Granulocyte-Macrophage Colony-Stimulating
... CSF cDNAs were obtained from the National Gene Vector Laboratories (The University of Michigan, Ann Arbor, MI), excised by restriction digest and The delivery of cytokines, or their encoding cDNA sequences, has inserted into bicistronic retroviral plasmids allowing coexpression of green been broadly ...
... CSF cDNAs were obtained from the National Gene Vector Laboratories (The University of Michigan, Ann Arbor, MI), excised by restriction digest and The delivery of cytokines, or their encoding cDNA sequences, has inserted into bicistronic retroviral plasmids allowing coexpression of green been broadly ...
The Injectable-Only Contraceptive
... or injectable contraceptives users where the majority of women are on MPA, is higher than that associated with no contraception or oral contraception [18,21–30]. While only a few studies have investigated the risks associated with the use of injectable NET-EN on HIV-1 acquisition, none have shown a ...
... or injectable contraceptives users where the majority of women are on MPA, is higher than that associated with no contraception or oral contraception [18,21–30]. While only a few studies have investigated the risks associated with the use of injectable NET-EN on HIV-1 acquisition, none have shown a ...
Penetration of Stratified Mucosa Cytolysins Augment Superantigen
... bind to the variable region of the -chain of the TCR (V-TCR) and MHC II on APCs such as macrophages (24 –28). This interaction leads to the proliferation and activation of a large number of T cells and the release of cytokines from both cell types. The production of TNF-␣ and - results in capilla ...
... bind to the variable region of the -chain of the TCR (V-TCR) and MHC II on APCs such as macrophages (24 –28). This interaction leads to the proliferation and activation of a large number of T cells and the release of cytokines from both cell types. The production of TNF-␣ and - results in capilla ...
T Cell Memory in the Context of Persistent Herpes Viral Infections
... The fact that memory CD8 T cells formed upon the resolution of an infection have a degree of heterogeneity in terms of anatomical localization, function and phenotype began to emerge already in the nineties, as two major subtypes were identified: central-memory T cells (TCM), and effector-memory T c ...
... The fact that memory CD8 T cells formed upon the resolution of an infection have a degree of heterogeneity in terms of anatomical localization, function and phenotype began to emerge already in the nineties, as two major subtypes were identified: central-memory T cells (TCM), and effector-memory T c ...
2015 Immunology Whitebook - Dalhousie Medical School
... T cells are referred to as CD4+ or CD8+ T cells based on their surface protein markers. CD4+ T cells are the “orchestra leaders” of the complex immune response. They are generally referred to as “helper” T cells. They help B cells become antibody producing cells and help other cells perform effe ...
... T cells are referred to as CD4+ or CD8+ T cells based on their surface protein markers. CD4+ T cells are the “orchestra leaders” of the complex immune response. They are generally referred to as “helper” T cells. They help B cells become antibody producing cells and help other cells perform effe ...
GVMA Paper – June 2004 Meeting
... of the molecularly defined response. Classical cytokines, like IL-10 and IFN-IL-12, “push” the immune system into a response that either favors antibody production or T cell killer activation, respectively. Other cytokines, including the chemokines, “pull” the responses toward a consensus response ...
... of the molecularly defined response. Classical cytokines, like IL-10 and IFN-IL-12, “push” the immune system into a response that either favors antibody production or T cell killer activation, respectively. Other cytokines, including the chemokines, “pull” the responses toward a consensus response ...
Markers of melanocytic tumours - iPath
... ¾ Run 7, 2003 ¾ 63 labs submitted s-100 stainings ¾ 66 labs submitted MSA stainings ¾ 35 labs submitted Melan A stainings ...
... ¾ Run 7, 2003 ¾ 63 labs submitted s-100 stainings ¾ 66 labs submitted MSA stainings ¾ 35 labs submitted Melan A stainings ...
TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue
... major histocompatibility complex (MHC) class II, comparable cystein protease profiles, and the capacity to differentiate into dendritic-like cells [8,9]. Thus, bone marrow–derived myeloid cells (BM-MC) might reflect microglial precursors and may serve as a natural vehicle for CNS cell and gene therapy ...
... major histocompatibility complex (MHC) class II, comparable cystein protease profiles, and the capacity to differentiate into dendritic-like cells [8,9]. Thus, bone marrow–derived myeloid cells (BM-MC) might reflect microglial precursors and may serve as a natural vehicle for CNS cell and gene therapy ...
Lung cancer-initiating cells: a novel target for cancer therapy
... Received: 9 November 2012 / Accepted: 20 December 2012 / Published online: 15 January 2013 # The Author(s) 2013. This article is published with open access at Springerlink.com ...
... Received: 9 November 2012 / Accepted: 20 December 2012 / Published online: 15 January 2013 # The Author(s) 2013. This article is published with open access at Springerlink.com ...
Immune System - Iowa State University Digital Repository
... cells in the nervous system, Langerhans cells in the skin, and Kupffer cells in the liver. Macrophages are capable of all the activities described above for neutrophils. Macrophages are said to be the second line of defense but are slower to arrive at sites of inflammation and are not as aggressive ...
... cells in the nervous system, Langerhans cells in the skin, and Kupffer cells in the liver. Macrophages are capable of all the activities described above for neutrophils. Macrophages are said to be the second line of defense but are slower to arrive at sites of inflammation and are not as aggressive ...
Tribodies: Fab-scFv fusion proteins as a platform to
... complexes on non-cytotoxic cells such as platelets and B-cells. However, experience with antitumor antibodies has shown that effective antibodies also have an influence on the target cell by the nature of the receptor (or even epitope) they target. Ways this can be done is by growth inhibition (e.g. ...
... complexes on non-cytotoxic cells such as platelets and B-cells. However, experience with antitumor antibodies has shown that effective antibodies also have an influence on the target cell by the nature of the receptor (or even epitope) they target. Ways this can be done is by growth inhibition (e.g. ...
Activation of a Nonclassical NKT Cell Subset in a Transgenic
... (NK cells) using sterile cell sorting and tested each subpopulation by adoptive transfer into HBV-Env-transgenic Rag⫺/⫺ recipients. Mice that received 1.2 ⫻ 106 NKT cells developed a severe hepatitis as evidenced by a large increase in serum ALT (2600% over baseline ALT; Figure 4B) and by histologic ...
... (NK cells) using sterile cell sorting and tested each subpopulation by adoptive transfer into HBV-Env-transgenic Rag⫺/⫺ recipients. Mice that received 1.2 ⫻ 106 NKT cells developed a severe hepatitis as evidenced by a large increase in serum ALT (2600% over baseline ALT; Figure 4B) and by histologic ...
Expanding roles for CD4+ T cells in immunity to viruses
... neutralizing antibodies present at the time of pathogen encounter can prevent rather than combat infection, thereby achieving ‘sterilizing’ immunity. Thus, it is crucial to understand the mechanisms by which CD4+ T cells help B cells during viral infection in order to define what is required for eff ...
... neutralizing antibodies present at the time of pathogen encounter can prevent rather than combat infection, thereby achieving ‘sterilizing’ immunity. Thus, it is crucial to understand the mechanisms by which CD4+ T cells help B cells during viral infection in order to define what is required for eff ...
Artificial Immune Systems: A New Computaional Intelligence Approach
... rapid immune response. Overall behavior of the immune system is an emergent property of many local interactions. So it is useful? ...
... rapid immune response. Overall behavior of the immune system is an emergent property of many local interactions. So it is useful? ...
Peptides Based on MHC-TCR Binding Motifs Ordered Autoimmune
... treating EAE in the Lewis rat, an animal model of MS. It may thus be possible to simplify and define the active components of a random copolymer like GA. We have designed an APL based on computer modeling. This strategy, designing molecules based on their predicted capacity to bind MHC class II, may ...
