Introductory Guide MedDRA Version 18.1
... Terminology (WHO-ART) and the International Classification of Diseases Ninth Revision (ICD-9). In the United States, the Food and Drug Administration’s (FDA) Coding Symbols for a Thesaurus of Adverse Reaction Terms (COSTART) was usually used in conjunction with Clinical Modification of ICD-9 (ICD- ...
... Terminology (WHO-ART) and the International Classification of Diseases Ninth Revision (ICD-9). In the United States, the Food and Drug Administration’s (FDA) Coding Symbols for a Thesaurus of Adverse Reaction Terms (COSTART) was usually used in conjunction with Clinical Modification of ICD-9 (ICD- ...
Genetic polymorphisms and drug interactions modulating
... Co-administration of the CYP3A inducer rifampin has been associated with negative urine oxycodone screening (Lee et al., 2006), as well as with a dramatic reduction in oxycodone exposure and pharmacodynamic effects in healthy volunteers (Nieminen et al., 2009). Inversely voriconazole increased oxyco ...
... Co-administration of the CYP3A inducer rifampin has been associated with negative urine oxycodone screening (Lee et al., 2006), as well as with a dramatic reduction in oxycodone exposure and pharmacodynamic effects in healthy volunteers (Nieminen et al., 2009). Inversely voriconazole increased oxyco ...
Prepared for NCI by Technical Resources International, Inc I.
... tumors in mice. As the initiation treatment, 50 umol HMF was applied to the shaven backs of 20 female CD-1 mice twice weekly for 5 weeks; as a positive control, 10 ug 7,12- dimethylbenz[a]anthracene (DMBA) was used and dimethylsulfoxide (DMSO) was the vehicle control. The promotion treatment began ...
... tumors in mice. As the initiation treatment, 50 umol HMF was applied to the shaven backs of 20 female CD-1 mice twice weekly for 5 weeks; as a positive control, 10 ug 7,12- dimethylbenz[a]anthracene (DMBA) was used and dimethylsulfoxide (DMSO) was the vehicle control. The promotion treatment began ...
Physiological and psychological effects of cannabis
... and the cerebral cortex was finally discovered and cloned in 1990 26 . A further, peripheral, receptor (CB2) was found in certain parts of the immune system (e.g., the spleen) in 199327 . Investigations carried out to date would seem to confirm that these receptors are capable of affecting neurophys ...
... and the cerebral cortex was finally discovered and cloned in 1990 26 . A further, peripheral, receptor (CB2) was found in certain parts of the immune system (e.g., the spleen) in 199327 . Investigations carried out to date would seem to confirm that these receptors are capable of affecting neurophys ...
2017
... Welcome to the 40th Annual ARO Midwinter Meeting, being held for the sixth time at the Marriott Waterfront in Baltimore, Maryland. This year’s meeting includes a record 1096 submitted abstracts, 13 symposia and 23 podium sessions. In addition, there will be daily mentoring sessions (Saturday, Sunday ...
... Welcome to the 40th Annual ARO Midwinter Meeting, being held for the sixth time at the Marriott Waterfront in Baltimore, Maryland. This year’s meeting includes a record 1096 submitted abstracts, 13 symposia and 23 podium sessions. In addition, there will be daily mentoring sessions (Saturday, Sunday ...
Role of beta-adrenergic receptors in the ventromedial prefrontal
... an immunohistochemistry assay. Our results show a reduction in Fos-protein expression between the first and the last extinction session. In a follow-up experiment, intra-vmPFC microinjection of isoproterenol before the first extinction session facilitated the extinction of contextual fear. This facili ...
... an immunohistochemistry assay. Our results show a reduction in Fos-protein expression between the first and the last extinction session. In a follow-up experiment, intra-vmPFC microinjection of isoproterenol before the first extinction session facilitated the extinction of contextual fear. This facili ...
Calcium Transients in the Garter Snake Vomeronasal Organ
... 2000). Binding of ES20 to VN receptors also results in increased levels of inositol 1,4,5-trisphosphate (IP3), suggesting that this signal cascade pathway may be involved in chemosensory transduction. In contrast, ES20 significantly reduces basal levels of cAMP as well as GTP␥S- or forskolin-induced ...
... 2000). Binding of ES20 to VN receptors also results in increased levels of inositol 1,4,5-trisphosphate (IP3), suggesting that this signal cascade pathway may be involved in chemosensory transduction. In contrast, ES20 significantly reduces basal levels of cAMP as well as GTP␥S- or forskolin-induced ...
