UvA-DARE (Digital Academic Repository) C
... immunosuppressed patients at risk3. Commensal fungal-derived ligands (i.e. β-1,6-glucans) can also drive chronic clonal expansion of mature B cells, and, in doing so, might contribute to the pathogenesis of B cell chronic lymphocytic leukemia (B-CLL)4. Although largely unrecognized, this view of fun ...
... immunosuppressed patients at risk3. Commensal fungal-derived ligands (i.e. β-1,6-glucans) can also drive chronic clonal expansion of mature B cells, and, in doing so, might contribute to the pathogenesis of B cell chronic lymphocytic leukemia (B-CLL)4. Although largely unrecognized, this view of fun ...
Can the Hair Follicle Become a Model for Studying Selected
... rodent models (of unclear relevance to human eye immunology) and on cultured human eye– derived cells that cannot faithfully mirror the complex cell–tissue interactions that underlie normal human ocular IP in situ. Therefore, accessible, instructive, and clinically relevant human in vitro models are ...
... rodent models (of unclear relevance to human eye immunology) and on cultured human eye– derived cells that cannot faithfully mirror the complex cell–tissue interactions that underlie normal human ocular IP in situ. Therefore, accessible, instructive, and clinically relevant human in vitro models are ...
Activation of a Nonclassical NKT Cell Subset in a Transgenic
... and Ferrari, 1995; Chisari et al., 1987, 1986, 1985; Guidotti et al., 1995). Transgenic mice are tolerant to viral gene products and do not develop liver disease (Wirth et al., 1995). However, adoptive transfer of lymphocytes from syngeneic, HBV-immunized donor mice into such recipients results in b ...
... and Ferrari, 1995; Chisari et al., 1987, 1986, 1985; Guidotti et al., 1995). Transgenic mice are tolerant to viral gene products and do not develop liver disease (Wirth et al., 1995). However, adoptive transfer of lymphocytes from syngeneic, HBV-immunized donor mice into such recipients results in b ...
Molecular profiling of breast cancer cell lines containing amplified
... FGFR signalling The 22 distinct FGFs vary in size from 17-34kDa but all share a conserved sequence of 120 amino acids (Eswarakumar et al. 2005). During embryonic development they are involved in cell proliferation, differentiation and migration. Loss of a single FGF has been shown by homologous rec ...
... FGFR signalling The 22 distinct FGFs vary in size from 17-34kDa but all share a conserved sequence of 120 amino acids (Eswarakumar et al. 2005). During embryonic development they are involved in cell proliferation, differentiation and migration. Loss of a single FGF has been shown by homologous rec ...
Document
... B. Answer b is incorrect. The human genome only has some 30,000 genes, therefore it could not contain a separate gene for every immunoglobulin molecule that is produced in the body. The correct answer is a— C. Answer c is incorrect. Antigen shifting is the process whereby a pathogen is able to “get ...
... B. Answer b is incorrect. The human genome only has some 30,000 genes, therefore it could not contain a separate gene for every immunoglobulin molecule that is produced in the body. The correct answer is a— C. Answer c is incorrect. Antigen shifting is the process whereby a pathogen is able to “get ...
Candida albicans Daniel Gozalbo , Victoria Maneu , María Luisa Gil
... it has been shown that Th17 cell activation also occurs in fungal infections and Th17 cell pathway plays an important regulatory function in promoting protective immunoresponses, particularly in mucocutaenous candidiasis (6, 17, 18). Moreover, the immune system must tolerate colonization with commen ...
... it has been shown that Th17 cell activation also occurs in fungal infections and Th17 cell pathway plays an important regulatory function in promoting protective immunoresponses, particularly in mucocutaenous candidiasis (6, 17, 18). Moreover, the immune system must tolerate colonization with commen ...
Trinity™ Multipotential Cellular Bone Matrix
... and muscle as well as components of the circulatory, excretory, reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in si ...
... and muscle as well as components of the circulatory, excretory, reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in si ...
