Commercial Poultry Production and Feed Additives
... Strong immune response with enhance resistance of poultry to infectious diseases Highly effective in reducing toxicity of metals such as silver, arsenic and lead, and shows slight effects against cadmium and mercury toxicity(E) ...
... Strong immune response with enhance resistance of poultry to infectious diseases Highly effective in reducing toxicity of metals such as silver, arsenic and lead, and shows slight effects against cadmium and mercury toxicity(E) ...
Negative Regulation of Toll-Like Receptor Signaling by
... was unable to bind to DNA (Fig. 3C) but retained the ability to interact with p65 and Bcl-3 (fig. S5). Ubiquitination of p50Y57A,G60D was dramatically reduced compared with that of WT p50 (Fig. 3D). This was associated with a significant increase in p50Y57A,G60D half-life (Fig. 3E). Taken together, ...
... was unable to bind to DNA (Fig. 3C) but retained the ability to interact with p65 and Bcl-3 (fig. S5). Ubiquitination of p50Y57A,G60D was dramatically reduced compared with that of WT p50 (Fig. 3D). This was associated with a significant increase in p50Y57A,G60D half-life (Fig. 3E). Taken together, ...
Biological Inventions
... A plant wherein a toxin gene having a base sequence of ATGACT･･････ is inserted and the said gene is expressed. Example 3: A transgenic non-human mammal, having a recombinant DNA obtained by linking a structural gene encoding any protein to the regulatory region of a gene involved in the production ...
... A plant wherein a toxin gene having a base sequence of ATGACT･･････ is inserted and the said gene is expressed. Example 3: A transgenic non-human mammal, having a recombinant DNA obtained by linking a structural gene encoding any protein to the regulatory region of a gene involved in the production ...
Document
... mountains with high humidity and low light. • The spores of Reishi have such tough outer husks that germination is next to impossible, which accounts for its rarity. ...
... mountains with high humidity and low light. • The spores of Reishi have such tough outer husks that germination is next to impossible, which accounts for its rarity. ...
Locally delivered polyclonal antibodies potentiate the efficacy
... pathogen can be significantly increased, they remain finite and microcidal in vitro at elevated doses. Clinically, however, these doses may be toxic, precluding use. Given the limited genomic and metabolic capacity of many pathogens, genetic acquisition of resistance against a specific antibiotic ma ...
... pathogen can be significantly increased, they remain finite and microcidal in vitro at elevated doses. Clinically, however, these doses may be toxic, precluding use. Given the limited genomic and metabolic capacity of many pathogens, genetic acquisition of resistance against a specific antibiotic ma ...
Marginal zone B-cells, a gatekeeper of innate
... subset in priming splenic T-cells and the subsequent development of T-cell-dependent IgG responses during infection. Recent studies suggest that in addition to TLR signaling in DCs, direct TLR-mediated activation of B-cells is also required for eliciting humoral immune responses. Thus, murine B-cell ...
... subset in priming splenic T-cells and the subsequent development of T-cell-dependent IgG responses during infection. Recent studies suggest that in addition to TLR signaling in DCs, direct TLR-mediated activation of B-cells is also required for eliciting humoral immune responses. Thus, murine B-cell ...
A Cyclin A-Protein Kinase Complex Possesses
... There are some indications that cyclin A, originally identified as a mitotic cyclin, may function in S phase. In mammalian cells, the cyclin A protein and its associated kinase activity appear during S phase, do not show as dramatic a peak in mitosis as cyclin B, and disappear prior to the disappear ...
... There are some indications that cyclin A, originally identified as a mitotic cyclin, may function in S phase. In mammalian cells, the cyclin A protein and its associated kinase activity appear during S phase, do not show as dramatic a peak in mitosis as cyclin B, and disappear prior to the disappear ...
Platelet-derived CD154 enables T-cell priming and
... platelets appear to be necessary for optimal CD8 T-cell responses to Ad5-mOVA, further studies were performed in the collagen model to determine whether collagen-induced enhancement of CD8 T-cell function was mediated by platelets. Mice whose platelets cannot be activated by collagen were immunized ...
... platelets appear to be necessary for optimal CD8 T-cell responses to Ad5-mOVA, further studies were performed in the collagen model to determine whether collagen-induced enhancement of CD8 T-cell function was mediated by platelets. Mice whose platelets cannot be activated by collagen were immunized ...
