Tissue adaptation: Implications for gut immunity and tolerance
... Although IELs exhibit cytotoxic potential, their killing activity is kept in check by tissue imprinting. A positive regulator of the cytotoxic activity of IEL populations is IL-15, a cytokine produced by a wide range of cells including epithelial, stromal, and several myeloid cell populations (Jabri ...
... Although IELs exhibit cytotoxic potential, their killing activity is kept in check by tissue imprinting. A positive regulator of the cytotoxic activity of IEL populations is IL-15, a cytokine produced by a wide range of cells including epithelial, stromal, and several myeloid cell populations (Jabri ...
ABBREVIATIONS ........................................................................... 3 INTRODUCTION............................................................................. 5
... of toxic substances, chemokines and cytokines. Further, they signal to the adaptive immune system by the release of different factors and monocytes/macrophages and DCs present antigens to adaptive cells through the major histocompatibility complex (MHC) II, expressed on their cell surface. Also, mac ...
... of toxic substances, chemokines and cytokines. Further, they signal to the adaptive immune system by the release of different factors and monocytes/macrophages and DCs present antigens to adaptive cells through the major histocompatibility complex (MHC) II, expressed on their cell surface. Also, mac ...
The Janus face of immunity : how anti-tumor
... Christina Gebauer. The Janus face of immunity : how anti-tumor immunity leads to autoimmunity in paraneoplastic neurological diseases. Immunology. Université Paul Sabatier - Toulouse III, 2016. English..
...
... Christina Gebauer. The Janus face of immunity : how anti-tumor immunity leads to autoimmunity in paraneoplastic neurological diseases. Immunology. Université Paul Sabatier - Toulouse III, 2016. English.
Identification of Gelsolin, a Ca`-dependent Regulatory Protein of
... Fig. 4 shows that, besides macrophages, human PMN leukocytes (lane a) and rabbit splenic lymphocytes (lane b) contained a crossreactive polypeptide which comigrated with purified rabbit macrophage gelsolin on polyacrylamide gels. On the basis of the similarity in molecular weight and immunologic cro ...
... Fig. 4 shows that, besides macrophages, human PMN leukocytes (lane a) and rabbit splenic lymphocytes (lane b) contained a crossreactive polypeptide which comigrated with purified rabbit macrophage gelsolin on polyacrylamide gels. On the basis of the similarity in molecular weight and immunologic cro ...
MHC Chpt. 7
... – Its products play role in discriminating self/non-self – Participant in both humoral and cell-mediated immunity ...
... – Its products play role in discriminating self/non-self – Participant in both humoral and cell-mediated immunity ...
Role of the PD‐1 Pathway in the Immune Response
... necrosis factor-a and interleukin-2 (IL-2). PD-1 can also inhibit T cell proliferation (5,36), and inhibit the upregulation of Bcl-xL, an antiapoptotic protein (33). Last, PD1 signaling decreases the expression of the transcription factors GATA-3, Tbet and Eomes, which are associated with T cell eff ...
... necrosis factor-a and interleukin-2 (IL-2). PD-1 can also inhibit T cell proliferation (5,36), and inhibit the upregulation of Bcl-xL, an antiapoptotic protein (33). Last, PD1 signaling decreases the expression of the transcription factors GATA-3, Tbet and Eomes, which are associated with T cell eff ...
Exosomes: From biogenesis and secretion to biological function
... to the release of the internal vesicles into the extracellular space (Fig. 1C). The released vesicles are then called exosomes. Many cell types release exosomes via this mechanism including hematopoietic cells, reticulocytes, B- and T-lymphocytes, dendritic cells, mast cells, platelets, intestinal e ...
... to the release of the internal vesicles into the extracellular space (Fig. 1C). The released vesicles are then called exosomes. Many cell types release exosomes via this mechanism including hematopoietic cells, reticulocytes, B- and T-lymphocytes, dendritic cells, mast cells, platelets, intestinal e ...
