Inducible Activation of TLR4 Confers Resistance to
... mechanisms by which they participate in this response have not been defined (20). To evaluate the consequences of TLR4 signaling within the lung epithelium on host defense against oxidant stress, we have developed an inducible transgenic model that selectively targets the expression of a constitutiv ...
... mechanisms by which they participate in this response have not been defined (20). To evaluate the consequences of TLR4 signaling within the lung epithelium on host defense against oxidant stress, we have developed an inducible transgenic model that selectively targets the expression of a constitutiv ...
Mdm2 Promotes Systemic Lupus Erythematosus and
... injections caused severe lymphoproliferation.11–13 We therefore speculated that, beyond its autoantigen and autoadjuvant effects, endogenous DNA might have also a mitogenic effect in SLE, similar to the mitogenic effect of bacterial DNA.14 Bacterial DNA was first described in 1995 as a B cell mitoge ...
... injections caused severe lymphoproliferation.11–13 We therefore speculated that, beyond its autoantigen and autoadjuvant effects, endogenous DNA might have also a mitogenic effect in SLE, similar to the mitogenic effect of bacterial DNA.14 Bacterial DNA was first described in 1995 as a B cell mitoge ...
Sperm-based contraceptive vaccine for wild rabbit
... and which are therefore candidates for MADP. Spots were picked using the Pro-Pick robotic system and subsequently digested with trypsin using an in-gel digestion protocol, followed by peptide fingerprint analysis by MALDI-Tof and protein sequence determination by Q-Tof mass spectrometry. Proteins we ...
... and which are therefore candidates for MADP. Spots were picked using the Pro-Pick robotic system and subsequently digested with trypsin using an in-gel digestion protocol, followed by peptide fingerprint analysis by MALDI-Tof and protein sequence determination by Q-Tof mass spectrometry. Proteins we ...
What the shark immune system can and cannot provide for the
... Expert Opin. Drug Discov. Downloaded from informahealthcare.com by Texas A&M Univ on 07/18/14 For personal use only. ...
... Expert Opin. Drug Discov. Downloaded from informahealthcare.com by Texas A&M Univ on 07/18/14 For personal use only. ...
Arterioscler Thromb Vasc Biol. - Arteriosclerosis, Thrombosis, and
... by coronary angiography16,17 and carotid intima-media thickness.18 –20 We have recently identified aldehyde-modified peptide sequences in apoB-100 that are targeted by autoantibodies present in human plasma.18 In this study, we have investigated the association between the plasma levels of 3 of thes ...
... by coronary angiography16,17 and carotid intima-media thickness.18 –20 We have recently identified aldehyde-modified peptide sequences in apoB-100 that are targeted by autoantibodies present in human plasma.18 In this study, we have investigated the association between the plasma levels of 3 of thes ...
What the shark immune system can and cannot provide for the
... Expert Opin. Drug Discov. Downloaded from informahealthcare.com by Texas A & M University on 05/16/14 For personal use only. ...
... Expert Opin. Drug Discov. Downloaded from informahealthcare.com by Texas A & M University on 05/16/14 For personal use only. ...
Molecular profiling of breast cancer cell lines containing amplified
... control) and another set of conditions on the heavier labelled cells. The weight difference produced by the labelling is small enough not to exert a biological effect but large enough to be detected by the mass spectrometer. A big advantage of this technique is that the unlabelled and labelled cells ...
... control) and another set of conditions on the heavier labelled cells. The weight difference produced by the labelling is small enough not to exert a biological effect but large enough to be detected by the mass spectrometer. A big advantage of this technique is that the unlabelled and labelled cells ...
CHAPTER 7 Immune defences against pathogens
... The mildest form of UC is a condition in which a person passes faeces, with or without blood, less than four times daily. The most severe form is fulminant UC, a very serious condition in which a person passes faeces more than ten times daily, has continuous rectal bleeding that requires blood trans ...
... The mildest form of UC is a condition in which a person passes faeces, with or without blood, less than four times daily. The most severe form is fulminant UC, a very serious condition in which a person passes faeces more than ten times daily, has continuous rectal bleeding that requires blood trans ...
