Immunopathogenesis of chronic periapical
... lambda (A) types. Different classes of antibodies may contain similar light chains, but each class has its own two heavy chains (y, p, CX,6, 6) which correspond to IgG, IgM, IgA, IgD, and IgE. Chemical and physical properties of human antibodies are shown in Table I. The immune response calls into a ...
... lambda (A) types. Different classes of antibodies may contain similar light chains, but each class has its own two heavy chains (y, p, CX,6, 6) which correspond to IgG, IgM, IgA, IgD, and IgE. Chemical and physical properties of human antibodies are shown in Table I. The immune response calls into a ...
Human perinatal immunity in physiological conditions and during
... Healthy living has its origin before birth. Although the intrauterine setting is considered to be a safe environment for the unborn, several threats are already present. One of them is exposure to microorganisms and subsequent inflammatory responses in both maternal (chorionic) and fetal (amniotic) ...
... Healthy living has its origin before birth. Although the intrauterine setting is considered to be a safe environment for the unborn, several threats are already present. One of them is exposure to microorganisms and subsequent inflammatory responses in both maternal (chorionic) and fetal (amniotic) ...
PATHOGENESIS OF AN EMERGING PATHOGEN – CRIMEAN
... the release of tumor necrosis factor (TNF), IL-6 and IL-10. Interestingly, conditioned media from CCHFV-infected moDCs activated ECs as indicated by enhanced intercellular adhesion molecule 1 (ICAM-1) expression. This effect was shown to be dependent on TNF. The work presented in this thesis provide ...
... the release of tumor necrosis factor (TNF), IL-6 and IL-10. Interestingly, conditioned media from CCHFV-infected moDCs activated ECs as indicated by enhanced intercellular adhesion molecule 1 (ICAM-1) expression. This effect was shown to be dependent on TNF. The work presented in this thesis provide ...
Natural killer cell cytotoxicity: how do they pull the trigger?
... thought to be the focal point for the exocytosis of secretory lysosomes, allowing them to release their content towards the target cell. Indeed, this is analogous to the lytic synapse formed between a CTL and its target, in which the cSMAC also corresponds to the site of secretory lysosome exocytosi ...
... thought to be the focal point for the exocytosis of secretory lysosomes, allowing them to release their content towards the target cell. Indeed, this is analogous to the lytic synapse formed between a CTL and its target, in which the cSMAC also corresponds to the site of secretory lysosome exocytosi ...
A New Mouse Model That Spontaneously Develops Chronic Liver
... have substantially different triggering factors and etiology it is generally thought that key components of the pathogenesis are shared [2, 3]. In this perspective, fibrosis could be regarded as a pathologic process with overlapping pathogenic factors. The liver is one of the organs where fibrosis c ...
... have substantially different triggering factors and etiology it is generally thought that key components of the pathogenesis are shared [2, 3]. In this perspective, fibrosis could be regarded as a pathologic process with overlapping pathogenic factors. The liver is one of the organs where fibrosis c ...
Thymus-Therapie in Practice
... humoral systems to combat micro-organisms, parasites and viruses. The ability to do this is particularly important in the removal of cells that have degenerated within the body and become “foreign”. The first cancer cells to develop should be destroyed by the immune response. A sufficient number of ...
... humoral systems to combat micro-organisms, parasites and viruses. The ability to do this is particularly important in the removal of cells that have degenerated within the body and become “foreign”. The first cancer cells to develop should be destroyed by the immune response. A sufficient number of ...
Atypical MHC class II-expressing antigen
... processed and presented on MHC molecules to be recognized by T cells. However, T cell activation requires more than the simple expression of MHC molecules by antigen-presenting cells (APCs). The activation of a naive T cell requires interaction with an APC that provides multiple signals (see the fig ...
... processed and presented on MHC molecules to be recognized by T cells. However, T cell activation requires more than the simple expression of MHC molecules by antigen-presenting cells (APCs). The activation of a naive T cell requires interaction with an APC that provides multiple signals (see the fig ...
Latent KSHV infection increases the vascular permeability of human
... We reported previously the generation of KSHV-infected HUVEC using the rKSHV.219 strain of KSHV, which expresses green fluorescent protein (GFP) under a EF-1␣ promoter and red fluorescent protein (RFP) under the promoter for the viral lytic gene PAN.33 The KSHV-infected cells are highly latent and o ...
