1 ANTITUMOR IMMUNITY AND THE ROLE OF IMMUNUNE
... most tumors express class I Major Histocompatibility Complex (MHC) antigens and not MHC class II antigens. This characteristic is significant because CTLs recognize peptide antigens presented by tumors on MHC class I molecules. If certain antigens are presented to CTLs on MHC I, then CTLs will direc ...
... most tumors express class I Major Histocompatibility Complex (MHC) antigens and not MHC class II antigens. This characteristic is significant because CTLs recognize peptide antigens presented by tumors on MHC class I molecules. If certain antigens are presented to CTLs on MHC I, then CTLs will direc ...
Licentiate thesis from the Department of Immunology,
... respectively. T cell receptors (TCR) recognize antigens only in the context of major histocompatibility complex (MHC) class I or class II molecules expressed on antigen APCs. TC cells are important in clearing infected and transformed cells in the body, while the function of TH cells is mainly cytok ...
... respectively. T cell receptors (TCR) recognize antigens only in the context of major histocompatibility complex (MHC) class I or class II molecules expressed on antigen APCs. TC cells are important in clearing infected and transformed cells in the body, while the function of TH cells is mainly cytok ...
Endotoxin can induce MyD88-deficient dendritic cells to support Th2
... concentration in alloMLR of LPS-stimulated wild-type DC was <10 pg/ml (data not shown), we have analyzed the function of IL-12±/±, IL-18±/± and IL-12/18±/± DC (Fig. 4). In response to LPS, all mutant DC showed up-regulation of CD40 expression at comparable levels with wild-type DC (Fig. 4A). Further ...
... concentration in alloMLR of LPS-stimulated wild-type DC was <10 pg/ml (data not shown), we have analyzed the function of IL-12±/±, IL-18±/± and IL-12/18±/± DC (Fig. 4). In response to LPS, all mutant DC showed up-regulation of CD40 expression at comparable levels with wild-type DC (Fig. 4A). Further ...
Pro5® Pentamer Applications
... • Pentamer staining is highly flexible • Pentamers can be used in combination with other cell surface and intracellular markers • Pentamers can be used to isolate antigen-specific cell populations • Results of Pentamer staining can be combined with other techniques, (e.g. ELISPOT) to gain a full pic ...
... • Pentamer staining is highly flexible • Pentamers can be used in combination with other cell surface and intracellular markers • Pentamers can be used to isolate antigen-specific cell populations • Results of Pentamer staining can be combined with other techniques, (e.g. ELISPOT) to gain a full pic ...
An introduction to immunology
... • Important to study what parts of a protein that binds to MHC molecules. • MHC I binds peptides with 8-10 aa • MHC II bind peptides with 12-25 aa • Potentials of peptide vaccines • Prediction of peptides is important!!!! ...
... • Important to study what parts of a protein that binds to MHC molecules. • MHC I binds peptides with 8-10 aa • MHC II bind peptides with 12-25 aa • Potentials of peptide vaccines • Prediction of peptides is important!!!! ...
IMMUNOBIOLOGY B cells in early and chronic HIV infection
... subpopulation in chronically infected compared to early HIV-infected individuals. This difference is consistent with past and present findings in that we have previously shown an inverse correlation between immature/transitional B cells and CD4+ T-cell count 6,7, and lower CD4+ T cell-counts were ob ...
... subpopulation in chronically infected compared to early HIV-infected individuals. This difference is consistent with past and present findings in that we have previously shown an inverse correlation between immature/transitional B cells and CD4+ T-cell count 6,7, and lower CD4+ T cell-counts were ob ...
A new vision of immunity: homeostasis of the superorganism
... (PPs), mesenteric lymph nodes (LNs), and the splenic white pulp remain small, and isolated lymphoid follicles (ILFs), present in hundreds in the lamina propria of normal mice, fail to develop.20 Furthermore, intestinal lymphocyte populations are markedly reduced, including intra-epithelial T cells, ...
