Identifying producers of antibacterial compounds by
... Microbially derived natural products are major sources of antibiotics and other medicines, but discovering new antibiotic scaffolds and increasing the chemical diversity of existing ones are formidable challenges. We have designed a screen to exploit the self-protection mechanism of antibiotic produ ...
... Microbially derived natural products are major sources of antibiotics and other medicines, but discovering new antibiotic scaffolds and increasing the chemical diversity of existing ones are formidable challenges. We have designed a screen to exploit the self-protection mechanism of antibiotic produ ...
List of abbreviations
... countries with more than one study, the most recent figures are included. 1 ...
... countries with more than one study, the most recent figures are included. 1 ...
Cells: building blocks of living organisms
... Organelles are discrete structures having specialized functions ...
... Organelles are discrete structures having specialized functions ...
Editorial Noncoding RNAs
... 959 cells; whereas a similar number of protein coding genes (∼25,000) in humans drives development and function of over 10 trillion cells. One major difference between the worm and human genomes is the relative proportion of noncoding DNA, which is seen to increase with complexity of body plan and ce ...
... 959 cells; whereas a similar number of protein coding genes (∼25,000) in humans drives development and function of over 10 trillion cells. One major difference between the worm and human genomes is the relative proportion of noncoding DNA, which is seen to increase with complexity of body plan and ce ...
Lecture 1 - "Hudel" Luecke
... Proteins are very complicated moleucules. With 20 different amino acids that can be arranged in any order to make a polypeptide of up to thousands of amino acids long, their potential for variety is extraordinary. This variety allows proteins to function as exquisitely specific enzymes that compose ...
... Proteins are very complicated moleucules. With 20 different amino acids that can be arranged in any order to make a polypeptide of up to thousands of amino acids long, their potential for variety is extraordinary. This variety allows proteins to function as exquisitely specific enzymes that compose ...
Class I tRNA
... RNA is concentrated at the interface with the 50S subunit. Both 30S and 50S subunits are self-assembled in vitro. In 30S subunit, S4 and S8 bind to 16S rRNA first, other proteins then join sequentially and cooperatively. ...
... RNA is concentrated at the interface with the 50S subunit. Both 30S and 50S subunits are self-assembled in vitro. In 30S subunit, S4 and S8 bind to 16S rRNA first, other proteins then join sequentially and cooperatively. ...
The Nrf2/ARE Pathway as a Potential Therapeutic Target in
... channel blocker, riluzole. Huntington’s disease has no approved therapeutics. In all cases, the approved therapeutics target neuronal activity, generally by affecting neurotransmitters or their receptors. The aim is usually to compensate for damage that has already occurred. Therefore, present thera ...
... channel blocker, riluzole. Huntington’s disease has no approved therapeutics. In all cases, the approved therapeutics target neuronal activity, generally by affecting neurotransmitters or their receptors. The aim is usually to compensate for damage that has already occurred. Therefore, present thera ...
Synonymous codon usage patterns in different parasitic
... 1996). Analysis of the synonymous codon usage pattern can improve our understanding of the mechanisms of biased usage of synonymous codons (Powell and Moriyama, 1997). The profiles of synonymous codon usage can reveal information about the molecular evolution of individual genes. They can also provi ...
... 1996). Analysis of the synonymous codon usage pattern can improve our understanding of the mechanisms of biased usage of synonymous codons (Powell and Moriyama, 1997). The profiles of synonymous codon usage can reveal information about the molecular evolution of individual genes. They can also provi ...
Identification of genes specifically required for the
... a hypothetical protein, whereas Gmet 2410 and Gmet 3229 are predicted to encode a superoxide dismutase, and a thioredoxinrelated protein, respectively. The strain in which Gmet 2833 was deleted was deficient in phenol metabolism as well as benzene metabolism (Figure 2), indicating that this gene of ...
... a hypothetical protein, whereas Gmet 2410 and Gmet 3229 are predicted to encode a superoxide dismutase, and a thioredoxinrelated protein, respectively. The strain in which Gmet 2833 was deleted was deficient in phenol metabolism as well as benzene metabolism (Figure 2), indicating that this gene of ...
