NIH Public Access - Transcell Biologics
... reside near the sinusoids and function as support cells for hematopoietic stem cells (HSC). Although MSCs comprise less than 0.1% of all bone marrow cells, they can be isolated from whole bone marrow aspirates by their ability to adhere to plastic and form colonies. Currently, there are no MSC-speci ...
... reside near the sinusoids and function as support cells for hematopoietic stem cells (HSC). Although MSCs comprise less than 0.1% of all bone marrow cells, they can be isolated from whole bone marrow aspirates by their ability to adhere to plastic and form colonies. Currently, there are no MSC-speci ...
Reciprocal modulation between TH17 and other helper T cell lineages
... irreversible event. T helper type 1 (TH1) cells stably express interferon (IFN)-g, whereas TH2 cells express IL-4 (Dong, 2008). The more recently defined TH17 cells, follicular helper T (Tfh) cells and induced regulatory T (iTreg) cells have been added into the CD4þ T cell subpopulations (Weaver and ...
... irreversible event. T helper type 1 (TH1) cells stably express interferon (IFN)-g, whereas TH2 cells express IL-4 (Dong, 2008). The more recently defined TH17 cells, follicular helper T (Tfh) cells and induced regulatory T (iTreg) cells have been added into the CD4þ T cell subpopulations (Weaver and ...
Article
... We next sought to analyze whether the control of MCMV spread was associated with an amplification of γδ T cells in infected organs. S2 Fig. shows the gating strategy used for γδ T cell flow cytometry analysis. After a slight decrease at day 3, γδ T cell numbers increased importantly in the lungs unt ...
... We next sought to analyze whether the control of MCMV spread was associated with an amplification of γδ T cells in infected organs. S2 Fig. shows the gating strategy used for γδ T cell flow cytometry analysis. After a slight decrease at day 3, γδ T cell numbers increased importantly in the lungs unt ...
Introduction - Philsci
... conditions, therefore, the immune system reacts constantly (and weakly) with the constituents of the body. Nonetheless, there is a difference between immune reaction and immune response: an immune 'reaction' refers to the interaction between immune receptors and antigenic patterns, whereas there is ...
... conditions, therefore, the immune system reacts constantly (and weakly) with the constituents of the body. Nonetheless, there is a difference between immune reaction and immune response: an immune 'reaction' refers to the interaction between immune receptors and antigenic patterns, whereas there is ...
Immunity by Design: An Artificial Immune System
... However, some attacks may be launched from many different machines, in which case the first method is unlikely to be successful. To detect such distributed coordinated attacks, we introduce a second method, called adaptive activation (labeled cytokine level in Figure 1). Whenever the match count of ...
... However, some attacks may be launched from many different machines, in which case the first method is unlikely to be successful. To detect such distributed coordinated attacks, we introduce a second method, called adaptive activation (labeled cytokine level in Figure 1). Whenever the match count of ...
Endogenous collagen peptide activation of CD1d
... specific to the CNS self-antigenic peptide myelin oligodendrocyte glycoprotein 79–96 (MOG79–96) was included for comparison. The mCII707–721–specific NKT cell line showed higher expression of Vα14-Jα18 than the conventional T cell line by real-time quantitative PCR (qPCR) (Figure 3D). Using a panel ...
... specific to the CNS self-antigenic peptide myelin oligodendrocyte glycoprotein 79–96 (MOG79–96) was included for comparison. The mCII707–721–specific NKT cell line showed higher expression of Vα14-Jα18 than the conventional T cell line by real-time quantitative PCR (qPCR) (Figure 3D). Using a panel ...
Anatomy and Histology of the Pancreas
... anastomosing ductules draining the lobules of the gland. It courses left to right and is enlarged by additional ducts. Through the tail and body, the duct lies midway between the superior and inferior margins and slightly posterior. The main duct turns caudal and posterior on reaching the head of th ...
