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thesis - KI Open Archive
... The immune system is a fascinating creation. Always awake and ready to respond, constantly battling with pathogens but also with the difficult task of balancing immunity and self-tolerance. In this introduction I attempt to give a brief overview of the immune system and specifically the cells I have ...
... The immune system is a fascinating creation. Always awake and ready to respond, constantly battling with pathogens but also with the difficult task of balancing immunity and self-tolerance. In this introduction I attempt to give a brief overview of the immune system and specifically the cells I have ...
O A Immunophenotyping of Lymphocyte Subpopulations and pre-inflammatory mediators in neonatal sepsis
... NK cells, which provided a survival benefit [7]. NK cells are both targets of interferon-gamma (IFN-γ) action and producers of IFN-γ, and it has been shown that NK cells constitute early sources of IFN-γ during infection [26]. IFN-γ plays an important role in both innate and adaptive immune response ...
... NK cells, which provided a survival benefit [7]. NK cells are both targets of interferon-gamma (IFN-γ) action and producers of IFN-γ, and it has been shown that NK cells constitute early sources of IFN-γ during infection [26]. IFN-γ plays an important role in both innate and adaptive immune response ...
CD4+ T-Cell-Independent Secondary Immune Responses to
... Pneumocystis infection upon adoptive transfer into Rag1(−/−) mice (3). As such, CD4+ T-cells have been a primary focus in the study of host defense against this pathogen. However, it has also been shown that adoptive transfer of hyperimmune serum mediates effective passive immunity to Pneumocystis i ...
... Pneumocystis infection upon adoptive transfer into Rag1(−/−) mice (3). As such, CD4+ T-cells have been a primary focus in the study of host defense against this pathogen. However, it has also been shown that adoptive transfer of hyperimmune serum mediates effective passive immunity to Pneumocystis i ...
among HLA-G, myeloid APCs, and regulatory cells
... up-regulation.36 Interestingly, the tryptophan catabolyzing enzyme indoleamine 2 3-dioxygenase (IDO) was shown to differentially modulate HLA-G expression in monocytes and myeloid DCs: IDO blocked HLA-G cell-surface expression on monocytes,37 but it induced HLA-G expression and shedding in myeloid D ...
... up-regulation.36 Interestingly, the tryptophan catabolyzing enzyme indoleamine 2 3-dioxygenase (IDO) was shown to differentially modulate HLA-G expression in monocytes and myeloid DCs: IDO blocked HLA-G cell-surface expression on monocytes,37 but it induced HLA-G expression and shedding in myeloid D ...
The immune response to yellow fever vaccination in aged individuals
... The innate immune system represents the first line of defense against infections and forms the basis for efficient initiation of a subsequent adaptive immune response. It comprises a number of different innate cell types, specialized in their functions, which have in common that they generically rec ...
... The innate immune system represents the first line of defense against infections and forms the basis for efficient initiation of a subsequent adaptive immune response. It comprises a number of different innate cell types, specialized in their functions, which have in common that they generically rec ...
Memory Cells in Old Age T Cells Are Potent + CD25
... There is strong circumstantial evidence that CMV may be a dominant factor to drive CD8⫹ T cell differentiation and hereby induce premature immune senescence (13). CMV-specific CD8⫹ T cells have also been shown to occur as large expanded clones that may dominate the repertoire (14). In a recent publi ...
... There is strong circumstantial evidence that CMV may be a dominant factor to drive CD8⫹ T cell differentiation and hereby induce premature immune senescence (13). CMV-specific CD8⫹ T cells have also been shown to occur as large expanded clones that may dominate the repertoire (14). In a recent publi ...
An essential role for decorin in bladder cancer invasiveness
... B cells (Fig 1), the pattern of immune infiltrate thus suggest an efficient anti‐tumour cytotoxic CD8þ T‐cell response against MB49, and an impairment of the immune response by regulatory T cells and possibly some IL17A‐expressing CD4þ (Th17) and CD8þ (Tc17) lymphocytes in MB49‐I tumours. MB49‐I has l ...
... B cells (Fig 1), the pattern of immune infiltrate thus suggest an efficient anti‐tumour cytotoxic CD8þ T‐cell response against MB49, and an impairment of the immune response by regulatory T cells and possibly some IL17A‐expressing CD4þ (Th17) and CD8þ (Tc17) lymphocytes in MB49‐I tumours. MB49‐I has l ...