488KB - The Doudna Lab - University of California, Berkeley
... N-terminal ATPase/DExD helicase domain, a small domain of unknown function (DUF283) and a C-terminal dsRNA-binding domain11. A sixth domain called PAZ is located a variable distance upstream of the two catalytic domains. Notably, a few Dicers seem to lack either the ATPase/ helicase domain or dsRNA- ...
... N-terminal ATPase/DExD helicase domain, a small domain of unknown function (DUF283) and a C-terminal dsRNA-binding domain11. A sixth domain called PAZ is located a variable distance upstream of the two catalytic domains. Notably, a few Dicers seem to lack either the ATPase/ helicase domain or dsRNA- ...
Rabbit genome editing with zinc finger nucleases
... selected parameter is chosen from (a) rate of elimination of the agent or its metabolite(s); (b) circulatory levels of the agent or its metabolite(s); (c) bioavailability of the agent or its metabolite(s); (d) rate of metabolism of the agent or its metabolite(s); (e) rate of clearance of the agent o ...
... selected parameter is chosen from (a) rate of elimination of the agent or its metabolite(s); (b) circulatory levels of the agent or its metabolite(s); (c) bioavailability of the agent or its metabolite(s); (d) rate of metabolism of the agent or its metabolite(s); (e) rate of clearance of the agent o ...
Identification of Functional Connections Between Calmodulin and the Yeast Actin Cytoskeleton.
... (Johnston et al. 1991; Brockerhoff et al. 1994) and the other is Nuf1p (Geiser et al. 1993; Kilmartin et al. 1993; Stirling et al. 1994). Myo2p is a class V myosin that is involved in polarized growth and functionally implicated in a post-Golgi stage of the secretory pathway (Johnston et al. 1991; G ...
... (Johnston et al. 1991; Brockerhoff et al. 1994) and the other is Nuf1p (Geiser et al. 1993; Kilmartin et al. 1993; Stirling et al. 1994). Myo2p is a class V myosin that is involved in polarized growth and functionally implicated in a post-Golgi stage of the secretory pathway (Johnston et al. 1991; G ...
The potential for toxin and antitoxin gene
... of decay after plasmid loss to enable PSK. My results suggest there is likely to be an evolutionary trend toward TA systems with high expression levels of very unstable antitoxins. Secreted barnase was also tested experimentally for its ability to induce PSK similar to bacteriocins, which exhibit a ...
... of decay after plasmid loss to enable PSK. My results suggest there is likely to be an evolutionary trend toward TA systems with high expression levels of very unstable antitoxins. Secreted barnase was also tested experimentally for its ability to induce PSK similar to bacteriocins, which exhibit a ...
TRANSLATION OF mRNA - E-Learning/An
... amino acid glycine. The codon AUG, which specifies methionine, is used as a start codon; it is usually the first codon that begins a polypeptide sequence. The AUG codon can also be used to specify additional methionines within the coding sequence. Finally, three codons are used to end the process of ...
... amino acid glycine. The codon AUG, which specifies methionine, is used as a start codon; it is usually the first codon that begins a polypeptide sequence. The AUG codon can also be used to specify additional methionines within the coding sequence. Finally, three codons are used to end the process of ...
Mutations to nonsense codons in human genetic
... the intervening years, there are several attractive aspects to such a strategy. First, tRNA genes have strong promoters, which are active in all cell types. The promoters for eukaryotic tRNA genes lie within the structural sequences encoding the tRNA molecule itself (2). Although there are elements ...
... the intervening years, there are several attractive aspects to such a strategy. First, tRNA genes have strong promoters, which are active in all cell types. The promoters for eukaryotic tRNA genes lie within the structural sequences encoding the tRNA molecule itself (2). Although there are elements ...
SCL and associated proteins distinguish active from
... HS2 of the human -globin locus control region (LCR), although the spacing between them is slightly larger.39 SCL is expressed at both early and late stages of hematopoietic development and is essential for normal hematopoietic stem cell (HSC) formation and later for the full differentiation of eryt ...
... HS2 of the human -globin locus control region (LCR), although the spacing between them is slightly larger.39 SCL is expressed at both early and late stages of hematopoietic development and is essential for normal hematopoietic stem cell (HSC) formation and later for the full differentiation of eryt ...
