Downloaded - Stem-cell and Brain Research Institute
... receptors such as Rev-erb␣, because fenofibrate, a PPAR␣ agonist, induces human and rat rev-erb␣ expression in liver through the direct binding of PPAR␣ on an atypical DR2 element located in the rev-erb␣ promoter (30, 43). It was recently shown that CLOCK plays an important role in lipid homeostasis ...
... receptors such as Rev-erb␣, because fenofibrate, a PPAR␣ agonist, induces human and rat rev-erb␣ expression in liver through the direct binding of PPAR␣ on an atypical DR2 element located in the rev-erb␣ promoter (30, 43). It was recently shown that CLOCK plays an important role in lipid homeostasis ...
Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant
... matrix) and at the cell surface as constituents of proteoglycans. These sugars, apart from having important structural roles in the ECM, are also fundamental modulators of many biological processes, such as development, cell proliferation, signalling and inflammation [1–3]. The great chemical hetero ...
... matrix) and at the cell surface as constituents of proteoglycans. These sugars, apart from having important structural roles in the ECM, are also fundamental modulators of many biological processes, such as development, cell proliferation, signalling and inflammation [1–3]. The great chemical hetero ...
Complex cocktails: the evolutionary novelty of venoms
... bioactive compounds. Venoms typically comprise a mixture of protein and peptides (commonly referred to as toxins), salts and organic components, such as amino acids and neurotransmitters [6,7,12–14]. The proteinaceous components are usually the most abundant. The composition and targeting of venom s ...
... bioactive compounds. Venoms typically comprise a mixture of protein and peptides (commonly referred to as toxins), salts and organic components, such as amino acids and neurotransmitters [6,7,12–14]. The proteinaceous components are usually the most abundant. The composition and targeting of venom s ...
Journal of Microbiology and Biotechnology
... In this study, evidences of IAA intermediates of IPA, IAAld, ILA, IAA, and TOL in the culture supernatant and feeding experiments suggested the existence of the only IPA pathway for IAA biosynthesis of P. polymyxa E681 (Fig. 2). Results of the IAA intermediates accumulated in the E681 culture demons ...
... In this study, evidences of IAA intermediates of IPA, IAAld, ILA, IAA, and TOL in the culture supernatant and feeding experiments suggested the existence of the only IPA pathway for IAA biosynthesis of P. polymyxa E681 (Fig. 2). Results of the IAA intermediates accumulated in the E681 culture demons ...
High Resolution Two-Dimensional Electrophoresis of Proteins*
... by a chase period of 30 min during which time the nematodes were fed unlabeled E. coli. After this time no labeled E. coli proteins could be detected. Sample ...
... by a chase period of 30 min during which time the nematodes were fed unlabeled E. coli. After this time no labeled E. coli proteins could be detected. Sample ...
PDF - Journal of Rare Disorders
... DNA muta ons are involved, disease manifests in early childhood and have more severe and diffuse expression. Unlike nuclear DNA muta ons, mitochondrial muta ons manifest the disease in adulthood with more indolent and mosaic fashion.31,32 The increasing clinical and gene c het ...
... DNA muta ons are involved, disease manifests in early childhood and have more severe and diffuse expression. Unlike nuclear DNA muta ons, mitochondrial muta ons manifest the disease in adulthood with more indolent and mosaic fashion.31,32 The increasing clinical and gene c het ...
Bioinformatics analysis of FRG1
... laevis (Hanel et al. 2009). Temporal analysis of frg1 mRNA levels by qRT-PCR showed a peak before midblastula transition (MBT), which is attributed to maternal stores of frg1. But, after MBT through stage 41, the transcript levels decreased progressively, suggesting an early requirement in developme ...
... laevis (Hanel et al. 2009). Temporal analysis of frg1 mRNA levels by qRT-PCR showed a peak before midblastula transition (MBT), which is attributed to maternal stores of frg1. But, after MBT through stage 41, the transcript levels decreased progressively, suggesting an early requirement in developme ...
