The autoimmunity of primary biliary cirrhosis and the clonal
... Morgagni in 1761 and the earliest report of non-obstructive biliary cirrhosis is attributed to Addison and Gull in 1851.5 The disease was put on the map clinically by Ahrens et al in 1950.6 Serum ‘antitissue’ autoantibodies were described in 1959 and PBC was nominated as an autoimmune disease in 196 ...
... Morgagni in 1761 and the earliest report of non-obstructive biliary cirrhosis is attributed to Addison and Gull in 1851.5 The disease was put on the map clinically by Ahrens et al in 1950.6 Serum ‘antitissue’ autoantibodies were described in 1959 and PBC was nominated as an autoimmune disease in 196 ...
Induction of CDPK (ZmCPK11)- and MAPK
... sequence data obtained from purified Z. mays 56-kDa CDPK the corresponding cDNA was cloned. The clone was designated as ZmCPK11. Expression of ZmCPK11 was found to be induced by wounding not only in injured but also in non-injured neighboring leaves (Szczegielniak et al. 2005). The physiological rol ...
... sequence data obtained from purified Z. mays 56-kDa CDPK the corresponding cDNA was cloned. The clone was designated as ZmCPK11. Expression of ZmCPK11 was found to be induced by wounding not only in injured but also in non-injured neighboring leaves (Szczegielniak et al. 2005). The physiological rol ...
Characterization of somatic antigens of adult
... rTES-30USM) [13]. Presently a Dot-ELISA test for toxocarosis is under evaluation which is considered as a reliable one as it presents many advantages as a basic diagnostic test. For example, it is highly stable, it does not require specialised tools to analyse the results, it has a lower cost and it ...
... rTES-30USM) [13]. Presently a Dot-ELISA test for toxocarosis is under evaluation which is considered as a reliable one as it presents many advantages as a basic diagnostic test. For example, it is highly stable, it does not require specialised tools to analyse the results, it has a lower cost and it ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren
... correlated with the expression of cytolytic molecules in the cell lines tested. Anti-granulysin antibodies reversed γδT cell-mediated inhibition, suggesting a role for granulysin in the parasite growth inhibition. Thus, our data suggest that Vγ9/Vδ2+ γδT cells inhibit the parasite growth by a granul ...
... correlated with the expression of cytolytic molecules in the cell lines tested. Anti-granulysin antibodies reversed γδT cell-mediated inhibition, suggesting a role for granulysin in the parasite growth inhibition. Thus, our data suggest that Vγ9/Vδ2+ γδT cells inhibit the parasite growth by a granul ...
Chapter 16
... for HIV and the centre-pole is likely to depend very strongly on the initial conditions, and it may be similar for two individuals, if they have similar backgrounds of antigenic exposures, and one of them is infected by the other. At the population level, this could account for stable differences be ...
... for HIV and the centre-pole is likely to depend very strongly on the initial conditions, and it may be similar for two individuals, if they have similar backgrounds of antigenic exposures, and one of them is infected by the other. At the population level, this could account for stable differences be ...
Chapter 16
... for HIV and the centre-pole is likely to depend very strongly on the initial conditions, and it may be similar for two individuals, if they have similar backgrounds of antigenic exposures, and one of them is infected by the other. At the population level, this could account for stable differences be ...
... for HIV and the centre-pole is likely to depend very strongly on the initial conditions, and it may be similar for two individuals, if they have similar backgrounds of antigenic exposures, and one of them is infected by the other. At the population level, this could account for stable differences be ...
Lecture Notes for Methods in Cell Biology
... acids and recombinant DNA. The first section will cover some basic biochemical procedures and equipment. Understanding these basic biochemical principals will assist in the subsequent discussions on proteins and nucleic acids. The section on characterization of proteins will describe some basic meth ...
... acids and recombinant DNA. The first section will cover some basic biochemical procedures and equipment. Understanding these basic biochemical principals will assist in the subsequent discussions on proteins and nucleic acids. The section on characterization of proteins will describe some basic meth ...
Mechanisms of Maternal Immune Tolerance During
... cells in the mouse. In this study, splenic T cells with a helper phenotype obtained from primiparous CBA/J mice pregnant by syngeneic matings were found to proliferate in response to co-culture with fetal thymus cells. Maternal anti-fetal lymphoproliferative responses were also shown to be blocked b ...