In vitro effects of different innate-immune stimulants on
... Figure 12: Antibacterial activity against Aeromonas salmonicida ssp. Achromogenes (ASA) by inhibition zone assay... ................................................................ 39-40 Figure 13: SDS PAGE gel analysis for proteins extracted from Salmo salar stimulated with HMB .. ................. ...
... Figure 12: Antibacterial activity against Aeromonas salmonicida ssp. Achromogenes (ASA) by inhibition zone assay... ................................................................ 39-40 Figure 13: SDS PAGE gel analysis for proteins extracted from Salmo salar stimulated with HMB .. ................. ...
Windows of opportunity for Ebola virus infection treatment
... To avoid ending up with a complex interaction model, IgG data were modeled independently to have a general profile of IgG responses, which is used later as an input in models of viral replication. This was done by using the IgG dynamics data after EBOV vaccination but before EBOV infection challenge ...
... To avoid ending up with a complex interaction model, IgG data were modeled independently to have a general profile of IgG responses, which is used later as an input in models of viral replication. This was done by using the IgG dynamics data after EBOV vaccination but before EBOV infection challenge ...
bt 6602 immunology dr.r.b.narayanan
... Development, maturation, activation and differentiation of T-cells and B-cells. TCR. Antibodies - Structure and Functions. Antibodies - Genes and Generation of diversity. Antigen-Antibody reactions. Antigen presenting cells. Major histocompatibility complex. Regulation of T-cell and B-cell responses ...
... Development, maturation, activation and differentiation of T-cells and B-cells. TCR. Antibodies - Structure and Functions. Antibodies - Genes and Generation of diversity. Antigen-Antibody reactions. Antigen presenting cells. Major histocompatibility complex. Regulation of T-cell and B-cell responses ...
Expanding the Genetic Code with Unnatural Amino Acids
... acids contain a variety of functional groups such as: hydroxyl (-OH), sulfhydryl or thiol (-SH), amines (-NH3), acids (-COOH), amides (CONH2) and methyl (CH3) groups which can be found in Figure 1. These functional groups can form tightly networked connections through noncovalent, ionic, hydrogen bo ...
... acids contain a variety of functional groups such as: hydroxyl (-OH), sulfhydryl or thiol (-SH), amines (-NH3), acids (-COOH), amides (CONH2) and methyl (CH3) groups which can be found in Figure 1. These functional groups can form tightly networked connections through noncovalent, ionic, hydrogen bo ...
Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins
... host-defense functions. Native CRP plays several important roles by calcium-dependent binding to specific ligands, such as PC in oxidized phospholipids on damaged cell membranes [6] or LDL [51], fibronectin [52, 53] and protein A [54]. The ability to bind nuclear structures at physiological ionic st ...
... host-defense functions. Native CRP plays several important roles by calcium-dependent binding to specific ligands, such as PC in oxidized phospholipids on damaged cell membranes [6] or LDL [51], fibronectin [52, 53] and protein A [54]. The ability to bind nuclear structures at physiological ionic st ...
Immune Epitope Database assays
... etc. that are just as complex as the above. We could not identify criteria that delineate ‘assay’ and ‘study design execution’ based on complexity ...
... etc. that are just as complex as the above. We could not identify criteria that delineate ‘assay’ and ‘study design execution’ based on complexity ...
Gene Section ELAVL1 (ELAV (embryonic lethal, abnormal vision,
... skeletal muscle, is frequently seen in patients with chronic diseases such as cancer. The bioactive gas nitric oxide has been identified as an important player in cancer-induced cachexia because NO is directly involved in the loss of MyoD mRNA (a key factor needed for the myogenic process, which is ...
... skeletal muscle, is frequently seen in patients with chronic diseases such as cancer. The bioactive gas nitric oxide has been identified as an important player in cancer-induced cachexia because NO is directly involved in the loss of MyoD mRNA (a key factor needed for the myogenic process, which is ...
Adhesion Proteins PCOL 582
... Depending on the association of alpha and beta subunits, integrins can bind to collagen, laminin, vitronectin, and fibronectin. ...
... Depending on the association of alpha and beta subunits, integrins can bind to collagen, laminin, vitronectin, and fibronectin. ...
