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Role of Prefrontal and Parietal Cortices in Associative - ACT-R
Role of Prefrontal and Parietal Cortices in Associative - ACT-R

... Dosenbach et al. 2006). They argue that activity in all these regions may reflect more general processes than just memory. Based on the ACT-R theory (Anderson, Bothell, et al. 2004), we have developed an interpretation of the activity in this circuit (e.g., Anderson 2005; Anderson et al. 2007; Danker ...
9-Sensation of Smell..
9-Sensation of Smell..

... distinguish different colors) • Buck got the idea that maybe smell receptors might be similar • She used a genetic technique called the Polymerase Chain Reaction (PCR) to find ...
The role of the medial frontal cortex in the
The role of the medial frontal cortex in the

... tested two hypotheses. We predicted that if people ‘simply maintain’ their emotional states, relative to not maintaining emotional states, participants would exhibit greater activation in the rMFC, amygdala and/or insula when maintaining emotional states. Alternatively, we predicted that if people ‘ ...
The human medial geniculate body
The human medial geniculate body

... organization, might occur in both. The present study describes several nuclei and types of neurons which could be homologous on the bases of structure and position, and a pattern of neuropil organization whose ...
Repetition suppression - Philosophical Transactions of the Royal
Repetition suppression - Philosophical Transactions of the Royal

... allows for relatively high spatial resolution measurements of human brain activity. It can therefore be used to localize neural activity to particular brain regions and map specialized psychological functions, such as face-, body- and place-related processing [9–11]. More recently, model-based fMRI ...
Pansynaptic Enlargement at Adult Cortical
Pansynaptic Enlargement at Adult Cortical

... enables the effects of either experience-dependent plasticity or perceptual learning (Guic-Robles et al. 1989; Harris et al. 1999) on the structure–function relationship at synapses to be studied in SI after altering whisker sensory input. Trimming a subset of the whiskers of mature rats for weeks r ...
Glutamate Inhibits GABA Excitatory Activity in
Glutamate Inhibits GABA Excitatory Activity in

... suggesting an ongoing spontaneous glutamate-mediated inhibition of excitatory GABA actions in developing neurons. Northern blots revealed that many mGluRs were expressed early in brain development, including times of synaptogenesis. Together these data suggest that in developing neurons glutamate ca ...
The role of the medial frontal cortex in the maintenance of emotional
The role of the medial frontal cortex in the maintenance of emotional

... generation of emotional responses, such as the rostral medial frontal cortex (rMFC), amygdala and/or insula. The rMFC is involved with the ‘meaning-making’ of emotional stimuligenerating the primary appraisals of the salience and relevance of emotional stimuli to the self (Roy et al., 2012), and th ...
cortical input to the basal forebrain
cortical input to the basal forebrain

... Abstract––The arborization pattern and postsynaptic targets of corticofugal axons in basal forebrain areas have been studied by the combination of anatomical tract-tracing and pre- and postembedding immunocytochemistry. The anterograde neuronal tracer Phaseolus vulgaris leucoagglutinin was iontophor ...
Lecture 016, CNS1 - SuperPage for Joel R. Gober, PhD.
Lecture 016, CNS1 - SuperPage for Joel R. Gober, PhD.

... circuits can be diverging, they can be converging or reverberating. These are the different ways that we talk about certain kinds of circuits. So for instance diverging circuits means that there’s going to be one neuron that’s going to share information with a number of other neurons, distally to t ...
Afferents of dopamine neurons
Afferents of dopamine neurons

... Bolam, Francis and Henderson (1991) Neuroscience 41:483-494 Ross, Mena-Segovia, Magill and Bolam unpublished ...
Modulation of early cortical processing during divided attention to
Modulation of early cortical processing during divided attention to

... 2011). Given the behavioral findings for the blinking spotlight hypothesis (VanRullen et al., 2007), there are three different possible scenarios for attentional suppression under this model (see Predictions section in Materials and methods). The current study therefore examined the topographic distr ...
Neurobiological Mechanisms of the Placebo Effect
Neurobiological Mechanisms of the Placebo Effect

... administration of a drug has a more powerful effect on brain metabolism than the unexpected administration (Volkow et al., 2003). These findings show that drug effects are reduced if expectations are absent and underscore how the knowledge about a treatment affects the therapeutic outcome. The place ...
The Big Picture File
The Big Picture File

... acetylcholine acts at the ganglia and at synapses between autonomic nerves and targets SS also uses norepinephrine and epinephrine (noradrenalin and adrenalin) operates at four major receptor types, collectively called adrenoreceptors http://pharmacology-notes-free.blogspot.co.uk/2012/01/neurotransm ...
Brain stem excitatory and inhibitory signaling pathways regulating
Brain stem excitatory and inhibitory signaling pathways regulating

