The effect of induced hyperthermia on the
... T-lymphocytes (T-cells) were increased at temperatures of 401C, while incubation at temperatures of 421C caused decreased activities of both ...
... T-lymphocytes (T-cells) were increased at temperatures of 401C, while incubation at temperatures of 421C caused decreased activities of both ...
Gold, M.C., M.W. Munks, M. Wagner, C.W. McMahon, A. Kelly, D.G. Kavanagh, M.K. Slifka, U.H. Koszinowski, D.H. Raulet, and A.B. Hill. 2004. Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response. J Immunol 172:6944-6953.
... long survival in the infected host, it is generally assumed that VIPRs will be necessary for this lifelong survival. In other words, the main phenotype of a VIPR-deficient virus would be predicted to be in the chronic phase of infection. Indeed, VIPR-deficient mutants of the gamma-2-herpesvirus muri ...
... long survival in the infected host, it is generally assumed that VIPRs will be necessary for this lifelong survival. In other words, the main phenotype of a VIPR-deficient virus would be predicted to be in the chronic phase of infection. Indeed, VIPR-deficient mutants of the gamma-2-herpesvirus muri ...
platelet proteins from diabetic subjects cause phenotypic changes in
... physiology the ratio of antithrombitic/prothrombitic molecules always favors antithrombotic nature of ECs. This ratio may be disrupted by hyperactive platelets. Activated platelets express various membrane receptors which are instrumental for platelet-platelet, platelet leukocyte and plateletendothe ...
... physiology the ratio of antithrombitic/prothrombitic molecules always favors antithrombotic nature of ECs. This ratio may be disrupted by hyperactive platelets. Activated platelets express various membrane receptors which are instrumental for platelet-platelet, platelet leukocyte and plateletendothe ...
ABBREVIATIONS ........................................................................... 3 INTRODUCTION............................................................................. 5
... The adaptive immune branch includes B and T cells, which have highly specific antigen receptors on their surface and recognize specific epitopes on pathogens or on soluble molecules. B cells are particularly important in the response against extracellular pathogens by secreting antibodies. T cells c ...
... The adaptive immune branch includes B and T cells, which have highly specific antigen receptors on their surface and recognize specific epitopes on pathogens or on soluble molecules. B cells are particularly important in the response against extracellular pathogens by secreting antibodies. T cells c ...
A dissection of T cell receptor signaling pathways
... Figure 4.2. Flowchart of the procedure for stimulating T cells in the RWV. ............................................... 46 Figure 4.3. Site-specific tyrosine phosphorylation of select TCR signaling molecules. ............................... 53 Figure 4.4. Site-specific tyrosine phosphorylation of ...
... Figure 4.2. Flowchart of the procedure for stimulating T cells in the RWV. ............................................... 46 Figure 4.3. Site-specific tyrosine phosphorylation of select TCR signaling molecules. ............................... 53 Figure 4.4. Site-specific tyrosine phosphorylation of ...
Mycobacterium tuberculosis Infection with Regulatory Mechanisms
... clear that a genetic component exists (22, 23). Nonetheless, a number of theories assert that specific components of the host immune response play the primary role in determining resistance to TB. There may exist a link between the genetic and immune components; however, this study explores the immu ...
... clear that a genetic component exists (22, 23). Nonetheless, a number of theories assert that specific components of the host immune response play the primary role in determining resistance to TB. There may exist a link between the genetic and immune components; however, this study explores the immu ...
O A Immunophenotyping of Lymphocyte Subpopulations and pre-inflammatory mediators in neonatal sepsis
... NK cells was recently found in neonates with sepsis [25]. Adults with severe sepsis showed an increase in NK cells, which provided a survival benefit [7]. NK cells are both targets of interferon-gamma (IFN-γ) action and producers of IFN-γ, and it has been shown that NK cells constitute early sources ...
... NK cells was recently found in neonates with sepsis [25]. Adults with severe sepsis showed an increase in NK cells, which provided a survival benefit [7]. NK cells are both targets of interferon-gamma (IFN-γ) action and producers of IFN-γ, and it has been shown that NK cells constitute early sources ...
