MINI-SERIES ‘‘T-CELL CO-STIMULATORY MOLECULES’’ Edited by M. Belvisi and K.F. Rabe
... natural CD25+ Tr into these mice [55]. In addition, forced expression of the FoxP3 gene, which encodes a transcription repressor, converts naive murine T-cells into Tr that phenotypically and functionally resemble natural CD25+ Tr. Although the absence of FOXP3 expression in patients with IPEX syndr ...
... natural CD25+ Tr into these mice [55]. In addition, forced expression of the FoxP3 gene, which encodes a transcription repressor, converts naive murine T-cells into Tr that phenotypically and functionally resemble natural CD25+ Tr. Although the absence of FOXP3 expression in patients with IPEX syndr ...
Chapter 20, Lymphatic System
... Surrounded by a fibrous capsule, it has trabeculae that extend inward and contains lymphocytes, macrophages, and huge numbers of erythrocytes Two distinct areas of the spleen are: White pulp – area containing mostly lymphocytes suspended on reticular fibers and involved in immune functions R ...
... Surrounded by a fibrous capsule, it has trabeculae that extend inward and contains lymphocytes, macrophages, and huge numbers of erythrocytes Two distinct areas of the spleen are: White pulp – area containing mostly lymphocytes suspended on reticular fibers and involved in immune functions R ...
The plasmacytoid dendritic cell: at the cross-roads in asthma
... pDCs and their known pattern recognition receptor systems pDCs are a relatively rare type of DC that reside predominantly in lymphoid tissues. Both human and murine pDCs express the surface antigen CD45RA and lack the myeloid marker CD11b, although subtle differences exist as human, but not murine, ...
... pDCs and their known pattern recognition receptor systems pDCs are a relatively rare type of DC that reside predominantly in lymphoid tissues. Both human and murine pDCs express the surface antigen CD45RA and lack the myeloid marker CD11b, although subtle differences exist as human, but not murine, ...
Human Cord Blood Leukocyte Innate Immune Responses
... Briefly, eight-well Lab Tek chambers (Nalge Nunc International, Naperville, IL, U.S.A.) were coated with varying concentrations of C1q or the control protein, human serum albumin (HSA). Phagocytic cells resuspended at 2.5 ⫻ 106/mL in phagocytosis buffer (RPMI, supplemented with 2 mM Lglutamine, 10 ...
... Briefly, eight-well Lab Tek chambers (Nalge Nunc International, Naperville, IL, U.S.A.) were coated with varying concentrations of C1q or the control protein, human serum albumin (HSA). Phagocytic cells resuspended at 2.5 ⫻ 106/mL in phagocytosis buffer (RPMI, supplemented with 2 mM Lglutamine, 10 ...
Identification of a particular HIV-specific CD8 T-cell
... Virus-specific CD8⫹ T cells play a central role in controlling viral infections. During acute viral infections, naive specific CD8⫹ T cells expand, differentiate, and acquire effector functions.1,2 After the acute phase, the CD8⫹ T-cell response generally subsides because of massive apoptosis of ant ...
... Virus-specific CD8⫹ T cells play a central role in controlling viral infections. During acute viral infections, naive specific CD8⫹ T cells expand, differentiate, and acquire effector functions.1,2 After the acute phase, the CD8⫹ T-cell response generally subsides because of massive apoptosis of ant ...
Anthrax Lethal Toxin-Mediated Killing of Human and Murine
... Bacillus anthracis, the causative agent of anthrax disease [1], releases lethal toxin (LT), which is sufficient to cause death in mice even in the absence of the bacterium [2]. Broad cytopathic and lethal effects associated with B. anthracis infection can be reproduced by LT injection of mice [3,4]. ...
... Bacillus anthracis, the causative agent of anthrax disease [1], releases lethal toxin (LT), which is sufficient to cause death in mice even in the absence of the bacterium [2]. Broad cytopathic and lethal effects associated with B. anthracis infection can be reproduced by LT injection of mice [3,4]. ...