Functional Characterization of the CD300e Leukocyte Receptor Tamara Brckalo
... (NK) cells to constitute the innate arm of the immune system. Monocytes originate in the bone marrow from a common myeloid progenitor shared with neutrophils, and are then released into peripheral blood where they circulate for several days before entering tissues. They constitute a systemic reservo ...
... (NK) cells to constitute the innate arm of the immune system. Monocytes originate in the bone marrow from a common myeloid progenitor shared with neutrophils, and are then released into peripheral blood where they circulate for several days before entering tissues. They constitute a systemic reservo ...
CD161 defines the subset of FoxP3+ T cells capable of producing
... To assess in vitro proliferation or anergy, sorted cells (CD1611 Treg [CD41 CD25hiCD127loCD1611], CD161– Treg [CD41CD25hiCD127loCD161–], and/or Tconv [CD41CD25–CD127hi]) were carboxyfluorescein diacetate succinimidyl ester (CFSE) labeled. Briefly, cells were labeled in 1 mM CFSE solution for 10 minute ...
... To assess in vitro proliferation or anergy, sorted cells (CD1611 Treg [CD41 CD25hiCD127loCD1611], CD161– Treg [CD41CD25hiCD127loCD161–], and/or Tconv [CD41CD25–CD127hi]) were carboxyfluorescein diacetate succinimidyl ester (CFSE) labeled. Briefly, cells were labeled in 1 mM CFSE solution for 10 minute ...
Active Infection and RIG-I Signaling Influenza A Virus Infection Is
... macrophages, dendritic cells, and mast cells. However, the role of mast cells during respiratory infections is an understudied area (7). Mast cells are tissue-sentinel cells of hematopoietic origins found in most vasculature tissue, but they are enriched in tissues that are at environmental interfac ...
... macrophages, dendritic cells, and mast cells. However, the role of mast cells during respiratory infections is an understudied area (7). Mast cells are tissue-sentinel cells of hematopoietic origins found in most vasculature tissue, but they are enriched in tissues that are at environmental interfac ...
Antibody Repertoire and Gene Expression Profile
... cells, whereas Tg expression of a B-1a-derived BCR leads to an increase of B-1a cells (2). The requirement for continuous BCR signaling and characteristic features of the Ab repertoire distinguishes B-1a cells from other B cell subsets (6 –10). Such characteristics are paralleled by specific differe ...
... cells, whereas Tg expression of a B-1a-derived BCR leads to an increase of B-1a cells (2). The requirement for continuous BCR signaling and characteristic features of the Ab repertoire distinguishes B-1a cells from other B cell subsets (6 –10). Such characteristics are paralleled by specific differe ...
NIH Public Access
... cells are captured by DCs in PPs, which migrate to MLNs and activate B cells in MLNs, eventually resulting in IgA production, which in turn prevents microbiota penetration. Another model posits that DCs directly sample commensal bacteria and/or other intact antigens in the intestinal lumen.56 The se ...
... cells are captured by DCs in PPs, which migrate to MLNs and activate B cells in MLNs, eventually resulting in IgA production, which in turn prevents microbiota penetration. Another model posits that DCs directly sample commensal bacteria and/or other intact antigens in the intestinal lumen.56 The se ...
Th2 Cytokines Down-Regulate TLR Expression and Function
... TLR2 and TLR4 ligands, and inhibitory molecules such as Tollinteracting protein have been shown to further restrict TLR signaling in IECs (5). Dysregulated TLR signaling in IECs may also be an important pathogenic factor in the development of chronic intestinal inflammation (12). Breaks within the i ...
... TLR2 and TLR4 ligands, and inhibitory molecules such as Tollinteracting protein have been shown to further restrict TLR signaling in IECs (5). Dysregulated TLR signaling in IECs may also be an important pathogenic factor in the development of chronic intestinal inflammation (12). Breaks within the i ...
Innate Type 2 Immunity Is Associated with Eosinophilic Pleural
... Eosinophilic pleural effusion (EPE), defined as greater than 10% eosinophilia in the pleural fluid, is often associated with the presence of air and/or blood in the pleural space (1). Although a common manifestation of various pleural diseases, the precise mechanism underlying EPE is largely unknown ...
