Antiviral agents targeting the influenza virus: a review and
... et al. 2011; Rawat et al. 2012) and their anti-influenza effects are evaluated using standardised in vitro screening methods. These methods include biochemical assays (Hung et al. 2012) and cellbased antiviral screens (Schmidtke et al. 2001), such as the plaque reduction assay to monitor viral repli ...
... et al. 2011; Rawat et al. 2012) and their anti-influenza effects are evaluated using standardised in vitro screening methods. These methods include biochemical assays (Hung et al. 2012) and cellbased antiviral screens (Schmidtke et al. 2001), such as the plaque reduction assay to monitor viral repli ...
What is migraine aura?
... name given to the many types of neurological symptoms that may occur just before or during a migraine headache. Migraine with aura is said to be experienced by 1 in 5 migraineurs, or in 20 - 30% of people. [1.]. For some time now medical professionals have believed aura to be caused due to blood ves ...
... name given to the many types of neurological symptoms that may occur just before or during a migraine headache. Migraine with aura is said to be experienced by 1 in 5 migraineurs, or in 20 - 30% of people. [1.]. For some time now medical professionals have believed aura to be caused due to blood ves ...
PART I B SUMMARY OF PRODUCT CHARACTERISTICS
... When midazolam was co-administered with clarithromycin tablets (500 mg twice daily), midazolam AUC was increased 2.7-fold after intravenous administration of midazolam and 7-fold after oral administration. Concomitant administration of oral midazolam and clarithromycin should be avoided. If intraven ...
... When midazolam was co-administered with clarithromycin tablets (500 mg twice daily), midazolam AUC was increased 2.7-fold after intravenous administration of midazolam and 7-fold after oral administration. Concomitant administration of oral midazolam and clarithromycin should be avoided. If intraven ...
Appendix 2: Underpinning Scientific Knowledge 2015
... The aim of this module is for the trainee to gain the knowledge underpinning the safe, appropriate and effective use of drugs for systemic therapy and symptomatic treatment of cancer. The knowledge defined in this section will be assessed in the Clinical Pharmacology module of the First FRCR examina ...
... The aim of this module is for the trainee to gain the knowledge underpinning the safe, appropriate and effective use of drugs for systemic therapy and symptomatic treatment of cancer. The knowledge defined in this section will be assessed in the Clinical Pharmacology module of the First FRCR examina ...
Third Amended Master Consolidated Class Action Complaint
... THE DEFENDANT DRUG MANUFACTURERS’ USE OF AWP FRAUD TO INCREASE AND MAINTAIN THE PRICE OF DRUGS OUTSIDE OF THE MEDICARE PART B CONTEXT ...............................................................51 ...
... THE DEFENDANT DRUG MANUFACTURERS’ USE OF AWP FRAUD TO INCREASE AND MAINTAIN THE PRICE OF DRUGS OUTSIDE OF THE MEDICARE PART B CONTEXT ...............................................................51 ...
Cannabis use and misuse
... and appreciation of cannabis and its potential impact on adolescents. Cannabis throughout history By some accounts, cannabis first appeared approximately four thousand years ago in the Chinese culture as a plant grown for use of its fiber to make clothing, paper, and rope (Abel, 1980). Over time, pe ...
... and appreciation of cannabis and its potential impact on adolescents. Cannabis throughout history By some accounts, cannabis first appeared approximately four thousand years ago in the Chinese culture as a plant grown for use of its fiber to make clothing, paper, and rope (Abel, 1980). Over time, pe ...
The molecular mechanisms common polymorphisms diug oxidation--evidence for
... Multiplicity and variable functional expression of cytochrome P-450 isozymes Over the last few years the extreme multiplicity of cytochrome P-450 isozymes has been realized. More than 10 different forms or isozymes have been isolated from livers of inbred strains of rodents. These isozymes show diff ...
... Multiplicity and variable functional expression of cytochrome P-450 isozymes Over the last few years the extreme multiplicity of cytochrome P-450 isozymes has been realized. More than 10 different forms or isozymes have been isolated from livers of inbred strains of rodents. These isozymes show diff ...
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and
... infections. Approximately 83% of acyclovir is excreted by kidney in its unchanged forms [13]. Renal excretion of acyclovir is reduced by probenecid, a typical inhibitor of OAT [13]. Although neither possesses a typical anionic moiety, the results suggest that the OAT system is responsible for the tu ...
... infections. Approximately 83% of acyclovir is excreted by kidney in its unchanged forms [13]. Renal excretion of acyclovir is reduced by probenecid, a typical inhibitor of OAT [13]. Although neither possesses a typical anionic moiety, the results suggest that the OAT system is responsible for the tu ...
