Gross Morphology of the Endocrine Glands
... In the hypophyseal portal system the arteries that supply the adenohypophysis (anterior lobe) will receive the blood supply from the Superior hypophyseal arteries coming from the internal carotid artery, we call them superior because they go superior to the pituitary (they actually go to the hypotha ...
... In the hypophyseal portal system the arteries that supply the adenohypophysis (anterior lobe) will receive the blood supply from the Superior hypophyseal arteries coming from the internal carotid artery, we call them superior because they go superior to the pituitary (they actually go to the hypotha ...
Peroxisome proliferator–activated receptor (PPAR){alpha
... rheumatoid arthritis patients are reported to have diminished testosterone levels compared with age-matched controls (23, 24), and androgen treatment relieves clinical symptoms in hypogonadal patients with rheumatoid arthritis (25). Recent studies suggest that androgens act directly on CD4+ cells to ...
... rheumatoid arthritis patients are reported to have diminished testosterone levels compared with age-matched controls (23, 24), and androgen treatment relieves clinical symptoms in hypogonadal patients with rheumatoid arthritis (25). Recent studies suggest that androgens act directly on CD4+ cells to ...
Delayed acquisition of Plasmodium falciparum antigen
... Liverpool School of Tropical Medicine, Liverpool, UK Full list of author information is available at the end of the article ...
... Liverpool School of Tropical Medicine, Liverpool, UK Full list of author information is available at the end of the article ...
Mast Cell Activation and Migration to Lymph Nodes during
... primary antibodies; goat anti–mouse MIP-1a or MIP-1b (R&D Systems), and affinity-purified polyclonal rabbit anti–mouse mast cell protease-5 (mMCP-5) (40), for 1 h at room temperature, followed by HRP-conjugated donkey anti–goat IgG (Serotec, Australian Laboratory Services, Sydney, Australia) for 1 h ...
... primary antibodies; goat anti–mouse MIP-1a or MIP-1b (R&D Systems), and affinity-purified polyclonal rabbit anti–mouse mast cell protease-5 (mMCP-5) (40), for 1 h at room temperature, followed by HRP-conjugated donkey anti–goat IgG (Serotec, Australian Laboratory Services, Sydney, Australia) for 1 h ...
Negative Regulation of Toll-Like Receptor Signaling by
... binding domain of p50 (20) gave rise to a DNA binding–defective mutant, p50Y57A,G60D, that was unable to bind to DNA (Fig. 3C) but retained the ability to interact with p65 and Bcl-3 (fig. S5). Ubiquitination of p50Y57A,G60D was dramatically reduced compared with that of WT p50 (Fig. 3D). This was a ...
... binding domain of p50 (20) gave rise to a DNA binding–defective mutant, p50Y57A,G60D, that was unable to bind to DNA (Fig. 3C) but retained the ability to interact with p65 and Bcl-3 (fig. S5). Ubiquitination of p50Y57A,G60D was dramatically reduced compared with that of WT p50 (Fig. 3D). This was a ...
Cytotoxic T-Lymphocyte–Defined Human Minor
... T-cell lines exhibiting recipient-specific cytolytic activity were cloned by limiting dilution in 96-well round-bottom plates. Each well received 200 µL of a cell suspension containing 5 3 104/mL g-irradiated (65 Gy) recipient-derived EBV-LCL as antigen-presenting cells (APC), 2.5 3 105/mL g-irradia ...
... T-cell lines exhibiting recipient-specific cytolytic activity were cloned by limiting dilution in 96-well round-bottom plates. Each well received 200 µL of a cell suspension containing 5 3 104/mL g-irradiated (65 Gy) recipient-derived EBV-LCL as antigen-presenting cells (APC), 2.5 3 105/mL g-irradia ...
Ontogeny of Erythropoiesis in the Mammalian Embryo
... cells are derived from more than one source during embryogenesis. This chapter will discuss the current understanding of the ontogeny of the primitive and definitive erythroid lineages in the mammalian embryo. Embryonic erythropoiesis is best understood in the context of adult erythropoiesis. In the ...
