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Anti-HIV Drugs
... • HIV protease inhibitors are specific to HIV protease because it differs significantly from human protease. • The 6 PI’s currently approved for clinical use were all designed by using structure-based drug design methods4. ...
... • HIV protease inhibitors are specific to HIV protease because it differs significantly from human protease. • The 6 PI’s currently approved for clinical use were all designed by using structure-based drug design methods4. ...
Newer Antihypertensive Drugs
... Renalase, a novel kidney-related peptide that might impact CV health. Renalase is the first known circulating amine oxidase in plasma that metabolizes catecholamines. ...
... Renalase, a novel kidney-related peptide that might impact CV health. Renalase is the first known circulating amine oxidase in plasma that metabolizes catecholamines. ...
Annex 2
... yy If urea, creatinine or potassium do rise excessively consider stopping concomitant nephrotoxic drugs (eg NSAIDs), other potassium supplements/retaining agents (triamterene, amiloride, spironolactone/ eplerenone) and, if there are no signs of congestion, reducing the dose of diuretic. The safety ...
... yy If urea, creatinine or potassium do rise excessively consider stopping concomitant nephrotoxic drugs (eg NSAIDs), other potassium supplements/retaining agents (triamterene, amiloride, spironolactone/ eplerenone) and, if there are no signs of congestion, reducing the dose of diuretic. The safety ...
MRI imaging of necrosis and PET imaging of radiation
... Purpose: Molecular targeted radiation protecting drugs can reduce the risk of injury to normal tissues in patients treated with radiotherapy. Inhibitors of enzyme GSK3β markedly attenuate radiation induced apoptosis in normal tissues but not in cancer. These drugs prevented radiation induced injury ...
... Purpose: Molecular targeted radiation protecting drugs can reduce the risk of injury to normal tissues in patients treated with radiotherapy. Inhibitors of enzyme GSK3β markedly attenuate radiation induced apoptosis in normal tissues but not in cancer. These drugs prevented radiation induced injury ...
Hyperkalemia Due to Drug Interactions
... It is also important to consider angiotensin II receptor blockers as similar to ACE inhibitors in that they both tend to increase the risk of hyperkalemia when combined with spironolactone or other potassium-sparing diuretics. How can the risk of hyperkalemia from ACE inhibitors plus spironolactone ...
... It is also important to consider angiotensin II receptor blockers as similar to ACE inhibitors in that they both tend to increase the risk of hyperkalemia when combined with spironolactone or other potassium-sparing diuretics. How can the risk of hyperkalemia from ACE inhibitors plus spironolactone ...
PHL 424 9th S - Home - KSU Faculty Member websites
... Clindamycin is a chlorine-substituted derivative of lincomycin, an antibiotic produced by Streptomyces lincolnensis Lincomycin, although structurally distinct, resembles erythromycin in activity, but it is toxic and no longer used ...
... Clindamycin is a chlorine-substituted derivative of lincomycin, an antibiotic produced by Streptomyces lincolnensis Lincomycin, although structurally distinct, resembles erythromycin in activity, but it is toxic and no longer used ...
3. Antiproliferative and antimetabolic drugs
... • CNS toxicity: tremor, convulsion, coma, etc. • Increased risk of neoplasia • Increased susceptibility to infections • Others: hirsutism, hypertension, hyperlipidemia, and gum hyperplasia , etc. ...
... • CNS toxicity: tremor, convulsion, coma, etc. • Increased risk of neoplasia • Increased susceptibility to infections • Others: hirsutism, hypertension, hyperlipidemia, and gum hyperplasia , etc. ...
3. Antiproliferative and antimetabolic drugs
... (2) Rejection of organ transplantation (3) Allergic diseases: urticaria, serum sicknss, contact dermatitis, drug allergic reactions, chronic severe asthma, status asthmaticus, angioneurotic edema, etc. ...
... (2) Rejection of organ transplantation (3) Allergic diseases: urticaria, serum sicknss, contact dermatitis, drug allergic reactions, chronic severe asthma, status asthmaticus, angioneurotic edema, etc. ...
Angiotensin-Converting Enzyme Inhibitors
... resistance but cause little change in heart rate With chronic ACE inhibition, AT II and aldosterone levels tend to return to pretreatment levels (AJC ...
... resistance but cause little change in heart rate With chronic ACE inhibition, AT II and aldosterone levels tend to return to pretreatment levels (AJC ...
16 Antidepressants
... • Side effects can include anxiety, restlessness, tremor, insomnia, seizures • Also marketed as a smoking cessation (Zyban®) ...
... • Side effects can include anxiety, restlessness, tremor, insomnia, seizures • Also marketed as a smoking cessation (Zyban®) ...
Drugs used to treat hypertension
... 2. Angiotensin-converting enzyme inhibitors (ACEI), blockers of AT1 rc. Adverse effects and contraindications of ACEI: -are generally well tolerated. Adverse effects include: First dose hypotension - particularly in those receiving diuretic therapy; the first dose should preferably be given at bedt ...
... 2. Angiotensin-converting enzyme inhibitors (ACEI), blockers of AT1 rc. Adverse effects and contraindications of ACEI: -are generally well tolerated. Adverse effects include: First dose hypotension - particularly in those receiving diuretic therapy; the first dose should preferably be given at bedt ...