Secretion by Human Monocytes Inducers of
... with STF resulted in significant increases in the percentage of cells in the monocyte scatter region (Fig. 3A) expressing TNF-a but not IL-1b (TNF-a1 IL-1b2 cells) (26%) and in IL-1b1 TNF-a1 cells (1.9%) (Fig. 3C). In these cultures, IL-1b alone (TNF-a2 IL-1b1 cells) was expressed in ;2% of the cell ...
... with STF resulted in significant increases in the percentage of cells in the monocyte scatter region (Fig. 3A) expressing TNF-a but not IL-1b (TNF-a1 IL-1b2 cells) (26%) and in IL-1b1 TNF-a1 cells (1.9%) (Fig. 3C). In these cultures, IL-1b alone (TNF-a2 IL-1b1 cells) was expressed in ;2% of the cell ...
Immune Senescence A Role for Immature Myeloid Cells in
... mo) for proinflammatory cytokines revealed that a higher percentage of splenic Gr1+CD11b+ cells were positive for IL-6 and IL-12(p40) compared with that of Gr1+CD11b+ cells present in SPLs of young mice (Fig. 2A). LPS stimulation of splenocytes showed that increased percentages of activated Gr1+CD11 ...
... mo) for proinflammatory cytokines revealed that a higher percentage of splenic Gr1+CD11b+ cells were positive for IL-6 and IL-12(p40) compared with that of Gr1+CD11b+ cells present in SPLs of young mice (Fig. 2A). LPS stimulation of splenocytes showed that increased percentages of activated Gr1+CD11 ...
Section 1 Nonspecific Defenses
... invader on its surface. An antigen (AN tih jihn) is a substance that triggers an immune response. Antigens typically include proteins and other parts of viruses or pathogen cells. Antigens are present on the surface of the infected body cell. White blood cells of the immune system are covered with r ...
... invader on its surface. An antigen (AN tih jihn) is a substance that triggers an immune response. Antigens typically include proteins and other parts of viruses or pathogen cells. Antigens are present on the surface of the infected body cell. White blood cells of the immune system are covered with r ...
Cell-Extrinsic Immune - The Journal of Immunology
... received support from the observation that disease in CTLA42/2 mice was abrogated when the CD28 pathway was interrupted by blockade (7) or deficiency (8) of their shared ligands (CD80 and CD86). However, the widely held belief that CTLA-4 worked via a “negative signal” was called into question when ...
... received support from the observation that disease in CTLA42/2 mice was abrogated when the CD28 pathway was interrupted by blockade (7) or deficiency (8) of their shared ligands (CD80 and CD86). However, the widely held belief that CTLA-4 worked via a “negative signal” was called into question when ...
Mdm2 Promotes Systemic Lupus Erythematosus and
... endogenous DNA might have also a mitogenic effect in SLE, similar to the mitogenic effect of bacterial DNA.14 Bacterial DNA was first described in 1995 as a B cell mitogen, but the underlying molecular mechanism has remained unknown. By using a comparative transcriptome analysis between RNA- and DNA ...
... endogenous DNA might have also a mitogenic effect in SLE, similar to the mitogenic effect of bacterial DNA.14 Bacterial DNA was first described in 1995 as a B cell mitogen, but the underlying molecular mechanism has remained unknown. By using a comparative transcriptome analysis between RNA- and DNA ...
Cytokines in anaesthesia - Oxford Academic
... helper lymphocytes (see below), macrophage activation is critically dependent on cytokine production. The complement system also plays a supportive role in the non-specific immune response. These proteins are synthesized in the liver and, when activated, augment phagocytosis and can cause direct cyt ...
... helper lymphocytes (see below), macrophage activation is critically dependent on cytokine production. The complement system also plays a supportive role in the non-specific immune response. These proteins are synthesized in the liver and, when activated, augment phagocytosis and can cause direct cyt ...
