The Imbalance of B-Lymphocyte Subsets in Subjects with Different
... through IgM mechanism in DIO mice [20]. IL-10producing B (B10) cells, namely, regulatory B cells, control T-cell responses and suppress inflammation via IL-10 [21, 22]. Depletion of B-cell-specific IL-10 deteriorated adipose tissue inflammation and insulin resistance in DIO mice, whereas adoptive trans ...
... through IgM mechanism in DIO mice [20]. IL-10producing B (B10) cells, namely, regulatory B cells, control T-cell responses and suppress inflammation via IL-10 [21, 22]. Depletion of B-cell-specific IL-10 deteriorated adipose tissue inflammation and insulin resistance in DIO mice, whereas adoptive trans ...
McSorley 2013 IJP - Rick Maizels` Group
... As mentioned above, many of the suppressive functions of parasite products are heat-stable, indicating they may be of carbohydrate nature. Elucidation of immunomodulatory carbohydrates from helminths has been hindered by a lack of tools for identification, manipulation and production of these molecul ...
... As mentioned above, many of the suppressive functions of parasite products are heat-stable, indicating they may be of carbohydrate nature. Elucidation of immunomodulatory carbohydrates from helminths has been hindered by a lack of tools for identification, manipulation and production of these molecul ...
Immunological Mechanisms and Natalizumab Treatment in Multiple Sclerosis Natalizumab Treatment in Multiple Sclerosis
... matter, the disease is also denoted by axonal damage and gliosis (Dutta and Trapp 2007). Depending on the size and anatomical localization of the lesion, the clinical result is reduction or loss of the corresponding neurological function. The onset of symptoms is often referred to as a relapse. With ...
... matter, the disease is also denoted by axonal damage and gliosis (Dutta and Trapp 2007). Depending on the size and anatomical localization of the lesion, the clinical result is reduction or loss of the corresponding neurological function. The onset of symptoms is often referred to as a relapse. With ...
Phagocytic ability declines with age in adult Drosophila hemocytes
... of Hemese-Gal4-driven green fluorescent protein (GFP), which specifically marks hemocytes (Kurucz et al., 2003; Zettervall et al., 2004), demonstrated that these cells are the predominant phagocytic cells in young and old flies. Knockdown of nimrod C1 or eater in heartassociated adult blood cells re ...
... of Hemese-Gal4-driven green fluorescent protein (GFP), which specifically marks hemocytes (Kurucz et al., 2003; Zettervall et al., 2004), demonstrated that these cells are the predominant phagocytic cells in young and old flies. Knockdown of nimrod C1 or eater in heartassociated adult blood cells re ...
Regulatory T cells control tolerogenic versus autoimmune response
... before sperm antibodies were detectable. We obtained unexpected results germane to the mechanism of Treg function and immune sequelae of vasectomy. First, vasectomized mice develop sperm-specific systemic tolerance despite sperm antigen presentation from an inflamed epididymis. Second, Treg depletion ...
... before sperm antibodies were detectable. We obtained unexpected results germane to the mechanism of Treg function and immune sequelae of vasectomy. First, vasectomized mice develop sperm-specific systemic tolerance despite sperm antigen presentation from an inflamed epididymis. Second, Treg depletion ...
The Benefits on Human Health by Supplementing Proline
... T helper lymphocytes develop along two lines of cell populations, TH1 and TH2. TH1 cells, which modulate cell-mediated immunity, produce the cytokines: IL-2, IFN-gamma, and TNFalpha. TH2 cells, which modulate humoral immunity, or antibody production, produce IL-4, IL-5, IL-6, IL-10, and IL-13 PRPs t ...
... T helper lymphocytes develop along two lines of cell populations, TH1 and TH2. TH1 cells, which modulate cell-mediated immunity, produce the cytokines: IL-2, IFN-gamma, and TNFalpha. TH2 cells, which modulate humoral immunity, or antibody production, produce IL-4, IL-5, IL-6, IL-10, and IL-13 PRPs t ...
Lymphatic System - El Camino College
... Right Lymphatic duct – collects lymph from right arm, right side of head, neck and thorax. When absent, the lymphatic trunks directly open into veins of the neck. Thoracic Duct – collects lymph from rest of the body. It arises inferiorly as an extended sac – Cisterna Chyli, in front of 1st and 2nd l ...
... Right Lymphatic duct – collects lymph from right arm, right side of head, neck and thorax. When absent, the lymphatic trunks directly open into veins of the neck. Thoracic Duct – collects lymph from rest of the body. It arises inferiorly as an extended sac – Cisterna Chyli, in front of 1st and 2nd l ...
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Title: Minor population of CD55-CD59- blood cells
... and achieve remission. However, for the remaining 30%, IST might even be harmful due to an increased risk of opportunistic infections, particularly in the absence of any remission. The immune pathophysiology of patients should thus be understood at diagnosis and IST should be applied only to those w ...
... and achieve remission. However, for the remaining 30%, IST might even be harmful due to an increased risk of opportunistic infections, particularly in the absence of any remission. The immune pathophysiology of patients should thus be understood at diagnosis and IST should be applied only to those w ...
Immunopathology of multiple sclerosis
... to accumulate and become permanent. This supports the concept that there is some degree of discord between the processes driving overt relapses and those driving chronic progression. Indeed, secondary progressive disease may not be a temporally distinct phase of the condition arising as a direct con ...
... to accumulate and become permanent. This supports the concept that there is some degree of discord between the processes driving overt relapses and those driving chronic progression. Indeed, secondary progressive disease may not be a temporally distinct phase of the condition arising as a direct con ...