Targeting lentiviral vectors to specific cell types in vivo
... ene therapy is the introduction of a functional gene into a target cell to provide a therapeutic advantage (1). A particularly desirable gene therapy protocol would be to precisely deliver a gene of interest to specific cells or organs in vivo by means of administration of a designed gene delivery v ...
... ene therapy is the introduction of a functional gene into a target cell to provide a therapeutic advantage (1). A particularly desirable gene therapy protocol would be to precisely deliver a gene of interest to specific cells or organs in vivo by means of administration of a designed gene delivery v ...
Scientific Category: VASCULAR BIOLOGY CEACAM1 myeloid cells
... angiogenesis in leishmaniasis has not been described so far. Here, we show that CD11b+ cells express high levels of the myeloid differentiation antigen carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). In experimental cutaneous leishmaniasis in C57BL/6 wild type (B6.WT) and B6.Cea ...
... angiogenesis in leishmaniasis has not been described so far. Here, we show that CD11b+ cells express high levels of the myeloid differentiation antigen carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). In experimental cutaneous leishmaniasis in C57BL/6 wild type (B6.WT) and B6.Cea ...
Towards a conceptual framework for innate immunity
... much more numerous, including natural killer (NK ) cells, dendritic cells (DC s), and macrophages. The receptors of innate system cells are entirely germlineencoded, in other words their structure is determined by the genome of the cell and has a fixed, genetically-determined specificity. Adaptive i ...
... much more numerous, including natural killer (NK ) cells, dendritic cells (DC s), and macrophages. The receptors of innate system cells are entirely germlineencoded, in other words their structure is determined by the genome of the cell and has a fixed, genetically-determined specificity. Adaptive i ...
The Immune System: Innate and Adaptive Body Defenses
... The respiratory tract mucosae also have structural modifications that counteract potential invaders. Tiny mucus-coated hairs inside the nose trap inhaled particles, and cilia on the mucosa of the upper respiratory tract sweep dust- and bacterialaden mucus toward the mouth, preventing it from enterin ...
... The respiratory tract mucosae also have structural modifications that counteract potential invaders. Tiny mucus-coated hairs inside the nose trap inhaled particles, and cilia on the mucosa of the upper respiratory tract sweep dust- and bacterialaden mucus toward the mouth, preventing it from enterin ...
Neurohormonal-cytokine interactions: Implications for
... Wills-Karp, 2001). The Th2 cytokines IL-4 and IL-13 induce B lymphocytes to express the e-germeline gene transcript, an essential precursor for immunoglobulin heavy chain rearrangement and IgE antibody (Ab) production. IL-5 is selective for eosinophils (Eo) and promotes maturation, activation and pr ...
... Wills-Karp, 2001). The Th2 cytokines IL-4 and IL-13 induce B lymphocytes to express the e-germeline gene transcript, an essential precursor for immunoglobulin heavy chain rearrangement and IgE antibody (Ab) production. IL-5 is selective for eosinophils (Eo) and promotes maturation, activation and pr ...
this PDF file - Cell and Biopharmaceutical Institute
... cells are undifferentiated cells which able to develop into many different cells of types in the body during early life and growth. There are five types of stem cells: embryonic stem cells, induced pluripotent stem cells, somatic stem cells, fetal stem cells and mesenchymal stem cells. Stem cell tra ...
... cells are undifferentiated cells which able to develop into many different cells of types in the body during early life and growth. There are five types of stem cells: embryonic stem cells, induced pluripotent stem cells, somatic stem cells, fetal stem cells and mesenchymal stem cells. Stem cell tra ...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
... single-positive lineage. CD8+ Foxp3+ cells are normally very rare but IL-2 signal transducers Jak3 or STAT5 (ref. 2). However, most evidence can be observed in experimental conditions of thwarted selection of indicates that transforming growth factor-β (TGF-β) is not required the CD4+ lineage16,28,2 ...
... single-positive lineage. CD8+ Foxp3+ cells are normally very rare but IL-2 signal transducers Jak3 or STAT5 (ref. 2). However, most evidence can be observed in experimental conditions of thwarted selection of indicates that transforming growth factor-β (TGF-β) is not required the CD4+ lineage16,28,2 ...
