Opinion of the Scientific Panel on Additives and Products or
... Commission to issue an opinion on the safety and the efficacy of a product containing Larginine produced by fermentation from Corynebacterium glutamicum (ATCC-13870) modified by conventional methods. It contains a minimum of 98 % L-arginine on dry matter basis (maximum 18% water). L-arginine is clas ...
... Commission to issue an opinion on the safety and the efficacy of a product containing Larginine produced by fermentation from Corynebacterium glutamicum (ATCC-13870) modified by conventional methods. It contains a minimum of 98 % L-arginine on dry matter basis (maximum 18% water). L-arginine is clas ...
Biochemical characterization of the initial steps of the Kennedy
... the agent of African sleeping sickness, GPCho accounts for approximately half of all phospholipids in both life-cycle stages, whereas GPEtn forms between 16 and 21 % [2]. These phospholipids contribute an important structural role to the membrane and, in addition, determine membrane fluidity and cel ...
... the agent of African sleeping sickness, GPCho accounts for approximately half of all phospholipids in both life-cycle stages, whereas GPEtn forms between 16 and 21 % [2]. These phospholipids contribute an important structural role to the membrane and, in addition, determine membrane fluidity and cel ...
- BioMedSearch
... effective anti-influenza agent (see [16]). E. coli, overexpressing PEPS, are widely used in the biosynthesis of shikimic acid as is over-expression of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) synthase whose use can be limited by feedback inhibition. Overexpression of feedback insensiti ...
... effective anti-influenza agent (see [16]). E. coli, overexpressing PEPS, are widely used in the biosynthesis of shikimic acid as is over-expression of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) synthase whose use can be limited by feedback inhibition. Overexpression of feedback insensiti ...
Molecular basis of hepatic carnitine palmitoyltransferase I deficiency
... Mitochondrial fatty acid b-oxidation is important for energy production, which is stressed by the different defects found in this pathway. Most of the enzyme deficiencies causing these defects are well characterized at both the protein and genomic levels. One exception is carnitine palmitoyltransfer ...
... Mitochondrial fatty acid b-oxidation is important for energy production, which is stressed by the different defects found in this pathway. Most of the enzyme deficiencies causing these defects are well characterized at both the protein and genomic levels. One exception is carnitine palmitoyltransfer ...
Pancreatic Hormones Introduction
... The insulin receptor contains an intrinsic protein kinase that specifically catalyzes the phosphorylation of tyrosine residues on proteins Cystein and its thiol (SH) group linking the aa to another Cystein aa may form part of a binding cleft for ligands ...
... The insulin receptor contains an intrinsic protein kinase that specifically catalyzes the phosphorylation of tyrosine residues on proteins Cystein and its thiol (SH) group linking the aa to another Cystein aa may form part of a binding cleft for ligands ...
The semi-phosphorylative Entner–Doudoroff pathway in
... selectivity in catalysing the cleavage of KDG as well as KDGal (2-keto-3-deoxygalactonate), both yielding GA and pyruvate. At the time the present study was submitted, the archaeal GAD had not yet been identified (however, see the Discussion section). T. tenax is a sulphur-dependent anaerobe that gr ...
... selectivity in catalysing the cleavage of KDG as well as KDGal (2-keto-3-deoxygalactonate), both yielding GA and pyruvate. At the time the present study was submitted, the archaeal GAD had not yet been identified (however, see the Discussion section). T. tenax is a sulphur-dependent anaerobe that gr ...
Landick R, Yanofsky C. 1987. Transcription
... pauses in the leader region, the opportunity is provided for loading of a ribosome at the leader peptide ribosome-binding site of the leader transcript. After a ribosome loads and begins translation, it approaches the paused polymerase. As it nears the paused polymerase it could disrupt the RNA paus ...
... pauses in the leader region, the opportunity is provided for loading of a ribosome at the leader peptide ribosome-binding site of the leader transcript. After a ribosome loads and begins translation, it approaches the paused polymerase. As it nears the paused polymerase it could disrupt the RNA paus ...