... anastomosing ductules draining the lobules of the gland. It courses left to right and is enlarged by additional ducts. Through the tail and body, the duct lies midway between the superior and inferior margins and slightly posterior. The main duct turns caudal and posterior on reaching the head of th ...
Positive and negative regulation of Natural Killer cells: Therapeutic
... into NK cells following stimulation with IL-2 or IL-15 [34,35]. Later studies showed that the stromal cell requirements could be bypassed by the addition of stem cell factor, (SCF, also known as c-kit ligand), fetal liver kinase 2 ligand (FLK2, also known as FMS-like tyrosine kinase 3 ligand or FLT3 ...
... into NK cells following stimulation with IL-2 or IL-15 [34,35]. Later studies showed that the stromal cell requirements could be bypassed by the addition of stem cell factor, (SCF, also known as c-kit ligand), fetal liver kinase 2 ligand (FLK2, also known as FMS-like tyrosine kinase 3 ligand or FLT3 ...
In Vitro Generation of Interleukin 10–producing - Direct-MS
... number of studies suggest that IL-10–producing T cells may be induced in the absence of Th1 and Th2 responses and are involved in establishing non responsiveness (15, 17–19). These regulatory T cells could thus be of potential use in therapeutic intervention during inflammatory pathology. For exampl ...
... number of studies suggest that IL-10–producing T cells may be induced in the absence of Th1 and Th2 responses and are involved in establishing non responsiveness (15, 17–19). These regulatory T cells could thus be of potential use in therapeutic intervention during inflammatory pathology. For exampl ...
Female Reproductive System
... With maturation, a primary follicle becomes a secondary follicle. In a secondary follicle, the theca differentiates into 2 layers: the theca interna and the theca externa. The theca interna is layer made up of highly vascularized cuboidal secretory cells that secrete estrogen. The theca externa is a ...
... With maturation, a primary follicle becomes a secondary follicle. In a secondary follicle, the theca differentiates into 2 layers: the theca interna and the theca externa. The theca interna is layer made up of highly vascularized cuboidal secretory cells that secrete estrogen. The theca externa is a ...
Immunomodulating polysaccharides from the lichen Thamnolia
... TNF-a secretion by rat peritoneal macrophages, thus showing similar pattern of activity apart from death of the rat spleen cells caused by Ths-4. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. Molecular size-immunomod ...
... TNF-a secretion by rat peritoneal macrophages, thus showing similar pattern of activity apart from death of the rat spleen cells caused by Ths-4. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. Molecular size-immunomod ...
Essential roles for Pot1b in HSC self-renewal and
... this mouse model because BM failure was never observed in mice lacking telomerase11,12 and was not apparent in 11-month-old Pot1b-null mice.20 In the current study, we uncover a critical role for Pot1b in maintaining HSC homeostasis. We show that Pot1b by itself, even in the setting of wild-type tel ...
... this mouse model because BM failure was never observed in mice lacking telomerase11,12 and was not apparent in 11-month-old Pot1b-null mice.20 In the current study, we uncover a critical role for Pot1b in maintaining HSC homeostasis. We show that Pot1b by itself, even in the setting of wild-type tel ...
PHENOTYPIC AND TRANSCRIPTIONAL BIOMARKERS IN ORGAN TRANSPLANTATION Isabel Puig-Pey Comas
... The success of organ transplantation is in very large part attributable to advances in immunosuppressive treatment (IS). Today, transplantation clinicians have an armamentarium of immunosuppressive agents at their disposal, all of which are used in various combinations both for induction and mainten ...
... The success of organ transplantation is in very large part attributable to advances in immunosuppressive treatment (IS). Today, transplantation clinicians have an armamentarium of immunosuppressive agents at their disposal, all of which are used in various combinations both for induction and mainten ...
Distinct Pathways of Hepatitis C Virus Uptake and - HAL
... cells by delivery of internalized virus to recycling endosomes. Thus, it is very likely that HCV- ...