Neisseria gonorrhoeae Variation of Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses
... important receptors that play an active role in the pathogenesis of GC, these proteins should be expressed at the site of GC entry, the female cervix and the male penile urethral tissue. DC-SIGNpos cells have been shown to be present in cervix [26], however it is currently unclear whether MGLpos cel ...
... important receptors that play an active role in the pathogenesis of GC, these proteins should be expressed at the site of GC entry, the female cervix and the male penile urethral tissue. DC-SIGNpos cells have been shown to be present in cervix [26], however it is currently unclear whether MGLpos cel ...
Expression of a dominant negative inhibitor of
... early cleavage stages. At the 32-cell stage in Xenopus, dye transfer activity is related to the plane of bilateral symmetry, and is stronger and more frequently detected among animal hemisphere blastomeres near the future dorsal midline than among ventral cells (Guthrie, 1984). The pattern of commun ...
... early cleavage stages. At the 32-cell stage in Xenopus, dye transfer activity is related to the plane of bilateral symmetry, and is stronger and more frequently detected among animal hemisphere blastomeres near the future dorsal midline than among ventral cells (Guthrie, 1984). The pattern of commun ...
7HealthandImmuneSystem11
... Some activated T cells (killer/ cytotoxic) also can find antigens and then destroy the invader. ...
... Some activated T cells (killer/ cytotoxic) also can find antigens and then destroy the invader. ...
Slides 12.23
... Our immune cells do not attack our own proteins Our cells in another person’s body can trigger an immune response because they are foreign Restricts donors for transplants Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
... Our immune cells do not attack our own proteins Our cells in another person’s body can trigger an immune response because they are foreign Restricts donors for transplants Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
A regulatory dendritic cell signature correlates with the clinical
... Anne Louise, PhD, He France, and Vienna, Austria Background: Given their pivotal role in the polarization of T-cell responses, molecular changes at the level of dendritic cells (DCs) could represent an early signature indicative of the subsequent orientation of adaptive immune responses during immun ...
... Anne Louise, PhD, He France, and Vienna, Austria Background: Given their pivotal role in the polarization of T-cell responses, molecular changes at the level of dendritic cells (DCs) could represent an early signature indicative of the subsequent orientation of adaptive immune responses during immun ...
Autoimmune Destruction of Pancreatic b Cells
... down-regulation of the TH1 immune response and upregulation of the TH2 immune response may be factors in the loss of the ability of T cells in a macrophagedepleted environment to kill b cells.69 T cell proliferation to islet antigens or GAD was significantly decreased when splenocytes from macrophag ...
... down-regulation of the TH1 immune response and upregulation of the TH2 immune response may be factors in the loss of the ability of T cells in a macrophagedepleted environment to kill b cells.69 T cell proliferation to islet antigens or GAD was significantly decreased when splenocytes from macrophag ...
Crosstalk between Red Blood Cells and the Immune System and Its
... atherosclerotic disease progression, via activation or attenuation of inflammatory responses. However, the mechanisms underlying macrophage polarization and activation within the plaque remain unclear [68, 69]. The interactions between macrophages and RBCs are important for RBC clearance and homeost ...
... atherosclerotic disease progression, via activation or attenuation of inflammatory responses. However, the mechanisms underlying macrophage polarization and activation within the plaque remain unclear [68, 69]. The interactions between macrophages and RBCs are important for RBC clearance and homeost ...
Immune recognition and rejection of allogeneic skin grafts
... The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate ...
... The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate ...
Progress in the fight against Inflammatory Diseases and Cancer
... of T lymphocytes to produce a specific cell – called a “T body” (or CAR T-Cell)– that can be used to fight cancer. These genetically-engineered T cells have been shown to effectively kill human tumor cells both in vitro, and in experimental model systems in animals. In preclinical animal models sy ...
... of T lymphocytes to produce a specific cell – called a “T body” (or CAR T-Cell)– that can be used to fight cancer. These genetically-engineered T cells have been shown to effectively kill human tumor cells both in vitro, and in experimental model systems in animals. In preclinical animal models sy ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.