Antibodies used for the detection of leukocyte subsets - HAL
... expressed the myeloid marker CD11b, suggesting that infiltrated macrophages and/or resident microglial cells multiply at the site of injury. Thus, accumulation of T-cells may indicate a continuous extravasation process at least up to 7 days after neurotoxin exposure. Yet, the number of CD3+ T cells ...
... expressed the myeloid marker CD11b, suggesting that infiltrated macrophages and/or resident microglial cells multiply at the site of injury. Thus, accumulation of T-cells may indicate a continuous extravasation process at least up to 7 days after neurotoxin exposure. Yet, the number of CD3+ T cells ...
Frozen and dry liposomal membrances
... An attempt was made by Spieles et al. (15) to associate ice formation with the hemolysis of frozen blood cells during isothermal storage after cooling to -196 °C with liquid nitrogen. They reconstituted an intracellular solution from dried blood cells and water, and investigated the devitrification ...
... An attempt was made by Spieles et al. (15) to associate ice formation with the hemolysis of frozen blood cells during isothermal storage after cooling to -196 °C with liquid nitrogen. They reconstituted an intracellular solution from dried blood cells and water, and investigated the devitrification ...
Liver Failure - Ontario Institute for Regenerative Medicine
... As far back as 2000, researchers showed that hepatocytes could grow in the body from non-liver cell sources. This phenomenon, called transdifferentiation, was originally observed in female patients who were given bone marrow transplants from male donors: the new liver cells in the female patients co ...
... As far back as 2000, researchers showed that hepatocytes could grow in the body from non-liver cell sources. This phenomenon, called transdifferentiation, was originally observed in female patients who were given bone marrow transplants from male donors: the new liver cells in the female patients co ...
Site-Specific Differences in T Cell Frequencies and Phenotypes in
... This Article is brought to you for free and open access by the Papers in the Biological Sciences at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Faculty Publications in the Biological Sciences by an authorized administrator of DigitalCommons@University of ...
... This Article is brought to you for free and open access by the Papers in the Biological Sciences at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Faculty Publications in the Biological Sciences by an authorized administrator of DigitalCommons@University of ...
Adaptive Immunity
... Objective Questions [Answer these in your own words] After understanding the classroom material and textbook reading, you should be able to: 1. Define an antigen and an epitope. [FOM 10/e: p. 697] 2. List and describe the four key responses of adaptive immunity. [FOM 10/e: pp. 697-698] 3. Describe ...
... Objective Questions [Answer these in your own words] After understanding the classroom material and textbook reading, you should be able to: 1. Define an antigen and an epitope. [FOM 10/e: p. 697] 2. List and describe the four key responses of adaptive immunity. [FOM 10/e: pp. 697-698] 3. Describe ...
LETTERS
... cross-reactive TCR clones negatively correlates with viral load. Our simulations show that a larger number of CTL clones in a more crossreactive T-cell repertoire recognize epitopes from the infecting viral strain (Fig. 2c). This is because the predicted higher precursor frequency for viral epitopes ...
... cross-reactive TCR clones negatively correlates with viral load. Our simulations show that a larger number of CTL clones in a more crossreactive T-cell repertoire recognize epitopes from the infecting viral strain (Fig. 2c). This is because the predicted higher precursor frequency for viral epitopes ...
CURRICULUM VITAE - University of Oxford
... trial. More recently, in collaboration with Professor Cerundolo, we have found that allergens generate neolipids which are novel ligands for CD1a, and can be presented to CD1arestricted T cells from human skin. We believe that this is an important finding, not only for CD1a and Langerhans cell biolo ...
... trial. More recently, in collaboration with Professor Cerundolo, we have found that allergens generate neolipids which are novel ligands for CD1a, and can be presented to CD1arestricted T cells from human skin. We believe that this is an important finding, not only for CD1a and Langerhans cell biolo ...
Nerve growth factor levels and localisation in human asthmatic bronchi
... The asthmatics exhibited significantly enhanced NGF levels in BALF. Intense NGFimmunoreactivity was observed in bronchial epithelium, smooth muscle cells and infiltrating inflammatory cells in the submucosa, and to a lesser extent in the connective tissue. The asthmatics exhibited a higher number of ...
... The asthmatics exhibited significantly enhanced NGF levels in BALF. Intense NGFimmunoreactivity was observed in bronchial epithelium, smooth muscle cells and infiltrating inflammatory cells in the submucosa, and to a lesser extent in the connective tissue. The asthmatics exhibited a higher number of ...
Immunology of asthma and chronic obstructive pulmonary disease
... eosinophils in asthma is not clear and the evidence that links their presence to airway hyper-responsiveness has been questioned by the finding that the administration of IL‑5-specific blocking antibodies that markedly reduce the number of eosinophils in the blood and sputum does not reduce airway h ...
... eosinophils in asthma is not clear and the evidence that links their presence to airway hyper-responsiveness has been questioned by the finding that the administration of IL‑5-specific blocking antibodies that markedly reduce the number of eosinophils in the blood and sputum does not reduce airway h ...