Value-added Conversion of Waste Cooking Oil, Post
... Biodiesel is an environmentally friendly alternative to petroleum diesel. It is biodegradable, nontoxic and has lower greenhouse gas emission profiles compared to petroleum diesel. Polyurethane (PU) products such as PU foams and PU coatings are widely used in many aspects of our life. Traditionally, ...
... Biodiesel is an environmentally friendly alternative to petroleum diesel. It is biodegradable, nontoxic and has lower greenhouse gas emission profiles compared to petroleum diesel. Polyurethane (PU) products such as PU foams and PU coatings are widely used in many aspects of our life. Traditionally, ...
Role of Mitochondria in Nonalcoholic Fatty Liver Disease
... This process is regulated by insulin and involves lipases (adipose tissue lipase (ATGL), hormone sensitive lipase (HSL), and monoglyceride lipase), co-lipases, and lipid droplet proteins [36]. Increasing calorie intake such as in obesity causes insulin resistance leading to increased adipose tissue ...
... This process is regulated by insulin and involves lipases (adipose tissue lipase (ATGL), hormone sensitive lipase (HSL), and monoglyceride lipase), co-lipases, and lipid droplet proteins [36]. Increasing calorie intake such as in obesity causes insulin resistance leading to increased adipose tissue ...
Design, Synthesis, and Antibacterial Properties of Dual
... been nothing but beneficial and advantageous to my growth as a scientist. I would also like to thank Dr. Carol Taylor for her understanding, assistance, and help in molding a biologist into an organic chemist. I would also like to thank my other committee members, Dr. Aaron Smith and Dr. David Donze ...
... been nothing but beneficial and advantageous to my growth as a scientist. I would also like to thank Dr. Carol Taylor for her understanding, assistance, and help in molding a biologist into an organic chemist. I would also like to thank my other committee members, Dr. Aaron Smith and Dr. David Donze ...
Involvement of Polyamine Catabolism in the Regulation of Glucose
... total cholesterol levels in SSAT mice by increasing the elimination of cholesterol from the body via bile acid synthesis. The hepatic expression of cholesterol 7Į-hydroxylase (CYP7A1), the rate-limiting gene in bile acid synthesis, was induced by PGC-1Į, the protein stability and activity of which w ...
... total cholesterol levels in SSAT mice by increasing the elimination of cholesterol from the body via bile acid synthesis. The hepatic expression of cholesterol 7Į-hydroxylase (CYP7A1), the rate-limiting gene in bile acid synthesis, was induced by PGC-1Į, the protein stability and activity of which w ...
Fulltext - Jultika
... Enzymes catalyze chemical changes in biological systems. Therefore, to understand the chemistry of living systems, it is important to understand the enzyme structure and the chemistry of the enzyme's functional groups which are involved in catalysis. In this study, structure and function relationshi ...
... Enzymes catalyze chemical changes in biological systems. Therefore, to understand the chemistry of living systems, it is important to understand the enzyme structure and the chemistry of the enzyme's functional groups which are involved in catalysis. In this study, structure and function relationshi ...
SODIUM-COUPLED TRANSPORTERS FOR KREBS CYCLE
... Intestinal brush border membrane vesicles from pig also express an intermediate affinity Na+/dicarboxylate cotransporter with a Km for succinate of 175 µM (69). The transport of both fumarate and citrate was sensitive to changes in membrane potential, and there was a strong stimulation of citrate up ...
... Intestinal brush border membrane vesicles from pig also express an intermediate affinity Na+/dicarboxylate cotransporter with a Km for succinate of 175 µM (69). The transport of both fumarate and citrate was sensitive to changes in membrane potential, and there was a strong stimulation of citrate up ...
Temperature-dependent effects of cadmium and purine nucleotides
... (ROS-mediated) and direct effects of cadmium, purine nucleotides or fatty acids on aconitase activity. For ROSmediated effects, mitochondrial suspensions in the assay medium were incubated for 20·min at the respective assay temperature in the absence of additives (control) or with addition of the va ...
