microRNA-155 Regulates the Generation of Immunoglobulin Class
... MicroRNA-155 (miR-155) is expressed by cells of the immune system following activation and has been shown to be required for antibody production following vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymusdependent and independent ...
... MicroRNA-155 (miR-155) is expressed by cells of the immune system following activation and has been shown to be required for antibody production following vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymusdependent and independent ...
TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the
... form a memory response against microbes that have evaded the innate response. There are two types of adaptive immunity, humoral and cell-mediated. Each type of adaptive immunity has the unique ability to achieve a memory of the response, thus subsequent reinfections can be quickly eliminated. Cross- ...
... form a memory response against microbes that have evaded the innate response. There are two types of adaptive immunity, humoral and cell-mediated. Each type of adaptive immunity has the unique ability to achieve a memory of the response, thus subsequent reinfections can be quickly eliminated. Cross- ...
The pathogenic role of rheumatoid factor in rheumatoid arthritis
... both B1 and B2 cells, but the culprit subset may be variable depending on the biological condi tion that induces RF production. B1 cells have been shown to compose a major fraction that secretes large amounts of IgM RFs against the stimulation with Staphylococcus aureus [12] ; RF secretion from B1 ...
... both B1 and B2 cells, but the culprit subset may be variable depending on the biological condi tion that induces RF production. B1 cells have been shown to compose a major fraction that secretes large amounts of IgM RFs against the stimulation with Staphylococcus aureus [12] ; RF secretion from B1 ...
Laboratory of Viral Immunology
... Est. in 1985, open cohort > 4000 women enrolled Average 4 clients/day most are HIV+ at entry, those not seroconvert within 2 yrs ...
... Est. in 1985, open cohort > 4000 women enrolled Average 4 clients/day most are HIV+ at entry, those not seroconvert within 2 yrs ...
a,
... C3b initiates formation of a membrane attack complex (MAC) MAC causes cell lysis by interfering with a cell’s ability to eject Ca2+ C3b also causes opsonization, and C3a causes ...
... C3b initiates formation of a membrane attack complex (MAC) MAC causes cell lysis by interfering with a cell’s ability to eject Ca2+ C3b also causes opsonization, and C3a causes ...
NIH Public Access - IUPUI ScholarWorks
... The complement system is an essential component of innate immunity and bridges between the innate and adaptive immune systems. Similar to viral PAMPs and cellular DAMPs, components of the complement pathway in the lung provide additional immunological cues to DC activation and antiviral immunity to ...
... The complement system is an essential component of innate immunity and bridges between the innate and adaptive immune systems. Similar to viral PAMPs and cellular DAMPs, components of the complement pathway in the lung provide additional immunological cues to DC activation and antiviral immunity to ...
Raulet, D.H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3:781-790.
... to be learned about the patterns of expression of the different ligands, a theme is that their expression by normal cells in adults is generally absent or present at low levels, but in pathological conditions their expression is often upregulated. This theme is most clearly exemplified by MICA or MI ...
... to be learned about the patterns of expression of the different ligands, a theme is that their expression by normal cells in adults is generally absent or present at low levels, but in pathological conditions their expression is often upregulated. This theme is most clearly exemplified by MICA or MI ...
Exosomes: Looking back three decades and into the future
... with the capacity to stimulate T cell responses (Théry et al., 2002). Macrophages also generate exosomes, and macrophages infected with Mycobacterium tuberculosis (Mtb) generate exosomes that can present Mtb antigen peptide–MHC-II complexes ...
... with the capacity to stimulate T cell responses (Théry et al., 2002). Macrophages also generate exosomes, and macrophages infected with Mycobacterium tuberculosis (Mtb) generate exosomes that can present Mtb antigen peptide–MHC-II complexes ...
thesis
... are nanometer-sized extracellular membrane vesicles of endosomal origin, which act as messengers between cells without the need of cell-cell contact. They are formed in multivesicular bodies in a way that they carry membrane proteins expressed in the same manner and orientation as on the cellular me ...
... are nanometer-sized extracellular membrane vesicles of endosomal origin, which act as messengers between cells without the need of cell-cell contact. They are formed in multivesicular bodies in a way that they carry membrane proteins expressed in the same manner and orientation as on the cellular me ...
