The Neuronal Endomembrane System
... rough endoplasmic reticulum components destined for processing in the Golgi apparatus. Its position is also ideal for playing a major role in the assembly of the saccules which constitute the Golgi apparatus. The present study was undertaken to critically analyze the normal morphology of this Golgi ...
... rough endoplasmic reticulum components destined for processing in the Golgi apparatus. Its position is also ideal for playing a major role in the assembly of the saccules which constitute the Golgi apparatus. The present study was undertaken to critically analyze the normal morphology of this Golgi ...
OglIb~3 Integrin Dissociation Induced by EDTA Results in
... 1.5 h at room temperature with the gold labeled secondary antibody used at 1:20 dilution in PBS/I% serum (the nature of the secondary antibody varies according to the primary antibody as detailed in Table I). After twv washes in PBSI0.5 % serum and two washes with PBS, the sections were postfixed fo ...
... 1.5 h at room temperature with the gold labeled secondary antibody used at 1:20 dilution in PBS/I% serum (the nature of the secondary antibody varies according to the primary antibody as detailed in Table I). After twv washes in PBSI0.5 % serum and two washes with PBS, the sections were postfixed fo ...
Collagen Diversity, Synthesis and Assembly
... cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Eyre et al., 2004). Strongest homology within the FACITs is in the C-terminal collageno ...
... cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Eyre et al., 2004). Strongest homology within the FACITs is in the C-terminal collageno ...
View/Open - eDiss - Georg-August
... and its function in the development of the cerk1-4 phenotype. Arabidopsis accessions were found to vary regarding the abundance of the shed CERK1 ectodomain. The presence of prolines within the extracellular stalk of CERK1 positively correlated with ectodomain abundance. CERK1 variants lacking speci ...
... and its function in the development of the cerk1-4 phenotype. Arabidopsis accessions were found to vary regarding the abundance of the shed CERK1 ectodomain. The presence of prolines within the extracellular stalk of CERK1 positively correlated with ectodomain abundance. CERK1 variants lacking speci ...
Stacks off tracks
... bioRxiv preprint first posted online Mar. 14, 2017; doi: http://dx.doi.org/10.1101/115840. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. ...
... bioRxiv preprint first posted online Mar. 14, 2017; doi: http://dx.doi.org/10.1101/115840. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. ...
Cell Calcium Viral calciomics: Interplays between Ca2+ and virus
... An increase in cytosolic Ca2+ , due to increased Ca2+ influx via NMDA type glutamate receptor and the release of Ca2+ from IP3 -sensitive internal stores via IP3 R, is observed in Tat-treated fetal neurons, astrocytes and microglia cells [37–39]. The Tatinduced dysregulation of intracellular Ca2+ lea ...
... An increase in cytosolic Ca2+ , due to increased Ca2+ influx via NMDA type glutamate receptor and the release of Ca2+ from IP3 -sensitive internal stores via IP3 R, is observed in Tat-treated fetal neurons, astrocytes and microglia cells [37–39]. The Tatinduced dysregulation of intracellular Ca2+ lea ...
Glutamate 83 and arginine 85 of helix H3 bend are key residues for
... Background: FtsZ is an essential cell division protein, which localizes at the middle of the bacterial cell to mediate cytokinesis. In vitro, FtsZ polymerizes and induces GTPase activity through longitudinal interactions to form the protofilaments, whilst lateral interactions result within formation ...
... Background: FtsZ is an essential cell division protein, which localizes at the middle of the bacterial cell to mediate cytokinesis. In vitro, FtsZ polymerizes and induces GTPase activity through longitudinal interactions to form the protofilaments, whilst lateral interactions result within formation ...
Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects
... transduced with Ad-GFP-LC3. The number of GFP-LC3 dots was low at baseline and there was no statistically significant difference between Ad-shScr- and Ad-shDrp1-transduced CMs (Figure 2B). However, there was significantly less chloroquine-induced accumulation of GFP-LC3 dots in Ad-shDrp1transduced C ...
... transduced with Ad-GFP-LC3. The number of GFP-LC3 dots was low at baseline and there was no statistically significant difference between Ad-shScr- and Ad-shDrp1-transduced CMs (Figure 2B). However, there was significantly less chloroquine-induced accumulation of GFP-LC3 dots in Ad-shDrp1transduced C ...
