Alk1 controls arterial endothelial cell migration in
... number of endothelial cells in AA1 (shaded green) decreased slightly over this time period (Fig. 2B; trend not significant). In alk1-deficient embryos, AA1 also contracted along the left-right axis, but morphology was dynamic and variable: the paired vessels often developed asymmetrically, with one ...
... number of endothelial cells in AA1 (shaded green) decreased slightly over this time period (Fig. 2B; trend not significant). In alk1-deficient embryos, AA1 also contracted along the left-right axis, but morphology was dynamic and variable: the paired vessels often developed asymmetrically, with one ...
Cord blood monocyte-derived inflammatory
... in natural regulatory T cell (nTreg) number and function (7) in cord blood, as well as persistence of IL-4/T helper 2 (TH2)–type immune responses in the first year of life (8). Whether these findings are related to each other and to the IL-4/TH2–dependent process of allergen-specific IgE production ...
... in natural regulatory T cell (nTreg) number and function (7) in cord blood, as well as persistence of IL-4/T helper 2 (TH2)–type immune responses in the first year of life (8). Whether these findings are related to each other and to the IL-4/TH2–dependent process of allergen-specific IgE production ...
Exploring S-Shaped Growth
... classic examples of S-shaped behavior. The cellular growth of a plant and physical and intellectual development in small children, along with the body's immune response, are all subject to S-shaped growth. This paper will begin by exploring population dynamics, taking as an example Jean's population ...
... classic examples of S-shaped behavior. The cellular growth of a plant and physical and intellectual development in small children, along with the body's immune response, are all subject to S-shaped growth. This paper will begin by exploring population dynamics, taking as an example Jean's population ...
INTERPLAY BETWEEN HELICOBACTER PYLORI AND THE
... mechanisms: clonal deletion in the thymus and anergy in the periphery (7, 8). However, at present there is a strong evidence that these two mechanisms responsible for self-tolerance are additionally supported by the action of T suppressor (Ts) cells also called T regulatory (Treg) cells. At present ...
... mechanisms: clonal deletion in the thymus and anergy in the periphery (7, 8). However, at present there is a strong evidence that these two mechanisms responsible for self-tolerance are additionally supported by the action of T suppressor (Ts) cells also called T regulatory (Treg) cells. At present ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren
... Malaria antigen-induced polarization of T cells into effectors Th1 and/or Th2 cells and their subsequent release of cytokines is known to affect antibody production. This thesis includes studies on early innate responses to the parasite, with a focus on γδT cells, and acquired specific responses in ...
... Malaria antigen-induced polarization of T cells into effectors Th1 and/or Th2 cells and their subsequent release of cytokines is known to affect antibody production. This thesis includes studies on early innate responses to the parasite, with a focus on γδT cells, and acquired specific responses in ...
Chapter 12 ppt
... Our cells in another person’s body can trigger an immune response because they are foreign Restricts donors for transplants ...
... Our cells in another person’s body can trigger an immune response because they are foreign Restricts donors for transplants ...
Danger Theory: The Link between AIS and IDS?
... [30]. These molecules are recognised by APCs, critical cells in the initiation of an immune response, which become activated leading to protective immune interactions. Overall there are two classes of danger signal; those which are generated endogenously i.e. by the body itself, and exogenous signal ...
... [30]. These molecules are recognised by APCs, critical cells in the initiation of an immune response, which become activated leading to protective immune interactions. Overall there are two classes of danger signal; those which are generated endogenously i.e. by the body itself, and exogenous signal ...
Mutations in the tyrosine kinase domain of FLT3 define a new
... studies in patients with AML, it is unknown whether similar mechanisms of resistance exist for these compounds. Previously, we and others have demonstrated that the small molecule PTK inhibitor SU5614 is a selective inhibitor of FLT3 that induces growth arrest and apoptosis in FLT3-transformed cells ...
... studies in patients with AML, it is unknown whether similar mechanisms of resistance exist for these compounds. Previously, we and others have demonstrated that the small molecule PTK inhibitor SU5614 is a selective inhibitor of FLT3 that induces growth arrest and apoptosis in FLT3-transformed cells ...
CD4 T cells promote tissue inflammation via CD40 signaling without
... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
thesis
... regulating their cytotoxic function. In our studies of apoptosis we found that placental exosomes carry the proapoptotic ligands FasL and TRAIL in their active form as a hexameric complex of two homotrimeric molecules, required for triggering of the apoptotic signaling pathways. This finding was su ...
... regulating their cytotoxic function. In our studies of apoptosis we found that placental exosomes carry the proapoptotic ligands FasL and TRAIL in their active form as a hexameric complex of two homotrimeric molecules, required for triggering of the apoptotic signaling pathways. This finding was su ...
Linköping University Post Print In vitro priming recapitulates in vivo HIV-1
... arise naturally in vivo in HIV-infected individuals and demonstrates that AT-2 HIV-1 is a excellent source of antigens that may have the capacity in a vaccine setting, not only to restimulate existing memory responses but also prime for new T cell responses or re-establish responses lost very early ...
