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Plasmacytoid dendritic cells and dermatological - HAL
... (SALT) and their antigen presenting functions was a matter of debate (11). In another study, the presence of plasmacytoid monocytes was established in 58% of biopsies removed from patients suffering from Jessner-Kanoff disease (75 biopsies) (12). It is now established that these plasmacytoid monocyt ...
... (SALT) and their antigen presenting functions was a matter of debate (11). In another study, the presence of plasmacytoid monocytes was established in 58% of biopsies removed from patients suffering from Jessner-Kanoff disease (75 biopsies) (12). It is now established that these plasmacytoid monocyt ...
Regulation of mucosal immune responses in effector sites
... result in a high level production of IL-2: these cells preferentially produce IL-4 (Harriman et al. 1992; Bailey et al. 1994a). Production of IL-2 by human lamina propria cells requires activation through the CD2 surface molecule rather than through CD3; when CD3 is ligated, IL-4 is preferentially s ...
... result in a high level production of IL-2: these cells preferentially produce IL-4 (Harriman et al. 1992; Bailey et al. 1994a). Production of IL-2 by human lamina propria cells requires activation through the CD2 surface molecule rather than through CD3; when CD3 is ligated, IL-4 is preferentially s ...
Deletion of the Zinc-Binding Motif of CD13
... Inhibitory MoAbs do not recognize mutant CD13IAPN molecules. NIH/CD13wt transfectants and NIH/CD13del transfectants were stained with a panel of 19 MoAbs specific for defined extracellular epitopes of CD13/APN, and then were analyzed by flow cytometry. All of the MoAbs recognized epitopes of normal ...
... Inhibitory MoAbs do not recognize mutant CD13IAPN molecules. NIH/CD13wt transfectants and NIH/CD13del transfectants were stained with a panel of 19 MoAbs specific for defined extracellular epitopes of CD13/APN, and then were analyzed by flow cytometry. All of the MoAbs recognized epitopes of normal ...
Myelin Recovery in Multiple Sclerosis: The Challenge of
... In PNS the transmembrane protein zero (P0) replaces PLP as the major protein (Schwann cells also express low levels of PLP). DM-20, which is identical but shorter than PLP because it lacks 35 amino acids, is also produced from the PLP gene. Low quantities of both PLP gene products are present in the ...
... In PNS the transmembrane protein zero (P0) replaces PLP as the major protein (Schwann cells also express low levels of PLP). DM-20, which is identical but shorter than PLP because it lacks 35 amino acids, is also produced from the PLP gene. Low quantities of both PLP gene products are present in the ...
Passive or Active Immunization with Myelin Basic Protein Promotes
... control rats injected with PBS in IFA. Morphometric analysis, immunohistochemical staining, and diffusion anisotropy magnetic resonance imaging showed that the behavioral outcome was correlated with tissue preservation. The results suggest that T cell-mediated immune activity, achieved by either ado ...
... control rats injected with PBS in IFA. Morphometric analysis, immunohistochemical staining, and diffusion anisotropy magnetic resonance imaging showed that the behavioral outcome was correlated with tissue preservation. The results suggest that T cell-mediated immune activity, achieved by either ado ...
of innate immunity
... early response of innate immunity and the later response of adaptive immunity. 2. Innate immune responses are initiated by recognition of common microbial structures (PAMPs) by PatternRecognition Receptors (PRRs) on innate immune cells. - Provide the first line of host defense - Activate and regulat ...
... early response of innate immunity and the later response of adaptive immunity. 2. Innate immune responses are initiated by recognition of common microbial structures (PAMPs) by PatternRecognition Receptors (PRRs) on innate immune cells. - Provide the first line of host defense - Activate and regulat ...
Basophils contribute to TH2-IgE responses in vivo via IL
... We compared the ability of conventional APCs and basophils to induce TH2 cell development in vitro in neutral and TH2 conditions (Fig. 2e). In the absence of any other APC, bone marrow–derived basophils were able to induce naive CD4+ T cells to develop into TH2 cells in neutral culture conditions as ...