... cells in the mouse. In this study, splenic T cells with a helper phenotype obtained from primiparous CBA/J mice pregnant by syngeneic matings were found to proliferate in response to co-culture with fetal thymus cells. Maternal anti-fetal lymphoproliferative responses were also shown to be blocked b ...
Serologic Analysis of the IgG Antibody Response in
... in contrast to wild-type infection, the vaccine probably does not confer lifelong immunity5; thus, booster immunization may be necessary in the adult population to prevent varicella outbreaks. Unfortunately, there is currently no reliable serodiagnostic test available that can differentiate between ...
... in contrast to wild-type infection, the vaccine probably does not confer lifelong immunity5; thus, booster immunization may be necessary in the adult population to prevent varicella outbreaks. Unfortunately, there is currently no reliable serodiagnostic test available that can differentiate between ...
to download. - Legacy For Life
... colostrum, even those colostrums taken from the first milking. Egg, in general, is more concentrated in antibodies and immune regulatory cofactors than colostrum. Chickens produce almost 20 times more antibodies per unit than cows are able to secret in their milk. Egg antibodies have also been prove ...
... colostrum, even those colostrums taken from the first milking. Egg, in general, is more concentrated in antibodies and immune regulatory cofactors than colostrum. Chickens produce almost 20 times more antibodies per unit than cows are able to secret in their milk. Egg antibodies have also been prove ...
PC235: 2008 Lecture 5 Quantitation
... •If you perform MRM analysis of isotopically labeled (light and heavy) peptides can perform quantitation analysis at very high sensitivity. •With a calibration curve of amount vs intensity, can approximate absolute ...
... •If you perform MRM analysis of isotopically labeled (light and heavy) peptides can perform quantitation analysis at very high sensitivity. •With a calibration curve of amount vs intensity, can approximate absolute ...
Palmitic Acid Activation of Dendritic Cells
... time, money, energy, ideas, support, passion, and sacrifice you have invested and poured into me to make me a great scientist. I will continually work to make you, my mentors proud, and to strive to attain the potential that you see in me. I would also like to thank my committee members for their gu ...
... time, money, energy, ideas, support, passion, and sacrifice you have invested and poured into me to make me a great scientist. I will continually work to make you, my mentors proud, and to strive to attain the potential that you see in me. I would also like to thank my committee members for their gu ...
High dose intravenous immunoglobulin treatment: Mechanisms of
... binding and modification of effector functions. Antigen binding is mediated via immune antibodies and a wide spectrum of autoantibodies. The effector functions include modulation of expression and function of Fc receptors, complement activation, complement binding, anti-inflammatory effects ensuing fr ...
... binding and modification of effector functions. Antigen binding is mediated via immune antibodies and a wide spectrum of autoantibodies. The effector functions include modulation of expression and function of Fc receptors, complement activation, complement binding, anti-inflammatory effects ensuing fr ...
WHEY PROTEINS AND IMMUNITY
... response. Based on the available literature, it appears that whey proteins are most effective at optimizing this key aspect of specific immunity.14 Some studies that have examined the effects of different proteins on cell-meditated immunity have shown a beneficial impact from whey proteins.64 In mic ...
... response. Based on the available literature, it appears that whey proteins are most effective at optimizing this key aspect of specific immunity.14 Some studies that have examined the effects of different proteins on cell-meditated immunity have shown a beneficial impact from whey proteins.64 In mic ...
Section 1 Nonspecific Defenses
... the respiratory tract. The virus has begun to infect and kill your cells. At this point, macrophages begin to engulf and destroy the virus. An infected body cell will display antigens of an invader on its surface. An antigen (AN tih jihn) is a substance that triggers an immune response. Antigens typ ...
... the respiratory tract. The virus has begun to infect and kill your cells. At this point, macrophages begin to engulf and destroy the virus. An infected body cell will display antigens of an invader on its surface. An antigen (AN tih jihn) is a substance that triggers an immune response. Antigens typ ...
Poster Abstracts - Midwinter Conference of Immunologists
... the surrounding microenvironment. These signals include cytokines and exosomes, which may change the phenotype of macrophages. Classically-activated macrophages, known for their M1 phenotype, are responsible for activating pro-inflammatory immune responses. Alternatively-activated macrophages, or M2 ...
