Characterization of mesenchymal stem cells under the stimulation of
... system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to repair damaged and inflamed tissues and regulate immune re ...
... system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to repair damaged and inflamed tissues and regulate immune re ...
LESSON 6 Your Immune System
... immediately. These B cells and T cells wait and are ready to react if the same kind of pathogen invades the body again. These cells are called memory B cells and memory T cells. These cells help your immune system stop diseases that have attacked before. ...
... immediately. These B cells and T cells wait and are ready to react if the same kind of pathogen invades the body again. These cells are called memory B cells and memory T cells. These cells help your immune system stop diseases that have attacked before. ...
Mycobacterium bovis Subsets following Infection with Virulent T Cell
... in patients with active TB (7–9). Mice deficient in gd T cells exhibit significantly larger and less-organized granulomas following infection with Mycobacterium (10, 11), suggesting a role for granuloma formation. In humans and rodent species, gd T cells represent ∼5% of circulating lymphocytes (12) ...
... in patients with active TB (7–9). Mice deficient in gd T cells exhibit significantly larger and less-organized granulomas following infection with Mycobacterium (10, 11), suggesting a role for granuloma formation. In humans and rodent species, gd T cells represent ∼5% of circulating lymphocytes (12) ...
BCR-ABL Protein Expression in Peripheral Blood
... were performed by the Division of Laboratory Medicine. CML and ALL were diagnosed according to standard criteria. Normal WBC were donated by volunteers from our laboratory. Cell lines. The K562I9 (positive control), HL-60,2"and KG-12' cell lines (negative controls) were grown inRPM1medium containing ...
... were performed by the Division of Laboratory Medicine. CML and ALL were diagnosed according to standard criteria. Normal WBC were donated by volunteers from our laboratory. Cell lines. The K562I9 (positive control), HL-60,2"and KG-12' cell lines (negative controls) were grown inRPM1medium containing ...
B cell sub-types following acute malaria and associations with
... not appear to readily produce antibodies [13, 20, 21]. This functional difference has led to the hypothesis that atypical MBCs may be ‘exhausted’ and may interfere with development of effective immunity [13, 21]. On the other hand, higher circulating proportions of atypical MBCs and immunity to mala ...
... not appear to readily produce antibodies [13, 20, 21]. This functional difference has led to the hypothesis that atypical MBCs may be ‘exhausted’ and may interfere with development of effective immunity [13, 21]. On the other hand, higher circulating proportions of atypical MBCs and immunity to mala ...
Lecture 15
... after few days & decline after a few weeks Subsequent exposure to same antigen causes secondary response Antibody production is much more rapid & sustained ...
... after few days & decline after a few weeks Subsequent exposure to same antigen causes secondary response Antibody production is much more rapid & sustained ...
The Cellular Basis of the Impaired Autologous Mixed Lymphocyte
... an increased number of monocytes. Although mononuclear cell preparations from patients with SLE have increased numbers of monocytes which may decrease mitogen-induced T-cell proliferation (8), in our studies lymphocyte preparations were depleted of monocytes. Antilymphocyte antibodies or immune comp ...
... an increased number of monocytes. Although mononuclear cell preparations from patients with SLE have increased numbers of monocytes which may decrease mitogen-induced T-cell proliferation (8), in our studies lymphocyte preparations were depleted of monocytes. Antilymphocyte antibodies or immune comp ...
Drosophila as a model for the two myeloid blood cell systems in
... Overview of Drosophila hematopoietic waves and the ontogeny of blood cell lineages Many elements of vertebrate hematopoiesis are evident in Drosophila. Drosophila blood cells, which are collectively called hemocytes, comprise undifferentiated prohemocyte progenitors and at least three differentiated ...
... Overview of Drosophila hematopoietic waves and the ontogeny of blood cell lineages Many elements of vertebrate hematopoiesis are evident in Drosophila. Drosophila blood cells, which are collectively called hemocytes, comprise undifferentiated prohemocyte progenitors and at least three differentiated ...