Actions of bufalin and cinobufotalin, two bufadienolides respectively
... ouabain-binding assay could be because not all the binding sites represent functional activity, in spite of not being displaced by mol/l ouabain. T h e order of potencies of the three drugs tested was the same in both tests. The greater potency of bufalin than ouabain in inhibiting canine renal Na+/ ...
... ouabain-binding assay could be because not all the binding sites represent functional activity, in spite of not being displaced by mol/l ouabain. T h e order of potencies of the three drugs tested was the same in both tests. The greater potency of bufalin than ouabain in inhibiting canine renal Na+/ ...
Effects of Residual Inhibition Phenomenon on Early Auditory Evoked
... “stays” in the peripheral auditory system, but under the dependency of other molecular pathways, (2) by passing time, tinnitus progressively recruits several anatomical structures in auditory (the peripheral and central auditory systems) and non-auditory (the limbic system and higher order brain str ...
... “stays” in the peripheral auditory system, but under the dependency of other molecular pathways, (2) by passing time, tinnitus progressively recruits several anatomical structures in auditory (the peripheral and central auditory systems) and non-auditory (the limbic system and higher order brain str ...
Comparison of Inhaled Corticosteroids: An Update
... these studies also provide results that vary between laboratories.15,16 The relative binding affinities correlate with relative potencies in carefully controlled clinical trials.17 It is clear from the relative potencies that some drugs (beclomethasone dipropionate, ciclesonide) act as prodrugs and ...
... these studies also provide results that vary between laboratories.15,16 The relative binding affinities correlate with relative potencies in carefully controlled clinical trials.17 It is clear from the relative potencies that some drugs (beclomethasone dipropionate, ciclesonide) act as prodrugs and ...
Medicinal properties of Ginger ( Zingiber officinale Article
... possesses anti-skin tumourpromoting effects, and that the mechanism of such effects may involve inhibition of tumour promoter-caused cellular, biochemical, and molecular changes in mouse skin. Anti-viral Rhinoviruses are among those viruses which cause the common cold therefore, the dried rhizomes o ...
... possesses anti-skin tumourpromoting effects, and that the mechanism of such effects may involve inhibition of tumour promoter-caused cellular, biochemical, and molecular changes in mouse skin. Anti-viral Rhinoviruses are among those viruses which cause the common cold therefore, the dried rhizomes o ...
disodium phosphate - PAN Pesticide Database
... gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energydependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested p ...
... gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energydependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested p ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... patches or contraceptive vaginal rings. Ethinyl estradiol-containing medications must be discontinued prior to starting therapy with VIEKIRA PAK [see Contraindications (4)]. Alternative methods of contraception (e.g, progestin only contraception or non-hormonal methods) are recommended during VIEKIR ...
... patches or contraceptive vaginal rings. Ethinyl estradiol-containing medications must be discontinued prior to starting therapy with VIEKIRA PAK [see Contraindications (4)]. Alternative methods of contraception (e.g, progestin only contraception or non-hormonal methods) are recommended during VIEKIR ...
Gelsemium sempervirens - Southwest School of Botanical Medicine
... the mistake of a servant of a Southern planter who was afflicted with fever. This servant by error gave his master a decoction of Gelsemium root, instead of the garden plant intended. Immediate loss of muscular power and great depression followed, all control of the limbs was lost, the eyelids droop ...
... the mistake of a servant of a Southern planter who was afflicted with fever. This servant by error gave his master a decoction of Gelsemium root, instead of the garden plant intended. Immediate loss of muscular power and great depression followed, all control of the limbs was lost, the eyelids droop ...
NUX VOMICA
... the medical authorities contributing the therapy of this special study. It is one of the most beautiful and most perfect of pharmaceutical preparations, rivalling Specific Medicine Gelsemium, Specific Medicine Collinsonia, etc., both in appearance, elegance and effectiveness. It is not standardized ...
... the medical authorities contributing the therapy of this special study. It is one of the most beautiful and most perfect of pharmaceutical preparations, rivalling Specific Medicine Gelsemium, Specific Medicine Collinsonia, etc., both in appearance, elegance and effectiveness. It is not standardized ...
34 ECDD 2006/4.3 ...
... Furthermore new developments show strong interactions between the opioid and the NMDA system in the brain of animals. In contrast to earlier findings new results point to NMDA receptors and not sigma-receptors as having a role in the morphine withdrawal response (Brent et al, 1993). Gonzalez et al ( ...
