Autoimmune Destruction of Pancreatic b Cells
... study suggested that a strong humoral response to GAD may actually be associated with less destructive pathology, as indicated by the negative correlation between insulitis and anti-GAD antibody levels. It was found that the initial immune response directed against pancreatic islets in NOD mice is a ...
... study suggested that a strong humoral response to GAD may actually be associated with less destructive pathology, as indicated by the negative correlation between insulitis and anti-GAD antibody levels. It was found that the initial immune response directed against pancreatic islets in NOD mice is a ...
Phagocytosis of apoptotic cells by macrophages in anti-neutrophil cytoplasmic antibody-
... Other causes of this accumulation could be an intrinsic defect in the cells involved in apoptotic cell clearance; for example, in the monocytes/MØs or in the neutrophils. It has been shown previously that the CD14+CD16+ subpopulation of monocytes is increased in several chronic inflammatory diseases ...
... Other causes of this accumulation could be an intrinsic defect in the cells involved in apoptotic cell clearance; for example, in the monocytes/MØs or in the neutrophils. It has been shown previously that the CD14+CD16+ subpopulation of monocytes is increased in several chronic inflammatory diseases ...
l WATER ADDED Ti) REDUCE
... concentrations of poorly Water soluble drugs. This discovery Was exploited to develop the invention, Which, in one aspect, features a stable nanoparticle comprising a compound; and a ...
... concentrations of poorly Water soluble drugs. This discovery Was exploited to develop the invention, Which, in one aspect, features a stable nanoparticle comprising a compound; and a ...
Janeway`s Immunobiology, 9th Edition Chapter 2: Innate Immunity
... Multiple choice: Women with urinary tract infections caused by E. coli are generally treated with a course of antibiotics. A common complication of the antibiotic treatment is the occurrence of a vaginal yeast infection caused by Candida albicans, an organism that is normally present in very low num ...
... Multiple choice: Women with urinary tract infections caused by E. coli are generally treated with a course of antibiotics. A common complication of the antibiotic treatment is the occurrence of a vaginal yeast infection caused by Candida albicans, an organism that is normally present in very low num ...
Pattern Generated by Oxidative Stress Th2
... pathology of a wide range of human diseases with prominent oxidative components (4–6). For many such conditions, including atherosclerosis, diabetes, Alzheimer’s disease, and alcohol liver disease, there exists a plethora of evidence in support of a critical role for innate immune engagement by lipo ...
... pathology of a wide range of human diseases with prominent oxidative components (4–6). For many such conditions, including atherosclerosis, diabetes, Alzheimer’s disease, and alcohol liver disease, there exists a plethora of evidence in support of a critical role for innate immune engagement by lipo ...
Glycolytic enzymes localize to ribonucleoprotein
... specification and contribute to the protection of germline DNA against transposons. These data provide the first evidence for the connection between metabolism and transposon silencing. The biochemical screen and mass spectrometry data reported here (Fig 1A) indicated that PyK is an abundant compone ...
... specification and contribute to the protection of germline DNA against transposons. These data provide the first evidence for the connection between metabolism and transposon silencing. The biochemical screen and mass spectrometry data reported here (Fig 1A) indicated that PyK is an abundant compone ...
Ectopic germinal center formation in Sjögren`s syndrome - BORA
... such as T and B cells, proliferating cells, follicular dendritic cells and plasma cells confirmed the ectopic GC formation. The pattern and distribution of homing and retentive chemokines CXCL12, CXCL13 and CCL21, and adhesion molecules/integrin pairs ICAM/LFA and VCAM/VLA, was described in various ...
... such as T and B cells, proliferating cells, follicular dendritic cells and plasma cells confirmed the ectopic GC formation. The pattern and distribution of homing and retentive chemokines CXCL12, CXCL13 and CCL21, and adhesion molecules/integrin pairs ICAM/LFA and VCAM/VLA, was described in various ...
Immunohistochemical localization of fatty acid transporters and
... CD36-deficient mice and humans did not show any apparent skin abnormalities (9). In accordance, our mouse model with genetic deletion of CD36 did not affect the essential expression of MCT1 or fatty acid binding proteins in the sebaceous glands. The epidermis of the skin intensely expresses MCT1 in ...
