Survival strategies of Borrelia burgdorferi, the etiologic agent of
... in disease-susceptible animals [19]. These studies suggested that disease susceptibility may be influenced more by lymphocyte hyporesponsiveness to IL-10 than by sheer production of this cytokine (by lymph node cells) in the presence of B. burgdorferi [19,20]. 2.3. Immune complexes B. burgdorferi ma ...
... in disease-susceptible animals [19]. These studies suggested that disease susceptibility may be influenced more by lymphocyte hyporesponsiveness to IL-10 than by sheer production of this cytokine (by lymph node cells) in the presence of B. burgdorferi [19,20]. 2.3. Immune complexes B. burgdorferi ma ...
Separation of Recombinant Human Erythropoietin (rEPO
... Recombinant human EPO protein is one of the most widely produced by many bio and pharmaceutical companies throughout the world for therapeutic agents. Erythropoietin protein (EPO) is a glycoprotein hormone found in plasma. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marr ...
... Recombinant human EPO protein is one of the most widely produced by many bio and pharmaceutical companies throughout the world for therapeutic agents. Erythropoietin protein (EPO) is a glycoprotein hormone found in plasma. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marr ...
Activators - U of M wiki
... different pathways including the initiators, sequence of reactions, important enzymes, and fragments. List the proteins which control the complement system and where they act. ...
... different pathways including the initiators, sequence of reactions, important enzymes, and fragments. List the proteins which control the complement system and where they act. ...
Naked RNA immunization with replicons derived from poliovirus and
... contain gene sequences encoding a foreign protein. Immunization with naked DNA vectors encoding the influenza virus NP has been shown to induce antibodies, cellular responses and protection against both homologous and crossstrain challenge infection by influenza A virus variants (Bot et al., 1996 ; ...
... contain gene sequences encoding a foreign protein. Immunization with naked DNA vectors encoding the influenza virus NP has been shown to induce antibodies, cellular responses and protection against both homologous and crossstrain challenge infection by influenza A virus variants (Bot et al., 1996 ; ...
of innate immunity
... Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA. ...
... Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA. ...
Antibody–drug conjugates nonclinical support: from early to late
... associated with its own set of challenges such as the selection of appropriate anticoagulant from the list of available anticoagulants such as EDTA, heparin or sodium citrate; the appropriate volume of blood collected in collection tubes to ensure optimum blood/anticoagulant ratio; and the freeze–th ...
... associated with its own set of challenges such as the selection of appropriate anticoagulant from the list of available anticoagulants such as EDTA, heparin or sodium citrate; the appropriate volume of blood collected in collection tubes to ensure optimum blood/anticoagulant ratio; and the freeze–th ...
Carcinoembryonic Antigens - The Journal of Cell Biology
... set of four alternatively spliced mRNAs which are expressed in several tumor cell lines, in human fetal liver, and in L-cell transfectants. Deduced amino acid sequences of the encoded isoantigens show extensive similarity to CEA and nonspecific cross-reacting antigens, but in addition demonstrate tr ...
... set of four alternatively spliced mRNAs which are expressed in several tumor cell lines, in human fetal liver, and in L-cell transfectants. Deduced amino acid sequences of the encoded isoantigens show extensive similarity to CEA and nonspecific cross-reacting antigens, but in addition demonstrate tr ...
Old and new vaccine approaches
... protein component(s) that lead to protective effect. Such protective proteins have, in some cases, been isolated from the organism, either secreted, as in the case of toxins, or extracted and isolated from the organism after its disruption, e.g. influenza surface antigens, and served as vaccines. Al ...
... protein component(s) that lead to protective effect. Such protective proteins have, in some cases, been isolated from the organism, either secreted, as in the case of toxins, or extracted and isolated from the organism after its disruption, e.g. influenza surface antigens, and served as vaccines. Al ...
Thymosin α1 accelerates restoration of T cell
... is related to the restoration of CD4q T cells. Thymosin a 1 was reported to have significant potentiating effects on thymocyte maturation as shown in Figs. 2 and 3 and immunologic functions which include promotion of IFN-g , interleukin-2 and interleukin-2 receptor production, enhanced proliferation ...
... is related to the restoration of CD4q T cells. Thymosin a 1 was reported to have significant potentiating effects on thymocyte maturation as shown in Figs. 2 and 3 and immunologic functions which include promotion of IFN-g , interleukin-2 and interleukin-2 receptor production, enhanced proliferation ...