... cells are derived from more than one source during embryogenesis. This chapter will discuss the current understanding of the ontogeny of the primitive and definitive erythroid lineages in the mammalian embryo. Embryonic erythropoiesis is best understood in the context of adult erythropoiesis. In the ...
Effects of intracellular and extracellular heat shock proteins on anti
... instructed and regulated by antigen-presenting cells (APCs). Dendritic cells (DC) are unique APCs because they are the only ones that are able to induce primary immune responses, thus permitting the establishment of immunological memory (Banchereau et al. 1998). DC progenitors in the bone marrow giv ...
... instructed and regulated by antigen-presenting cells (APCs). Dendritic cells (DC) are unique APCs because they are the only ones that are able to induce primary immune responses, thus permitting the establishment of immunological memory (Banchereau et al. 1998). DC progenitors in the bone marrow giv ...
Control of Herpes Simplex Virus Type 1 Latency in Human
... The major histocompatibility complex (MHC) is a large cluster of genes, encoding membrane glycoproteins that bind pathogen-derived peptides and display them on the cell surface to T cells. In humans, these genes are encoded on chromosome 6 and are called human leukocyte antigen (HLA). To defend the ...
... The major histocompatibility complex (MHC) is a large cluster of genes, encoding membrane glycoproteins that bind pathogen-derived peptides and display them on the cell surface to T cells. In humans, these genes are encoded on chromosome 6 and are called human leukocyte antigen (HLA). To defend the ...
Supplementary data Blood samples and laboratory assays This
... very light multimer bands. (B) The image was taken after 6-minute-exposure. VWF multimer patterns of P3 and P3B were normal while those of P1 and P2 were still absent. (C) Schematic diagram of VWF. Arrows indicate the locations of four mutations in the D1 domain on the whole pro-VWF. Figure S2: Rest ...
... very light multimer bands. (B) The image was taken after 6-minute-exposure. VWF multimer patterns of P3 and P3B were normal while those of P1 and P2 were still absent. (C) Schematic diagram of VWF. Arrows indicate the locations of four mutations in the D1 domain on the whole pro-VWF. Figure S2: Rest ...
Characterisation of the immune response after - diss.fu
... apoptosis. Nevertheless, a significant number of cells persists and become memory cells after antigen elimination. A hallmark of protective immunity is determined by the clonally selection of antigenspecific B cells that generate neutralizing antibodies (Pulendran and Ahmed 2006). B lymphocytes, mar ...
... apoptosis. Nevertheless, a significant number of cells persists and become memory cells after antigen elimination. A hallmark of protective immunity is determined by the clonally selection of antigenspecific B cells that generate neutralizing antibodies (Pulendran and Ahmed 2006). B lymphocytes, mar ...
An essential role for decorin in bladder cancer invasiveness
... present at higher frequency in MB49, whereas regulatory CD4þ/ Foxp3þ cells were more abundant in MB49‐I, leading to a very high ratio of cytotoxic to regulatory T lymphocytes in MB49 but not in MB49‐I tumours (Fig 2A). In contrast, we did not observe any difference in NK cells or in gd T lymphocytes ...
... present at higher frequency in MB49, whereas regulatory CD4þ/ Foxp3þ cells were more abundant in MB49‐I, leading to a very high ratio of cytotoxic to regulatory T lymphocytes in MB49 but not in MB49‐I tumours (Fig 2A). In contrast, we did not observe any difference in NK cells or in gd T lymphocytes ...
Roles of dopamine receptor subtypes in
... lymphocytes is shown a possibility underlying mechanisms of dopamineinduced cell proliferation. Dopamine receptors have been isolated, characterized and subdivided into two families, D1-like and D2-like receptors, on the basis of their biochemical and pharmacological properties (Vallone et al. 2000) ...
... lymphocytes is shown a possibility underlying mechanisms of dopamineinduced cell proliferation. Dopamine receptors have been isolated, characterized and subdivided into two families, D1-like and D2-like receptors, on the basis of their biochemical and pharmacological properties (Vallone et al. 2000) ...
Simplify Immunophenotyping Using Kits and
... lymphocytes that mediate antigen‐ specific immune responses ...