... We reported previously the generation of KSHV-infected HUVEC using the rKSHV.219 strain of KSHV, which expresses green fluorescent protein (GFP) under a EF-1␣ promoter and red fluorescent protein (RFP) under the promoter for the viral lytic gene PAN.33 The KSHV-infected cells are highly latent and o ...
Illuminating Neonatal Sepsis as Age-Specific Systemic Inflammatory
... activation by low dose LPS and are primed by even low doses of TNF for subsequent stimulation with lipopolysaccharid (LPS) from gram-negative bacteria. The essential clue is that neonatal monocytes in contrast to adult monocytes are not yet able to regulate their immune responses down. Soon to be pu ...
... activation by low dose LPS and are primed by even low doses of TNF for subsequent stimulation with lipopolysaccharid (LPS) from gram-negative bacteria. The essential clue is that neonatal monocytes in contrast to adult monocytes are not yet able to regulate their immune responses down. Soon to be pu ...
ABATEMENT OF TYPE 1 DIABETES AS A RESULT OF
... other PCB congeners, however, this compound is unique because it is halogenated with chlorine atoms at the 2, 2’, 4, 4’, 5, 5’ carbons (Figure 1). Due to this halogenation, PCB-153 has a high heat capacity, low conductance, and are highly soluble in ...
... other PCB congeners, however, this compound is unique because it is halogenated with chlorine atoms at the 2, 2’, 4, 4’, 5, 5’ carbons (Figure 1). Due to this halogenation, PCB-153 has a high heat capacity, low conductance, and are highly soluble in ...
Human Bone Progenitor Cells for Clinical
... found that the cell-seeded scaffolds improved the bone formation compared to cell-free scaffolds in this model. Even though the final outcome was an improvement of bone formation, a thorough analysis concerning associated immune responses with the implantation of a xenograft tissue is necessary. Thi ...
... found that the cell-seeded scaffolds improved the bone formation compared to cell-free scaffolds in this model. Even though the final outcome was an improvement of bone formation, a thorough analysis concerning associated immune responses with the implantation of a xenograft tissue is necessary. Thi ...
Review
... One of the major challenges in immunology is the understanding of cellular and molecular mechanisms involved in the discrimination between pathogens and autoantigens. Thymic clonal deletion and induction of anergy or apoptosis of self-reactive T cells upon exposure to self-antigen have been consider ...
... One of the major challenges in immunology is the understanding of cellular and molecular mechanisms involved in the discrimination between pathogens and autoantigens. Thymic clonal deletion and induction of anergy or apoptosis of self-reactive T cells upon exposure to self-antigen have been consider ...
Induced disruption of the transforming growth factor
... numerous physiologic processes including development, hematopoiesis, wound healing, and immune response. The 3 isoforms of this growth factor that have been identified in mammals (TGF-1, -2, and -3) are encoded by distinct genetic loci and share a high level of homology. They act on virtually all ...
... numerous physiologic processes including development, hematopoiesis, wound healing, and immune response. The 3 isoforms of this growth factor that have been identified in mammals (TGF-1, -2, and -3) are encoded by distinct genetic loci and share a high level of homology. They act on virtually all ...
Differential infection patterns of CD4 T cells and
... monoclonal antibodies to CD152/CTLA-4 (clone BNI3; BD Biosciences PharMingen) and Ki-67 (clone B56; BD Biosciences PharMingen). The SIV infection frequency of naive, central memory, TFH, and effector memory CD4⫹ T cells was determined by real-time PCR analysis of flow cytometrically sorted subsets. ...
... monoclonal antibodies to CD152/CTLA-4 (clone BNI3; BD Biosciences PharMingen) and Ki-67 (clone B56; BD Biosciences PharMingen). The SIV infection frequency of naive, central memory, TFH, and effector memory CD4⫹ T cells was determined by real-time PCR analysis of flow cytometrically sorted subsets. ...
Cutting Edge Commentary: A Copernican Revolution? Doubts About
... “self” is defined solely in the thymus during the neonatal period; yet in discussions of danger, it has often been this vulnerable conception of “self” that is trotted out as the reigning “paradigm” and then demolished with a triumphant fanfare (17, 30). While it may be true that immunologists have ...