Therapeutic targeting of autophagy in neurodegenerative and
... the autophagosomes close to lysosomes, enabling fusion of these different organelles, after which the lysosomal hydrolases degrade the autophagic contents (Fig. 1). There are two additional forms of autophagy that will not be considered in detail in this review. Microautophagy involves the direct se ...
... the autophagosomes close to lysosomes, enabling fusion of these different organelles, after which the lysosomal hydrolases degrade the autophagic contents (Fig. 1). There are two additional forms of autophagy that will not be considered in detail in this review. Microautophagy involves the direct se ...
SCARFACE Encodes an ARF-GAP That Is Required for Normal
... We compared cotyledon vein pattern and root development in sfc-1, sfc-6, and sfc-7 mutants (Table 1). Root length, lateral root numbers, and cotyledon vein pattern features (numbers of areoles, VIs, and branch points) showed a clear trend, with sfc-1 having the most severe defects, sfc-6 intermediat ...
... We compared cotyledon vein pattern and root development in sfc-1, sfc-6, and sfc-7 mutants (Table 1). Root length, lateral root numbers, and cotyledon vein pattern features (numbers of areoles, VIs, and branch points) showed a clear trend, with sfc-1 having the most severe defects, sfc-6 intermediat ...
Interactions of Annexins with the mu Subunits of the Clathrin
... might therefore function to initiate calcium-regulated coated pit formation at the cell surface or on intracellular organelles. ...
... might therefore function to initiate calcium-regulated coated pit formation at the cell surface or on intracellular organelles. ...
Effect of bile salts on the DNA and membrane integrity of enteric
... The digestive system typically combats potentially pathogenic microbes through the production of several bactericidal agents along the tract. Some of these bactericidal agents are gastric secretions, hydrochloric acid and bile. These agents have distinct roles in ensuring infections do not arise, bu ...
... The digestive system typically combats potentially pathogenic microbes through the production of several bactericidal agents along the tract. Some of these bactericidal agents are gastric secretions, hydrochloric acid and bile. These agents have distinct roles in ensuring infections do not arise, bu ...
Type XIII collagen. Structural and functional characterization of the
... in various tissues and that it is mostly localized to cell-cell and cell-matrix contacts. In order to study type XIII collagen at the molecular level, the protein was expressed in insect cells as a homotrimer. The recombinant protein was found to reside in the plasma membrane of insect cells with it ...
... in various tissues and that it is mostly localized to cell-cell and cell-matrix contacts. In order to study type XIII collagen at the molecular level, the protein was expressed in insect cells as a homotrimer. The recombinant protein was found to reside in the plasma membrane of insect cells with it ...
Increased Association Between Rough Endoplasmic Reticulum
... to chromosome 17 (12, 13). The precise role of tau in neurodegeneration, however, remains obscure. The contribution of tau to neurodegeneration was confirmed in mouse models in which wild-type human tau is overexpressed. Although these models do not entirely recapitulate the landmarks of tauopathies ...
... to chromosome 17 (12, 13). The precise role of tau in neurodegeneration, however, remains obscure. The contribution of tau to neurodegeneration was confirmed in mouse models in which wild-type human tau is overexpressed. Although these models do not entirely recapitulate the landmarks of tauopathies ...
Color Atlas of Otoscopy
... the contraindications stated by the manufacturers differ from the statements made in the present book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Every dosage schedule or every form of application used is entirely at t ...
... the contraindications stated by the manufacturers differ from the statements made in the present book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Every dosage schedule or every form of application used is entirely at t ...
Sucrose metabolism: regulatory mechanisms and pivotal roles in
... from transgenic potatoes shows that the normal developmental shift to sucrose cleavage by sucrose synthase in wildtype tubers improves not only their adenylate balance, starch biosynthesis, and respiratory costs, but also their endogenous oxygen levels relative to those of tubers that overexpress al ...
... from transgenic potatoes shows that the normal developmental shift to sucrose cleavage by sucrose synthase in wildtype tubers improves not only their adenylate balance, starch biosynthesis, and respiratory costs, but also their endogenous oxygen levels relative to those of tubers that overexpress al ...
PATELLIN1/2 interact with CVL1 and CVP2 to regulate vascular
... recycling and degradation pathways (Pahari et al., 2014; Spitzer et al., 2009). Therefore, the TGN localization of these gene products and the disruption of vascular continuity observed when they are mutated suggest that these vascular genes function in vesicle formation and targeting pathways at th ...