... We compared the ability of conventional APCs and basophils to induce TH2 cell development in vitro in neutral and TH2 conditions (Fig. 2e). In the absence of any other APC, bone marrow–derived basophils were able to induce naive CD4+ T cells to develop into TH2 cells in neutral culture conditions as ...
Instructions for Handling PDF Galley Proofs
... out in several laboratories, including ours, to better define these immune regulatory pathways and ultimately identify targets for immune-based interventions aimed at reducing the HIV-associated chronic immune activation. A second hypothesized mechanism to explain the resolution of immune activation ...
... out in several laboratories, including ours, to better define these immune regulatory pathways and ultimately identify targets for immune-based interventions aimed at reducing the HIV-associated chronic immune activation. A second hypothesized mechanism to explain the resolution of immune activation ...
Amniotic Derived Stem Cells: Role and Function in Regenerative
... present. ASCs are known to express the cell markers of all three germ layers, but their exact origin still seems to play a role in how they act later in later stages of differentiation. AFDSCs reach the outer area of the fluid by shedding from the amniotic cavity of developing skin, respiratory appa ...
... present. ASCs are known to express the cell markers of all three germ layers, but their exact origin still seems to play a role in how they act later in later stages of differentiation. AFDSCs reach the outer area of the fluid by shedding from the amniotic cavity of developing skin, respiratory appa ...
- Nottingham ePrints
... radicals damage T cells, reducing their number, inhibiting the T cell receptor complex and inhibiting cell-mediated immune functions [8,15,19,21]. They induce the development of Tregs and T cell anergy [8,22]. They play a crucial role in promoting tumour angiogenesis, tumour invasion and formation o ...
... radicals damage T cells, reducing their number, inhibiting the T cell receptor complex and inhibiting cell-mediated immune functions [8,15,19,21]. They induce the development of Tregs and T cell anergy [8,22]. They play a crucial role in promoting tumour angiogenesis, tumour invasion and formation o ...
High Temperature Affects Cytokine Release by Human Peripheral
... heat shock factor-1 serving as a trigger for development of heat shock response with subsequent production of inflammatory cytokines by immune cells. Heat shock proteins are produced intracellular, but under stress conditions they are unconstrained from the cells and initiate the production of infla ...
... heat shock factor-1 serving as a trigger for development of heat shock response with subsequent production of inflammatory cytokines by immune cells. Heat shock proteins are produced intracellular, but under stress conditions they are unconstrained from the cells and initiate the production of infla ...
REVIEWS - Advances in Clinical and Experimental Medicine
... birth to 2–3 years of age, then it reaches its highest weight (30–40 g), and then begins to shrink in the period of adolescence (because of the influence of sex hormones present in the bloodstream). Its proper functioning during childhood ensures that the immune system is in good condition [3]. Scie ...
... birth to 2–3 years of age, then it reaches its highest weight (30–40 g), and then begins to shrink in the period of adolescence (because of the influence of sex hormones present in the bloodstream). Its proper functioning during childhood ensures that the immune system is in good condition [3]. Scie ...
Sequence analysis of T-cell repertoires in health and disease
... own cellular space. T cells, which mediate cellular immunity, express heterodimeric (αβ or γδ) cell surface receptors (T-cell receptors, or TCRs). The vast majority of these are αβ TCRs, which engage heterologous cells presenting peptide antigens bound to major histocompatibility complex (MHC) [22]. ...
... own cellular space. T cells, which mediate cellular immunity, express heterodimeric (αβ or γδ) cell surface receptors (T-cell receptors, or TCRs). The vast majority of these are αβ TCRs, which engage heterologous cells presenting peptide antigens bound to major histocompatibility complex (MHC) [22]. ...
A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1
... plays a role in leukocyte trafficking, antigen presentation, cellular activation, and adhesion of Cytotoxic T lymphocytes (CTL) to their targets. In addition to its role in the immune response, LFA-1 and its ligands are incorporated into the viral envelope as HIV-1 buds from the cell surface [1]. Th ...
... plays a role in leukocyte trafficking, antigen presentation, cellular activation, and adhesion of Cytotoxic T lymphocytes (CTL) to their targets. In addition to its role in the immune response, LFA-1 and its ligands are incorporated into the viral envelope as HIV-1 buds from the cell surface [1]. Th ...
