Drugs used for treatment of AIDS
... transcriptase inhibitor zidovudine but this drugs or even in combination of drugs from this group were unable to suppress virus for long periods of time and patient eventually dies ...
... transcriptase inhibitor zidovudine but this drugs or even in combination of drugs from this group were unable to suppress virus for long periods of time and patient eventually dies ...
Matrix metalloproteinase inhibitors in rheumatic diseases
... that large patient numbers are needed, possibly in excess of 200 for each arm of the trial. In addition, to evaluate the eVectiveness of an MMP inhibitor over time, the expected rate of progression has to be estimated in order to assess the sample size as well as the target profile for the inhibitor ...
... that large patient numbers are needed, possibly in excess of 200 for each arm of the trial. In addition, to evaluate the eVectiveness of an MMP inhibitor over time, the expected rate of progression has to be estimated in order to assess the sample size as well as the target profile for the inhibitor ...
MICROBIOTIX, INC
... bacterial adhesion, evasion of host immune response, nutrient acquisition and host cell invasion. Interference with the display of surface proteins on the bacterial cell membrane by inhibition of sortase A is an effective mechanistic approach to antibacterial therapy. Currently, no sortase inhibitor ...
... bacterial adhesion, evasion of host immune response, nutrient acquisition and host cell invasion. Interference with the display of surface proteins on the bacterial cell membrane by inhibition of sortase A is an effective mechanistic approach to antibacterial therapy. Currently, no sortase inhibitor ...
Study guide for research assistants
... can be used to re-make pyrimidine nucleotides. • Dihydroorotate dehydrogenase (DHODH) is "flavin-dependent." This just means that a flavin (flavin mononucleotide, to be specific) is one of its substrates. • The IC50's (concentrations that achieve 50% inhibition of enzyme activity) reported here give ...
... can be used to re-make pyrimidine nucleotides. • Dihydroorotate dehydrogenase (DHODH) is "flavin-dependent." This just means that a flavin (flavin mononucleotide, to be specific) is one of its substrates. • The IC50's (concentrations that achieve 50% inhibition of enzyme activity) reported here give ...
24th Symposium on Medicinal Chemistry in Eastern England Programme
... From PSK1404 to GLPG0187, clinical candidate: How to overcome toxicity in the integrin receptor antagonist program ...
... From PSK1404 to GLPG0187, clinical candidate: How to overcome toxicity in the integrin receptor antagonist program ...
Design and Synthesis of Small Molecule Inhibitors of
... negatively correlated with levels of HDL-cholesterol in vivo. Disruption of EL activity, either through antibody directed inhibition, or gene knock-out, has been shown to increase levels of HDL-C in rabbits and mice on both normal and high-fat diets. Because the active site of EL contains serine-pro ...
... negatively correlated with levels of HDL-cholesterol in vivo. Disruption of EL activity, either through antibody directed inhibition, or gene knock-out, has been shown to increase levels of HDL-C in rabbits and mice on both normal and high-fat diets. Because the active site of EL contains serine-pro ...