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TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3
TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3

... saccharin water for one week (100 mg/kg for three days, 150 mg/kg for four days). Rats treated using this protocol are tolerant, 59,60 but show no signs of spontaneous or precipitated withdrawal. 67 Though rats are offered what are apparently relatively “high” doses of flurazepam, benzodiazepine lev ...
Insula function in anorexia nervosa
Insula function in anorexia nervosa

... various sensations as taste, the perception of pain, intestinal tension, itch, dyspnoea and temperature3. The integration of these interoceptive feelings are crucial for the establishing of the ‘self’ as it forms the link between cognitive and emotional processes and the current state of the body3. ...
Report - Ben Hayden
Report - Ben Hayden

... both risk level and behavioral preference for the risky option; the current report complements these previous findings by probing how neuronal activity in CGp contributes to the neural processes that link specific reward outcomes to individual decisions. To do this, we analyzed the activity of 58 ne ...
What is the function of the claustrum? - Christof Koch
What is the function of the claustrum? - Christof Koch

... et al. 2002). The claustrum is interconnected with the frontal lobe—including motor cortex, prefrontal cortex and cingulate cortex—visual cortical regions in the occipital lobe, temporal and temporopolar cortices, parietooccipital and posterior parietal cortex, the frontoparietal operculum, somatose ...
View/Open
View/Open

... surrounding basal regions of the brain, presumably to help control some of the body’s behavioral functions. Thus, the visual pathways can be divided roughly into an old system to the midbrain and base of the forebrain and a new system for direct transmission of visual signals into the visual cortex ...
High acetylcholine sets circuit dynamics for attention and
High acetylcholine sets circuit dynamics for attention and

... containing vasoactive intestinal protein (Porter et al., 1999). Depending on the magnitude of this direct depolarizing effect on interneurons, it can result in periods of apparent enhanced inhibition after cholinergic application in slices (McCormick and Prince, 1986) or the enhancement of inhibitio ...
Developmental structure in brain evolution
Developmental structure in brain evolution

... of multiple regressions on allometric data for 131 mammalian species, however, suggests that for 9 of 11 brain structures taxonomic and body size factors are less important than covariance of these major structures with each other. Which structure grows biggest is largely predicted by a conserved or ...
Where in the brain is morality?
Where in the brain is morality?

... social content. In other words, if brain region X were recruited more for moral than nonmoral stimuli, brain region X could be implicated in specifically moral cognition only if the two stimuli sets differed along the dimension of morality (Poldrack, 2006). However, in spite of attempts to anticipat ...
Gee JNeuro 2012 - Stanford University
Gee JNeuro 2012 - Stanford University

... which activate NMDA receptors, possibly explaining why this phenomenon has not been reported previously. Notably, we could still elicit this afterdepolarization for some time after the cessation of synaptic stimulation. In addition to NMDA receptors, the quinpirole-induced afterdepolarization also d ...
Synesthetic personification
Synesthetic personification

The role of the medial prefrontal cortex in learning and reward Ph.D
The role of the medial prefrontal cortex in learning and reward Ph.D

... During instrumental conditioning the experimenter arranges contingencies between behavior of the animal and a reinforcing outcome (independently of behavior). Several psychological processes contribute to learning and instrumental performance (Dickinson, 1994). Behavior of humans and animals is ofte ...
Effects of the Metabotropic Glutamate Receptor Antagonist MCPG
Effects of the Metabotropic Glutamate Receptor Antagonist MCPG

... consequence of PI turnover is the generation of two second messengers, diacylglycerol and phosphatidylinositol trisphosphate, leading in turn to activation of protein kinase C and the release of intracellular calcium stores (Berridge, 1984). Thus, it has been suggested that differences in the patter ...
Neuronal-Derived Nitric Oxide and Somatodendritically Released
Neuronal-Derived Nitric Oxide and Somatodendritically Released

... Correspondence should be addressed to Dr. Jessica A. Filosa, Department of Physiology, Georgia Regents University, 1120 15th Street, CA 2092, Augusta, GA 30912. E-mail: [email protected]. ...
the organization of behavioral repertoire in motor cortex
the organization of behavioral repertoire in motor cortex

... circuitry? One potential risk in studying complex actions is that it might hinder a mechanistic or reductionist understanding of movement control. Traditionally, motor control is studied by examining simple components of movements. This review, however, argues that much greater insight can be gained ...
Impaired Cl Extrusion in Layer V Pyramidal Neurons of Chronically
Impaired Cl Extrusion in Layer V Pyramidal Neurons of Chronically