... Eosinophilic pleural effusion (EPE), defined as greater than 10% eosinophilia in the pleural fluid, is often associated with the presence of air and/or blood in the pleural space (1). Although a common manifestation of various pleural diseases, the precise mechanism underlying EPE is largely unknown ...
Trinity™ Multipotential Cellular Bone Matrix
... and muscle as well as components of the circulatory, excretory, reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in si ...
... and muscle as well as components of the circulatory, excretory, reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in si ...
Characterization of mesenchymal stem cells under the stimulation of
... Infective factors cause the perpetuation of inflammation as a result of the permanent exposure of the immune system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeut ...
... Infective factors cause the perpetuation of inflammation as a result of the permanent exposure of the immune system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeut ...
Prevention of collagen-induced arthritis by gene delivery of
... prostaglandin E2 and collagenase by synovial cells, contributes to fibrosis and facilitates inflammatory cell infiltration by promoting adhesion of neutrophils and lymphocytes to endothelial cells. This has led to the hypothesis that excessive production of TNF-␣ may be important in the pathogenesis ...
... prostaglandin E2 and collagenase by synovial cells, contributes to fibrosis and facilitates inflammatory cell infiltration by promoting adhesion of neutrophils and lymphocytes to endothelial cells. This has led to the hypothesis that excessive production of TNF-␣ may be important in the pathogenesis ...
In vitro and in vivo model of a novel immunotherapy
... The targets tested included Jeko-1, BJAB, and LCL cells labeled with 25Ci of 51Cr (Perkin-Elmer) for 45 minutes, as well as primary CLL cells and normal B lymphocytes, each labeled with 50 Ci of 51Cr for 1 hour. Target cells (5 ⫻ 103) were then cocultured in triplicate with T cells at effector:tar ...
... The targets tested included Jeko-1, BJAB, and LCL cells labeled with 25Ci of 51Cr (Perkin-Elmer) for 45 minutes, as well as primary CLL cells and normal B lymphocytes, each labeled with 50 Ci of 51Cr for 1 hour. Target cells (5 ⫻ 103) were then cocultured in triplicate with T cells at effector:tar ...
Phagocytes may counteract the “open window” situation during a
... believed to be responsible for the exercise-induced changes in the immune system. Indeed, the ...
... believed to be responsible for the exercise-induced changes in the immune system. Indeed, the ...
Profound CD4+/CCR5+ T cell expansion is induced by CD8+
... Figure 1. CD8+ lymphocyte depletion abrogates the postpeak decline in viral replication rates during acute SIVmac239 infection. (A and B) Comparison of log-transformed, acute-phase plasma viral load profiles of (A) 23 SIVmac239-infected, untreated normal progressors versus (B) 7 RMs treated with 10 ...
... Figure 1. CD8+ lymphocyte depletion abrogates the postpeak decline in viral replication rates during acute SIVmac239 infection. (A and B) Comparison of log-transformed, acute-phase plasma viral load profiles of (A) 23 SIVmac239-infected, untreated normal progressors versus (B) 7 RMs treated with 10 ...
Long-Term Protective Immunity Induced Against
... shares common antigens with T. cruzi, have been tested as inducers of cross-protection. Unfortunately, most of these immunizations were only able to delay manifestations of the disease or at best decrease the associated pathology. Long-term protection could be achieved only when using Th1-driving ad ...
... shares common antigens with T. cruzi, have been tested as inducers of cross-protection. Unfortunately, most of these immunizations were only able to delay manifestations of the disease or at best decrease the associated pathology. Long-term protection could be achieved only when using Th1-driving ad ...
Induced disruption of the transforming growth factor
... numerous physiologic processes including development, hematopoiesis, wound healing, and immune response. The 3 isoforms of this growth factor that have been identified in mammals (TGF-1, -2, and -3) are encoded by distinct genetic loci and share a high level of homology. They act on virtually all ...
... numerous physiologic processes including development, hematopoiesis, wound healing, and immune response. The 3 isoforms of this growth factor that have been identified in mammals (TGF-1, -2, and -3) are encoded by distinct genetic loci and share a high level of homology. They act on virtually all ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.