Document
... this patient (91 contrast-enhancing lesions; Fig. 3). Such MRI activwith a negative value of –2 or less, and was stable between –1 and +1 ity was very atypical for this patient, who had been monitored (Table 1). As T cells specific for APL were induced in all patients (Fig. monthly for more than 9 y ...
... this patient (91 contrast-enhancing lesions; Fig. 3). Such MRI activwith a negative value of –2 or less, and was stable between –1 and +1 ity was very atypical for this patient, who had been monitored (Table 1). As T cells specific for APL were induced in all patients (Fig. monthly for more than 9 y ...
Sex steroid hormones
... neointimal hyperplasia, 4) determine the mechanisms and target cells for ARmediated regulation of B cell homeostasis, and 5) determine the mechanisms and target cells for AR-mediated regulation of T cell homeostasis in mice. Concluding the results in this thesis, we found that testosterone exerts it ...
... neointimal hyperplasia, 4) determine the mechanisms and target cells for ARmediated regulation of B cell homeostasis, and 5) determine the mechanisms and target cells for AR-mediated regulation of T cell homeostasis in mice. Concluding the results in this thesis, we found that testosterone exerts it ...
Prevention of collagen-induced arthritis by gene delivery of
... down-regulating the effector function of Th1-type cells. A link between TNF-␣ and Th1-type responses was also observed in TNF-␣ knock-out mice, which were shown to be incapable of mounting IgG2a antibody responses when challenged with antigens.19 However, it is not yet clear whether down-regulation ...
... down-regulating the effector function of Th1-type cells. A link between TNF-␣ and Th1-type responses was also observed in TNF-␣ knock-out mice, which were shown to be incapable of mounting IgG2a antibody responses when challenged with antigens.19 However, it is not yet clear whether down-regulation ...
Natural regulatory T cells in infectious disease - Direct-MS
... response to them often results in tissue damage. This tissue damage might be more intense were it not for many regulatory mechanisms that contain the ‘zeal’ of both innate and adaptive effector responses. The once-disfavored idea that suppressor cells with antigen specificity form part of the regula ...
... response to them often results in tissue damage. This tissue damage might be more intense were it not for many regulatory mechanisms that contain the ‘zeal’ of both innate and adaptive effector responses. The once-disfavored idea that suppressor cells with antigen specificity form part of the regula ...
An Interpretative Introduction to the Immune System
... The behaviour of lymphocytes is strongly influenced by affinities: a lymphocyte will only be activated (this can be termed a “detection event”) when the number of receptors bound exceeds some threshold6. Thus, a lymphocyte will only be activated by pathogens if its receptors have sufficiently high a ...
... The behaviour of lymphocytes is strongly influenced by affinities: a lymphocyte will only be activated (this can be termed a “detection event”) when the number of receptors bound exceeds some threshold6. Thus, a lymphocyte will only be activated by pathogens if its receptors have sufficiently high a ...
Caspase-8 regulates the expression of pro- and anti
... pro-inflammatory cytokines. TLR3, which recognizes dsRNA, signals only via the adaptor TRIF (TIR-domaincontaining adapter-inducing interferon-b), which ultimately leads to activation of the transcription factor interferon regulatory factor 3 (IRF3) and NF-kB. TLR4 can signal via both the MyD88- and ...
... pro-inflammatory cytokines. TLR3, which recognizes dsRNA, signals only via the adaptor TRIF (TIR-domaincontaining adapter-inducing interferon-b), which ultimately leads to activation of the transcription factor interferon regulatory factor 3 (IRF3) and NF-kB. TLR4 can signal via both the MyD88- and ...
