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06 Auxin - goldsword.com
06 Auxin - goldsword.com

... AUX/IAA genes are induced over longer time frames by auxin (up to 30 min.) The members of this gene family act as transcriptional regulators, influencing transcription through interaction with auxin response factors (ARFs). A repressor protein called Transport Inhibitor Response 1 (TIR1) is also inv ...
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Important Factors Influencing Protein Crystallization (PDF
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... mitogen-activated protein kinase; NF, nuclear factor; ROS, reactive oxygen species; eIF, eukaryotic initiation factor; P, phosphorylated; HMB, βHydroxy-β-Methylbutyrate; EPA, eicosapentaenoic acid. *Effects on protein degradation and synthesis in the presence of HMB/EPA. Eley HL, et al. Am J Physiol ...
Iron Sulfur Proteins and their Synthetic Analogues: Structure
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Comparative Analysis of Two C-Terminal Kinesin Motor
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IB496-April 10 - School of Life Sciences
IB496-April 10 - School of Life Sciences

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Richards, F.M. The Protein Folding Problem. Scientific American, pp
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... the cellular defense against glycation and oxidative stress. It comprises two enzymes: Glo-1 and Glo-2. The accumulation of MG is highly deleterious, as this metabolite is one of the most potent glycating agents present in cells. It readily reacts with lipids and nucleic acids and with lysine and ar ...
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... encoded in the genetic code [12]. There are only 20 standard amino acids that exist in living organism. Sometimes these amino acids are chemically modified in the protein after protein synthesis [11]. In total the number of different proteins, which it is possible to produce from 20 amino acids is ...
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... cleavage system followed by lipoic acid synthesis. The lipoylated Gcv3p is then required for lipoylation of other lipoic acid-dependent enzyme complexes – pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KDH). (Hiltunen et al. 2010a, 1196–1198) Kursu (2010, 70) states in his thesis t ...
Molecular characterization of the uncultivatable hemotropic
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Presentazione standard di PowerPoint
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... PPAR-α also suppresses the acute phase inflammatory response via PPRE-binding-dependent61, 62 and -independent mechanisms63(Table 1): PPAR-α represses cytokine-induced and LPS-induced secretion of IL-1, IL-6 and TNF-α and the expression of adhesion molecules ICAε-1 and VCAM-1 in vitro and in vivo, i ...
solute - Life Science Academy
solute - Life Science Academy

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Local protein synthesis in neuronal axons: why and

... a series of important discoveries that have firmly established local protein synthesis as one of key mechanisms underlying activity-dependent structural changes in the synapse (3). In contrast to the dendrite, however, polyribosomes were not readily detected on the other side of the synapse, the axo ...
SUBUNITS FROM REDUCED .AND S
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... Examination of the reduced and carboxymethylated protein in 8M ureaacrylamide gels revealed that the protein migrated as one band at high loadings of protein [Fig. 3(d)], but at lower protein concentrations there was evidence of splitting (Fig. 4). A band which is not stained intensely by amido blac ...
Protein Folding Cell and Mol Biology Lab
Protein Folding Cell and Mol Biology Lab

... important for thermostability; it is a cis proline at the end of the loop (the same Pro 202 we "found" earlier). Changes in the gray amino acids did not have significant effects. In View4 with the mutants on, invoke the "KALEIDOSCOPE" function by pressing the 'k' key. Then rotate slowly, optimizing ...
Protein kinase inhibition: natural and synthetic variations on a theme
Protein kinase inhibition: natural and synthetic variations on a theme

... that the human genome alone encodes over 2000 protein kinases. Since these enzymes regulate almost every process in the eukaryotic cell by serving as on/off switches, it is critical that every kinase be tightly regulated physiologically. They are turned off and on by very precise signals; thus if on ...
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Paracrine signalling



Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.
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