Antibody Repertoire and Gene Expression Profile
... cells was more restricted, because 45.9% did not exhibit nontemplated (N) nucleotides in their VH-D and D-JH junctions compared with splenic B-1a (23.1%) and peritoneal B-1b cells (11.5%) (Table I). A similar increase of CDR3 diversity was observed in normal mice: 45.8% of IgH chains from peritoneal ...
... cells was more restricted, because 45.9% did not exhibit nontemplated (N) nucleotides in their VH-D and D-JH junctions compared with splenic B-1a (23.1%) and peritoneal B-1b cells (11.5%) (Table I). A similar increase of CDR3 diversity was observed in normal mice: 45.8% of IgH chains from peritoneal ...
Anabolic androgenic steroids effects on the immune system: a review
... abuse have been described, their effect on the immune system has not been clearly elucidated. The literature generally indicates that supraphysiologic doses of AAS with an intact steroid nucleus are immunosuppressive, that is they reduce immune cell number and function. While those with alterations ...
... abuse have been described, their effect on the immune system has not been clearly elucidated. The literature generally indicates that supraphysiologic doses of AAS with an intact steroid nucleus are immunosuppressive, that is they reduce immune cell number and function. While those with alterations ...
Modulation of cellular innate immune responses by lactobacilli
... Many PRRs are part of a major family known as toll-like receptors (TLRs) present in multicellular organisms [3]. They are predominantly transmembrane proteins found on professional immune cells such as macrophages. These proteins have an extracellular portion able to bind certain invariant structure ...
... Many PRRs are part of a major family known as toll-like receptors (TLRs) present in multicellular organisms [3]. They are predominantly transmembrane proteins found on professional immune cells such as macrophages. These proteins have an extracellular portion able to bind certain invariant structure ...
Sex differences in resident immune cell phenotype
... by the mobilization and subsequent infiltration of leukocytes into tissues, together with excessive production of cytokines such as TNF␣ and IL6. The mechanisms that bestow protection from infection in females are assumed to be mediated by female sex hormones, in particular 17-estradiol, which can ...
... by the mobilization and subsequent infiltration of leukocytes into tissues, together with excessive production of cytokines such as TNF␣ and IL6. The mechanisms that bestow protection from infection in females are assumed to be mediated by female sex hormones, in particular 17-estradiol, which can ...
Homeostasis and function of T cells in healthy - UvA-DARE
... CD8+ T cells 4. We and others have shown that the presence of large numbers of these CD27ˉCD45RA+ and CD57+CD28ˉ CD8+ T cells, which are largely overlapping populations, is associated with latent cytomegalovirus (CMV) infection 5-8. Therefore CMV infection may contribute to immunosenescence. It is g ...
... CD8+ T cells 4. We and others have shown that the presence of large numbers of these CD27ˉCD45RA+ and CD57+CD28ˉ CD8+ T cells, which are largely overlapping populations, is associated with latent cytomegalovirus (CMV) infection 5-8. Therefore CMV infection may contribute to immunosenescence. It is g ...
Analysis of immune deviation elicited by antigens injected
... in 1991 that immune privilege is extended to allogeneic tumor cells injected into the vitreous cavity (VC).10 Because an important goal of our research is to transplant retinal tissues into the subretinal space, our interests were focused on immune reactions after inoculation of antigens into the su ...
... in 1991 that immune privilege is extended to allogeneic tumor cells injected into the vitreous cavity (VC).10 Because an important goal of our research is to transplant retinal tissues into the subretinal space, our interests were focused on immune reactions after inoculation of antigens into the su ...
Characterization of CD56 CD16 natural killer (NK) cells: A highly
... atural killer (NK) cells, which account for up to 15% of peripheral blood lymphocytes, are well known as important effectors of the innate immune system (1, 2). In addition, NK cells are an important source of cytokines that regulate hematopoiesis and link the innate to the adaptive immune response ...
... atural killer (NK) cells, which account for up to 15% of peripheral blood lymphocytes, are well known as important effectors of the innate immune system (1, 2). In addition, NK cells are an important source of cytokines that regulate hematopoiesis and link the innate to the adaptive immune response ...
ABSTRACT - Johns Hopkins University
... neutrophils (7). In dendritic cells (DCs), galectin-3 has been shown to influence the strength of antigen activation (8). Galectin-3, therefore, is a ubiquitous protein that is involved in every step of the immune response. Galectin-3 and its role in the PDA tumor microenvironment Several studies h ...
... neutrophils (7). In dendritic cells (DCs), galectin-3 has been shown to influence the strength of antigen activation (8). Galectin-3, therefore, is a ubiquitous protein that is involved in every step of the immune response. Galectin-3 and its role in the PDA tumor microenvironment Several studies h ...
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... patients with nontumorous diseases. In both the glioblastoma and the nontumor group the EGF production of cultured monocytes was not influenced by medication, especially not by dexamethasone therapy. In a recently published paper10 we could demonstrate that the long-term survival of monocytes derive ...
... patients with nontumorous diseases. In both the glioblastoma and the nontumor group the EGF production of cultured monocytes was not influenced by medication, especially not by dexamethasone therapy. In a recently published paper10 we could demonstrate that the long-term survival of monocytes derive ...