... recycling and degradation pathways (Pahari et al., 2014; Spitzer et al., 2009). Therefore, the TGN localization of these gene products and the disruption of vascular continuity observed when they are mutated suggest that these vascular genes function in vesicle formation and targeting pathways at th ...
collagen in odontogenic tumours
... formation of collagen and subsequent expansion of the extracellular space, the cells in this zone were plump and it appeared less cellular than in the surrounding connective tissue. Collagen in the surrounding connective tissue was oriented in parallel bundles and the ectomesenchymal cells were inac ...
... formation of collagen and subsequent expansion of the extracellular space, the cells in this zone were plump and it appeared less cellular than in the surrounding connective tissue. Collagen in the surrounding connective tissue was oriented in parallel bundles and the ectomesenchymal cells were inac ...
Acyl-CoA oxidase is imported as a heteropentameric, cofactor
... the acquisition and maintenance of the oligomeric conformation by other proteins imported into the peroxisome are assisted by a specialized set of cytosolic chaperones or whether they can occur spontaneously in the cytosol. Furthermore, it is unknown if any peroxisomal protein can preassemble with i ...
... the acquisition and maintenance of the oligomeric conformation by other proteins imported into the peroxisome are assisted by a specialized set of cytosolic chaperones or whether they can occur spontaneously in the cytosol. Furthermore, it is unknown if any peroxisomal protein can preassemble with i ...
FOCAL ADHESION KINASE: IN COMMAND AND CONTROL OF
... different signalling proteins differentially bind to Tyr397-phosphorylated FAK in response to particular cell stimuli or whether simultaneously there are different complexes with a larger pool of activated FAK. In this respect, we favour a sequential association model whereby the binding of cellular ...
... different signalling proteins differentially bind to Tyr397-phosphorylated FAK in response to particular cell stimuli or whether simultaneously there are different complexes with a larger pool of activated FAK. In this respect, we favour a sequential association model whereby the binding of cellular ...
lysis strategy of streptococcus pneumoniae bacteriophages
... of pneumococci in spite of the striking absence of a signal sequence that could target it to the extracytoplasmic environment. This may constitute the first evidence, on phages encoding only holins and lysins in their lytic cassettes, of an exolysin without a secretion signal that is translocated th ...
... of pneumococci in spite of the striking absence of a signal sequence that could target it to the extracytoplasmic environment. This may constitute the first evidence, on phages encoding only holins and lysins in their lytic cassettes, of an exolysin without a secretion signal that is translocated th ...
The Drosophila Sec7 domain guanine nucleotide exchange factor
... the six annotated ARF-GEF homologs in Drosophila are involved in COPI vesicle formation at the Golgi. Despite a wealth of studies in cultured mammalian cells, very little is known about the function of GBF1 family ARF-GEFs during animal development. Here we describe the identification and functional ...
... the six annotated ARF-GEF homologs in Drosophila are involved in COPI vesicle formation at the Golgi. Despite a wealth of studies in cultured mammalian cells, very little is known about the function of GBF1 family ARF-GEFs during animal development. Here we describe the identification and functional ...
Myosin V Plays an Essential Role in the Thyroid Hormone
... was found in the Triton-insoluble pellet in both thyroid hormone-deficient and T4-treated cells as determined by densitometry (data not shown). In control experiments, no specific immune complexes were observed in the 200-kDa range of immunoblots of astrocyte cell lysate, indicating that the antiact ...
... was found in the Triton-insoluble pellet in both thyroid hormone-deficient and T4-treated cells as determined by densitometry (data not shown). In control experiments, no specific immune complexes were observed in the 200-kDa range of immunoblots of astrocyte cell lysate, indicating that the antiact ...
Physiology and molecular biology of petal senescence
... released by mitochondria, and proteins that control the release of compounds through membranes, have no apparent counterpart in plant cells, indicating that the regulation of cell death during petal senescence is quite different from the regulation of cell death in animal cells. Tonoplast rupture (o ...
... released by mitochondria, and proteins that control the release of compounds through membranes, have no apparent counterpart in plant cells, indicating that the regulation of cell death during petal senescence is quite different from the regulation of cell death in animal cells. Tonoplast rupture (o ...
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane) is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. The basic function of the cell membrane is to protect the cell from its surroundings. It consists of the phospholipid bilayer with embedded proteins. Cell membranes are involved in a variety of cellular processes such as cell adhesion, ion conductivity and cell signalling and serve as the attachment surface for several extracellular structures, including the cell wall, glycocalyx, and intracellular cytoskeleton. Cell membranes can be artificially reassembled.