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Exam 1, Problem 6
Exam 1, Problem 6

... The probability of getting a value of 1.44 is likely to occur in the gene 100-nt population ...
Krebs Intro and CycleON
Krebs Intro and CycleON

... It takes 2 H+ to cross the F1 particle to provide enough energy to make ATP. Because the electron transport chain oxidizes NADH or FADH2 and uses the energy to phosphorylate ADP, this is also known as oxidative ...
ch_02_Chemical Organization
ch_02_Chemical Organization

... •  Long chains of carbon and hydrogen with a carboxyl group (COOH) at one end •  Are relatively nonpolar, except the carboxyl group •  Fatty acids may be: •  Saturated with hydrogen (no covalent bonds) •  Unsaturated (one or more double bonds) •  Monounsaturated = one double bond •  Polyunsaturated ...
Drug-specific Sites of Topoisomerase II DNA
Drug-specific Sites of Topoisomerase II DNA

... satellite III DNA and the histone gene cluster) since their chromatin structures have been well characterized (see below); thus, the results may provide significant information on enzyme and drug activities also in human malignant cells. Our analysis has been focused on VM-26, dh-EPI (a potent doxor ...
Supplemental Methods
Supplemental Methods

Chemistry 30 - SharpSchool
Chemistry 30 - SharpSchool

... Jill Agnew ...
genotyping arabidopsis - STLCC.edu :: Users` Server
genotyping arabidopsis - STLCC.edu :: Users` Server

... called “Activator” (Ac) is necessary for the transposition of Ds. Ds is believed to be a mutant transposon, lacking the gene for transposase. Ac carries the transposase gene, and no matter where in the genome it is located, it supplies the enzyme for the transposition of Ds. It is possible to cross ...
When epigenetics meets alternative splicing: the roles of DNA
When epigenetics meets alternative splicing: the roles of DNA

... structures evolved: one located in high GC content regions and the other in low GC content regions. During mammalian and avian evolution GC-rich regions underwent a GC increase that resulted in even higher GC values. Genes located in these high GC content regions have a much less pronounced differen ...
knockdown
knockdown

... BLAST breaks a search into stages Searches for short matches of fixed length W between query and database If there is a matching word W, performs an ungapped alignment between the query and database sequence, extending the match in each direction High-scoring matches then subjected to a gapped align ...
Chapter 2
Chapter 2

... In transcription, RNA (italics) positions next to DNA: C – G, G – C, A - T, or U – A In translation, t-RNA (italics) positions next to mRNA (italics): C – G, G – C, A - U, or U - A ...
Use of infrared and visible light radiation as modulator of protein
Use of infrared and visible light radiation as modulator of protein

... particular proteins and their target at a distance [10,11]. Thus protein interactions can be viewed as a resonant energy transfer between the interacting molecules. This energy can be transferred through oscillations of a physical field, possibly electromagnetic in nature [1]. Since there is eviden ...
1st set of Journal Clubs this Wednesday!
1st set of Journal Clubs this Wednesday!

... Positive control: ‘An activator causes the accelerator pedal to be pushed.’ Cis-acting sequence: Can only function if on same piece of DNA that its regulating Trans-acting factor: A gene product that can act in ‘trans’ i.e. diffuse to a location at a distance from where it was made. ...
Biological Chemistry: Engineering New Functions for Natural Systems
Biological Chemistry: Engineering New Functions for Natural Systems

... simulating biochemical effects of some diseases . A zinc finger nuclease is even in clinical trials for HIV gene therapy, as of May 2012 .[3] Scientists engineer the binding domain on these zinc finger proteins so they can control where to insert a new gene in a chromosome . But the nucleases tend ...
Detecting Constituent Sequences by Means of HP Pattern–Based
Detecting Constituent Sequences by Means of HP Pattern–Based

... as a formal language and built a set of regular grammars to describe this language. In order to face with the structure of the proteins we used hydrophobic-hydrophilic model (HP model) [10][14][7], in which amino acids are subdivided into two classes Hydrophobic (H) and Hydrophilic (P). We translate ...
Microsporidia: Why Make Nucleotides if You Can Steal Them?
Microsporidia: Why Make Nucleotides if You Can Steal Them?

... including humans and economically important fish and insects. Surviving and flourishing inside another eukaryotic cell is a very specialised lifestyle that requires evolutionary innovation. Genome sequence analyses show that microsporidia have lost most of the genes needed for making primary metabol ...
HUMAN BIOCHEMISTRY
HUMAN BIOCHEMISTRY

...  Foods containing these three components will also provide the essential vitamins and the fifteen essential minerals, which include calcium, magnesium, sodium, iron, and sulfur, along with trace elements like iodine and chromium.  In addition, a daily intake of about 2 dm3 (2 liters) of water is r ...
документ
документ

... 5.4.99.5) and a number of other several enzymes are proved to be an active producers of this amino acid (Umbarger, 1978). That is why the best Phe producing strains once selected were the mutants partially or completely dependent on Tyr or Trp for growth. The reports about the other regulative mecha ...
Protein Synthesis Name “An English sentence building metaphor
Protein Synthesis Name “An English sentence building metaphor

... Name Date ...
Distribution of Node-to-Node Distance in a Cubic Lattice of Binding
Distribution of Node-to-Node Distance in a Cubic Lattice of Binding

Isomerisms
Isomerisms

... A research worker reported that there are six possible would be dichlorobenzoic acid, C6H3Cl2COOH which would be decarboxylated to dichloroenzenes, C6H4Cl2. One of the six, three isomeric acids gave the same dichlorobenzene X, two gave a dichlorobenzene Y and one acid gave another dichlorobenzene Z. ...
Synthetic Zinc Finger Transcription Factor Action at
Synthetic Zinc Finger Transcription Factor Action at

... acids 532– 624) was used as the backbone to assemble 10 distinct zinc finger DNA binding domains. The design determinants of these proteins will be described elsewhere2; however, the amino acid sequences chosen to recognize particular sequences are illustrated in Table I. Our strategy to synthesize ...
Antibiotic resistance genes are carried on plasmids
Antibiotic resistance genes are carried on plasmids

... basic part of its genetic makeup. This term is no longer commonly used for plasmids, since it is now clear that a region of homology with the chromosome such as a transposon makes a plasmid into an episome. While some plasmids like to insert themselves into the chromosome as "episomes" (what's an ep ...
SBI 4UI Review of Biochemistry Name: Learning Goals R Y G
SBI 4UI Review of Biochemistry Name: Learning Goals R Y G

... group, a carboxyl group and a side “R” group along with a H atom. It is the R group that will determine the type of amino acid. know there are essential and non-essential amino acids. know how these monomers can attach using peptide bonds to form polymers called polypeptides. The polypeptides can fo ...
3. The Molecules of Cells
3. The Molecules of Cells

... of biological molecules to the functioning of living cells and to human health • Molecular interactions, such as those between the gene for lactase production, the enzyme lactase, and the milk sugar lactose, drive all biological processes ...
Alpha oxidation
Alpha oxidation

... which on entering the krebs cycle are completely oxidised to CO2 and hence as a general rule. Fatty acid can not be used for gluconeogenesis. • However, propionate is entering into the citric acid cycle at a point after CO2 elimination steps, so propionate can be channeled to gluconeogenesis. • Thus ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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