Autoimmunity to glomerular antigens in
... [l8], and mesangial IgA deposits are usually clinically silent in hepatic cirrhosis and coeliac disease [19,20]. These anomalies have focused attention on other factors, such as a role for an antigen in immune aggregates in sera, and on the possibility that mesangial IgG or IgM deposits may be a nec ...
... [l8], and mesangial IgA deposits are usually clinically silent in hepatic cirrhosis and coeliac disease [19,20]. These anomalies have focused attention on other factors, such as a role for an antigen in immune aggregates in sera, and on the possibility that mesangial IgG or IgM deposits may be a nec ...
The Regulation of HPV Late Gene Expression and the Potential
... of all cervical cancers, the second most common cancer in females worldwide. Expression of HPV L1 and L2 late genes is found only in terminally differentiated epithelial cells. As L1 and L2 proteins are highly immunogenic, it is suggested that their suppression may prevent detection of the virus by ...
... of all cervical cancers, the second most common cancer in females worldwide. Expression of HPV L1 and L2 late genes is found only in terminally differentiated epithelial cells. As L1 and L2 proteins are highly immunogenic, it is suggested that their suppression may prevent detection of the virus by ...
Short-term stress experienced at time of immunization induces a
... rather than immunosuppression would be adaptive during acute stress, since it is unlikely that eons of evolution would select for a system exquisitely designed to escape the jaws and claws of a lion only to succumb to wounds and pathogens. Previous studies have shown that whereas chronic stress is i ...
... rather than immunosuppression would be adaptive during acute stress, since it is unlikely that eons of evolution would select for a system exquisitely designed to escape the jaws and claws of a lion only to succumb to wounds and pathogens. Previous studies have shown that whereas chronic stress is i ...
Epigenetic Regulation of Innate Immunity by microRNAs
... PAMPs and initiate intracellular signaling through toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and other pathways which induce production of pro-inflammatory cytokines and type I interferons. Recently, different members of tripartite motif containing proteins (TRIM) family of proteins w ...
... PAMPs and initiate intracellular signaling through toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and other pathways which induce production of pro-inflammatory cytokines and type I interferons. Recently, different members of tripartite motif containing proteins (TRIM) family of proteins w ...
Unit_1_revision_sheets
... products include peptides. Peptides are short chains of amino acids. These peptides cannot be absorbed by facilitated diffusion and leave the gut in faeces. Some people have coeliac disease. The epithelial cells of people with coeliac disease do not absorb the products of digestion very well. In the ...
... products include peptides. Peptides are short chains of amino acids. These peptides cannot be absorbed by facilitated diffusion and leave the gut in faeces. Some people have coeliac disease. The epithelial cells of people with coeliac disease do not absorb the products of digestion very well. In the ...
The regulation of B cell responses in systemic autoimmunity
... and some are intracellular and the various family members are categorized based on what class of PAMP they bind. The TLR that was first identified as a PRR was TLR4 for its ability to bind LPS; a major component of gram-negative bacteria. Intracellular TLR3, -7, -8 and -9 are instead located in the ...
... and some are intracellular and the various family members are categorized based on what class of PAMP they bind. The TLR that was first identified as a PRR was TLR4 for its ability to bind LPS; a major component of gram-negative bacteria. Intracellular TLR3, -7, -8 and -9 are instead located in the ...
(CD32) Phenotype and Level of Expression
... temperature. These quantities were more than 10-fold the amounts required to achieve saturation binding. After two washes in RCD buffer, the platelets were incubated with a 1:40 dilution of affinity-purified F(ab')z fragments of fluorescein isothiocyanate (F1TC)-conjugated goat antimouse IgG (Jackso ...
... temperature. These quantities were more than 10-fold the amounts required to achieve saturation binding. After two washes in RCD buffer, the platelets were incubated with a 1:40 dilution of affinity-purified F(ab')z fragments of fluorescein isothiocyanate (F1TC)-conjugated goat antimouse IgG (Jackso ...
Systems biology in vaccine design
... a particular disease upon administration to an animal/ human. A vaccine typically contains one or several antigens that resemble a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antigenic proteins or its toxins + adjuvant. The antigens st ...