... cells by delivery of internalized virus to recycling endosomes. Thus, it is very likely that HCV- ...
NIH Public Access
... inflammasome — a large multiprotein complex formed by an NLR, the adaptor protein ASC (apoptosis- associated speck-like protein containing a caspase recruitment domain) and procaspase 1 (REF. 11). The assembly of the inflammasome leads to the activation of caspase 1, which cleaves pro-interleukin-1β ...
... inflammasome — a large multiprotein complex formed by an NLR, the adaptor protein ASC (apoptosis- associated speck-like protein containing a caspase recruitment domain) and procaspase 1 (REF. 11). The assembly of the inflammasome leads to the activation of caspase 1, which cleaves pro-interleukin-1β ...
microRNA-155 Regulates the Generation of Immunoglobulin Class
... Deficiency in miR-155 leads to reduced IgG1 secretion and impaired affinity maturation in a B cell autonomous manner We wished to determine whether the impaired antibody production was intrinsic to B cells. To this end, we created mixed chimeras by transferring 20% of either wild type, or miR-155-de ...
... Deficiency in miR-155 leads to reduced IgG1 secretion and impaired affinity maturation in a B cell autonomous manner We wished to determine whether the impaired antibody production was intrinsic to B cells. To this end, we created mixed chimeras by transferring 20% of either wild type, or miR-155-de ...
The New England Journal of Medicine Volume 336 - hem
... idiosyncratic reactions, and only rare patients, who may have ingested small amounts of a drug, have the complication of bone marrow failure. Drug associations with aplastic anemia have been established in prospective, population-based epidemiologic studies. In Europe and Israel in the 1980s, about ...
... idiosyncratic reactions, and only rare patients, who may have ingested small amounts of a drug, have the complication of bone marrow failure. Drug associations with aplastic anemia have been established in prospective, population-based epidemiologic studies. In Europe and Israel in the 1980s, about ...
In Vitro Antigen-induced Antibody Responses to Hepatitis B Surface
... immunization (Fig. 1 A) no specific antibody was detected even in the cultures stimulated with the T cell-dependent polyclonal B cell activator PWM (P > 0.2). By 2 wk after immunization (Fig. 1 B) there was marked spontaneous production of anti-HBs IgG culture, which could not be further enhanced by ...
... immunization (Fig. 1 A) no specific antibody was detected even in the cultures stimulated with the T cell-dependent polyclonal B cell activator PWM (P > 0.2). By 2 wk after immunization (Fig. 1 B) there was marked spontaneous production of anti-HBs IgG culture, which could not be further enhanced by ...
Normal B Cells Express 51p1-Encoded Ig Heavy Chains That Are
... five 51p1-like variants, but does not react with any of the eight VH1-69 variants that are more closely related to hv1263 (12). Genetic analysis demonstrated that several variants likely arose from VH1-69 gene duplications (13). As such, individuals may possess zero to four copies of any one VH1-69 ...
... five 51p1-like variants, but does not react with any of the eight VH1-69 variants that are more closely related to hv1263 (12). Genetic analysis demonstrated that several variants likely arose from VH1-69 gene duplications (13). As such, individuals may possess zero to four copies of any one VH1-69 ...
Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans
... also evident in the peripheral blood (Fig. 2C–E). Thus, enhanced egress from LNs does not account for the decreased frequency of CTLA-4 KO 5C.C7 T cells in the presence of WT 5C.C7 T cells. Longitudinal analysis of T cell responses in blood shows that the presence of CTLA-4 on WT T cells decreases t ...
... also evident in the peripheral blood (Fig. 2C–E). Thus, enhanced egress from LNs does not account for the decreased frequency of CTLA-4 KO 5C.C7 T cells in the presence of WT 5C.C7 T cells. Longitudinal analysis of T cell responses in blood shows that the presence of CTLA-4 on WT T cells decreases t ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.