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Effect of dietary administration of lipoic acid on protein
Effect of dietary administration of lipoic acid on protein

... consequence of a triage allocation response to micronutrient shortage. 1) Episodic shortage of micronutrients were common throughout evolution. 2) natural selection favors short-term survival at the expense of long-term health when they are in conflict 3) this was achieved by allocating scarce micro ...
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... • Complex carbohydrates are called polysaccharides • They are polymers of monosaccharides - long chains of simple sugar units • Polysaccharides have storage and structural roles • The structure and function of a polysaccharide are determined by its sugar monomers and the positions of ...
world journal of pharmaceutical research
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... As shown in Figure 3, in the glycolysis step, glucose is broken down to two molecules of pyruvate via a series of enzymatic reactions that occur in the cytoplasm (anaerobic). The breakdown of glucose releases enough energy to immediately give a net gain of two ATP molecules by substrate-level ATP sy ...
Evolution of the citric acid cycle and respiratory
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A. Reaction Mechanisms and Catalysis (1) proximity effect (2) acid

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... •Starch: storage of glucose in the roots and other tissues of plants. Consists entirely of glucose. •Cellulose: Forms cable-like fibers in walls that enclose plant cells, known as cell wall. Composed of glucose, but monomers are linked in different ...
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... very good examples of such an evolutionary behaviour (Fig. 1). With regard to the conservative glycine and proline residues flanking in loops the strand β2 of many (β/α)8 -barrel enzymes, the three glycolytic enzymes were also revealed to be structurally different (Janeèek, 1996): ENOL contains both ...
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Powerpoint - Oregon State University
Powerpoint - Oregon State University

... product. When the release of the colored substrate by the enzyme is studied, there is a VERY rapid release of the colored substrate. After that initial burst of activity, the remaining yellow color is released slowly. Explain this observation. The reaction catalyzed occurs in two steps. The first st ...
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Proliferation-Independent Control of Tumor Glycolysis by PDGFR
Proliferation-Independent Control of Tumor Glycolysis by PDGFR

... have suggested that metabolic changes are key alterations contributing to tumorigenesis and tumor progression. Ongoing work seeks to link these changes to the genetic alterations underlying oncogenesis (1–4). Normal tissues use aerobic respiration to metabolize glucose in the presence of physiologic ...
Chapter 3 - Los Angeles City College
Chapter 3 - Los Angeles City College

... 2. Induced fit model: After enzyme binds to substrate, it changes shape and lowers activation energy of the reaction by one of several mechanisms: • Straining chemical bonds of the substrate • Bringing two or more reactants close together • Providing “micro-environment” conducive to reaction 3. Rele ...
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2 H+

... molecules are broken down in a series of steps §  Electrons from organic compounds are usually first transferred to NAD+, a coenzyme §  As an electron acceptor, NAD+ functions as an oxidizing agent during cellular respiration §  Each NADH (the reduced form of NAD+) represents stored energy that is t ...
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Enzymes

... Exergonic: a reaction that gives off energy • (the reactants have more energy in their bonds than the products) Endergonic: a reaction that needs energy • (the reactants have less energy in their bonds than the products) http://videos.howstuffworks.com/discovery/28733-assignment-discovery-enzymecata ...
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Glycolysis



Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy compounds ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide).Glycolysis is a determined sequence of ten enzyme-catalyzed reactions. The intermediates provide entry points to glycolysis. For example, most monosaccharides, such as fructose and galactose, can be converted to one of these intermediates. The intermediates may also be directly useful. For example, the intermediate dihydroxyacetone phosphate (DHAP) is a source of the glycerol that combines with fatty acids to form fat.Glycolysis is an oxygen independent metabolic pathway, meaning that it does not use molecular oxygen (i.e. atmospheric oxygen) for any of its reactions. However the products of glycolysis (pyruvate and NADH + H+) are sometimes disposed of using atmospheric oxygen. When molecular oxygen is used in the disposal of the products of glycolysis the process is usually referred to as aerobic, whereas if the disposal uses no oxygen the process is said to be anaerobic. Thus, glycolysis occurs, with variations, in nearly all organisms, both aerobic and anaerobic. The wide occurrence of glycolysis indicates that it is one of the most ancient metabolic pathways. Indeed, the reactions that constitute glycolysis and its parallel pathway, the pentose phosphate pathway, occur metal-catalyzed under the oxygen-free conditions of the Archean oceans, also in the absence of enzymes. Glycolysis could thus have originated from chemical constraints of the prebiotic world.Glycolysis occurs in most organisms in the cytosol of the cell. The most common type of glycolysis is the Embden–Meyerhof–Parnas (EMP pathway), which was discovered by Gustav Embden, Otto Meyerhof, and Jakub Karol Parnas. Glycolysis also refers to other pathways, such as the Entner–Doudoroff pathway and various heterofermentative and homofermentative pathways. However, the discussion here will be limited to the Embden–Meyerhof–Parnas pathway.The entire glycolysis pathway can be separated into two phases: The Preparatory Phase – in which ATP is consumed and is hence also known as the investment phase The Pay Off Phase – in which ATP is produced.↑ ↑ 2.0 2.1 ↑ ↑ ↑ ↑ ↑ ↑
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