... a particular disease upon administration to an animal/ human. A vaccine typically contains one or several antigens that resemble a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antigenic proteins or its toxins + adjuvant. The antigens st ...
MD (Biochemistry)
... UNIT I Constituents of human cell, their structure & functions. Properties of cell membrane and transport across membrane. Cytoskeletons. Functions of muscle proteins, hemoglobin, albumin and porins. UNIT II Chemistry of blood clotting. Composition and diagnosis significance of cerebrospinal fluid a ...
... UNIT I Constituents of human cell, their structure & functions. Properties of cell membrane and transport across membrane. Cytoskeletons. Functions of muscle proteins, hemoglobin, albumin and porins. UNIT II Chemistry of blood clotting. Composition and diagnosis significance of cerebrospinal fluid a ...
Organ-specific Autoimmune Disease: A Deficiency of
... effector T cells. One possibility is to invoke the notion that immunogenic APCs presenting PNS antigens primarily carry B7-1, while immunogenic APCs with islet antigens are predominantly B7-2 positive (Fig. 2). Salomon et al. raise the possibility that a compensatory increase in B7-1 expression occu ...
... effector T cells. One possibility is to invoke the notion that immunogenic APCs presenting PNS antigens primarily carry B7-1, while immunogenic APCs with islet antigens are predominantly B7-2 positive (Fig. 2). Salomon et al. raise the possibility that a compensatory increase in B7-1 expression occu ...
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific
... bears the risk of the unintentional induction of tolerance to pathogen-derived antigens [112]. The usage of undirected nanoparticles or liposomes most likely target highly phagocytically active macrophages rather than DCs. Therefore, a more DC-specific antigen delivery technique is required. In cons ...
... bears the risk of the unintentional induction of tolerance to pathogen-derived antigens [112]. The usage of undirected nanoparticles or liposomes most likely target highly phagocytically active macrophages rather than DCs. Therefore, a more DC-specific antigen delivery technique is required. In cons ...
Protein Li SDS PAGE
... Asp and Glu are acidic, His, Lys and Arg are basic, SH of Cys and phenol of Tyr are weakly acidic. The whole charge of the protein – besides the amino acid composition - depends on the pH of the medium. In mild alkaline condition most proteins have net negative charge, therefore they migrate toward ...
... Asp and Glu are acidic, His, Lys and Arg are basic, SH of Cys and phenol of Tyr are weakly acidic. The whole charge of the protein – besides the amino acid composition - depends on the pH of the medium. In mild alkaline condition most proteins have net negative charge, therefore they migrate toward ...
roles in innate immune receptors: host - pathogen
... NOD3/NLRC3, NOD4/NLRC5, NOD5/NLRX1, CIITA) have diverse functions including acting as co-activators and NF-kB activating platforms. The remaining two groups consist of NLRs known to be involved in inflammasome formation. The NLRP (NACHT, LRR and PYD domains-containing protein) subfamily include NLR ...
... NOD3/NLRC3, NOD4/NLRC5, NOD5/NLRX1, CIITA) have diverse functions including acting as co-activators and NF-kB activating platforms. The remaining two groups consist of NLRs known to be involved in inflammasome formation. The NLRP (NACHT, LRR and PYD domains-containing protein) subfamily include NLR ...
New therapeutic approaches for Human African trypanosomiasis
... functionalized PEGlycated-chitosan nanoparticles...................... 55 C.2. Nanoparticles characterization methods. ...................................... 55 C.3. Determination of pentamidine loaded into the chitosan nanoparticles................................................................... ...
... functionalized PEGlycated-chitosan nanoparticles...................... 55 C.2. Nanoparticles characterization methods. ...................................... 55 C.3. Determination of pentamidine loaded into the chitosan nanoparticles................................................................... ...
Identification of a novel N-terminal hydrophobic sequence that
... is the proline knot, a ~72 amino acid hydrophobic sequence found in the middle of plant oleosins. The proline knot is thought to direct the protein to the droplet from its site of insertion in the ER, leaving flanking hydrophilic residues in the cytoplasm. The flanking sequences may also participate ...
... is the proline knot, a ~72 amino acid hydrophobic sequence found in the middle of plant oleosins. The proline knot is thought to direct the protein to the droplet from its site of insertion in the ER, leaving flanking hydrophilic residues in the cytoplasm. The flanking sequences may also participate ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.