... treating EAE in the Lewis rat, an animal model of MS. It may thus be possible to simplify and define the active components of a random copolymer like GA. We have designed an APL based on computer modeling. This strategy, designing molecules based on their predicted capacity to bind MHC class II, may ...
Immune selection in neoplasia: towards a microevolutionary model
... factor, and affects activation, proliferation and differentiation of both innate and adaptive immune cells (Chouaib et al, 1997). Studies have identified expression and secretion of TGF-β in bladder tumours (Eder et al, 1997), gastric carcinoma (Morisaki et al, 1996), breast and hepatocellular carci ...
... factor, and affects activation, proliferation and differentiation of both innate and adaptive immune cells (Chouaib et al, 1997). Studies have identified expression and secretion of TGF-β in bladder tumours (Eder et al, 1997), gastric carcinoma (Morisaki et al, 1996), breast and hepatocellular carci ...
Th17 development
... B7-DC (B7-DC Xab)17 or by adding a mixture of Th17 inducing cytokines (IL-1, IL-21 and most potently: IL-6)11. IL-6 was also shown to downregulate FOXP3 expression11. This important Treg transcription factor in turn, can bind to RORγt, preventing Th17 differentiation. Taken together, these findings ...
... B7-DC (B7-DC Xab)17 or by adding a mixture of Th17 inducing cytokines (IL-1, IL-21 and most potently: IL-6)11. IL-6 was also shown to downregulate FOXP3 expression11. This important Treg transcription factor in turn, can bind to RORγt, preventing Th17 differentiation. Taken together, these findings ...
t The Immune System in the Oldest-Old Clinical and Immunological Studies in
... an increase from 1.5 % fifty years earlier. The immune system undergoes dramatic changes at high age, sometimes referred to as “immunosenescence”. However, the natures of these changes, and in particular, their clinical consequences are incompletely understood. In a previous longitudinal study, a se ...
... an increase from 1.5 % fifty years earlier. The immune system undergoes dramatic changes at high age, sometimes referred to as “immunosenescence”. However, the natures of these changes, and in particular, their clinical consequences are incompletely understood. In a previous longitudinal study, a se ...
28-29_Per_tolerance_Regulatory T-cells_LA
... Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations. (a,b) Duodenal biopsies from patient B.II.4 (a) and A.III.3 (b) stained for CD4. (c) Highresolution chest computed tomography scan of the lungs from patient E.II.3. Arrows point to granulomatous-lymphocytic infiltration in bot ...
... Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations. (a,b) Duodenal biopsies from patient B.II.4 (a) and A.III.3 (b) stained for CD4. (c) Highresolution chest computed tomography scan of the lungs from patient E.II.3. Arrows point to granulomatous-lymphocytic infiltration in bot ...
transplantation - Shandong University
... – An allogenetic MHC molecule with a bound peptide can mimic the determinant formed by a self MHC molecule plus foreign peptide – A cross-reaction of a normal TCR, which was selected to recognize a self MHC molecules plus foreign peptide, with an allogenetic MHC molecule plus peptide ...
... – An allogenetic MHC molecule with a bound peptide can mimic the determinant formed by a self MHC molecule plus foreign peptide – A cross-reaction of a normal TCR, which was selected to recognize a self MHC molecules plus foreign peptide, with an allogenetic MHC molecule plus peptide ...
Mesenchymal Stem Cells
... [12]. Many reports have also described MSCs as having immunosuppressive properties, specifically that MSCs can modulate many T-cell functions including cell activation [39, 40]. This suppression appears to be independent of MHC matching between the MSCs and the T cells. Some reports have demonstrate ...
... [12]. Many reports have also described MSCs as having immunosuppressive properties, specifically that MSCs can modulate many T-cell functions including cell activation [39, 40]. This suppression appears to be independent of MHC matching between the MSCs and the T cells. Some reports have demonstrate ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.