Immunomodulatory Roles of Lymphatic Vessels
... A puzzling element in lymphatic-mediated tumor dissemination is that lymph nodes are normally inhospitable sites for tumor cell growth. This was shown, for example, by implanting B16 melanoma cells into na€ve lymph nodes of syngeneic mice, whereupon the tumor cells were readily rejected by cytotoxi ...
... A puzzling element in lymphatic-mediated tumor dissemination is that lymph nodes are normally inhospitable sites for tumor cell growth. This was shown, for example, by implanting B16 melanoma cells into na€ve lymph nodes of syngeneic mice, whereupon the tumor cells were readily rejected by cytotoxi ...
The Immune System - Wiley-VCH
... (Section 1.4). We then introduce the major classes of molecule involved in functions such as the detection of infection, the recruitment of cells to infected sites, communication between cells and tissues, signalling within cells, and, usually, elimination of the infectious agent (Section 1.5). The ...
... (Section 1.4). We then introduce the major classes of molecule involved in functions such as the detection of infection, the recruitment of cells to infected sites, communication between cells and tissues, signalling within cells, and, usually, elimination of the infectious agent (Section 1.5). The ...
Butyrate and Mucosal Inflammation: New Scientific
... Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are bacterial metabolites generated via the fermentation of dietary fibers. Luminal SCFAs are recognized as a preferred energy substrate for the colonic epithelium. As early as the 1980s, SCFAs were observed to offer therape ...
... Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are bacterial metabolites generated via the fermentation of dietary fibers. Luminal SCFAs are recognized as a preferred energy substrate for the colonic epithelium. As early as the 1980s, SCFAs were observed to offer therape ...
in MUC1-Transgenic Mice Cells CD8 T Cells by Dendritic/Tumor
... infections, are processed and presented through the MHC class I-restricted pathway to CTL (2). In contrast, exogenous proteins from the extracellular environment are processed and displayed in association with class II molecules and recognized by CD4⫹ T cells (3). Certain exogenous Ags can also be p ...
... infections, are processed and presented through the MHC class I-restricted pathway to CTL (2). In contrast, exogenous proteins from the extracellular environment are processed and displayed in association with class II molecules and recognized by CD4⫹ T cells (3). Certain exogenous Ags can also be p ...
Thymosin α1 accelerates restoration of T cell
... is related to the restoration of CD4q T cells. Thymosin a 1 was reported to have significant potentiating effects on thymocyte maturation as shown in Figs. 2 and 3 and immunologic functions which include promotion of IFN-g , interleukin-2 and interleukin-2 receptor production, enhanced proliferation ...
... is related to the restoration of CD4q T cells. Thymosin a 1 was reported to have significant potentiating effects on thymocyte maturation as shown in Figs. 2 and 3 and immunologic functions which include promotion of IFN-g , interleukin-2 and interleukin-2 receptor production, enhanced proliferation ...
Peritoneal repair and post-surgical adhesion formation
... in rats (Ellis et al., 1965). On day 3, the entire defect was covered by a sheet of cells. Trypan Blue was not detected by microscopy in any of the cells covering the wound. By day 5, the new surface mesothelium achieved continuity with the surrounding edges of the previously undamaged mesothelium. ...
... in rats (Ellis et al., 1965). On day 3, the entire defect was covered by a sheet of cells. Trypan Blue was not detected by microscopy in any of the cells covering the wound. By day 5, the new surface mesothelium achieved continuity with the surrounding edges of the previously undamaged mesothelium. ...
Anatomy of paranasal sinuses
... The post wall separates the frontal sinus from the anterior cranial fossa, is much thinner. Floor is formed by the upper part of the orbits. Both frontal sinuses have their ostia at the most dependant portion of the cavity(posteriomedially) So these sinuses are rarely involved with infectious diseas ...
... The post wall separates the frontal sinus from the anterior cranial fossa, is much thinner. Floor is formed by the upper part of the orbits. Both frontal sinuses have their ostia at the most dependant portion of the cavity(posteriomedially) So these sinuses are rarely involved with infectious diseas ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.