... (PPs), mesenteric lymph nodes (LNs), and the splenic white pulp remain small, and isolated lymphoid follicles (ILFs), present in hundreds in the lamina propria of normal mice, fail to develop.20 Furthermore, intestinal lymphocyte populations are markedly reduced, including intra-epithelial T cells, ...
Testicular defense systems: immune privilege and innate
... included the pregnant uterus and testis.8 The testis represents a distinct immunoprivileged site where both allo-antigens and immunogenic auto-antigens can be tolerated without evoking detrimental immune responses.9 Properties of testicular immune privilege The phenomenon of testicular immune privil ...
... included the pregnant uterus and testis.8 The testis represents a distinct immunoprivileged site where both allo-antigens and immunogenic auto-antigens can be tolerated without evoking detrimental immune responses.9 Properties of testicular immune privilege The phenomenon of testicular immune privil ...
Barcelona-Cincinnati technique for limbal transplantation
... required, present a reduced risk of rejection due to the absence of antigen-presenting Langerhan´s cells.13 As a direct relationship between ocular surface stem cell transplantation failure and immune rejection has been reported, it is critical that patients are closely monitored for rejection and f ...
... required, present a reduced risk of rejection due to the absence of antigen-presenting Langerhan´s cells.13 As a direct relationship between ocular surface stem cell transplantation failure and immune rejection has been reported, it is critical that patients are closely monitored for rejection and f ...
030710 Medium- and Large
... maintain the activation of T cells. The activation of adventitial dendritic cells is an early event in the vasculitis. In temporal arteries from patients with polymyalgia rheumatica, which lack inflammatory infiltrates, the dendritic cells are no longer immature and have acquired the activation mark ...
... maintain the activation of T cells. The activation of adventitial dendritic cells is an early event in the vasculitis. In temporal arteries from patients with polymyalgia rheumatica, which lack inflammatory infiltrates, the dendritic cells are no longer immature and have acquired the activation mark ...
Document
... Most of the lymphocytes that are not T cells are B lymphocytes (B cells). Processed in the bone marrow. Function in specific immunity. B cells combat bacterial infections as well as some viral infections by secreting antibodies into the blood and lymph. Provide humoral immunity (blood and lymph are ...
... Most of the lymphocytes that are not T cells are B lymphocytes (B cells). Processed in the bone marrow. Function in specific immunity. B cells combat bacterial infections as well as some viral infections by secreting antibodies into the blood and lymph. Provide humoral immunity (blood and lymph are ...
Chapter I Overview of Immunology
... I. Innate immunity ( natural immunity/ non-specific immunity ) Innate immunity: Protection against infection that relies on mechanisms that exist before infection,are capable of a rapid response to microbes,and react in essentially the same way to repeated infections. Exists at birth Be the fi ...
... I. Innate immunity ( natural immunity/ non-specific immunity ) Innate immunity: Protection against infection that relies on mechanisms that exist before infection,are capable of a rapid response to microbes,and react in essentially the same way to repeated infections. Exists at birth Be the fi ...
File - wilson science WEBSITE
... • Antigen receptors are generated by random rearrangement of DNA • As lymphocytes mature in bone marrow or the thymus, they are tested for self-reactivity • Lymphocytes with receptors specific for the body’s own molecules are destroyed by apoptosis, or rendered nonfunctional ...
... • Antigen receptors are generated by random rearrangement of DNA • As lymphocytes mature in bone marrow or the thymus, they are tested for self-reactivity • Lymphocytes with receptors specific for the body’s own molecules are destroyed by apoptosis, or rendered nonfunctional ...
... to determine the context of these signals. Efficiency is important for T cells for several reasons: T cell receptors (TCRs) must be able to recognize a few activating peptide-MHC (pMHC) complexes (∼10) in a sea of selfpMHC on the surface of an antigen-presenting cell (APC). Furthermore, the differenc ...