... CD36-deficient mice and humans did not show any apparent skin abnormalities (9). In accordance, our mouse model with genetic deletion of CD36 did not affect the essential expression of MCT1 or fatty acid binding proteins in the sebaceous glands. The epidermis of the skin intensely expresses MCT1 in ...
Atypical serological profiles in hepatitis B virus infection Robério A
... possibilities associated with anti-HBc production [11]. Therefore, a selective immune system defect could lead the immune tolerance to the HBc and, consequently, the lack of production of corresponding antibody, justifying, therefore, the existence of this serological profile [12, 13]. The phenomeno ...
... possibilities associated with anti-HBc production [11]. Therefore, a selective immune system defect could lead the immune tolerance to the HBc and, consequently, the lack of production of corresponding antibody, justifying, therefore, the existence of this serological profile [12, 13]. The phenomeno ...
Novel technologies and emerging biomarkers for personalized
... variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape for cancer patients. However, despite the current success of these therapies, not all patients respond to immunotherapy and even those that do often experience ...
... variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape for cancer patients. However, despite the current success of these therapies, not all patients respond to immunotherapy and even those that do often experience ...
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by
... within the in vivo microenvironment. This is due in large part to the lack of reagents that can distinguish between the native and proteolyzed forms of ECM proteins. To this end, we have utilized SI to develop MAbs that recognize proteolyzed and denatured forms of genetically distinct collagen molec ...
... within the in vivo microenvironment. This is due in large part to the lack of reagents that can distinguish between the native and proteolyzed forms of ECM proteins. To this end, we have utilized SI to develop MAbs that recognize proteolyzed and denatured forms of genetically distinct collagen molec ...
Zaenab Aljassim thesis-6_1
... the live bacille Calmette-Guérin (BCG) vaccine with efficacy varying between 0% and 60% depending on the population demographics. DNA, cellular fractions of the pathogen, and subunit vaccines failed to provide protection beyond what the BCG vaccine can provide. Streptomyces, phylogenetic relatives o ...
... the live bacille Calmette-Guérin (BCG) vaccine with efficacy varying between 0% and 60% depending on the population demographics. DNA, cellular fractions of the pathogen, and subunit vaccines failed to provide protection beyond what the BCG vaccine can provide. Streptomyces, phylogenetic relatives o ...
The CS2 fimbrial antigen from escherichia coli, purification
... The CS2 fimbrial antigen was isolated by salt and isoelectric precipitation and by column chromatography. The purified antigen was free Of other fimbrial proteins present on the same bacterial strain. Analysis of the N-terminal amino acid sequence indicated extensive homology with the CFA1 fimbrial ...
... The CS2 fimbrial antigen was isolated by salt and isoelectric precipitation and by column chromatography. The purified antigen was free Of other fimbrial proteins present on the same bacterial strain. Analysis of the N-terminal amino acid sequence indicated extensive homology with the CFA1 fimbrial ...
Body Defenses
... General Info: defensins are proteins that active against bacteria, fungi and both enveloped and non-enveloped viruses, found in epithelial cells ...
... General Info: defensins are proteins that active against bacteria, fungi and both enveloped and non-enveloped viruses, found in epithelial cells ...
BCA Assay
... Tech Tip protocol: Eliminate interfering substances from samples for BCA™ Protein Assay Tech Tip protocol: Shorten BCA™ Protein Assay incubation using a microwave oven ...
... Tech Tip protocol: Eliminate interfering substances from samples for BCA™ Protein Assay Tech Tip protocol: Shorten BCA™ Protein Assay incubation using a microwave oven ...
N E W S L E T T E R - Australasian Society for Immunology
... largely focus on sub-unit single antigen approaches, we have found that vaccines based on whole parasites induce an immune response that can protect multiple strains of ...
... largely focus on sub-unit single antigen approaches, we have found that vaccines based on whole parasites induce an immune response that can protect multiple strains of ...
Intact PTH
... with a half-life of less than four minutes. Intact PTH assays are important for the differentiation of primary hyperparathyroidism from the other (nonparathyroid-mediated) forms of hypercalcemia, such as malignancy, sarcoidosis and thyrotoxicosis. The measurement of parathyroid hormone is the most s ...
... with a half-life of less than four minutes. Intact PTH assays are important for the differentiation of primary hyperparathyroidism from the other (nonparathyroid-mediated) forms of hypercalcemia, such as malignancy, sarcoidosis and thyrotoxicosis. The measurement of parathyroid hormone is the most s ...