Targeting of Proteins to the Outer Envelope Membrane Uses a
... import of nuclear-encodedchloroplastic proteins into chloroplasts, as described above. The envelope plays a major role in the biosynthesis of various lipids including galactolipids, the predominant lipids in chloroplastic membranes (Douce and Joyard, 1990). Therefore, knowledge about the chloroplast ...
... import of nuclear-encodedchloroplastic proteins into chloroplasts, as described above. The envelope plays a major role in the biosynthesis of various lipids including galactolipids, the predominant lipids in chloroplastic membranes (Douce and Joyard, 1990). Therefore, knowledge about the chloroplast ...
MHC Molecules
... Complex (MHC) • In all vertebrates there is a genetic region that has a major influence on graft survival • This region is referred to as the Major Histocompatibility Complex (MHC) • Individuals identical for this region can exchange grafts more successfully than MHC non-identical combinations • Unl ...
... Complex (MHC) • In all vertebrates there is a genetic region that has a major influence on graft survival • This region is referred to as the Major Histocompatibility Complex (MHC) • Individuals identical for this region can exchange grafts more successfully than MHC non-identical combinations • Unl ...
immunology syllabus 2013 - The University of Texas Medical School
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
Antigen-non-specific regulation centered on CD25+Foxp3+
... immune responses, but this negative feedback may be unable to detect an excessive response that threatens to cause self-destruction. Here, we propose that antigen-non-specific interplay between Tregs and Teffs is one of the three most important mechanisms for preventing self-inflicted damage. First, ...
... immune responses, but this negative feedback may be unable to detect an excessive response that threatens to cause self-destruction. Here, we propose that antigen-non-specific interplay between Tregs and Teffs is one of the three most important mechanisms for preventing self-inflicted damage. First, ...
Review of existing experimental methods for assessing the outcome
... pathogens, often under varying environmental (e.g. seasonal changes) or physiological (e.g. stress) conditions. The functions of the immune system are categorised into two major components, innate response and adaptive response, each of which is classified according to the speed and specificity of t ...
... pathogens, often under varying environmental (e.g. seasonal changes) or physiological (e.g. stress) conditions. The functions of the immune system are categorised into two major components, innate response and adaptive response, each of which is classified according to the speed and specificity of t ...
B-cell depletion inhibits arthritis in a collagen
... depletion in patients with autoimmune disorders.20,25 At present, the mechanism by which removal of pathogenic B cells and their precursors, but not antibody-secreting plasma cells, leads to clinical improvement remains elusive.20 Given that B cells exist as lymphoid aggregates within the synovium o ...
... depletion in patients with autoimmune disorders.20,25 At present, the mechanism by which removal of pathogenic B cells and their precursors, but not antibody-secreting plasma cells, leads to clinical improvement remains elusive.20 Given that B cells exist as lymphoid aggregates within the synovium o ...
A Novel Size-Based Sorting Mechanism of Pinocytic Luminal
... Province, Zhejiang School of Medicine, Hangzhou 310058, China, E-mail: [email protected] or [email protected]. DOI:10.1523/JNEUROSCI.4389-14.2015 Copyright © 2015 the authors 0270-6474/15/352674-15$15.00/0 ...
... Province, Zhejiang School of Medicine, Hangzhou 310058, China, E-mail: [email protected] or [email protected]. DOI:10.1523/JNEUROSCI.4389-14.2015 Copyright © 2015 the authors 0270-6474/15/352674-15$15.00/0 ...
Cytokine responses in human Lyme borreliosis
... midgut tissue but the proteins were not necessary for infection, dissemination or pathogenesis in mice (Yang et al. 2004). In contrast, OspC is important for infection shown by a OspC-deficient B. burgdorferi s. l. inability to infect mice (Grimm et al. 2004). The heterogeneity of the different prot ...
... midgut tissue but the proteins were not necessary for infection, dissemination or pathogenesis in mice (Yang et al. 2004). In contrast, OspC is important for infection shown by a OspC-deficient B. burgdorferi s. l. inability to infect mice (Grimm et al. 2004). The heterogeneity of the different prot ...
PDF - University of California, San Francisco
... proteolysis experiments that separate the 97-kilodalton enzyme into two domains, an NHz-terminal membrane-bounddomainof 339 residues and a COOHterminal water-soluble domain of 548 residues that projects into the cytoplasm and contains the catalytic site. These domains were identified by reaction wit ...
... proteolysis experiments that separate the 97-kilodalton enzyme into two domains, an NHz-terminal membrane-bounddomainof 339 residues and a COOHterminal water-soluble domain of 548 residues that projects into the cytoplasm and contains the catalytic site. These domains were identified by reaction wit ...