... the surrounding microenvironment. These signals include cytokines and exosomes, which may change the phenotype of macrophages. Classically-activated macrophages, known for their M1 phenotype, are responsible for activating pro-inflammatory immune responses. Alternatively-activated macrophages, or M2 ...
Vaccination with recombinant fusion proteins incorporating Toll
... thereby serve as the link between the innate and adaptive immune response [13–15]. In this study we have examined the ability of recombinant antigen-PAMP fusion proteins to elicit more immunogenic responses in vivo. Flagellin is a highly conserved bacterial protein that elicits TLR5-dependent inflam ...
... thereby serve as the link between the innate and adaptive immune response [13–15]. In this study we have examined the ability of recombinant antigen-PAMP fusion proteins to elicit more immunogenic responses in vivo. Flagellin is a highly conserved bacterial protein that elicits TLR5-dependent inflam ...
Arthritis Res. Ther. 13:R129 - Centre for Microbial Diseases and
... the pathogenesis of the disease [21]. Efficacious therapeutic strategies have been developed to target each of these cytokines. Despite this, a major consideration regarding therapeutic agents targeting inflammatory cytokines such as TNF-a is the increased associated risk of infections and neoplasm ...
... the pathogenesis of the disease [21]. Efficacious therapeutic strategies have been developed to target each of these cytokines. Despite this, a major consideration regarding therapeutic agents targeting inflammatory cytokines such as TNF-a is the increased associated risk of infections and neoplasm ...
How some mycoplasmas evade host immune responses. Microbe 2
... may result from blebbing of mycoplasmal cell membrane into this space. When observed by phase and transmission electron microscopy (TEM), mycoplasmal cells form filaments and other cellular protrusions (Fig. 2B). Membrane constrictions could lead to shedding of membranous blebs from the mycoplasma. ...
... may result from blebbing of mycoplasmal cell membrane into this space. When observed by phase and transmission electron microscopy (TEM), mycoplasmal cells form filaments and other cellular protrusions (Fig. 2B). Membrane constrictions could lead to shedding of membranous blebs from the mycoplasma. ...
Photosynthesis genes in marine viruses yield proteins during host
... to light-induced damage10; thus, its de novo synthesis is required for sustained photosynthesis 10. High-light-inducible proteins (HLIPs) protect the photosynthetic apparatus from photodamage by dissipating excess light energy11. Numerous cyanophages contain photosynthesis genes (psbA and at least o ...
... to light-induced damage10; thus, its de novo synthesis is required for sustained photosynthesis 10. High-light-inducible proteins (HLIPs) protect the photosynthetic apparatus from photodamage by dissipating excess light energy11. Numerous cyanophages contain photosynthesis genes (psbA and at least o ...
Chapter 1: Induction Therapy
... compared with lymphocyte-depleting agents (nine RCTs, n = 1166, RR 1.27, 1.00–1.61), but the risk of graft loss (12 RCTs, n = 1430, RR 1.10, 0.73–1.65), and mortality was not significantly different (13 RCTs, n = 1670, RR 1.28, 0.74–2.20). Compared with lymphocyte-depleting agents, the risk of CMV i ...
... compared with lymphocyte-depleting agents (nine RCTs, n = 1166, RR 1.27, 1.00–1.61), but the risk of graft loss (12 RCTs, n = 1430, RR 1.10, 0.73–1.65), and mortality was not significantly different (13 RCTs, n = 1670, RR 1.28, 0.74–2.20). Compared with lymphocyte-depleting agents, the risk of CMV i ...
A hemolysis–hemagglutination assay for characterizing
... Assessment of immune function in free-living vertebrates is emerging as an important tool in evolutionary and ecological research. The types of assays that can be employed with wild animals, however, are constrained by the stress that results from capture and handling, the unreliability of recapturi ...
... Assessment of immune function in free-living vertebrates is emerging as an important tool in evolutionary and ecological research. The types of assays that can be employed with wild animals, however, are constrained by the stress that results from capture and handling, the unreliability of recapturi ...
Immunology and Evolution of Infectious Disease
... I start at the most basic level, the nature of binding and recognition between host and parasite molecules. I summarize the many different ways in which parasites generate new variants in order to escape molecular recognition. Next, I build up the individual molecular interactions into the dynamics o ...
... I start at the most basic level, the nature of binding and recognition between host and parasite molecules. I summarize the many different ways in which parasites generate new variants in order to escape molecular recognition. Next, I build up the individual molecular interactions into the dynamics o ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.