• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Significant progress made towards individualized cancer
Significant progress made towards individualized cancer

... we have found a way to bypass this problem and demonstrate what form a practicable strategy with acceptable outlay might take. We describe both fundamental immunological insights and technological advances that should allow us to deliver truly personalized immunotherapy to cancer patients." In pre-c ...
Oped: Obama`s `precision medicine initiative` is a moon worth
Oped: Obama`s `precision medicine initiative` is a moon worth

... family tree. But Gregg, now in his 50s, has a chance to outlive his family history, because, in 1987, with federal funding, Huntsman Cancer Institute researchers identified mutations in the APC gene as the underlying cause of an inherited colon cancer predisposition called familial adenomatous polyp ...
Chapter 3: Tumor Viruses
Chapter 3: Tumor Viruses

... Transfection of DNA provides a strategy for detecting nonviral oncogenes ...
Genetic Disorders - armstrong
Genetic Disorders - armstrong

...  Sickle cell disease is most commonly found in African American populations. This disease was discovered over 80 years ago, but has not been given the attention it deserves. ...
problem set
problem set

... Genes that control cell growth and proliferation are commonly mutated in cancers (Fig. 24.11). Gain-of-function mutations that increase the activity of growth-promoting signaling molecules (I), receptors (II), intracellular signal transduction pathways (III), or TFs (IV) are associated with cancers. ...
Fig. 1 - OpenWetWare
Fig. 1 - OpenWetWare

... Renal cell carcinoma • 54,000 new cases of kidney cancer in 2008 and ~13,000 deaths – Among the 10 most common types of cancer • Treatment – Nephrectomy--surgical removal – Cryotherapy and/or radiation; poor response to chemotherapy – Several tyrosine kinase and mTOR inhibitors – Immunotherapy--IL- ...
Breast|Ovarian|Uterine26 gene list
Breast|Ovarian|Uterine26 gene list

... EPCAM ...
Human Genome Project - College Heights Secondary School
Human Genome Project - College Heights Secondary School

... • Disseminate genome information • Consider ethical, legal, and social issues associated with this research ...
Scotland - Ovarian Cancer Action
Scotland - Ovarian Cancer Action

... My maternal/paternal (select one) father/brother /uncle/grandfather/ (select one) was diagnosed with/breast cancer aged (insert age). There is a possibility that they carried a BRCA1/2 gene mutation, and if they did, there is a strong possibility that the gene will have been passed onto me. While th ...
Notes 4-4
Notes 4-4

... Engage – Discover Activity – Page 131 Objectives: 1. Explain what forms the genetic code. 2. Describe how a cell produces proteins. 3. Identify how mutations can affect an organism. 4-4 The DNA Connection A. The Genetic Code 1. The main function of genes is to control the production of proteins in a ...
medical necessity letter
medical necessity letter

... genetic testing for the above named patient. The personal and/or family history reported on the test requisition form raises significant concern for an inherited predisposition to breast cancer and indicates a reasonable probability of detecting a causative gene mutation. There are many genes known ...
Cell Mutations
Cell Mutations

... What happens when there is a mutation? ...
The 2 alleles on chromosome 13q14 must be inactivated
The 2 alleles on chromosome 13q14 must be inactivated

... differentiated pool & lose replicative potential The molecular level of antigrowth signals exert their effects on G1-S checkpoint of the cell cycle, controlled by Rb gene ...
Cancer powerpoint
Cancer powerpoint

... We are making progress: The modern drug Gleevec stops certain cancers by blocking the kinase activity of protein tyrosine kinases ...
Stem Cells from Skin Cells?!?
Stem Cells from Skin Cells?!?

... Used the animal’s own cells- no immune rejection!  Transfected with all four genes, but cmyc taken out after time- prevent tumors!  Sickle Cell Anemia has known genetic basis-so target that gene and change it back to normal!  Inject it back into the animal after radiation to reconstitute the w ...
Educational Items Section Cancer Prone Diseases Atlas of Genetics and Cytogenetics
Educational Items Section Cancer Prone Diseases Atlas of Genetics and Cytogenetics

... damage, P53 activates the transcription of genes implicated in the cell-cycle arrest and genes implicated in apoptosis; these activations allow either the cells to repair DNA damage before entering further in the cell cycle, or to be eliminated. - P53 is the most frequently (50%) mutated gene in can ...
Normal - Cancer de Mama
Normal - Cancer de Mama

... coming years! ...
Control of the Cell Cycle PPT
Control of the Cell Cycle PPT

... Production of enzymes at the wrong time Environmental factors ...
CA Breast cancer
CA Breast cancer

... Any mutations in the above genes causes breast cancer. After 1994 many other genes were discovered that were linked to the cause of breast cancer. But these genes don’t directly involve in tumor formation. ...
Jeopardy
Jeopardy

... 400 Humans have how many α and β functional hemoglobins? 400 Bonus: nonfunctional nucleotide sequences? 500 How are cDNA libraries created? Cancer 100 special genes that code proteins that promote normal cell growth and division 100 Bonus: cells that inhibit cell growth 100 Bonus: what are cancer ca ...
Mutations Can Change the Meaning of Genes
Mutations Can Change the Meaning of Genes

... How Mutations Affect Genes Mutation: any change in the nucleotide sequence of DNA  Types of Mutations:  Base substitutions: replacement of one nucleotide w/ another. May or may not affect protein  Base deletions & Base insertions:  May be more harmful b/c all subsequent codons will be altered ...
nature v. nurture
nature v. nurture

... predispositions for lots of diseases, like diabetes, cancer and heart disease." Human cells have tens of thousands of genes inside them, each with its own job, such as producing energy or overseeing cell division. But only certain genes are active at any given time or in any cell type while the rest ...
Human-Disease_DNA_Analysis-Study
Human-Disease_DNA_Analysis-Study

... d. cDNA (complementary DNA) 10. in this technique, billions of copies of DNA are made in a few hours: a. Hybridization c. Gel electrophoresis b. PCR d. Denaturation 11. Which of the following is not true about cancer: a. It is a genetic disease at the cellular level b. More than 120 kinds of cancer ...
With the completion of the human genome sequence, we now have
With the completion of the human genome sequence, we now have

... Since the completion of the human genome sequence, we now have access to more information than ever before about our genetic make-up. The human genome contains 3 billion base pairs of DNA, encoding an estimated 25,000 genes, which are the basic units of heredity. This course addresses questions such ...
Mutations - KingsfieldBiology
Mutations - KingsfieldBiology

... DNA of an organism is known as a mutation.  Mutations can occur in either somatic cells (body cell) and germ cells (those that produce the gametes (these can be passed on!)).  Changes in the structure or number of a whole chromosome is know as a chromosome mutation  Changes which affect a single ...
< 1 ... 494 495 496 497 498 499 500 501 502 504 >

Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report