Disease
... Key concepts about immunity-I 1. The immune system has evolved to protect us from the invasion of pathogens. Meanwhile, microbes have evolved to survive in the host. 2. Innate and adaptive immune responses (for vertebrates) => An integrated system of host defense => Cells & molecules function coope ...
... Key concepts about immunity-I 1. The immune system has evolved to protect us from the invasion of pathogens. Meanwhile, microbes have evolved to survive in the host. 2. Innate and adaptive immune responses (for vertebrates) => An integrated system of host defense => Cells & molecules function coope ...
Disruption of Antigen-induced Inflammatory
... 1353.) Key words: CD40 • CD40L • airways inflammation • IL-5, IL-4 • TNFa ...
... 1353.) Key words: CD40 • CD40L • airways inflammation • IL-5, IL-4 • TNFa ...
and anti-inflammatory phenomena in the physiopathology of type 2
... lymphoid cells drive a bias towards a type 2 immune response, secreting cytokines such as interleukin-4 (IL-4), IL-5 and IL-13, which maintain AT macrophages in an anti-inflammatory, M2-like state. However, this picture is not so simplified. Indeed, IL-10 and IL-33 are also secreted; invariant natur ...
... lymphoid cells drive a bias towards a type 2 immune response, secreting cytokines such as interleukin-4 (IL-4), IL-5 and IL-13, which maintain AT macrophages in an anti-inflammatory, M2-like state. However, this picture is not so simplified. Indeed, IL-10 and IL-33 are also secreted; invariant natur ...
Growth Hormone Synthesized and Secreted by Human Thymocytes
... GH is mediated by IGF-I, we stimulated thymocytes with increasing doses of recombinant GH (Genentech, South San Francisco, CA), and a significant (P < 0.001) increase in medium IGF-I concentrations was observed (Fig. 10). Recombinant GH-stimulated [3H]thymidine incorporation into human thymocytes wa ...
... GH is mediated by IGF-I, we stimulated thymocytes with increasing doses of recombinant GH (Genentech, South San Francisco, CA), and a significant (P < 0.001) increase in medium IGF-I concentrations was observed (Fig. 10). Recombinant GH-stimulated [3H]thymidine incorporation into human thymocytes wa ...
T Cell Memory in the Context of Persistent Herpes Viral Infections
... cells; it was only half century later, in the mid-60s, that Jacques Miller suggested that there was not just one but two subsets of lymphocytes, a bone-marrow-dependent antibody-producing cells and a thymus-dependent helper cell that were called T cells [1,2]. Since then, many facets of T-cell funct ...
... cells; it was only half century later, in the mid-60s, that Jacques Miller suggested that there was not just one but two subsets of lymphocytes, a bone-marrow-dependent antibody-producing cells and a thymus-dependent helper cell that were called T cells [1,2]. Since then, many facets of T-cell funct ...
The Body`s Defenses
... • Increased local blood supply leads to the characteristic swelling, redness, and heat of inflammation. ...
... • Increased local blood supply leads to the characteristic swelling, redness, and heat of inflammation. ...
Program
... the genetic polymorphism greatly influence the quality of the immune response differing from one individual to another or from one mouse strain to another. Of note, heritability of premature death due to infection is higher than any death due to other causes. However, single nucleotide polymorphisms ...
... the genetic polymorphism greatly influence the quality of the immune response differing from one individual to another or from one mouse strain to another. Of note, heritability of premature death due to infection is higher than any death due to other causes. However, single nucleotide polymorphisms ...
Three cheers for the goblet cell: maintaining homeostasis in
... becomes compacted [27, 29, 36]. Both the small and large intestine are covered by mucus comprised mainly of Muc2, but the mucus covering the small intestine is unattached and in a single layer, whereas the colon maintains a two-layered mucous gel, with the inner layer providing a bacteria-free envi ...
... becomes compacted [27, 29, 36]. Both the small and large intestine are covered by mucus comprised mainly of Muc2, but the mucus covering the small intestine is unattached and in a single layer, whereas the colon maintains a two-layered mucous gel, with the inner layer providing a bacteria-free envi ...
The Schwann cell
... immunocompetent cells within the peripheral nervous system (PNS), which, in addition to their physiological roles, exhibit a broad spectrum of immune-related functions and might be involved in the local immune response in the PNS. ...
... immunocompetent cells within the peripheral nervous system (PNS), which, in addition to their physiological roles, exhibit a broad spectrum of immune-related functions and might be involved in the local immune response in the PNS. ...
Human T-cell leukemia virus type I (HTLV
... also been reported to inhibit TGF-β signaling by binding to Smad2, 3 and 4 or CBP/p300 [38,39]. Inhibition of TGF-β signaling enables HTLV-I-infected cells to escape TGF-β-mediated growth inhibition. ATL cells have been reported to show remarkable chromosomal abnormalities [40], which should be impl ...
... also been reported to inhibit TGF-β signaling by binding to Smad2, 3 and 4 or CBP/p300 [38,39]. Inhibition of TGF-β signaling enables HTLV-I-infected cells to escape TGF-β-mediated growth inhibition. ATL cells have been reported to show remarkable chromosomal abnormalities [40], which should be impl ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.