Adaptive Immune Responses in the Intestinal Mucosa of
... colitis (LC). Collagenous colitis was first described by the Swedish pathologist C. Lindström in 1976 (1) where he described a case report of a middle-aged woman with chronic diarrhoea whose colonic biopsies showed a sub-epithelial collagen layer comparable to that observed in collagenous sprue. The ...
... colitis (LC). Collagenous colitis was first described by the Swedish pathologist C. Lindström in 1976 (1) where he described a case report of a middle-aged woman with chronic diarrhoea whose colonic biopsies showed a sub-epithelial collagen layer comparable to that observed in collagenous sprue. The ...
Evaluating the efficacy, safety and possible selenium
... Aim. The aim of the study was to evaluate the efficacy, safety and possible mechanism of action of potassium humate loaded with selenium Objectives. The objectives of the study were to evaluate the possible in vitro cytotoxic effect of potassium humate loaded with selenium (Phse) on the growth of pr ...
... Aim. The aim of the study was to evaluate the efficacy, safety and possible mechanism of action of potassium humate loaded with selenium Objectives. The objectives of the study were to evaluate the possible in vitro cytotoxic effect of potassium humate loaded with selenium (Phse) on the growth of pr ...
(cross-)presentation by human blood BDCA3
... state, DCs continuously sample their environment by receptormediated endocytosis, pinocytosis, and phagocytosis. Once DCs also encounter danger signals, such as those present in pathogens, endogenous danger molecules, inflammatory cytokines, or immune complexes, they become activated and migrate to ...
... state, DCs continuously sample their environment by receptormediated endocytosis, pinocytosis, and phagocytosis. Once DCs also encounter danger signals, such as those present in pathogens, endogenous danger molecules, inflammatory cytokines, or immune complexes, they become activated and migrate to ...
Disruption of Dendritic Cell Instruction Virus and Its Avirulent Vaccine
... a combination of maturation stimuli from different sources, which they integrate and translate into different qualities of adaptive T cell responses. Innate lymphocytes, which are already active before the onset of adaptive T cell responses, are crucial for DC maturation. For example, CD1c-restricte ...
... a combination of maturation stimuli from different sources, which they integrate and translate into different qualities of adaptive T cell responses. Innate lymphocytes, which are already active before the onset of adaptive T cell responses, are crucial for DC maturation. For example, CD1c-restricte ...
A Model to Predict Cell-Mediated Immune
... clear that a genetic component exists (22, 23). Nonetheless, a number of theories assert that specific components of the host immune response play the primary role in determining resistance to TB. There may exist a link between the genetic and immune components; however, this study explores the immu ...
... clear that a genetic component exists (22, 23). Nonetheless, a number of theories assert that specific components of the host immune response play the primary role in determining resistance to TB. There may exist a link between the genetic and immune components; however, this study explores the immu ...
Vaccine immunology - World Health Organization
... represents a significant challenge for the development of specific vaccines such as against HIV-1.14 Current vaccines mostly mediate protection through the induction of highly specific IgG serum antibodies (Table 2–2). Under certain circumstances, however, passive antibodymediated immunity is inefficien ...
... represents a significant challenge for the development of specific vaccines such as against HIV-1.14 Current vaccines mostly mediate protection through the induction of highly specific IgG serum antibodies (Table 2–2). Under certain circumstances, however, passive antibodymediated immunity is inefficien ...
A robust, high-throughput assay to determine the phagocytic activity
... inhibitory), and FcγR3 (low affinity, activating). Thus, FcRs for IgG antibodies include both high and low affinity, as well as activating and inhibitory receptors, each of which may have differential affinities for various IgG glycoforms, and may be expressed at different levels on different cell t ...
... inhibitory), and FcγR3 (low affinity, activating). Thus, FcRs for IgG antibodies include both high and low affinity, as well as activating and inhibitory receptors, each of which may have differential affinities for various IgG glycoforms, and may be expressed at different levels on different cell t ...
Proliferation T Cell + Nonredundantly Stimulates CD8
... homeostasis. IL-7 is critical for T lymphopoiesis and promotes survival of naive, activated, and memory T cells (3), while IL-15 selectively promotes proliferative renewal of activated/memory CD8⫹ T cells (4). The role of IL-2 is more complex. IL-2- and IL-2R␣-deficient mice develop T lymphoprolifer ...