Suppression of adaptive immune responses during primary SIV
... BLOOD, 15 APRIL 2010 䡠 VOLUME 115, NUMBER 15 ...
... BLOOD, 15 APRIL 2010 䡠 VOLUME 115, NUMBER 15 ...
poster - Natural Killer Cell Symposium
... Natural killer (NK) cells are lymphocytes of the innate immune system that deliver a selective cytotoxic effect against target cells such as virally infected and tumor cells. NK cell function involves cytokine secretion and tissue remodeling. NK cellular cytotoxicity is delicately balanced by signal ...
... Natural killer (NK) cells are lymphocytes of the innate immune system that deliver a selective cytotoxic effect against target cells such as virally infected and tumor cells. NK cell function involves cytokine secretion and tissue remodeling. NK cellular cytotoxicity is delicately balanced by signal ...
Robertson et al. 2003 Seminal priming
... after implantation (Guimond et al., 1997; Arck et al., 1999) but, to date, the mechanisms regulating their ontogeny are not understood. Clues as to the functional relevance of the T-cell response to pregnancy come from the observation that successful pregnancy is associated with a systemic state of ...
... after implantation (Guimond et al., 1997; Arck et al., 1999) but, to date, the mechanisms regulating their ontogeny are not understood. Clues as to the functional relevance of the T-cell response to pregnancy come from the observation that successful pregnancy is associated with a systemic state of ...
Tolerogenic dendritic cell-based immunotherapy in Crohn’s disease Raquel Cabezón Cabello
... epithelial cells, named Goblet cells. When mucosal barrier function is disrupted, permeability is compromised; therefore the risk of bacterial break-through and intestinal inflammation is higher. Indeed, a study showed that MUC1 mRNA expression in humans was reduced in the inflamed ileum of Crohn’s ...
... epithelial cells, named Goblet cells. When mucosal barrier function is disrupted, permeability is compromised; therefore the risk of bacterial break-through and intestinal inflammation is higher. Indeed, a study showed that MUC1 mRNA expression in humans was reduced in the inflamed ileum of Crohn’s ...
Blackcurrant phenolic extract induces hemeoxygenase
... consumption (2, 3). Fruits are high in various polyphenolic compounds and there is evidence developing that such compounds may have immune modulatory actions which are additional to antioxidant properties. Our recent findings suggest that some polyphenolic compounds may suppress the induction of eosi ...
... consumption (2, 3). Fruits are high in various polyphenolic compounds and there is evidence developing that such compounds may have immune modulatory actions which are additional to antioxidant properties. Our recent findings suggest that some polyphenolic compounds may suppress the induction of eosi ...
The non-steroidal SEGRA, BAY1155975, in contrast to
... irreversible side-effects. Therefore, new glucocorticoid receptor (GR) ligands with should have potent anti-inflammatory efficacy but a reduced side-effect profile have been developed. Non-steroidal selective glucocorticoid receptor agonists (SEGRAs) represent a new class of GR ligands with an impro ...
... irreversible side-effects. Therefore, new glucocorticoid receptor (GR) ligands with should have potent anti-inflammatory efficacy but a reduced side-effect profile have been developed. Non-steroidal selective glucocorticoid receptor agonists (SEGRAs) represent a new class of GR ligands with an impro ...
- Iranian Journal of Immunology
... Today, organ transplantation is one of the most effective therapeutic methods used for patients with organ failures. However, graft rejection is still the major problem in allogeneic transplantations. Recently, mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplant ...
... Today, organ transplantation is one of the most effective therapeutic methods used for patients with organ failures. However, graft rejection is still the major problem in allogeneic transplantations. Recently, mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplant ...
and anti-inflammatory phenomena in the physiopathology of type 2
... found in the AT[15]. Although a definitive standard set of markers for the identification of M2 cells is not available yet, a group of molecules often reported in the literature to be associated with this type of cell has been used, since adopting a single marker would be unrealistic[16]. Arginase-1 ...
... found in the AT[15]. Although a definitive standard set of markers for the identification of M2 cells is not available yet, a group of molecules often reported in the literature to be associated with this type of cell has been used, since adopting a single marker would be unrealistic[16]. Arginase-1 ...