... smooth muscle relaxation (212). Similarly, peripheral chemoreceptors and baroreceptors acting centrally can readily affect cholinergic outflow to the airways. Although stimulation of the carotid bodies reflexly elicits bronchoconstriction (157) and submucosal gland secretion (50) and facilitates bro ...
GABA - International Journal of Pharma and Bio Sciences
GABA - International Journal of Pharma and Bio Sciences

... conformation of GABA was responsible for activating the receptor, Johnson and his colleagues synthesised a number of conformationally restricted analogues of GABA and noted that cis-4-aminocrotonic acid (CACA), which has a partially folded conformation, depressed the firing of cat spinal neurones in ...
Role of High-Affinity Receptors and Membrane Transporters in
Role of High-Affinity Receptors and Membrane Transporters in

... between neurons and between axon terminals and target cells has advanced significantly since Elliott (1904), Loewi (1921), and Dale (1934) first elaborated on the concept that epinephrine and acetylcholine (ACh)2 are released from the neuron and may be able to transmit signals toward target cells. T ...
download file
download file

... increases synchronization, and decreasing receptive Weld size by pairing diVerent tone frequencies with NB stimulation decreases synchronization. These observations seem to support the conclusion that neural synchronization is simply an artifact caused by common inputs. However, pairing tone trains ...
MMNeuropharm2011
MMNeuropharm2011

... a single dose. In the case of nicotine, a presynaptic increase in glutamate release through alpha7-containing receptors may represent the trigger for a more enduring plasticity (Mansvelder and McGehee, 2000). On the other hand benzodiazepines trigger the plasticity by dishinibiting the DA neurons vi ...
- Hayden Lab
- Hayden Lab

... the value of the safe offer) was lower than for medium (blue) gambles (0.52). This difference, and also the fact that both large- and medium-reward PSEs were lower than 1, indicates strong riskseeking tendencies (cf. McCoy and Platt, 2005). This riskseeking pattern is consistent with what we and oth ...
Making Mirrors: Premotor Cortex Stimulation
Making Mirrors: Premotor Cortex Stimulation

... of the timing of the influence of PMv on M1 during mirror motor facilitation. Moreover, the same technique can be used to compare the influence exerted by PMv and PMd. In paired-pulse TMS, a conditioning pulse is applied to the brain area under investigation. This areaʼs task-related influence on M1 ...
primary visual cortex and visual awareness
primary visual cortex and visual awareness

... Visual attention can be directed to a particular region of space, visual feature or object, and can enhance the neural processing of attended stimuli and suppress the processing of irrelevant stimuli. Behavioural studies indicate that attention is necessary but not sufficient for visual awareness — ...
Dorsal Anterior Cingulate Cortex: A Bottom-Up View
Dorsal Anterior Cingulate Cortex: A Bottom-Up View

... The function of the dorsal anterior cingulate cortex (dACC) is one of the major puzzles in cognitive and systems neuroscience. Papez (1937) classified the entire cingulum as part of the brain’s limbic system, thus linking the dACC with emotional processes. Early human lesion studies certainly suppor ...
neural representation and the cortical code
neural representation and the cortical code

... The content of a neuronal signal is the message or information that the signal provides when decoded. This can be assessed using the classical approach based upon the tuning curve, or it can be assessed using more recent stimulus reconstruction methods. Studies of tuning in each sensory modality hav ...
Thalamocortical inputs trigger a propagating envelope of gamma
Thalamocortical inputs trigger a propagating envelope of gamma

... can be visualized by staining for AChE (Robertson et al. 1991; Broide et al. 1996). In the auditory system, AChE is expressed by neurons in the ventral division of the MG (MGv) and delineates the extent of their terminal arbors in the middle layers of primary auditory cortex (Robertson et al. 1991). ...
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Aging brain

Age is a major risk factor for most common neurodegenerative diseases, including Mild cognitive impairment, Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. While much research has focused on diseases of aging, there are few informative studies on the molecular biology of the aging brain (usually spelled ageing brain in British English) in the absence of neurodegenerative disease or the neuropsychological profile of healthy older adults. However, research does suggest that the aging process is associated with several structural, chemical, and functional changes in the brain as well as a host of neurocognitive changes. Recent reports in model organisms suggest that as organisms age, there are distinct changes in the expression of genes at the single neuron level. This page is devoted to reviewing the changes associated with healthy aging.
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