... Furthermore new developments show strong interactions between the opioid and the NMDA system in the brain of animals. In contrast to earlier findings new results point to NMDA receptors and not sigma-receptors as having a role in the morphine withdrawal response (Brent et al, 1993). Gonzalez et al ( ...
phytochemical and pharmacological
... Natural products (including plants, animals and minerals) have been the basis of treatment of human diseases. History of medicine dates back practically to the existence of human civilization. Modern medicine system has gradually developed over the years by scientific and observational efforts of sc ...
... Natural products (including plants, animals and minerals) have been the basis of treatment of human diseases. History of medicine dates back practically to the existence of human civilization. Modern medicine system has gradually developed over the years by scientific and observational efforts of sc ...
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase
... Gram-negative sepsis. VIP has been shown to attenuate the deleterious consequences of this pathologic phenomenon. In this study we have investigated the effects of VIP and the structurally related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP38) on the production of TNF-a by ...
... Gram-negative sepsis. VIP has been shown to attenuate the deleterious consequences of this pathologic phenomenon. In this study we have investigated the effects of VIP and the structurally related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP38) on the production of TNF-a by ...
Azithromycin for Injection, USP
... are higher following the intravenous regimen throughout the 24-hour interval. The pharmacokinetic parameters on day 5 of azithromycin 250-mg capsules following a 500-mg oral loading dose to healthy young adults (age 18-40 years old) were as follows: Cmax: 0.24 mcg/mL, AUC24: 2.1 mcg•h/mL. Azithromyc ...
... are higher following the intravenous regimen throughout the 24-hour interval. The pharmacokinetic parameters on day 5 of azithromycin 250-mg capsules following a 500-mg oral loading dose to healthy young adults (age 18-40 years old) were as follows: Cmax: 0.24 mcg/mL, AUC24: 2.1 mcg•h/mL. Azithromyc ...
Epidural Analgesia and Anesthesia
... proximity to their site of action either at receptors in the spinal cord or at nerves as they leave the spinal cord. Binding to specific receptors is maximized, producing more profound analgesia and allowing a lower total drug dose to be used compared with systemic administration. This dose reductio ...
... proximity to their site of action either at receptors in the spinal cord or at nerves as they leave the spinal cord. Binding to specific receptors is maximized, producing more profound analgesia and allowing a lower total drug dose to be used compared with systemic administration. This dose reductio ...
Emerging Drug Trends- Salvia Divinorum
... become a drug of concern. Although trailing Ecstasy in rates of use, it is now more commonly used than both LSD and PCP among 18-25 year olds. The DEA is currently investigating Salvia for possible classification under Schedule I of the Controlled Substances Act, but until a firm position is taken a ...
... become a drug of concern. Although trailing Ecstasy in rates of use, it is now more commonly used than both LSD and PCP among 18-25 year olds. The DEA is currently investigating Salvia for possible classification under Schedule I of the Controlled Substances Act, but until a firm position is taken a ...
Full Text
... identification of new drugs a critical unmet need. Highthroughput screening offers a powerful tool to identify new drug candidates for these patients. However, commonly available screening approaches rely on in vitro cell-based assays (Masimirembwa et al., 2001; Snowden and Green, 2008; Ko and Gelb, ...
... identification of new drugs a critical unmet need. Highthroughput screening offers a powerful tool to identify new drug candidates for these patients. However, commonly available screening approaches rely on in vitro cell-based assays (Masimirembwa et al., 2001; Snowden and Green, 2008; Ko and Gelb, ...
morphology and synaptic connections of ultrafine primary axons
... caliber as their ending-bearing segments in lamina I, i.e., -0.3 to 0.5 pm in diameter, which corresponds to the diameters of most of the unmyelinated axons that have been seen in electron micrographs of Lissauer’s tract (K. Chung et al., 1979; Gobel and Falls, 1979). The preterminal segments in Lis ...
... caliber as their ending-bearing segments in lamina I, i.e., -0.3 to 0.5 pm in diameter, which corresponds to the diameters of most of the unmyelinated axons that have been seen in electron micrographs of Lissauer’s tract (K. Chung et al., 1979; Gobel and Falls, 1979). The preterminal segments in Lis ...
Cytochrome P450 2D6 (CYP2D6) Pharmacogenetic Competency
... • A 14-year old girl received a prescription for a codeine-containing analgesic for hip pain. • The patient received 15 mg of codeine and the mother noticed that she was having trouble breathing, gasping and opening her mouth widely to search for air. • She was admitted to the ER and given a dose of ...
... • A 14-year old girl received a prescription for a codeine-containing analgesic for hip pain. • The patient received 15 mg of codeine and the mother noticed that she was having trouble breathing, gasping and opening her mouth widely to search for air. • She was admitted to the ER and given a dose of ...