CHAPTER 7 Immune defences against pathogens
... and tissues. White blood cells are greatly outnumbered in the blood by the oxygen-carrying red blood cells. White blood cells are present in normal blood at concentrations in the range of 4000 to 10 000 cells per microlitre. Contrast this with red blood cells, which are present at concentrations ran ...
... and tissues. White blood cells are greatly outnumbered in the blood by the oxygen-carrying red blood cells. White blood cells are present in normal blood at concentrations in the range of 4000 to 10 000 cells per microlitre. Contrast this with red blood cells, which are present at concentrations ran ...
Characterization of CD56 CD16 natural killer (NK) cells: A highly
... are an important source of cytokines that regulate hematopoiesis and link the innate to the adaptive immune response through a bidirectional cross-talk with dendritic cells (3, 4). NK cells are able to lyse tumor and virally infected cells without prior sensitization while sparing normal cells that ...
... are an important source of cytokines that regulate hematopoiesis and link the innate to the adaptive immune response through a bidirectional cross-talk with dendritic cells (3, 4). NK cells are able to lyse tumor and virally infected cells without prior sensitization while sparing normal cells that ...
Sleep April.indd
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
Immunology for physicists - Laboratoire de Physique Statistique
... spend considerable time resident in lymphoid organs, such as the bone marrow, the thymus, the spleen, and lymph nodes. Lymphocytes are subdivided into two major classes: B cells and T cells. B lymphocytes secrete antibodies, one of the major protective molecules in our bodies. T cells function mainl ...
... spend considerable time resident in lymphoid organs, such as the bone marrow, the thymus, the spleen, and lymph nodes. Lymphocytes are subdivided into two major classes: B cells and T cells. B lymphocytes secrete antibodies, one of the major protective molecules in our bodies. T cells function mainl ...
Publications de l`équipe - Centre de recherche de l`Institut Curie
... Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes which transfer functional MHC-peptide complexes to other DCs. Since immature and mature DCs induce different functional T cell responses (i.e., tolerance versus priming), we asked whe ...
... Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes which transfer functional MHC-peptide complexes to other DCs. Since immature and mature DCs induce different functional T cell responses (i.e., tolerance versus priming), we asked whe ...
Deep Insight Section Th17 cells: inflammation and regulation in Oncology and Haematology
... CD4+ T cells play a pivotal role in host defense, but are also recognized to have pathogenic roles such as in autoimmunity, asthma, cancer and allergic responses (Zhu et al., 2010). On activation by co-stimulatory molecules and particular cytokines, naïve CD4+ T cells can differentiate into the dist ...
... CD4+ T cells play a pivotal role in host defense, but are also recognized to have pathogenic roles such as in autoimmunity, asthma, cancer and allergic responses (Zhu et al., 2010). On activation by co-stimulatory molecules and particular cytokines, naïve CD4+ T cells can differentiate into the dist ...
Increase in Peripheral Blood Intermediate Monocytes is Associated
... patients showed higher CD11b expression compared to those of the Graves and HC groups (Fig. 2A). CD62L is an adhesion molecule that is present on the surface of inflammatory monocytes, and its expression has been linked to the capacity of monocytes to preferentially migrate to the sites of inflammat ...
... patients showed higher CD11b expression compared to those of the Graves and HC groups (Fig. 2A). CD62L is an adhesion molecule that is present on the surface of inflammatory monocytes, and its expression has been linked to the capacity of monocytes to preferentially migrate to the sites of inflammat ...
Plasmacytoid predendritic cells initiate psoriasis through interferon
... onset of the lesions is commonly followed by chronic relapses of the disease triggered by infections, mechanical stress, and drugs (5). Although it is still unclear how these environmental factors drive the pathogenic T cell cascade, it has been suggested that innate immune pathways may provide the ...
... onset of the lesions is commonly followed by chronic relapses of the disease triggered by infections, mechanical stress, and drugs (5). Although it is still unclear how these environmental factors drive the pathogenic T cell cascade, it has been suggested that innate immune pathways may provide the ...
T cell
![](https://commons.wikimedia.org/wiki/Special:FilePath/Healthy_Human_T_Cell.jpg?width=300)
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.