Ramipril - Developing Anaesthesia
... There have been no reports following the use ramipril during breastfeeding, and the effects on the breastfed infant are unknown. Consider an alternative medicine where possible. Shorter acting angiotensin converting enzyme (ACE) inhibitors such as captopril or enalapril are preferred and considered ...
... There have been no reports following the use ramipril during breastfeeding, and the effects on the breastfed infant are unknown. Consider an alternative medicine where possible. Shorter acting angiotensin converting enzyme (ACE) inhibitors such as captopril or enalapril are preferred and considered ...
Drugs Used in Coagulation Disorders
... • Bleeding (most common) • Hypercoagulability early in therapy → dermal ...
... • Bleeding (most common) • Hypercoagulability early in therapy → dermal ...
Simvastatin and atorvastatin: beware of potential CYP3A4
... isoenzyme CYP3A4. Medicines that inhibit or induce this enzyme (Table 1) are likely to affect the plasma concentration of these statins, resulting in either an increased risk of adverse effects (e.g. myopathy and rhabdomyolyis) or a reduction in the effectiveness of treatment.2 For example, one stud ...
... isoenzyme CYP3A4. Medicines that inhibit or induce this enzyme (Table 1) are likely to affect the plasma concentration of these statins, resulting in either an increased risk of adverse effects (e.g. myopathy and rhabdomyolyis) or a reduction in the effectiveness of treatment.2 For example, one stud ...
Premature births, protease inhibitors and progesterone
... main protease inhibitor in the blood and keep it elevated for about 24 hours. In this way, many regimens containing protease inhibitors can be taken just once daily. Ritonavir has this effect in a large part because it impairs the activity of enzymes in the intestine and liver that can break down pro ...
... main protease inhibitor in the blood and keep it elevated for about 24 hours. In this way, many regimens containing protease inhibitors can be taken just once daily. Ritonavir has this effect in a large part because it impairs the activity of enzymes in the intestine and liver that can break down pro ...
Inotropic Agents
... • Occurs in 10% of the population over 75 • Can result in death through progressive heart damage or sudden death • Overworking of the heart leads to cardiomegaly and myocardial hypertrophy ...
... • Occurs in 10% of the population over 75 • Can result in death through progressive heart damage or sudden death • Overworking of the heart leads to cardiomegaly and myocardial hypertrophy ...
Drugs for Dementia
... Parkinsonian symptoms; this may induce or exacerbate extrapyramidal side effects. Monitoring 1. Adverse effects: Most common side effects are gastrointestinal disturbance (nausea, vomiting, and diarrhoea). 2. Concurrent medication: Medication should be reviewed at each visit in order to identify pot ...
... Parkinsonian symptoms; this may induce or exacerbate extrapyramidal side effects. Monitoring 1. Adverse effects: Most common side effects are gastrointestinal disturbance (nausea, vomiting, and diarrhoea). 2. Concurrent medication: Medication should be reviewed at each visit in order to identify pot ...
Anticoagulants
... • Fast action intravenously or by injection (not absorbed through the stomach or intestinal wall) • peak after injection 2 - 4 hr • Complex metabolism (long chains broken up) • half life 1 - 5 hr; cleared by the reticuloendothelial system and some excreted in urine. • A few Drug-drug interactions • ...
... • Fast action intravenously or by injection (not absorbed through the stomach or intestinal wall) • peak after injection 2 - 4 hr • Complex metabolism (long chains broken up) • half life 1 - 5 hr; cleared by the reticuloendothelial system and some excreted in urine. • A few Drug-drug interactions • ...
Chapter 49 Antiviral Agents
... during labor and zidovudine syrup to the neonate from birth through 6 weeks of age has been shown to reduce the rate of vertical (mother-to-newborn) transmission of HIV by up to 23% ...
... during labor and zidovudine syrup to the neonate from birth through 6 weeks of age has been shown to reduce the rate of vertical (mother-to-newborn) transmission of HIV by up to 23% ...
2 Non-steroidal anti-inflammatory drugs
... • Half-life 11 hours (twice/day). • Food decrease its absorption. • Highly bound to plasma proteins. • Clinical uses & Adverse effects: • Discussed before with general uses and general adverse effects of selective COX-2 inhibitors. ...
... • Half-life 11 hours (twice/day). • Food decrease its absorption. • Highly bound to plasma proteins. • Clinical uses & Adverse effects: • Discussed before with general uses and general adverse effects of selective COX-2 inhibitors. ...
From Natural Product to clinical trial
... patients failing HIV therapy due to drug resistance Good activity in 369, 370, 371 on Gag amino acid sequence mutant, less activity in polymorphism(variants) 20μg/mL bevirimat is required for a robust response ...
... patients failing HIV therapy due to drug resistance Good activity in 369, 370, 371 on Gag amino acid sequence mutant, less activity in polymorphism(variants) 20μg/mL bevirimat is required for a robust response ...
... and heart failure for over 10 years, information has accumulated not only on ACE inhibitors as a therapeutic class but also on a number of individual drugs. Many more have been studied in pre-clinical and early clinical research (up to 70 compounds) in addition to the ten agents currently licensed f ...