman 2008). For these and other projects it is critical to design single neuron models that can quantitatively capture the activity of real neurons. Single neuron models can be classified into two major categories: detailed biophysical models and simple phenomenological models. Following the work ...
Physiology
Physiology

... This is important because it enables neurons of the neuronal pool to receive signals from different sources (fig. 2-5). The effect produced will be the resultant of all the inputs whether excitatory or inhibitory; e.g. motor neurons of the ventral horn of the spinal gray matter receive inputs from t ...
PPT - Altogen Biosystems
PPT - Altogen Biosystems

... Kits, Transfection Reagents and Electroporation Delivery Products ...
Chapter 3
Chapter 3

... Diversity in Neurons • Both structural and functional features are used to classify the various neurons in the body. • On the basis of the number of processes extending from the cell body (structure), neurons are classified as multipolar, biopolar, and unipolar (Figure 12.4). • Most neurons in the ...
Auditory–vocal mirroring in songbirds
Auditory–vocal mirroring in songbirds

... mediated perhaps by their long-range projections to area X or by the excitatory synapses that their local collaterals make on HVCRA cells and HVC interneurons [66]. In the former scenario, the singing-related activity of HVCX cells could influence to what extent the AFP contributes to performance va ...
Ch 12
Ch 12

... Diversity in Neurons • Both structural and functional features are used to classify the various neurons in the body. • On the basis of the number of processes extending from the cell body (structure), neurons are classified as multipolar, biopolar, and unipolar (Figure 12.4). • Most neurons in the ...
PDF version - UTRGV Faculty Web
PDF version - UTRGV Faculty Web

... complied with the animal care guidelines of the University of Melbourne and the laws of Australia. Animals were anaesthetised by chilling for at least 30 minutes before dissection. Dissections were performed in chilled seawater. I removed the abdomen at the thoracicabdomen joint, trimmed the protrud ...
Central nervous system control of food intake and body
Central nervous system control of food intake and body

... has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any ...
Evidence for implication of primate area V1 in neural 3
Evidence for implication of primate area V1 in neural 3

30 Hearing - Semantic Scholar
30 Hearing - Semantic Scholar

... into electrical signals and forwards them to the brain. The cochlea, however, is not simply a passive detector. Our ability to recognize small differences in sounds stems from the auditory system's capacity to distinguish among frequency components and to inform us of both the tones present and thei ...
A new approach to neural cell culture for long
A new approach to neural cell culture for long

... permeable to oxygen (O2) and carbon dioxide (CO2), and relatively impermeable to water vapor. This prevents contamination and greatly reduces evaporation, allowing the use of a non-humidified incubator. We have employed this technique to grow dissociated cortical cultures from rat embryos on multi-e ...
PDF
PDF

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Channelrhodopsin



Channelrhodopsins are a subfamily of retinylidene proteins (rhodopsins) that function as light-gated ion channels. They serve as sensory photoreceptors in unicellular green algae, controlling phototaxis: movement in response to light. Expressed in cells of other organisms, they enable light to control electrical excitability, intracellular acidity, calcium influx, and other cellular processes. Channelrhodopsin-1 (ChR1) and Channelrhodopsin-2 (ChR2) from the model organism Chlamydomonas reinhardtii are the first discovered channelrhodopsins. Variants have been cloned from other algal species, and more are expected.
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