Inflammation in the Bovine Female Reproductive Tract
... referred to the review by Stevenson (54). Briefly, in the cycling female, the hypothalamic “pulse generator” releases bursts of GnRH, which in turn stimulate the pulsatile release of gonadotrophins (FSH and LH) from the adenohypophysis. These pulses of gonadotrophins induce growth in a cohort of sma ...
... referred to the review by Stevenson (54). Briefly, in the cycling female, the hypothalamic “pulse generator” releases bursts of GnRH, which in turn stimulate the pulsatile release of gonadotrophins (FSH and LH) from the adenohypophysis. These pulses of gonadotrophins induce growth in a cohort of sma ...
The sympathetic nervous response in inflammation
... anti- or pro-inflammatory’. It is better to say ‘norepinephrine modulates immune function in a context-dependent manner’. It gets even more complex when the release of cotransmitters, which is dependent on the firing rate of sympathetic nerve fibers [59], and neuroanatomical facts are taken into acc ...
... anti- or pro-inflammatory’. It is better to say ‘norepinephrine modulates immune function in a context-dependent manner’. It gets even more complex when the release of cotransmitters, which is dependent on the firing rate of sympathetic nerve fibers [59], and neuroanatomical facts are taken into acc ...
Human Invariant Natural Killer T cells possess
... cytokine production by DCs,12–14 promotion of CD4+ and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid an ...
... cytokine production by DCs,12–14 promotion of CD4+ and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid an ...
PLGA manuscript_final submission
... current ACVs is of importance and development of new generation of vaccines with long-lasting immunity is needed for better control of this disease. There are several ...
... current ACVs is of importance and development of new generation of vaccines with long-lasting immunity is needed for better control of this disease. There are several ...
everyday immune defence
... Adaptive immunity is called into action if the innate immune system is overwhelmed. Also known as acquired immunity, this response is highly specific to the pathogen that induces it. ...
... Adaptive immunity is called into action if the innate immune system is overwhelmed. Also known as acquired immunity, this response is highly specific to the pathogen that induces it. ...
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression
... Mesenchymal stem cells (MSCs) are multipotent stromal cells found in the bone marrow that differentiate into a wide variety of cell types that include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). Mesenchymal stem cells provide a basis ...
... Mesenchymal stem cells (MSCs) are multipotent stromal cells found in the bone marrow that differentiate into a wide variety of cell types that include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). Mesenchymal stem cells provide a basis ...
Immune regulation during pregnancy in relation to allergy
... recognition and effector molecules, such as natural antibodies and the complement system, can bind to microbes. They act like opsonins and enhance the ability of macrophages, neutrophils and dendritic cells to phagocytose the microbes. Adaptive immune responses are initiated when antigen or antigen- ...
... recognition and effector molecules, such as natural antibodies and the complement system, can bind to microbes. They act like opsonins and enhance the ability of macrophages, neutrophils and dendritic cells to phagocytose the microbes. Adaptive immune responses are initiated when antigen or antigen- ...
Perforin and interferon- activities independently
... cytotoxicity in immunity against tumor development. The development of gene-targeted mice deficient in perforin (pfp)2 and the discovery of several members of the tumor necrosis factor (TNF) superfamily with the capacity to induce tumor cell apoptosis3-5 have paved the way to determining which effec ...
... cytotoxicity in immunity against tumor development. The development of gene-targeted mice deficient in perforin (pfp)2 and the discovery of several members of the tumor necrosis factor (TNF) superfamily with the capacity to induce tumor cell apoptosis3-5 have paved the way to determining which effec ...
Immune responses to human papillomavirus
... to encounter antigen. Each mature B cell bears a unique membrane-bound B cell receptor, an immunoglobulin, or antibody molecule that is specific for a discrete motif or epitope on an antigen. Once the naı̈ve B cell encounters antigen and is activated, it undertakes a tightly regulated proliferation ...
... to encounter antigen. Each mature B cell bears a unique membrane-bound B cell receptor, an immunoglobulin, or antibody molecule that is specific for a discrete motif or epitope on an antigen. Once the naı̈ve B cell encounters antigen and is activated, it undertakes a tightly regulated proliferation ...
B Cell Receptor Signaling in Human B Cells
... This study was conducted at the Department of Clinical Microbiology, Institute of Clinical Medicine, University of Kuopio. I express my deepest gratitude to my supervisor Professor Jukka Pelkonen, M.D., Ph.D. for his enthusiasm for science and open mind for new ideas. I want especially to thank Jukk ...
... This study was conducted at the Department of Clinical Microbiology, Institute of Clinical Medicine, University of Kuopio. I express my deepest gratitude to my supervisor Professor Jukka Pelkonen, M.D., Ph.D. for his enthusiasm for science and open mind for new ideas. I want especially to thank Jukk ...
The Influence of 1,25-dihydroxyvitamin D on the Cross-Priming of Lymphocytic
... Figure 5. The HEK-NP cell model to study the effects of cross-presentation ............................... 11 Figure 6. A schematic of vitamin D3 metabolism ......................................................................... 13 Figure 7. The effects of 1,25-(OH)2D3 on the regulation of vitamin ...
... Figure 5. The HEK-NP cell model to study the effects of cross-presentation ............................... 11 Figure 6. A schematic of vitamin D3 metabolism ......................................................................... 13 Figure 7. The effects of 1,25-(OH)2D3 on the regulation of vitamin ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.