Safety and Side Effects of CBD
... various anti-cancer drugs also bind to these membranebound, energy-dependent efflux transporters (Bergamaschi et al., 2011). It has to be pointed out here, that the used CBD concentrations can be considered supraphysiological. 3 µM CBD approximately corresponds to plasma concentrations of 1 µg/ml. O ...
... various anti-cancer drugs also bind to these membranebound, energy-dependent efflux transporters (Bergamaschi et al., 2011). It has to be pointed out here, that the used CBD concentrations can be considered supraphysiological. 3 µM CBD approximately corresponds to plasma concentrations of 1 µg/ml. O ...
Is ecstasy MDMA? - Department of Psychology
... complaints from ecstasy users about their MDMA supplies. A survey of 100 American college users reported no concerns over their purity (Peroutka et al. 1988; Peroutka 1989). Similarly in Australia, Solowij et al. (1992) noted that there were “high levels of purity in Sydney”, although it was recogni ...
... complaints from ecstasy users about their MDMA supplies. A survey of 100 American college users reported no concerns over their purity (Peroutka et al. 1988; Peroutka 1989). Similarly in Australia, Solowij et al. (1992) noted that there were “high levels of purity in Sydney”, although it was recogni ...
Disclosure Migraine Associated Vertigo (MAV) Case (patient DA)
... Harker, L. A. and C. Rassekh (1988). "Migraine equivalent as a cause of episodic ...
... Harker, L. A. and C. Rassekh (1988). "Migraine equivalent as a cause of episodic ...
- International Journal of Applied Research in Natural
... rich source of new active compounds which are less toxic and less costly when compared to the ...
... rich source of new active compounds which are less toxic and less costly when compared to the ...
The Potential of Stimuli-Responsive Nanogels in Drug and Active
... NGs have a size comprised in the colloidal scale, ranging from 1 to 1000 nm. Nanoparticles (NPs) are solid and spherical structures, submicron-sized, prepared from polymeric materials and/or metallic compounds. NPs can be classified as nanocapsules (the active agent forms a matrix combined with the ...
... NGs have a size comprised in the colloidal scale, ranging from 1 to 1000 nm. Nanoparticles (NPs) are solid and spherical structures, submicron-sized, prepared from polymeric materials and/or metallic compounds. NPs can be classified as nanocapsules (the active agent forms a matrix combined with the ...
Chronic tolerance to recreational MDMA
... who had been taking Ecstasy for around 4 years. They noted: ‘The most frequently reported long-term effect of MDMA was tolerance to its effects over time’, with around 85–95% reporting a decline in subjective efficacy. In a follow-up investigation into reasons for quitting Ecstasy, Verheyden et al. ...
... who had been taking Ecstasy for around 4 years. They noted: ‘The most frequently reported long-term effect of MDMA was tolerance to its effects over time’, with around 85–95% reporting a decline in subjective efficacy. In a follow-up investigation into reasons for quitting Ecstasy, Verheyden et al. ...
Methadone-Drug Interactions
... in terms of its presence and activity in the liver (Eap et al. 2002; Leavitt et al. 2000). This enzyme also is found in the gastrointestinal tract, so methadone metabolism actually can begin before the drug enters the circulatory system (Hardman et al. 1996). The amount of this enzyme in the intesti ...
... in terms of its presence and activity in the liver (Eap et al. 2002; Leavitt et al. 2000). This enzyme also is found in the gastrointestinal tract, so methadone metabolism actually can begin before the drug enters the circulatory system (Hardman et al. 1996). The amount of this enzyme in the intesti ...
Spontaneous generation of prion infectivity in fatal familial insomnia
... susceptible to infection by an exogenous agent, remains viable (Barron et al., 2001; Chesebro, 2003; Manson et al., 1999; Manuelidis, 2007; Weissmann and Flechsig, 2003). To create a unique model of inherited prion disease and determine if familial PrP mutations can spontaneously give rise to infec ...
... susceptible to infection by an exogenous agent, remains viable (Barron et al., 2001; Chesebro, 2003; Manson et al., 1999; Manuelidis, 2007; Weissmann and Flechsig, 2003). To create a unique model of inherited prion disease and determine if familial PrP mutations can spontaneously give rise to infec ...
The Socio-Economic Impact of Amphetamine Type Stimulants in
... This preparation of this report was funded by the New Zealand Police with money received from the Cross Departmental Research Pool (CDRP), which is administered by the Ministry of Research Science and Technology (MoRST). We acknowledge the assistance and collaborative efforts of officials from the O ...