The Use of Monoclonal Antibodies and Flow
... than that of normal cells, a result also obtained by Shichishima et al"; this suggests that the PNH I cells of PNH may not be entirely normal in their content of GPI-linked proteins. A very small number of cells not reacting with the antibodies was found in the blood of a few normal control subjects ...
... than that of normal cells, a result also obtained by Shichishima et al"; this suggests that the PNH I cells of PNH may not be entirely normal in their content of GPI-linked proteins. A very small number of cells not reacting with the antibodies was found in the blood of a few normal control subjects ...
Novel drug therapies in myeloid leukemia
... fragments of tumor cells are released and taken up by antigen-presenting cells (APCs) such as dendritic cells (DCs) where they are presented on the surface by the major histocompatibility complex class II (MHCII) to prime CD4 + T-cells or by MHC I to generate tumor specific CD8 + T-cells [44,45] . T ...
... fragments of tumor cells are released and taken up by antigen-presenting cells (APCs) such as dendritic cells (DCs) where they are presented on the surface by the major histocompatibility complex class II (MHCII) to prime CD4 + T-cells or by MHC I to generate tumor specific CD8 + T-cells [44,45] . T ...
Placental regulation of maternal-fetal interactions and
... and stroke in later life (Barker et al., 1990; Warning et al., 2011). Moreover, the placenta’s central role in regulating nutrient transport, endocrine function and immune tolerance implicates its involvement in growth restriction, hypoxia and related neurological complications (Jansson and Powell, ...
... and stroke in later life (Barker et al., 1990; Warning et al., 2011). Moreover, the placenta’s central role in regulating nutrient transport, endocrine function and immune tolerance implicates its involvement in growth restriction, hypoxia and related neurological complications (Jansson and Powell, ...
IOSR Journal of Electrical and Electronics Engineering (IOSR-JEEE)
... that is it is the ability of our body to detect only the unknown antigens without reacting against the self cells.During the stage of embryonic development the T-cells migrate to a immune system organ called thymus till puberty.During this time the T-cells are exposed to a comprehensive version of s ...
... that is it is the ability of our body to detect only the unknown antigens without reacting against the self cells.During the stage of embryonic development the T-cells migrate to a immune system organ called thymus till puberty.During this time the T-cells are exposed to a comprehensive version of s ...
Licentiate thesis from the Department of Immunology, Wenner-Gren Institute,
... any pathogen common to a given individuals specific environment. These branches are, however, not two entirely separate systems but the adaptive is dependent on the innate components to function and the innate immune responses are much more efficient when aided by adaptive components. The cells of t ...
... any pathogen common to a given individuals specific environment. These branches are, however, not two entirely separate systems but the adaptive is dependent on the innate components to function and the innate immune responses are much more efficient when aided by adaptive components. The cells of t ...
T-cell exhaustion in allograft rejection and tolerance
... rejection or acceptance has previously been demonstrated in a study [43] showing that simultaneous transplantation of two kidneys and two hearts resulted in long-term graft acceptance, whereas single allogeneic heart and kidney graft were rejected acutely. Another study [35 ] extended these observat ...
... rejection or acceptance has previously been demonstrated in a study [43] showing that simultaneous transplantation of two kidneys and two hearts resulted in long-term graft acceptance, whereas single allogeneic heart and kidney graft were rejected acutely. Another study [35 ] extended these observat ...
Federica Chessa Dr. sc. hum. Dendritic cell function in different renal
... subgroup of bone marrow-derived leukocytes which also includes renal macrophages. Renal mononuclear phagocytes form a network of stellate cells which spans the interstitial spaces between the renal tubules. Renal DCs are essential for the maintenance of tissue homeostasis, as they sample innocuous a ...
... subgroup of bone marrow-derived leukocytes which also includes renal macrophages. Renal mononuclear phagocytes form a network of stellate cells which spans the interstitial spaces between the renal tubules. Renal DCs are essential for the maintenance of tissue homeostasis, as they sample innocuous a ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.