Radioimmunotherapy Is More Effective than Antifungal Treatment
... RIT efficacy [7], which is obviously absent in vitro. It has been demonstrated that mice mount an intense antibody response to fungal melanin that includes antibodies of immunoglobulin M and immunoglobulin G isotypes, which points to the stimulation of the immune system by melanin [12]. Given that a ...
... RIT efficacy [7], which is obviously absent in vitro. It has been demonstrated that mice mount an intense antibody response to fungal melanin that includes antibodies of immunoglobulin M and immunoglobulin G isotypes, which points to the stimulation of the immune system by melanin [12]. Given that a ...
Licentiate thesis from the Department of Immunology
... of the invading organism, through the release of toxic reactive oxygen and nitrogen intermediates, or killing by lysosomal enzymes following fusion with the bacterial phagosome. The receptors that have been implicated in the uptake of mycobacteria include mannose receptors (MRs) that recognize manno ...
... of the invading organism, through the release of toxic reactive oxygen and nitrogen intermediates, or killing by lysosomal enzymes following fusion with the bacterial phagosome. The receptors that have been implicated in the uptake of mycobacteria include mannose receptors (MRs) that recognize manno ...
TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue
... that there is a continuous and lifelong turnover of perivascular brain macrophages replenished by bone marrow– derived cells. Furthermore, it has been demonstrated that bone marrow cells are recruited to sites of axonal degeneration [4,5] or to beta-amyloid depositions in Alzheimer disease animal mo ...
... that there is a continuous and lifelong turnover of perivascular brain macrophages replenished by bone marrow– derived cells. Furthermore, it has been demonstrated that bone marrow cells are recruited to sites of axonal degeneration [4,5] or to beta-amyloid depositions in Alzheimer disease animal mo ...
The Influence of 1,25-dihydroxyvitamin D on the Cross-Priming of Lymphocytic
... Biologically active 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) binds the vitamin D receptor (VDR) to exert its effect on target cells. VDR expression is found in a number of immune cells including professional antigen-presenting cells such as dendritic cells. It has been found that the actions of 1,25- ...
... Biologically active 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) binds the vitamin D receptor (VDR) to exert its effect on target cells. VDR expression is found in a number of immune cells including professional antigen-presenting cells such as dendritic cells. It has been found that the actions of 1,25- ...
High-resolution mapping of protein sequence
... structures of ~50 amino acids9. These domains serve as proteinprotein interaction modules, binding to one of several conserved peptide motifs (Fig. 1a). We displayed a WW domain because its structure has been solved and because the folding, thermodynamic stability and binding preferences of WW domai ...
... structures of ~50 amino acids9. These domains serve as proteinprotein interaction modules, binding to one of several conserved peptide motifs (Fig. 1a). We displayed a WW domain because its structure has been solved and because the folding, thermodynamic stability and binding preferences of WW domai ...
Immunoinformatics - UWI St. Augustine
... • The Innate immunity: first line of defense – rapid nonspecific responses – recognition of conserved structures present in many microorganisms • lipopolysaccharides in bacterial cell walls or proteins in flagella ...
... • The Innate immunity: first line of defense – rapid nonspecific responses – recognition of conserved structures present in many microorganisms • lipopolysaccharides in bacterial cell walls or proteins in flagella ...
Chapter 22 PPT. - HCC Learning Web
... system and the immune response. • 22-9 Give examples of interactions between the lymphatic system and other organ systems we have studied so far and explain how the nervous and endocrine systems influence the immune response. ...
... system and the immune response. • 22-9 Give examples of interactions between the lymphatic system and other organ systems we have studied so far and explain how the nervous and endocrine systems influence the immune response. ...
Introduction Multiple Sclerosis (MS) is a highly degenerative, auto
... Greenhalgh AD, David S. 2014 Apr. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. Hamada M, Goethals S, de Vries S, Brette R, Kole M. 2016. Covariation of axon initial segment location and dendritic tree normalize ...
... Greenhalgh AD, David S. 2014 Apr. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. Hamada M, Goethals S, de Vries S, Brette R, Kole M. 2016. Covariation of axon initial segment location and dendritic tree normalize ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.