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finalexamcrib201213NED 33.5 KB
finalexamcrib201213NED 33.5 KB

... weeks), which is essentially a short unit test, and is worth 64%, and cumulative content, which is essentially a mini-final and is worth 36%. The total value is 100%, all multiple choice questions, each worth 2 points. For those of you math whizzes, that is 50 questions. :~p Euk regulation: 1-32; Cu ...
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Slide 1

... 2) The cell’s nuclear membrane disappears. 3) Two organelles called centrioles make cytoskeleton-like threads that pull half of the chromosomes toward each end of the cell. 4) The cell membrane pinches off in the middle, breaking the parent cell into two daughter cells. 5) New nuclear membranes form ...
Organism Genome (kb) Form
Organism Genome (kb) Form

... Chromatin and histones • In eukaryotes, the first level of DNA packing is the chromatin fibre • Chromatin is formed by wrapping the DNA around complexes of the 4 histone proteins (2 molecules each of histones H2A, H2B, H3, H4) to form “beads on string” arrangement - the beads are nucleosomes • See ...
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PDF

... expression of the transcription factors Drifter, Runt, Homothorax and Brainspecific homeobox. The birth order of the medulla neurons correlates with the expression pattern of these factors, they report, and each neuronal type exhibits an extensive but defined pattern of migration that disrupts the c ...
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PDF

... expression of the transcription factors Drifter, Runt, Homothorax and Brainspecific homeobox. The birth order of the medulla neurons correlates with the expression pattern of these factors, they report, and each neuronal type exhibits an extensive but defined pattern of migration that disrupts the c ...
PDF
PDF

... expression of the transcription factors Drifter, Runt, Homothorax and Brainspecific homeobox. The birth order of the medulla neurons correlates with the expression pattern of these factors, they report, and each neuronal type exhibits an extensive but defined pattern of migration that disrupts the c ...
B1 – You and your genes
B1 – You and your genes

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Supplementary Material (doc 44K)

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... developing gonads (which differentiate into the Sertoli and granulosa cells of the testes and ovaries, respectively) ‘tell’ the germ cells which sex to become. Retinoic acid is thought to control this process by inducing meiosis in the developing ovaries but not in the testes where it is metabolised ...
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... stressor. Phenotypic diversity can be produced by fluctuations in gene expression and is observed in many stress response mechanisms. In this study, we show another general role of noise in gene expression. By simulating a transcription factor that activates several downstream genes (singleinput mod ...
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PowerPoint-Präsentation

... assessed using the Illumina HumanMethylation450 BeadChip platform. Analysis of data was performed using Genome-Studio (Illumina). Gene expression data were collected from Affymetrix HG-U133Plus 2.0 transcriptomes analysed in the BioRetis database. Mapping of CpG sites with genes was performed using ...
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DNA Recombination

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Epigenetics in stem-cell differentiation

Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on its position within the body. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence.The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells are controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.This regulation of chromatin through epigenetic modifications is a molecular mechanism that will determine whether the cell will continue to differentiate into the desired fate. A research study performed by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells.
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