Activated Monocytes Impacts Presentation by Dendritic Cells and
... of cells, composed of several subsets, all of which can express high levels of CD11c and MHC class II (MHC-II) (19). In the mouse spleen, resident DCs can be divided into two main subsets based on the expression of CD8a, DEC205, and DCIR2: CD8+DEC205+ and CD82DCIR2+ DCs. In the steady state, both sp ...
... of cells, composed of several subsets, all of which can express high levels of CD11c and MHC class II (MHC-II) (19). In the mouse spleen, resident DCs can be divided into two main subsets based on the expression of CD8a, DEC205, and DCIR2: CD8+DEC205+ and CD82DCIR2+ DCs. In the steady state, both sp ...
Downloaded - Open Biology
... (qPCR). The selected genes included the inflammatory cytokines TNFa and IL6; macrophage cationic protein-2 (MCP2) and C-X-C type receptor-1 (CXCR1); toll-like receptor-2 (TLR2), caveolin-1 (CAV1) and CD1d; host antibacterial molecules NADP(H) oxidase (NOX1), nitric oxide synthase (NOS2) and defensin ...
... (qPCR). The selected genes included the inflammatory cytokines TNFa and IL6; macrophage cationic protein-2 (MCP2) and C-X-C type receptor-1 (CXCR1); toll-like receptor-2 (TLR2), caveolin-1 (CAV1) and CD1d; host antibacterial molecules NADP(H) oxidase (NOX1), nitric oxide synthase (NOS2) and defensin ...
Inflammation in the Bovine Female Reproductive Tract
... metritis to any and all inflammatory processes that production is transient, and follicles that do not ovuinvolve the uterus. To improve communication among late become atretic via apoptosis of follicular clinicians and researchers, the inflammatory condigranulosa cells (58). Two to three waves of s ...
... metritis to any and all inflammatory processes that production is transient, and follicles that do not ovuinvolve the uterus. To improve communication among late become atretic via apoptosis of follicular clinicians and researchers, the inflammatory condigranulosa cells (58). Two to three waves of s ...
All Activated CD8 T Cells A Transgenic Mouse Model Genetically Tags
... comprised of two transgenic mouse lines; one has a truncated human granzyme B promoter driving the expression of Cre recombinase (GBC) in activated T cells, and the other has a T cellspecific human CD2 promoter driving the expression of a lox-Pflanked transcriptional truncated yeast His3 gene and po ...
... comprised of two transgenic mouse lines; one has a truncated human granzyme B promoter driving the expression of Cre recombinase (GBC) in activated T cells, and the other has a T cellspecific human CD2 promoter driving the expression of a lox-Pflanked transcriptional truncated yeast His3 gene and po ...
Review Article Thyroid dysfunction: an autoimmune aspect
... Thyroid dysfunction: an autoimmune aspect innate and acquired and thus generate pro inflammatory cytokines. IL-12, IFN-γ, TNF-α play an important role in initiating adaptive immune response [42]. IL-1β has variety of effects on other cells, like it can alter cell signaling, migration, cytokine prod ...
... Thyroid dysfunction: an autoimmune aspect innate and acquired and thus generate pro inflammatory cytokines. IL-12, IFN-γ, TNF-α play an important role in initiating adaptive immune response [42]. IL-1β has variety of effects on other cells, like it can alter cell signaling, migration, cytokine prod ...
Reciprocal modulation between TH17 and other helper T cell lineages
... irreversible event. T helper type 1 (TH1) cells stably express interferon (IFN)-g, whereas TH2 cells express IL-4 (Dong, 2008). The more recently defined TH17 cells, follicular helper T (Tfh) cells and induced regulatory T (iTreg) cells have been added into the CD4þ T cell subpopulations (Weaver and ...
... irreversible event. T helper type 1 (TH1) cells stably express interferon (IFN)-g, whereas TH2 cells express IL-4 (Dong, 2008). The more recently defined TH17 cells, follicular helper T (Tfh) cells and induced regulatory T (iTreg) cells have been added into the CD4þ T cell subpopulations (Weaver and ...
Tesi unita 08 - Padua@Research
... Efforts to elucidate the molecular mechanisms of T. pallidum virulence have been hampered by some of its characteristics, which make it difficult to be cultured in vitro. Little is know about how T. pallidum causes the syphilis, and in particular how T. pallidum survives within the host despite the ...
... Efforts to elucidate the molecular mechanisms of T. pallidum virulence have been hampered by some of its characteristics, which make it difficult to be cultured in vitro. Little is know about how T. pallidum causes the syphilis, and in particular how T. pallidum survives within the host despite the ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.