... lymphocytes that mediate antigen‐ specific immune responses ...
Two types of BCR interactions are positively
... of CLL2-4. Signals propagated through the BCR have been shown to increase leukemic cell survival in vitro5,6 and there is growing evidence that such signals are continuously delivered to the leukemic cells in vivo. This evidence particularly refers to data obtained from gene expression profiling (GE ...
... of CLL2-4. Signals propagated through the BCR have been shown to increase leukemic cell survival in vitro5,6 and there is growing evidence that such signals are continuously delivered to the leukemic cells in vivo. This evidence particularly refers to data obtained from gene expression profiling (GE ...
Identification of a T cell surface molecule using a monoclonal
... T cell activation is a crucial step for initiating adaptive immune responses.1-3 Initiation of T cell activation requires extracellular ligation of the T cell receptor (TCR) with antigen presented by antigenpresenting cells, and the subsequent formation of dynamic signaling complexes.2,4-6 On T cell ...
... T cell activation is a crucial step for initiating adaptive immune responses.1-3 Initiation of T cell activation requires extracellular ligation of the T cell receptor (TCR) with antigen presented by antigenpresenting cells, and the subsequent formation of dynamic signaling complexes.2,4-6 On T cell ...
Matings? Immunological Barrier to Interspecies During Pregnancy in
... has provided a rich environment for theory and experimentation at the interfaces between mother and fetus, and between immunology and reproduction. Three recent studies in mice have provided evidence that maternal CTL responses to paternal MHC class I Ags are disrupted by pregnancy (2–5). In the cas ...
... has provided a rich environment for theory and experimentation at the interfaces between mother and fetus, and between immunology and reproduction. Three recent studies in mice have provided evidence that maternal CTL responses to paternal MHC class I Ags are disrupted by pregnancy (2–5). In the cas ...
- Wiley Online Library
... subcutaneous TME's compared to controls (A and B, respectively). The difference was more pronounced in subcutaneous tumors than intratibial tumors (A and B). Macrophages in spleens of tumor bearing mice were increased in comparison to controls (C). This increase was more pronounced in subcutaneous t ...
... subcutaneous TME's compared to controls (A and B, respectively). The difference was more pronounced in subcutaneous tumors than intratibial tumors (A and B). Macrophages in spleens of tumor bearing mice were increased in comparison to controls (C). This increase was more pronounced in subcutaneous t ...
Modulation of Allospecific CTL Responses During Pregnancy in
... has provided a rich environment for theory and experimentation at the interfaces between mother and fetus, and between immunology and reproduction. Three recent studies in mice have provided evidence that maternal CTL responses to paternal MHC class I Ags are disrupted by pregnancy (2–5). In the cas ...
... has provided a rich environment for theory and experimentation at the interfaces between mother and fetus, and between immunology and reproduction. Three recent studies in mice have provided evidence that maternal CTL responses to paternal MHC class I Ags are disrupted by pregnancy (2–5). In the cas ...
Active Infection and RIG-I Signaling Influenza A Virus Infection Is
... macrophages, dendritic cells, and mast cells. However, the role of mast cells during respiratory infections is an understudied area (7). Mast cells are tissue-sentinel cells of hematopoietic origins found in most vasculature tissue, but they are enriched in tissues that are at environmental interfac ...
... macrophages, dendritic cells, and mast cells. However, the role of mast cells during respiratory infections is an understudied area (7). Mast cells are tissue-sentinel cells of hematopoietic origins found in most vasculature tissue, but they are enriched in tissues that are at environmental interfac ...
Competition Causes Interclonal Salmonella Attenuated Cells during
... These data suggested that the Salmonella burden in the spleen could be directly responsible for the specific activation of a large number of CD4 T cells to produce IFN-␥ ex vivo. However, even if this were true, it still would not account for the vast majority of the expanded CD4⫹CD11ahigh populatio ...
... These data suggested that the Salmonella burden in the spleen could be directly responsible for the specific activation of a large number of CD4 T cells to produce IFN-␥ ex vivo. However, even if this were true, it still would not account for the vast majority of the expanded CD4⫹CD11ahigh populatio ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.