... homeostasis. IL-7 is critical for T lymphopoiesis and promotes survival of naive, activated, and memory T cells (3), while IL-15 selectively promotes proliferative renewal of activated/memory CD8⫹ T cells (4). The role of IL-2 is more complex. IL-2- and IL-2R␣-deficient mice develop T lymphoprolifer ...
Nowrin
... The neonate, whether premature or of normal gestational age, is a unique host from an immunologic perspective. Many components of the immune system funct ion less well in neonates compared with adults, giving rise to the concept of an "immunodeficiency of immaturity"{Schelonka, 1998 #290}, although ...
... The neonate, whether premature or of normal gestational age, is a unique host from an immunologic perspective. Many components of the immune system funct ion less well in neonates compared with adults, giving rise to the concept of an "immunodeficiency of immaturity"{Schelonka, 1998 #290}, although ...
Th2 Cytokines Down-Regulate TLR Expression and Function
... adaptive immune responses upon stimulation with their specific ligands (1). Primary human intestinal epithelial cells (IECs)3 and model IEC lines express membrane-associated and cytoplasmic TLRs and their associated molecules (2–5), which establish an effective double line of innate immune defense a ...
... adaptive immune responses upon stimulation with their specific ligands (1). Primary human intestinal epithelial cells (IECs)3 and model IEC lines express membrane-associated and cytoplasmic TLRs and their associated molecules (2–5), which establish an effective double line of innate immune defense a ...
Epithelial antimicrobial peptides and proteins: their role in
... Recruitment of leukocytes is an essential element in the defence against infections. It results in the influx of phagocytes which ingest and kill the invading microorganisms and includes cells, essential in the initiation and propagation of a specific immune response. Inflammatory cells may cause ti ...
... Recruitment of leukocytes is an essential element in the defence against infections. It results in the influx of phagocytes which ingest and kill the invading microorganisms and includes cells, essential in the initiation and propagation of a specific immune response. Inflammatory cells may cause ti ...
The dynamics of T cells during persistent Staphylococcus aureus
... Adaptive immune response is required for an efficient containment of S. aureus during a persistent infection We (von Köckritz-Blickwede et al, 2008) and others (Mölne et al, 2000; Verdrengh & Tarkowski, 1997) have shown that neutrophil recruitment is critical for effective control of bacterial gro ...
... Adaptive immune response is required for an efficient containment of S. aureus during a persistent infection We (von Köckritz-Blickwede et al, 2008) and others (Mölne et al, 2000; Verdrengh & Tarkowski, 1997) have shown that neutrophil recruitment is critical for effective control of bacterial gro ...
Strategies and Implications for Prime
... vaccination, since this number strongly correlates with host protection [5, 27, 34]. Currently, the best approach known to generate these high numbers of cells is to utilize a system of prime-boost vaccination, which relies on the re-stimulation of antigenspecific immune cells following primary memo ...
... vaccination, since this number strongly correlates with host protection [5, 27, 34]. Currently, the best approach known to generate these high numbers of cells is to utilize a system of prime-boost vaccination, which relies on the re-stimulation of antigenspecific immune cells following primary memo ...
Immunity to brucellosis
... (NK) cells, natural killer T (NKT) cells and γδ T cells. In comparison with conventional antigen-specific T cells (αβTCR CD4+ and CD8+ T lymphocytes), they are a smaller proportion of peripheral blood cell populations and recognise non-peptidic antigens (glycolipids and phospholipids) without MHC re ...
... (NK) cells, natural killer T (NKT) cells and γδ T cells. In comparison with conventional antigen-specific T cells (αβTCR CD4+ and CD8+ T lymphocytes), they are a smaller proportion of peripheral blood cell populations and recognise non-peptidic antigens (glycolipids and phospholipids) without MHC re ...
Myelin Recovery in Multiple Sclerosis: The Challenge of
... in the adult CNS. In the adult brain and spinal cord, OPCs are ubiquitous and represent a large percentage of the total cell population, as much as 9% of cells in white matter and 3% in gray matter [35,36]. Although both processes share many similarities, and the study of developmental myelination c ...
... in the adult CNS. In the adult brain and spinal cord, OPCs are ubiquitous and represent a large percentage of the total cell population, as much as 9% of cells in white matter and 3% in gray matter [35,36]. Although both processes share many similarities, and the study of developmental myelination c ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.