ErbB2/HER2: Its Contribution to Basic Cancer Biology and the
... a juxtamembranedomain (~40 residues), an intracellular tyrosine kinase domain (~260 residues), and a C-terminal regulatory region (~232residues) (Burgess et al., 2003). Intriguingly, the structures of ErbB2 and ErbB3 are unique among the ErbB family. ErbB2 is an orphan receptor, but it always has a ...
... a juxtamembranedomain (~40 residues), an intracellular tyrosine kinase domain (~260 residues), and a C-terminal regulatory region (~232residues) (Burgess et al., 2003). Intriguingly, the structures of ErbB2 and ErbB3 are unique among the ErbB family. ErbB2 is an orphan receptor, but it always has a ...
Slide 1
... Protein-to-protein variation of Thermo Scientific Pierce Protein Assays. For each of the protein assays presented here, 14 proteins were assayed using the standard test tube protocol. The net (blank corrected) average absorbance for each protein was calculated. The net absorbance for each protein is ...
... Protein-to-protein variation of Thermo Scientific Pierce Protein Assays. For each of the protein assays presented here, 14 proteins were assayed using the standard test tube protocol. The net (blank corrected) average absorbance for each protein was calculated. The net absorbance for each protein is ...
+Tec - Blood Journal
... nonreceptor PTKs. Therefore, these three kinases should constitute a novel subfamily among the nonreceptor type PTKs. All members of the Tec family are abundantly expressed in hematopoietic tissues. Because the Btk kinase plays a pivotal role in Ig production in B cells, the other members of the Tec ...
... nonreceptor PTKs. Therefore, these three kinases should constitute a novel subfamily among the nonreceptor type PTKs. All members of the Tec family are abundantly expressed in hematopoietic tissues. Because the Btk kinase plays a pivotal role in Ig production in B cells, the other members of the Tec ...
Gq-dependent signalling by the lysophosphatidic acid receptor
... Figure 1 Selective expression of LPA3 receptors and stimulation of Gαq mediated PI hydrolysis, Rho kinase and PKC by LPA in gastric smooth muscle (A) Lysates were prepared from freshly dispersed smooth muscle cells (fsm), cultured smooth muscle cells (csm) and brain (b). The proteins were resolved b ...
... Figure 1 Selective expression of LPA3 receptors and stimulation of Gαq mediated PI hydrolysis, Rho kinase and PKC by LPA in gastric smooth muscle (A) Lysates were prepared from freshly dispersed smooth muscle cells (fsm), cultured smooth muscle cells (csm) and brain (b). The proteins were resolved b ...
Selective kinase inhibitors as tools for neuroscience research
... Keywords: Kinase inhibitor Small molecule Signaling ...
... Keywords: Kinase inhibitor Small molecule Signaling ...
SAM Teachers Guide - RI
... What are some specific jobs of proteins that require them to have a distinct 3D structure? (Possible answers: enzymes, roles in signal transduction, DNA synthesis, etc.) What types of situations may impact how a protein would function? Generate ideas about temperature, whether it is surrounded b ...
... What are some specific jobs of proteins that require them to have a distinct 3D structure? (Possible answers: enzymes, roles in signal transduction, DNA synthesis, etc.) What types of situations may impact how a protein would function? Generate ideas about temperature, whether it is surrounded b ...
In the prevailing view Conducitn is usually considered to act as a
... head interaction surface of the axin DIX domain preventing its homopolymerisation, but leaves the tail interaction surface intact for interaction with Dvl2 (Fiedler et al., 2011). We propose that this results in blunting of Dvl2 polymers leading to smaller complexes no longer visible as puncta (see ...
... head interaction surface of the axin DIX domain preventing its homopolymerisation, but leaves the tail interaction surface intact for interaction with Dvl2 (Fiedler et al., 2011). We propose that this results in blunting of Dvl2 polymers leading to smaller complexes no longer visible as puncta (see ...
Protein Physics by Computer. Step by Step: Protein Visualization
... chromoproteins, that use separate cofactors, the chromophore in GFP is produced from three adjacend amino acids by an cyclization and oxidation step, and the only nececcity to do so is the presence of oxygen. GFP and its variants are easily expressed in E. coli and many other types of cells and ofte ...
... chromoproteins, that use separate cofactors, the chromophore in GFP is produced from three adjacend amino acids by an cyclization and oxidation step, and the only nececcity to do so is the presence of oxygen. GFP and its variants are easily expressed in E. coli and many other types of cells and ofte ...
