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Virginia Gil
Virginia Gil

... viruses do not fit our usual definition of life. Viruses share the characteristic that they can be double stranded DNA or RNA. It is however, very different from eukaryotic chromosome, which have linear DNA molecules associated with a considerable amount of protein. Viruses do not fir our definition ...
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BIO 304: General Genetics, Fall 2003
BIO 304: General Genetics, Fall 2003

... replication and repair, gene expression, regulation of gene expression as well as topics involved in biotechnology. Upon completion of this course, you are expected to be able to: •Define and describe the chemical structure of both DNA and RNA at the molecular and macromolecular level. •Describe the ...
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... During each PCR cycle, the target DNA sequence is doubled. • By the end of the third cycle, one-fourth of the molecules correspond exactly to the target sequence, with both strands of the correct length. (See white boxes in Cycle 3.) • After 20 or so cycles, the target sequence molecules outnumber a ...
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Cre-Lox recombination



In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.
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