BIOS QTL browser - BBMRI-NL
... The BIOS consortium aims at integrating these layers of data, in order to uncover molecular pathways involved in health and disease. ...
... The BIOS consortium aims at integrating these layers of data, in order to uncover molecular pathways involved in health and disease. ...
PpASCL, a moss ortholog of antherspecific chalcone synthaselike
... P. patens ortholog of Arabidopsis PKSA. We also generated structure models of PpASCL and Arabidopsis PKSA to study their substrate specificity. • Physcomitrella patens orthologs of Arabidopsis genes for sporopollenin biosynthesis were found to be expressed in the sporophyte generation. Similarly to ...
... P. patens ortholog of Arabidopsis PKSA. We also generated structure models of PpASCL and Arabidopsis PKSA to study their substrate specificity. • Physcomitrella patens orthologs of Arabidopsis genes for sporopollenin biosynthesis were found to be expressed in the sporophyte generation. Similarly to ...
The mitochondrial carnitine/acylcarnitine carrier: Function
... Oxidation of fatty acids in mitochondria coupled to oxidative phosphorylation is the most important pathway for the production of metabolic energy during fasting. This process occurs in the mitochondrial matrix where the enzymes of fatty acid b-oxidation are located. Fatty acyl groups are transporte ...
... Oxidation of fatty acids in mitochondria coupled to oxidative phosphorylation is the most important pathway for the production of metabolic energy during fasting. This process occurs in the mitochondrial matrix where the enzymes of fatty acid b-oxidation are located. Fatty acyl groups are transporte ...
Practice Guidelines for the Molecular Diagnosis of Haemophilia B.
... • Could the ethnic origin of the patient affect interpretation of polymorphism/candidate mutation status for a given base change? The family should be tested to determine whether the nucleotide alteration tracks with the disease and a panel of normal DNA samples of the same ethnic origin (where poss ...
... • Could the ethnic origin of the patient affect interpretation of polymorphism/candidate mutation status for a given base change? The family should be tested to determine whether the nucleotide alteration tracks with the disease and a panel of normal DNA samples of the same ethnic origin (where poss ...
Cloning and Polymorphisms of Yak Lactate Dehydrogenase b Gene
... LDH activity in heart and skeletal muscles has been reported in pikas from high altitudes when compared to pikas from low altitudes, which helps the pikas in high altitudes to improve anaerobic activity and to enhance lactate removal in muscles [4], since high LDH activity can catalyze more pyruvate ...
... LDH activity in heart and skeletal muscles has been reported in pikas from high altitudes when compared to pikas from low altitudes, which helps the pikas in high altitudes to improve anaerobic activity and to enhance lactate removal in muscles [4], since high LDH activity can catalyze more pyruvate ...
Single Processing Center Models for Human Dicer and Bacterial
... Dicer is a multidomain ribonuclease that processes double-stranded RNAs (dsRNAs) to 21 nt small interfering RNAs (siRNAs) during RNA interference, and excises microRNAs from precursor hairpins. Dicer contains two domains related to the bacterial dsRNAspecific endonuclease, RNase III, which is known ...
... Dicer is a multidomain ribonuclease that processes double-stranded RNAs (dsRNAs) to 21 nt small interfering RNAs (siRNAs) during RNA interference, and excises microRNAs from precursor hairpins. Dicer contains two domains related to the bacterial dsRNAspecific endonuclease, RNase III, which is known ...
structure and mechanism of dna polymerases
... region. The 8‐kDa domain contains a 5’‐deoxyribose phosphate (dRP) lyase activity that is needed for the process of BER, whereas the large domain contains the DNA polymerase. During BER, the phosphodiester backbone of an abasic site is cleaved 5’ to the sugar moiety by an abasic site endonuclease (M ...