... arise naturally in vivo in HIV-infected individuals and demonstrates that AT-2 HIV-1 is a excellent source of antigens that may have the capacity in a vaccine setting, not only to restimulate existing memory responses but also prime for new T cell responses or re-establish responses lost very early ...
Jenny Walldén Studies of immunological risk factors in type 1 diabetes
... If the innate immune system is bypassed or overwhelmed by the pathogens, the adaptive immune response is required. The adaptive immune response provides a specific response, with an enormous ability to recognize different antigens, and the responsiveness is improved on repeated exposure, providing i ...
... If the innate immune system is bypassed or overwhelmed by the pathogens, the adaptive immune response is required. The adaptive immune response provides a specific response, with an enormous ability to recognize different antigens, and the responsiveness is improved on repeated exposure, providing i ...
Anatomical variants in the sino-nasal region : a pictorial review
... The posterior ethmoid has a variable relationship with the sphenoid sinus and is intimately related to the optic nerve. The surgeon cannot assume that the sphenoid sinus is directly posterior to the posterior ethmoid sinus. In some cases, the posterior ethmoid cell may extend laterally or superiorly ...
... The posterior ethmoid has a variable relationship with the sphenoid sinus and is intimately related to the optic nerve. The surgeon cannot assume that the sphenoid sinus is directly posterior to the posterior ethmoid sinus. In some cases, the posterior ethmoid cell may extend laterally or superiorly ...
Female sex hormones regulate the Th17 immune response to sperm
... an influx of neutrophils to the mucosa of the FRT (Rozeboom et al., 1999; Gorgens et al., 2005; Schuberth et al., 2008). In humans, semen was shown to induce a local recruitment of leukocytes, detected only after coitus without a condom (Sharkey et al., 2012a). Moreover, the presence of antisperm ant ...
... an influx of neutrophils to the mucosa of the FRT (Rozeboom et al., 1999; Gorgens et al., 2005; Schuberth et al., 2008). In humans, semen was shown to induce a local recruitment of leukocytes, detected only after coitus without a condom (Sharkey et al., 2012a). Moreover, the presence of antisperm ant ...
The Effects of Glutathione Depletion on the Immune System In the
... The adaptive immune response involves cells that are able to recognize and respond to pathogens and remember them in order to mount a swifter defense in case of future infection. As an important component of the adaptive immune system, glutathione is essential in the process of antigen-presenting ce ...
... The adaptive immune response involves cells that are able to recognize and respond to pathogens and remember them in order to mount a swifter defense in case of future infection. As an important component of the adaptive immune system, glutathione is essential in the process of antigen-presenting ce ...
Tesi unita 08 - Padua@Research
... survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In the present study, we investigated the role of a T. pallidum protein, called antigen 4D or TpF1 in the pathogenesis of syphilis. TpF1 is an oligomeric protein of 190 kDa localised in ...
... survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In the present study, we investigated the role of a T. pallidum protein, called antigen 4D or TpF1 in the pathogenesis of syphilis. TpF1 is an oligomeric protein of 190 kDa localised in ...
Capacity of Epstein–Barr virus to infect monocytes and inhibit their
... (Strnad et al., 1982), which is specific for the EBV envelope glycoprotein gp42 (Li et al., 1995), E1D1 (Oba & Hutt-Fletcher, 1988) [reacting with the EBV gH/gL complex (Li et al., 1995)], 72A1 (Hoffman et al., 1980), specific for the EBV gp350/220 glycoprotein, and CL59 (Molesworth et al., 2000), s ...
... (Strnad et al., 1982), which is specific for the EBV envelope glycoprotein gp42 (Li et al., 1995), E1D1 (Oba & Hutt-Fletcher, 1988) [reacting with the EBV gH/gL complex (Li et al., 1995)], 72A1 (Hoffman et al., 1980), specific for the EBV gp350/220 glycoprotein, and CL59 (Molesworth et al., 2000), s ...
Spontaneous generation and survival of blood
... CD11c⫺ CD123hi DCs have the ability to produce substantial amounts of interferon-␣ on stimulation with pathogens.9 The ability to produce DC-like cells from monocytes cultured in GM-CSF plus IL-4 (and other mixtures) in vitro has introduced yet another potential DC precursor population into our cons ...
... CD11c⫺ CD123hi DCs have the ability to produce substantial amounts of interferon-␣ on stimulation with pathogens.9 The ability to produce DC-like cells from monocytes cultured in GM-CSF plus IL-4 (and other mixtures) in vitro has introduced yet another potential DC precursor population into our cons ...
Licentiate thesis from the Department of Immunology
... gene-deficient mice (Caruso et al., 1999), have demonstrated that the CD4+ T cell subset is required for control of infection. The primary effector function of CD4+ T cells is the production of cytokines; first and foremost interferon-γ (IFN-γ), which is crucial for induction of microbicidal activi ...
... gene-deficient mice (Caruso et al., 1999), have demonstrated that the CD4+ T cell subset is required for control of infection. The primary effector function of CD4+ T cells is the production of cytokines; first and foremost interferon-γ (IFN-γ), which is crucial for induction of microbicidal activi ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.