An Identification Guide for Avian Blood Components
... of the heterophils can be used to infer the severity of an immune response. These toxic heterophils were present in a bird that was infected with blood parasites. Toxic heterophils appear more basophilic overall, with hypersegmented nuclei, and varying degrees of basophilic granules depending on the ...
... of the heterophils can be used to infer the severity of an immune response. These toxic heterophils were present in a bird that was infected with blood parasites. Toxic heterophils appear more basophilic overall, with hypersegmented nuclei, and varying degrees of basophilic granules depending on the ...
Exosomes: Looking back three decades and into the future
... membrane, resulting in release via the exosome secretion pathway. MVE formation is now rather well understood, necessary components of the endosomal complex required for transport (ESCRT) pathway have been identified (Henne et al., 2011), and provocative studies on the mechanism of inward vesicle bu ...
... membrane, resulting in release via the exosome secretion pathway. MVE formation is now rather well understood, necessary components of the endosomal complex required for transport (ESCRT) pathway have been identified (Henne et al., 2011), and provocative studies on the mechanism of inward vesicle bu ...
Dual role for B-1a cells in immunity to influenza virus infection
... S. pneumoniae after their adoptive transfer into Rag1⫺/⫺ recipient mice (17). B-1a cells did not mount anti–PPS-3 responses after immunization with heat-killed S. pneumoniae. Instead, they secreted high amounts of natural antibodies against phosphocholine, which is another antigenic determinant on S ...
... S. pneumoniae after their adoptive transfer into Rag1⫺/⫺ recipient mice (17). B-1a cells did not mount anti–PPS-3 responses after immunization with heat-killed S. pneumoniae. Instead, they secreted high amounts of natural antibodies against phosphocholine, which is another antigenic determinant on S ...
The regulation of B cell responses in systemic autoimmunity
... Our immune system is a complex network made up of physical barriers and specialized proteins, cells and organs that all work together to prevent pathogens from causing disease in the body. Once the immune system has successfully mounted an immune response upon intrusion of a pathogen it will mount a ...
... Our immune system is a complex network made up of physical barriers and specialized proteins, cells and organs that all work together to prevent pathogens from causing disease in the body. Once the immune system has successfully mounted an immune response upon intrusion of a pathogen it will mount a ...
Influence of a medium pH and ionic strength on the adhesion of
... substances to the substrate surface (4). However, strengthening of the bonds with time has been also found in experiments with quartz fibers (5). Effect of the slow destruction of boundary layers, which were losing their stability due to mutual overlap, was observed. As a result, adhesion strength i ...
... substances to the substrate surface (4). However, strengthening of the bonds with time has been also found in experiments with quartz fibers (5). Effect of the slow destruction of boundary layers, which were losing their stability due to mutual overlap, was observed. As a result, adhesion strength i ...
T Cells
... 22-2 Structures of Body Defenses • Lymphocyte Distribution • Tissues maintain different T cell and B cell populations • Lymphocytes wander through tissues • Enter blood vessels or lymphatics for transport • Can survive many years ...
... 22-2 Structures of Body Defenses • Lymphocyte Distribution • Tissues maintain different T cell and B cell populations • Lymphocytes wander through tissues • Enter blood vessels or lymphatics for transport • Can survive many years ...
Chronic Inflammation
... Persistent toxic substances such as alcohol produce chronic inflammation, notably in the pancreas and liver. The toxic substance is not antigenic, but by causing cell necrosis it may result in alteration of host molecules so that they become antigenic and evoke an immune ...
... Persistent toxic substances such as alcohol produce chronic inflammation, notably in the pancreas and liver. The toxic substance is not antigenic, but by causing cell necrosis it may result in alteration of host molecules so that they become antigenic and evoke an immune ...
Murine Effector Cells Crosstalk between Human IgG Isotypes and
... Development of human therapeutic Abs has led to reduced immunogenicity and optimal interactions with the human immune system in patients. Humanization had as a consequence that efficacy studies performed in mouse models, which represent a crucial step in preclinical development, are more difficult t ...
... Development of human therapeutic Abs has led to reduced immunogenicity and optimal interactions with the human immune system in patients. Humanization had as a consequence that efficacy studies performed in mouse models, which represent a crucial step in preclinical development, are more difficult t ...
Document
... 5. Sella turcica 6. Inner table of skull bone 7. Outer table of skull bone 8. Internal occipital protuberance 9. Sphenoid air sinus ...
... 5. Sella turcica 6. Inner table of skull bone 7. Outer table of skull bone 8. Internal occipital protuberance 9. Sphenoid air sinus ...
Types of Leukemia
... Cytogenetics: The lab looks at the chromosomes of cells from samples of blood, bone marrow, or lymph nodes. If abnormal chromosomes are found, the test can show what type of leukemia you have. For example, people with CML have an abnormal chromosome called the Philadelphia chromosome. Spinal tap: Yo ...
... Cytogenetics: The lab looks at the chromosomes of cells from samples of blood, bone marrow, or lymph nodes. If abnormal chromosomes are found, the test can show what type of leukemia you have. For example, people with CML have an abnormal chromosome called the Philadelphia chromosome. Spinal tap: Yo ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.