... region. The 8‐kDa domain contains a 5’‐deoxyribose phosphate (dRP) lyase activity that is needed for the process of BER, whereas the large domain contains the DNA polymerase. During BER, the phosphodiester backbone of an abasic site is cleaved 5’ to the sugar moiety by an abasic site endonuclease (M ...
SQA CfE Higher Human Biology Unit 1: Human Cells
... All living things are characterised by levels of organisation that are hierarchical. The cell is the lowest level of organisation that can exist independently. Multicellular organisms, like humans, have cells organised into groups of cells called tissues, the next level of organisation. Tissues are ...
... All living things are characterised by levels of organisation that are hierarchical. The cell is the lowest level of organisation that can exist independently. Multicellular organisms, like humans, have cells organised into groups of cells called tissues, the next level of organisation. Tissues are ...
Mutant selection and phenotypic and genetic characterization of
... To date, there remains a discrepancy between the tolerance of C. thermocellum to exogenously added ethanol and the maximum levels of ethanol produced by this organism. While strains tolerant to exogenously added ethanol have been isolated, a concomitant increase in ethanol titer has not occurred in ...
... To date, there remains a discrepancy between the tolerance of C. thermocellum to exogenously added ethanol and the maximum levels of ethanol produced by this organism. While strains tolerant to exogenously added ethanol have been isolated, a concomitant increase in ethanol titer has not occurred in ...
Plant and Soil.
... of view. Analyses of ribosomal RNA gene sequences provide a solid basis to infer phylogenies in the Rhizobiaceae family. These studies confirmed that Rhizobium and Bradyrhizobium are only distantly related and showed that Rh&obium and Bradyrhizobium are related to other groups of bacteria that are n ...
... of view. Analyses of ribosomal RNA gene sequences provide a solid basis to infer phylogenies in the Rhizobiaceae family. These studies confirmed that Rhizobium and Bradyrhizobium are only distantly related and showed that Rh&obium and Bradyrhizobium are related to other groups of bacteria that are n ...
Pseudouridine at position 55 in tRNA controls the contents of other
... hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these mutant proteins. Nucleoside analysis revealed that ...
... hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these mutant proteins. Nucleoside analysis revealed that ...
Attachment 2 - Food Standards Australia New Zealand
... been genetically modified (GM) for tolerance to the herbicide glyphosate. The modified sugar beet is referred to as glyphosate-tolerant sugar beet line H7-1 but is know commercially as Roundup Ready® sugar beet. Weed competition in commercial sugarbeet fields constitutes a significant crop productio ...
... been genetically modified (GM) for tolerance to the herbicide glyphosate. The modified sugar beet is referred to as glyphosate-tolerant sugar beet line H7-1 but is know commercially as Roundup Ready® sugar beet. Weed competition in commercial sugarbeet fields constitutes a significant crop productio ...
From Sequence to Structure
... Replication of the AIDS virus HIV depends on the action of a protein-cleaving enzyme called HIV protease. This enzyme is the target for protease-inhibitor drugs (shown in grey). (PDB 1a8k) ...
... Replication of the AIDS virus HIV depends on the action of a protein-cleaving enzyme called HIV protease. This enzyme is the target for protease-inhibitor drugs (shown in grey). (PDB 1a8k) ...
Unsaturated Fatty Acids Increase Plasminogen Activator Inhibitor
... Abstract—In vivo studies have demonstrated a strong positive correlation between plasma very low density lipoprotein (VLDL) triglyceride and plasma plasminogen activator inhibitor-1 (PAI-1) activity levels. Furthermore, VLDL has been shown to induce PAI-1 secretion from cultured endothelial cells. I ...
... Abstract—In vivo studies have demonstrated a strong positive correlation between plasma very low density lipoprotein (VLDL) triglyceride and plasma plasminogen activator inhibitor-1 (PAI-1) activity levels. Furthermore, VLDL has been shown to induce PAI-1 secretion from cultured endothelial cells. I ...