... This preparation of this report was funded by the New Zealand Police with money received from the Cross Departmental Research Pool (CDRP), which is administered by the Ministry of Research Science and Technology (MoRST). We acknowledge the assistance and collaborative efforts of officials from the O ...
Ketoconazole and Itraconazole Pharmacokinetic
... cyclosporine, phenytoin and warfarin. It is therefore, possible that the increases in AUC0-∞, Cmax, tl/2 and MRT, seen in this study, when CIP was given together with KTC may be due to the inhibition of cytochromes by KTC. Similarly the fluoroquinolone antibiotics cause both class-specific and agent ...
... cyclosporine, phenytoin and warfarin. It is therefore, possible that the increases in AUC0-∞, Cmax, tl/2 and MRT, seen in this study, when CIP was given together with KTC may be due to the inhibition of cytochromes by KTC. Similarly the fluoroquinolone antibiotics cause both class-specific and agent ...
Understanding the process of multisensory integration
... the same event, and the neural inputs they generate are integrated more strongly than those from cues that are temporally displaced from one another. However, the present results from studies of cat SC neurons show that this "temporal principle" of multisensory integration is more nuanced than previ ...
... the same event, and the neural inputs they generate are integrated more strongly than those from cues that are temporally displaced from one another. However, the present results from studies of cat SC neurons show that this "temporal principle" of multisensory integration is more nuanced than previ ...
Amphotericin B as a mycolic acid specific targeting agent in tuberculosis
... linked to Amphotericin B via a Schiff base to a linker molecule, terephthalaldehyde. Although this molecule showed a loss of biological activity, a discovery was made by serendipity that could have great impact in understanding how Mycobacterium tuberculosis enters and survives in the host macrophag ...
... linked to Amphotericin B via a Schiff base to a linker molecule, terephthalaldehyde. Although this molecule showed a loss of biological activity, a discovery was made by serendipity that could have great impact in understanding how Mycobacterium tuberculosis enters and survives in the host macrophag ...
Full-Text PDF
... Poor solubility is one of the main problems faced by researchers during drug development. Commonly, even with the use of current computational “filters” to minimize this problem, compounds that are active in vitro may lack adequate pharmacokinetic properties and/or may be difficult to formulate [1]. ...
... Poor solubility is one of the main problems faced by researchers during drug development. Commonly, even with the use of current computational “filters” to minimize this problem, compounds that are active in vitro may lack adequate pharmacokinetic properties and/or may be difficult to formulate [1]. ...
The cerebral cortex of Albert Einstein: a description and preliminary
... providing appropriate curation for such materials and related items in order to achieve that potential. For the first time, the photographs that have recently come to light permit detailed identifications of sulci and other features of the external morphology of Einstein’s entire cerebral cortex, wh ...
... providing appropriate curation for such materials and related items in order to achieve that potential. For the first time, the photographs that have recently come to light permit detailed identifications of sulci and other features of the external morphology of Einstein’s entire cerebral cortex, wh ...
Versican Expression During Embryonic Development in the Mouse
... only the α chain), and V3 (which contains neither GAG chain) [8],[11] (Figure 1). V1 versican promotes cell growth, aggregation, and a mesenchymal-epithelial transition, while the V2 isoform appears to have an inhibitory effect [11],[12],[13],[14]. The V2 (most likely exclusive to brain), V3, V1, an ...
... only the α chain), and V3 (which contains neither GAG chain) [8],[11] (Figure 1). V1 versican promotes cell growth, aggregation, and a mesenchymal-epithelial transition, while the V2 isoform appears to have an inhibitory effect [11],[12],[13],[14]. The V2 (most likely exclusive to brain), V3, V1, an ...
Nowhere to hide: interrogating different metabolic parameters of Plasmodium
... sporozoites for transmission back to humans [7]. Commitment to sexual development is postulated to take place in the first 20 h of the preceding erythrocytic cycle [8]. All merozoites from a single schizont will become either male or female gametocytes [9] with gender predetermined in the schizont c ...
... sporozoites for transmission back to humans [7]. Commitment to sexual development is postulated to take place in the first 20 h of the preceding erythrocytic cycle [8]. All merozoites from a single schizont will become either male or female gametocytes [9] with gender predetermined in the schizont c ...
The cerebral cortex of Albert Einstein: a
... providing appropriate curation for such materials and related items in order to achieve that potential. For the first time, the photographs that have recently come to light permit detailed identifications of sulci and other features of the external morphology of Einstein’s entire cerebral cortex, wh ...
... providing appropriate curation for such materials and related items in order to achieve that potential. For the first time, the photographs that have recently come to light permit detailed identifications of sulci and other features of the external morphology of Einstein’s entire cerebral cortex, wh ...