The testis in immune privilege
... spermatocytes move through the junctional complex by a coordinated opening and closing of the barrier (74). Interestingly, as JAMs play a crucial role in leukocyte transmigration (75), it is tempting to speculate that they perform a similar role in the testis by facilitating the transfer of leptoten ...
... spermatocytes move through the junctional complex by a coordinated opening and closing of the barrier (74). Interestingly, as JAMs play a crucial role in leukocyte transmigration (75), it is tempting to speculate that they perform a similar role in the testis by facilitating the transfer of leptoten ...
Biological significance of structural differences between two highly
... (Fig. 1A), because it lies in proximity to a.a. 116–129 in the Uev1 molecular structure (Fig. 1C). The Uev1D30-F104S single amino acid substitution abrogated binding by LN2A, but did not affect ...
... (Fig. 1A), because it lies in proximity to a.a. 116–129 in the Uev1 molecular structure (Fig. 1C). The Uev1D30-F104S single amino acid substitution abrogated binding by LN2A, but did not affect ...
The role of peanut-specific T cell
... memory Th cells. These differences are specific for peanut responses since we could not see any difference between PA and NA responses to a control food antigen (ovalbumin): in these donors control responses show no clear subset predominance of skin-homing or gut-homing memory Th cells. This result ...
... memory Th cells. These differences are specific for peanut responses since we could not see any difference between PA and NA responses to a control food antigen (ovalbumin): in these donors control responses show no clear subset predominance of skin-homing or gut-homing memory Th cells. This result ...
HIS-Select Nickel Affinity Gel (P6611) - Technical - Sigma
... 6. Wash the affinity gel two times with at least 500 µl of Wash Buffer without imidazole. Gently mix the affinity gel for 10 seconds, then centrifuge for 30 seconds at 5,000 × g. Save the Wash Buffer solutions for analysis either as a single pool or three fractions. 7. Elute the target protein with ...
... 6. Wash the affinity gel two times with at least 500 µl of Wash Buffer without imidazole. Gently mix the affinity gel for 10 seconds, then centrifuge for 30 seconds at 5,000 × g. Save the Wash Buffer solutions for analysis either as a single pool or three fractions. 7. Elute the target protein with ...
The Amino Acid Sequences of the Myelin
... third of the MAG polypeptide. This fusion protein was used in an epitope selection experiment (61), in which antibodies that specifically cross-reacted with the M10 fusion protein (immobilized on nitrocellulose paper) were isolated from the polyclonal MAG antiserum. The reactivity of the affinitypur ...
... third of the MAG polypeptide. This fusion protein was used in an epitope selection experiment (61), in which antibodies that specifically cross-reacted with the M10 fusion protein (immobilized on nitrocellulose paper) were isolated from the polyclonal MAG antiserum. The reactivity of the affinitypur ...
The importance of the type I interferon system in autoimmunity
... transcription factors Stat1 and Stat2, which finally associate with interferon regulatory factor 9 (IRF-9). The Stat1/ Stat2/IRF-9 complex translocates to the nucleus and binds to IFN-stimulated response elements (ISRE) and induces the IFN signature. Besides the antiviral properties, type I IFN infl ...
... transcription factors Stat1 and Stat2, which finally associate with interferon regulatory factor 9 (IRF-9). The Stat1/ Stat2/IRF-9 complex translocates to the nucleus and binds to IFN-stimulated response elements (ISRE) and induces the IFN signature. Besides the antiviral properties, type I IFN infl ...
transplantation - Shandong University
... • Graft versus host disease (GVHD) – A disease caused by GVHR, which can damage the host 2006-7year ...
... • Graft versus host disease (GVHD) – A disease caused by GVHR, which can damage the host 2006-7year ...
immunosuppressive drugs after solid organ transplantation
... in the early 1990s.27 MMF is a prodrug that is rapidly metabolised to its active metabolite mycophenolic acid. A few years ago, mycophenolic acid also became available directly as Myfortic®. MMF inhibits lymphocyte function by blocking purine biosynthesis via inhibition of the enzyme inosine monopho ...
... in the early 1990s.27 MMF is a prodrug that is rapidly metabolised to its active metabolite mycophenolic acid. A few years ago, mycophenolic acid also became available directly as Myfortic®. MMF inhibits lymphocyte function by blocking purine biosynthesis via inhibition of the enzyme inosine monopho ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.