Second bioinformatics lab:Exercise on disease
... Summarizing, insulin or a growth factor binds to a receptor, two bound receptors come together (dimerization) and activate each other. Each growth factor receptor is a tyrosine kinase that puts a phosphate (i.e., phosphorylate) on tyrosines (a particular amino acid) located on the other receptor’s t ...
... Summarizing, insulin or a growth factor binds to a receptor, two bound receptors come together (dimerization) and activate each other. Each growth factor receptor is a tyrosine kinase that puts a phosphate (i.e., phosphorylate) on tyrosines (a particular amino acid) located on the other receptor’s t ...
Leader The molecular basis of disorders of red cell enzymes
... The situation with the sporadic variety is different. The same mutation appears to have arisen independently in cases in diVerent areas.17 This suggests that mutations capable of causing chronic haemolysis are restricted to a small number of changes that can produce an enzyme with low red cell activ ...
... The situation with the sporadic variety is different. The same mutation appears to have arisen independently in cases in diVerent areas.17 This suggests that mutations capable of causing chronic haemolysis are restricted to a small number of changes that can produce an enzyme with low red cell activ ...
SAM Teachers Guide - RI
... What are some specific jobs of proteins that require them to have a distinct 3D structure? (Possible answers: enzymes, roles in signal transduction, DNA synthesis, etc.) What types of situations may impact how a protein would function? Generate ideas about temperature, whether it is surrounded b ...
... What are some specific jobs of proteins that require them to have a distinct 3D structure? (Possible answers: enzymes, roles in signal transduction, DNA synthesis, etc.) What types of situations may impact how a protein would function? Generate ideas about temperature, whether it is surrounded b ...
cell biology and membrane biochemistry
... Biological membrane is the barriers that separate the cellular content of the cell or that of an organelle from its environment. This barrier is essential for the cell/organelle to sustain life and maintain its identity. Biological membranes are not just inert barriers but are dynamic, semi permeabl ...
... Biological membrane is the barriers that separate the cellular content of the cell or that of an organelle from its environment. This barrier is essential for the cell/organelle to sustain life and maintain its identity. Biological membranes are not just inert barriers but are dynamic, semi permeabl ...
Agonism with the omega-3 fatty acids α-linolenic acid
... The newly discovered G protein-coupled receptor GPR120 has recently been shown to stimulate secretion of the gut hormones glucagon-like peptide-1 and cholecystokinin upon binding of free fatty acids, thrusting it to the forefront of drug discovery efforts for treatment of type 2 diabetes as well as ...
... The newly discovered G protein-coupled receptor GPR120 has recently been shown to stimulate secretion of the gut hormones glucagon-like peptide-1 and cholecystokinin upon binding of free fatty acids, thrusting it to the forefront of drug discovery efforts for treatment of type 2 diabetes as well as ...
TONE UP. GET LEAN. BE STRONG.
... The body is able to make non-essential amino acids from other amino acids in the body. The body, however, is not able to make essential amino acids; the only way to get them is through diet. One of the best ways to ensure you are meeting your needs is by eating highquality protein foods. Protein sou ...
... The body is able to make non-essential amino acids from other amino acids in the body. The body, however, is not able to make essential amino acids; the only way to get them is through diet. One of the best ways to ensure you are meeting your needs is by eating highquality protein foods. Protein sou ...
Functions of the Cell Wall in the Interactions of Plant Cells: Analysis
... Fig. 3 Illustration of the localization of two extracellular proteins in a mature carrot seed. The two proteins, namely, the soluble glycoprotein EDGP (extracellular dermal glycoprotein) and the insoluble protein EICC (extracellular insoluble cystatin of carrot), were originally detected in the cult ...
... Fig. 3 Illustration of the localization of two extracellular proteins in a mature carrot seed. The two proteins, namely, the soluble glycoprotein EDGP (extracellular dermal glycoprotein) and the insoluble protein EICC (extracellular insoluble cystatin of carrot), were originally detected in the cult ...
Asymmetric cell division and axis formation in the embryo
... traverses the spermatheca and encounters a sperm cell. The newly fertilized zygote then moves into the uterus where the remainder of early embryogenesis takes place. In wild-type animals, sperm usually enters the egg opposite from the side of the oocyte nucleus. In addition to DNA, the sperm donates ...
... traverses the spermatheca and encounters a sperm cell. The newly fertilized zygote then moves into the uterus where the remainder of early embryogenesis takes place. In wild-type animals, sperm usually enters the egg opposite from the side of the oocyte nucleus. In addition to DNA, the sperm donates ...
5-Cell and Molecular Biology (Golgi etc)
... • Lysosomes were initially discovered by biochemical fractionations of cell extracts ...