Nerve activates contraction
... Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings ...
... Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings ...
Vaccine immunology - World Health Organization
... represents a significant challenge for the development of specific vaccines such as against HIV-1.14 Current vaccines mostly mediate protection through the induction of highly specific IgG serum antibodies (Table 2–2). Under certain circumstances, however, passive antibodymediated immunity is inefficien ...
... represents a significant challenge for the development of specific vaccines such as against HIV-1.14 Current vaccines mostly mediate protection through the induction of highly specific IgG serum antibodies (Table 2–2). Under certain circumstances, however, passive antibodymediated immunity is inefficien ...
Perforin activates clathrin- and dynamin
... Figure 1. PFN and GzmB are rapidly endocytosed into EEA-1ⴙ outsized early endosomes. (A-B) Within 5 minutes of treatment with sublytic native hPFN and hGzmB, large intracellular and membrane bound endosomes (gigantosomes) coimmunostain for GzmB (A) or PFN (B) and the early endosomal marker EEA-1. Im ...
... Figure 1. PFN and GzmB are rapidly endocytosed into EEA-1ⴙ outsized early endosomes. (A-B) Within 5 minutes of treatment with sublytic native hPFN and hGzmB, large intracellular and membrane bound endosomes (gigantosomes) coimmunostain for GzmB (A) or PFN (B) and the early endosomal marker EEA-1. Im ...
Regulation of innate and adaptive immune responses by
... TLRs are widely expressed in many cell types, including epithelial and endothelial cells, although these non-hematopoietic cell types normally express only selected subsets of TLRs (12, 57). In contrast, hemotopoetically derived cells, such as monocytes, macrophages, neutrophils and dendritic cells ...
... TLRs are widely expressed in many cell types, including epithelial and endothelial cells, although these non-hematopoietic cell types normally express only selected subsets of TLRs (12, 57). In contrast, hemotopoetically derived cells, such as monocytes, macrophages, neutrophils and dendritic cells ...
Pathways Molecule-Dependent and
... is estimated that 30,000 –50,000 cases of JEV occur each year, resulting in 10,000 –15,000 deaths, although this number may be underestimated (22, 23). Additionally, 30 – 60% of surviving patients suffer from serious long-term neuropsychiatric sequelae (27, 28). However, the pathogenesis of JEV-asso ...
... is estimated that 30,000 –50,000 cases of JEV occur each year, resulting in 10,000 –15,000 deaths, although this number may be underestimated (22, 23). Additionally, 30 – 60% of surviving patients suffer from serious long-term neuropsychiatric sequelae (27, 28). However, the pathogenesis of JEV-asso ...
Adaptive Immune Responses in the Intestinal Mucosa of
... is often associated with nocturnal diarrhoea (9). Abdominal pain and weight loss is significantly common. Furthermore faecal incontinence may affect these patients, which is one of the major factors for the low quality of life of these patients (9-11) . The onset of CC can be sudden in about 40 % of ...
... is often associated with nocturnal diarrhoea (9). Abdominal pain and weight loss is significantly common. Furthermore faecal incontinence may affect these patients, which is one of the major factors for the low quality of life of these patients (9-11) . The onset of CC can be sudden in about 40 % of ...
Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are
... their phenotype and their localization in lymphoid tissues (16). Iwasaki and Kelsall have recently identified and characterized 3 distinct subsets of DCs in murine Peyer’s patches (17,18): 1) CD11b⫹,CD8␣⫺ DCs with a myeloid lineage, residing in the subepithelial region; 2) CD11b⫺,CD8␣⫹ DCs with a ly ...
... their phenotype and their localization in lymphoid tissues (16). Iwasaki and Kelsall have recently identified and characterized 3 distinct subsets of DCs in murine Peyer’s patches (17,18): 1) CD11b⫹,CD8␣⫺ DCs with a myeloid lineage, residing in the subepithelial region; 2) CD11b⫺,CD8␣⫹ DCs with a ly ...
T cell
![](https://commons.wikimedia.org/wiki/Special:FilePath/Healthy_Human_T_Cell.jpg?width=300)
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.