Minimal metabolic pathway structure is consistent with
... constraints of the network. The MinSpan pathways have a couple notable properties. First, unlike convex analysis approaches (Llaneras & Pico, 2010), MinSpan pathways can be computed for genome-scale metabolic networks. Second, the sparsest basis (Fig 1B) maximally segregates the network into cluster ...
... constraints of the network. The MinSpan pathways have a couple notable properties. First, unlike convex analysis approaches (Llaneras & Pico, 2010), MinSpan pathways can be computed for genome-scale metabolic networks. Second, the sparsest basis (Fig 1B) maximally segregates the network into cluster ...
Chromatin Association of Gcn4 Is Limited by Post
... domains that recognize DNA elements referred to as upstream activator sequences (UAS) in budding yeast, located proximal to their cognate promoters, or enhancers in higher eukaryotes, which can be situated several hundred kilobases away from the genes that they regulate (Hahn and Young 2011; Shlyuev ...
... domains that recognize DNA elements referred to as upstream activator sequences (UAS) in budding yeast, located proximal to their cognate promoters, or enhancers in higher eukaryotes, which can be situated several hundred kilobases away from the genes that they regulate (Hahn and Young 2011; Shlyuev ...
The SOX9 upstream region prone to chromosomal aberrations
... existing in strategies available to prevent and treat these diseases. Post-transcriptional and post-translational mechanisms undoubtedly participate in modulating SOX9 protein level and activity, but above that, it is clear that transcription is a first and critical level of regulation of SOX9 (6). ...
... existing in strategies available to prevent and treat these diseases. Post-transcriptional and post-translational mechanisms undoubtedly participate in modulating SOX9 protein level and activity, but above that, it is clear that transcription is a first and critical level of regulation of SOX9 (6). ...
Molecular evolutionary analysis of the American pika
... inhabiting alpine environments. For alpine mammals, metabolic heat production and cellular mechanisms to cope with hypoxia are critical for survival and reproduction. Thus, because of the pikas’ long association with alpine environments, they may have genetically adapted to alpine conditions. Here, ...
... inhabiting alpine environments. For alpine mammals, metabolic heat production and cellular mechanisms to cope with hypoxia are critical for survival and reproduction. Thus, because of the pikas’ long association with alpine environments, they may have genetically adapted to alpine conditions. Here, ...
Myocyte Enhancer Factor 2 Transcription Factors in Heart
... are highly-regulated by signaling cascades that control MEF2’s function as a transcriptional switch. We highlight the many signaling pathways and kinases that regulate MEF2-HDAC interactions, MEF2 post-translational modification, and how these pathways influence MEF2 activity. We also discuss the ge ...
... are highly-regulated by signaling cascades that control MEF2’s function as a transcriptional switch. We highlight the many signaling pathways and kinases that regulate MEF2-HDAC interactions, MEF2 post-translational modification, and how these pathways influence MEF2 activity. We also discuss the ge ...
PDF
... 973,749 bp (termed FERRO_contig000001), 962,266 bp (FERRO_contig000002) and 59,722 bp (FERRO_contig000001). The gaps between these contigs are thought to contain ribosomal RNA gene clusters since both ends of FERRO_contig000001 and one end of each of the other two contigs contain ribosomal RNA genes ...
... 973,749 bp (termed FERRO_contig000001), 962,266 bp (FERRO_contig000002) and 59,722 bp (FERRO_contig000001). The gaps between these contigs are thought to contain ribosomal RNA gene clusters since both ends of FERRO_contig000001 and one end of each of the other two contigs contain ribosomal RNA genes ...
How Does the Polled Trait Work?
... The Jersey bull we’re offering now, Akhenaton of Netherhall-PP is also homozygous polled. We will continue to test promising young polled bulls to develop more homozygous polled sires, while still selecting for the other important traits. On the facing page we show several Punnett squares, such as y ...
... The Jersey bull we’re offering now, Akhenaton of Netherhall-PP is also homozygous polled. We will continue to test promising young polled bulls to develop more homozygous polled sires, while still selecting for the other important traits. On the facing page we show several Punnett squares, such as y ...