... “self” is defined solely in the thymus during the neonatal period; yet in discussions of danger, it has often been this vulnerable conception of “self” that is trotted out as the reigning “paradigm” and then demolished with a triumphant fanfare (17, 30). While it may be true that immunologists have ...
Negative-Strand RNA Viruses Maturation and Adaptive Immunity by
... DC maturation after SeV infection is independent of MyD88mediated signaling In mice, TLR7, TLR8, and TLR9 are expressed in myeloid DCs, pivotal in the initiation of adaptive immunity (29). To test the requirement for TLR7, 8, or 9 stimulation in the induction of myeloid DC maturation, we took advant ...
... DC maturation after SeV infection is independent of MyD88mediated signaling In mice, TLR7, TLR8, and TLR9 are expressed in myeloid DCs, pivotal in the initiation of adaptive immunity (29). To test the requirement for TLR7, 8, or 9 stimulation in the induction of myeloid DC maturation, we took advant ...
b - Repositório da Universidade de Lisboa
... After this incredible emotional rollercoaster there is a great bunch of people that for sure need to be mentioned. A big thank you to: Naomi for always being there to help, brainstorm or just listen; Donovan for all the mouse help, chocolates and for worrying about me; Peter for the ranting and shar ...
... After this incredible emotional rollercoaster there is a great bunch of people that for sure need to be mentioned. A big thank you to: Naomi for always being there to help, brainstorm or just listen; Donovan for all the mouse help, chocolates and for worrying about me; Peter for the ranting and shar ...
Slide 1
... was measured by quantitative flow cytometry of intracellular content of perforin, with data expressed as relative number of molecules of perforin per CD3CD56+ lymphocyte (rMolPer/NK cell). ...
... was measured by quantitative flow cytometry of intracellular content of perforin, with data expressed as relative number of molecules of perforin per CD3CD56+ lymphocyte (rMolPer/NK cell). ...
Multiple Mechanisms of Immune Suppression by B
... IL-10–producing B cells are found in this population. Indeed, IL-10–producing B cells can be found among most major subsets of splenic B cells, albeit at smaller frequencies than that seen among CD5+CD1dhigh B cells (42). Given that no set of surface markers identifies all IL-10–producing B cells, i ...
... IL-10–producing B cells are found in this population. Indeed, IL-10–producing B cells can be found among most major subsets of splenic B cells, albeit at smaller frequencies than that seen among CD5+CD1dhigh B cells (42). Given that no set of surface markers identifies all IL-10–producing B cells, i ...
Increased CTLA-4+T cells and an increased ratio of monocytes with
... down regulated NK cell and NK-T cell populations and up regulation of suppressor regulatory T cells (Tregs) [7]. These mechanisms together and alone are thought to represent the mechanism of tumor cell evasion from host’s immune surveillance. Several reports exist of various immune abnormalities in ...
... down regulated NK cell and NK-T cell populations and up regulation of suppressor regulatory T cells (Tregs) [7]. These mechanisms together and alone are thought to represent the mechanism of tumor cell evasion from host’s immune surveillance. Several reports exist of various immune abnormalities in ...
cell-mediated immunity.
... Fever is beneficial as it tells us something is wrong. Fever creates an unfavorable environment for an invader. Fever may stimulate the immune system. ...
... Fever is beneficial as it tells us something is wrong. Fever creates an unfavorable environment for an invader. Fever may stimulate the immune system. ...
Presentazione di PowerPoint
... Fever is beneficial as it tells us something is wrong. Fever creates an unfavorable environment for an invader. Fever may stimulate the immune system. ...
... Fever is beneficial as it tells us something is wrong. Fever creates an unfavorable environment for an invader. Fever may stimulate the immune system. ...
The Imbalance of B-Lymphocyte Subsets in Subjects with Different
... through IgM mechanism in DIO mice [20]. IL-10producing B (B10) cells, namely, regulatory B cells, control T-cell responses and suppress inflammation via IL-10 [21, 22]. Depletion of B-cell-specific IL-10 deteriorated adipose tissue inflammation and insulin resistance in DIO mice, whereas adoptive trans ...
... through IgM mechanism in DIO mice [20]. IL-10producing B (B10) cells, namely, regulatory B cells, control T-cell responses and suppress inflammation via IL-10 [21, 22]. Depletion of B-cell-specific IL-10 deteriorated adipose tissue inflammation and insulin resistance in DIO mice, whereas adoptive trans ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.