Full-Text PDF
... are a group of integral transmembrane proteins that facilitate the transport of substrates and ions across biological membranes [1]. SLC transporters are located in various membranes, such as plasma-, lysosomal-, inner mitochondrial-, peroxisomal membrane, and endoplasmic reticulum in an organ or ce ...
... are a group of integral transmembrane proteins that facilitate the transport of substrates and ions across biological membranes [1]. SLC transporters are located in various membranes, such as plasma-, lysosomal-, inner mitochondrial-, peroxisomal membrane, and endoplasmic reticulum in an organ or ce ...
Local Activation of Dendritic Cells Leads to Insulitis and
... and to initiation of autoimmunity. A relative deficit in regulatory T-cells concomitant with the expression of major histocompatibility complex (MHC) molecules, allowing the development of an autoreactive T-cell repertoire, further contributes to the pathogenesis of type 1 diabetes in NOD mice, BB r ...
... and to initiation of autoimmunity. A relative deficit in regulatory T-cells concomitant with the expression of major histocompatibility complex (MHC) molecules, allowing the development of an autoreactive T-cell repertoire, further contributes to the pathogenesis of type 1 diabetes in NOD mice, BB r ...
Immune Response to Self Nuclear Autoantigen Determines the Fate
... which are a prototype model of human SLE, the pathway of peripheral tolerance to eliminate self-reactive lymphocytes is impaired due to the deficient Fas/Fas ligand system (8). The importance of peripheral tolerance has already been demonstrated using Tg mice in which the extrathymic organs express ...
... which are a prototype model of human SLE, the pathway of peripheral tolerance to eliminate self-reactive lymphocytes is impaired due to the deficient Fas/Fas ligand system (8). The importance of peripheral tolerance has already been demonstrated using Tg mice in which the extrathymic organs express ...
Common Features of Mucosal and Peripheral Antibody Responses
... cific IgG and IgA responses in sera and mucosal secretions at the peak time point (P ⬍ 0.01; paired t test), and these responses declined by approximately 0.5 log (range, 0.17 to 0.57 log; median, 0.54) by 20 to 24 weeks following the final immunization (Fig. 2A). Consistent with prior reports (5), ...
... cific IgG and IgA responses in sera and mucosal secretions at the peak time point (P ⬍ 0.01; paired t test), and these responses declined by approximately 0.5 log (range, 0.17 to 0.57 log; median, 0.54) by 20 to 24 weeks following the final immunization (Fig. 2A). Consistent with prior reports (5), ...
Immune response to tuberculosis infection
... Polymerase chain reaction (PCR) is a recently developed test for the direct detection of mycobacterial DNA in samples such as blood, sputum, mucus or milk. It is based on DNA amplification by DNA polymerase and specific primer sets. Unfortunately, there is a high rate of false positives using this m ...
... Polymerase chain reaction (PCR) is a recently developed test for the direct detection of mycobacterial DNA in samples such as blood, sputum, mucus or milk. It is based on DNA amplification by DNA polymerase and specific primer sets. Unfortunately, there is a high rate of false positives using this m ...
The Cardiovascular System: The Blood
... Blood clots sometimes form within the cardiovascular system. Clots initiated by roughened endothelial surfaces of a blood vessel resulting from atherosclerosis, which is induce adhesion of platelets. Intravascular clots may form when blood flows too slowly (stasis). Clotting in an unbroken blood ves ...
... Blood clots sometimes form within the cardiovascular system. Clots initiated by roughened endothelial surfaces of a blood vessel resulting from atherosclerosis, which is induce adhesion of platelets. Intravascular clots may form when blood flows too slowly (stasis). Clotting in an unbroken blood ves ...
jait0302_08 - Journal of Advances in Information Technology
... genetic algorithms and artificial immune systems are examples of bio-inspired systems used to this end. An Artificial Immune System (AIS) [20, 21, 22] is a type of optimization algorithm inspired from the principles and processes of the vertebrate immune system. One of the most used variant of AIS i ...
... genetic algorithms and artificial immune systems are examples of bio-inspired systems used to this end. An Artificial Immune System (AIS) [20, 21, 22] is a type of optimization algorithm inspired from the principles and processes of the vertebrate immune system. One of the most used variant of AIS i ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.