Chapter 15 The Lymphatic System and Immunity
... Immune System Cells – Development of B cells • Second stage—activated B cell – contact with antigens, bind to antibodies, plus signal chemicals from T cells – B cell then divides and forms two clones of cells— plasma (effector) cells and memory cells – Plasma cells secrete antibodies into blood; me ...
... Immune System Cells – Development of B cells • Second stage—activated B cell – contact with antigens, bind to antibodies, plus signal chemicals from T cells – B cell then divides and forms two clones of cells— plasma (effector) cells and memory cells – Plasma cells secrete antibodies into blood; me ...
Memorizing innate instructions requires a sufficiently specific
... memory cells are typically more prompt than primary immune responses (16±24,47,48), because memory cells are more sensitive to low antigen doses, have less stringent requirements for co-stimulation and have already been instructed for the appropriate type of response. Tissue damage by pathogens upon ...
... memory cells are typically more prompt than primary immune responses (16±24,47,48), because memory cells are more sensitive to low antigen doses, have less stringent requirements for co-stimulation and have already been instructed for the appropriate type of response. Tissue damage by pathogens upon ...
Review Article Bridging Innate and Adaptive Antitumor Immunity
... together with the evidence for immune control over tumor growth, are major arguments in favor of immunotherapy or cancer vaccine approaches. Although the main processes involved in these two aspects of immunity are mostly the same, the context is different. A major difference between microbial pathoge ...
... together with the evidence for immune control over tumor growth, are major arguments in favor of immunotherapy or cancer vaccine approaches. Although the main processes involved in these two aspects of immunity are mostly the same, the context is different. A major difference between microbial pathoge ...
Immune Profiling by High Throughput Sequencing of B and T Cell
... Killer T cells, marked by the surface expression of CD8, recognize short peptides (~8-10 amino acids) presented on the surface of cells by human leukocyte antigen (HLA) Class I molecules(1). Helper T cells, marked by the surface expression of CD4, recognize longer peptides (~12-16 nucleotides) prese ...
... Killer T cells, marked by the surface expression of CD8, recognize short peptides (~8-10 amino acids) presented on the surface of cells by human leukocyte antigen (HLA) Class I molecules(1). Helper T cells, marked by the surface expression of CD4, recognize longer peptides (~12-16 nucleotides) prese ...
CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients , S. Boniface*,
... ABSTRACT: Obliterative bronchiolitis (OB) is the major cause of long-term lung allograft loss resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ ...
... ABSTRACT: Obliterative bronchiolitis (OB) is the major cause of long-term lung allograft loss resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ ...
Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy
... a vehicle to deliver the therapeutic payload to distant tumor sites by protecting them from host immune surveillance as well as preventing the uptake by the off-target organ. Many different cell types have been extensively evaluated as vehicles for oncolytic virotherapy. In this review, we will disc ...
... a vehicle to deliver the therapeutic payload to distant tumor sites by protecting them from host immune surveillance as well as preventing the uptake by the off-target organ. Many different cell types have been extensively evaluated as vehicles for oncolytic virotherapy. In this review, we will disc ...
Alternative Activation Is an Innate Response to Injury That Requires CD4
... cycle of these cells, as well as the cells and mediators that are necessary for the induction and upkeep of AAM!, have not been well characterized beyond a requirement for type 2 cytokines. This is in contrast to the type 1 proinflammatory pathway in which the interplay between innate and adaptive i ...
... cycle of these cells, as well as the cells and mediators that are necessary for the induction and upkeep of AAM!, have not been well characterized beyond a requirement for type 2 cytokines. This is in contrast to the type 1 proinflammatory pathway in which the interplay between innate and adaptive i ...
Hedgehog Signaling and Maintenance of Homeostasis in the
... the crypt and give rise to transit amplifying cells. These cells either move downward to form Paneth cells (only in the small intestine) or upward to form the other intestinal cell lineages. ...
... the crypt and give rise to transit amplifying cells. These cells either move downward to form Paneth cells (only in the small intestine) or upward to form the other intestinal cell lineages. ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.