... • Lysosomes were initially discovered by biochemical fractionations of cell extracts ...
Fast Search Protein Structure Prediction Algorithm for Almost Perfect
... Homology modeling works on the principle that although each protein adopts a unique structure, there are only ~2,000 common folds between the various super families identified thus far. ...
... Homology modeling works on the principle that although each protein adopts a unique structure, there are only ~2,000 common folds between the various super families identified thus far. ...
Prokaryotic Annotation at TIGR
... In 1998 we recognized that it would be really useful to have a set of role categories that could be used by all species and we started a project in that direction Also in 1998, I met Michael Ashburner and Suzi Lewis and learned of their efforts with GO, we decided to stop our project and wait to use ...
... In 1998 we recognized that it would be really useful to have a set of role categories that could be used by all species and we started a project in that direction Also in 1998, I met Michael Ashburner and Suzi Lewis and learned of their efforts with GO, we decided to stop our project and wait to use ...
Nucleotide Metabolism Nucleotide sources - Rose
... Nucleotide Metabolism Nucleotide sources In humans, dietary nucleotide bases are rarely incorporated into nucleotides. As a result, humans must synthesize their own nucleotide bases. (With the exception of a few parasitic prokaryotes, all organisms can synthesize nucleotides.) Although all nucleated ...
... Nucleotide Metabolism Nucleotide sources In humans, dietary nucleotide bases are rarely incorporated into nucleotides. As a result, humans must synthesize their own nucleotide bases. (With the exception of a few parasitic prokaryotes, all organisms can synthesize nucleotides.) Although all nucleated ...
Cellular mechanisms regulating protein synthesis and skeletal
... review on this topic]. Serine/threonine kinase Akt/PKB is a well-established target of PI3K, and Akt/PKB phosphorylation of glycogen synthase kinase 3 (GSK-3) leads to its inhibition and an increase in global protein synthesis through increase in the activity of eukaryotic initiation factor 2B (eIF2 ...
... review on this topic]. Serine/threonine kinase Akt/PKB is a well-established target of PI3K, and Akt/PKB phosphorylation of glycogen synthase kinase 3 (GSK-3) leads to its inhibition and an increase in global protein synthesis through increase in the activity of eukaryotic initiation factor 2B (eIF2 ...
Reddy, Kirthi: Analysis of Caenorhabditis elegans protein T09E8.2
... expected. The most statistically significant match found (E value of 0.007) is the erythrocyte membrane-associated giant protein antigen of the malaria parasite. The alignment of this protein with T09E8.2 is not very long and has many gaps, which makes the significance of this alignment rather uncon ...
... expected. The most statistically significant match found (E value of 0.007) is the erythrocyte membrane-associated giant protein antigen of the malaria parasite. The alignment of this protein with T09E8.2 is not very long and has many gaps, which makes the significance of this alignment rather uncon ...
Protein Tertiary and Quaternary Structure
... Quaternary structure – Some proteins have multiple polypeptide chains (quaternary structure). – Arrangement of polypeptides in multimeric proteins is generally symmetrical. – Quaternary structure can play important functional roles for multi- 2 subunit proteins, especially in regulation. ...
... Quaternary structure – Some proteins have multiple polypeptide chains (quaternary structure). – Arrangement of polypeptides in multimeric proteins is generally symmetrical. – Quaternary structure can play important functional roles for multi- 2 subunit proteins, especially in regulation. ...
1. Introduction
... is the link between external resources and the inner workings of the organism. Many biochemical reactions have been studied in great detail and most of them are remarkably well conserved over a wide range of species: in fact, the metabolic pathways of the central carbon metabolism (primary metabolis ...
... is the link between external resources and the inner workings of the organism. Many biochemical reactions have been studied in great detail and most of them are remarkably well conserved over a wide range of species: in fact, the metabolic pathways of the central carbon metabolism (primary metabolis ...
A Comparative Genomic Method for Computational
... Conclusion • DnaA regulation may couple lipid cellular processes to DNA replication – this may be accomplished by the transcription factor activity of DnaA upstream of phospholipid biosynthesis genes fadL, acpP, fabF, accD, plsC, psd, and pgsA – changes in expression of the phospholipid biosynthesi ...
... Conclusion • DnaA regulation may couple lipid cellular processes to DNA replication – this may be accomplished by the transcription factor activity of DnaA upstream of phospholipid biosynthesis genes fadL, acpP, fabF, accD, plsC, psd, and pgsA – changes in expression of the phospholipid biosynthesi ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.