... All experiments were carried out according to protocols approved by the Stanford Institutional Animal Care and Use Committee. Fortyfour Sprague-Dawley rats aged P36-46 (P0 ⫽ date of birth) were used for in vitro recordings. Partially isolated islands of sensory-motor cortex (“undercuts”) were produc ...
08. pons + midbrain
08. pons + midbrain

... -It contains subdivision part, the pars compacta, which consists of pigmented, melanin-containing neurones that synthesize dopamine as their transmitter. -It project to caudate nucleus+putamen of basal ganglia in the forebrain. --It has extra-pyramidal motor function, concerned with movements. -lesi ...
Chapter 122: Neurocircuitry Of Parkinson`s Disease
Chapter 122: Neurocircuitry Of Parkinson`s Disease

... into subcircuits, each centered on specific cortical motor and premotor areas. Associative and limbic areas project preferentially to the parvocellular part of the VA and the dorsal VL nucleus (80,155,259), and may be transmitted in turn to prefrontal cortical areas (111,198), as well as motor and s ...
Control of Appetite and Food Preference by NMDA Receptor and Its
Control of Appetite and Food Preference by NMDA Receptor and Its

... post-synaptic glutamate receptor and is important for excitatory neurotransmission. It is expressed throughout the nervous system, and is important for long-term potentiation. It requires both ligand (glutamate) and co-agonist (D-serine or glycine) for efficient opening of the channel to allow calci ...
Psilocybin Final Project-PDF
Psilocybin Final Project-PDF

... ORAL: In humans, Psilocybin and psilocin can be found in blood Plasma 20–40 min after oral administration of psilocybin Maximum levels of psilocin are achieved between 80 and 105 min The half-life• ORAL INGESTION: 2.5 hours • INTRAVENOUS: 1.23 hours 80% of Psilocin in plasma was found to be in a con ...
PDF
PDF

... Microstimulation activates not only the neuronal elements near the electrode tip, but also a network of neurons sharing connections with those directly stimulated. Thus, the effect of electrical stimulation is thought to depend on the recruitment of physiologically relevant brain circuits. Stimulati ...
gaba-mediated inhibition correlates with orientation selectivity in
gaba-mediated inhibition correlates with orientation selectivity in

... for how synaptic circuitry of the cortex performs a complex computation (Ferster and Miller, 2000). The role of inhibition in establishing sharp orientation selectivity is still debated. Several studies suggested that inhibition has no effect on sharpening orientation selectivity: neurons retain the ...
Eye fields in the frontal lobes of primates
Eye fields in the frontal lobes of primates

... agents; and Ž5. the application of various imaging procedures to localize areas involved in eye-movement control. This review focuses extensively on research conducted using these methods. We will compare and contrast the function and organization of the two eye fields in the frontal lobes based on ...
Negative mood-induction modulates default mode network resting
Negative mood-induction modulates default mode network resting

... individuals with remitted depression and healthy controls. The authors found that individuals with remitted depression showed greater connectivity between the PCC and parahippocampal gyri following the sad mood induction compared to healthy controls [11]. Whereas these previous studies reveal import ...
Print this article - University of Toronto Journal of Undergraduate Life
Print this article - University of Toronto Journal of Undergraduate Life

... occurrence of these fluctuations is due to the manner of levodopa intake [29]. It is hypothesized that orally administered levodopa stimulates dopamine receptors in a pulsatile fashion [29]. Because dopamine receptors normally receive tonic stimulation, the intermittent availability of dopamine resu ...
α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form
α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form

... a unique role in the neuropathology of Alzheimer’s disease [16]. These studies suggest that the function and pharmacology of α7-containing nAChRs in the brain may be more diverse than has previously been appreciated, and that the function of native α7 nAChRs may depend on multiple interaction partne ...
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Aging brain

Age is a major risk factor for most common neurodegenerative diseases, including Mild cognitive impairment, Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. While much research has focused on diseases of aging, there are few informative studies on the molecular biology of the aging brain (usually spelled ageing brain in British English) in the absence of neurodegenerative disease or the neuropsychological profile of healthy older adults. However, research does suggest that the aging process is associated with several structural, chemical, and functional changes in the brain as well as a host of neurocognitive changes. Recent reports in model organisms suggest that as organisms age, there are distinct changes in the expression of genes at the single neuron level. This page is devoted to reviewing the changes associated with healthy aging.
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