... (ROS-mediated) and direct effects of cadmium, purine nucleotides or fatty acids on aconitase activity. For ROSmediated effects, mitochondrial suspensions in the assay medium were incubated for 20·min at the respective assay temperature in the absence of additives (control) or with addition of the va ...
Identification of genes specifically required for the
... a hypothetical protein, whereas Gmet 2410 and Gmet 3229 are predicted to encode a superoxide dismutase, and a thioredoxinrelated protein, respectively. The strain in which Gmet 2833 was deleted was deficient in phenol metabolism as well as benzene metabolism (Figure 2), indicating that this gene of ...
... a hypothetical protein, whereas Gmet 2410 and Gmet 3229 are predicted to encode a superoxide dismutase, and a thioredoxinrelated protein, respectively. The strain in which Gmet 2833 was deleted was deficient in phenol metabolism as well as benzene metabolism (Figure 2), indicating that this gene of ...
Effects upon metabolic pathways and energy production by Sb(III
... more Sb(III) would enter bacterial cells, however, the cytoplasmic AnoA and the oxidative stress response proteins were significantly up-regulated, which may contribute to the increased Sb(III) oxidation efficiency. Moreover, the carbon metabolism was also activated to generate more energy against S ...
... more Sb(III) would enter bacterial cells, however, the cytoplasmic AnoA and the oxidative stress response proteins were significantly up-regulated, which may contribute to the increased Sb(III) oxidation efficiency. Moreover, the carbon metabolism was also activated to generate more energy against S ...
GLUCOKINASE ACTIVATORS: A GLUCOSE SENSOR ROLE IN PANCREATIC ISLETS AND HEPATOCYTE
... IV, also referred to as glucokinase, differs from other hexokinases in kinetics and functions. Human hexokinase IV, hexokinase D, and ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1. The location of the phosphorylation on a subcellular level occurs when glucokinase translocates between the cytoplasm ...
... IV, also referred to as glucokinase, differs from other hexokinases in kinetics and functions. Human hexokinase IV, hexokinase D, and ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1. The location of the phosphorylation on a subcellular level occurs when glucokinase translocates between the cytoplasm ...
Metabolic decision making by protein-metabolite - ETH E
... decisions in the model bacterium Escherichia coli. Specifically, we focus on protein‐metabolite interactions in two regulatory layers, namely transcriptional (chapters 2 to 5) and posttranslational (chapters 5 to 7) enzyme regulation. In chapter 2, we review our current understanding o ...
... decisions in the model bacterium Escherichia coli. Specifically, we focus on protein‐metabolite interactions in two regulatory layers, namely transcriptional (chapters 2 to 5) and posttranslational (chapters 5 to 7) enzyme regulation. In chapter 2, we review our current understanding o ...
ppt for
... Interspecies: no constraint intraspecies: constraint in Africans; mild constraint in non-African • Explanation1: strength of selective constraint my simply differ between these two time scales. • Explanation2: interspecies substitution rate, but not the derived allele frequency distribution, is aff ...
... Interspecies: no constraint intraspecies: constraint in Africans; mild constraint in non-African • Explanation1: strength of selective constraint my simply differ between these two time scales. • Explanation2: interspecies substitution rate, but not the derived allele frequency distribution, is aff ...
Cloning and functional characterization of a new subtype of the
... called Nm, which shows significantly weaker Li⫹ tolerance and pH sensitivity than the hepatic system N (1, 13). Two different types of system N have been described in the brain (21, 33). The system present in astrocytes is similar to the hepatic system N, whereas the system present in neurons is dis ...
... called Nm, which shows significantly weaker Li⫹ tolerance and pH sensitivity than the hepatic system N (1, 13). Two different types of system N have been described in the brain (21, 33). The system present in astrocytes is similar to the hepatic system N, whereas the system present in neurons is dis ...
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.